Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants

The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs...
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Gespeichert in:

Autor*in:	Efrosiniia Talalai [verfasserIn] Denis Gorobets [verfasserIn] Gilad Halpert [verfasserIn] Avishai M. Tsur [verfasserIn] Harald Heidecke [verfasserIn] Yair Levy [verfasserIn] Abdulla Watad [verfasserIn] Miri Blank [verfasserIn] Izhak Michaelevski [verfasserIn] Yehuda Shoenfeld [verfasserIn] Howard Amital [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	silicone breast implants autoantibodies autonomic nervous system dysautonomia G-protein coupled-receptors

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 12(2023), 11, p 1510
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:11, p 1510

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells12111510

Katalog-ID:	DOAJ094280274

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spelling	10.3390/cells12111510 doi (DE-627)DOAJ094280274 (DE-599)DOAJ6dbb89bd1a114119861f1fecc72767a1 DE-627 ger DE-627 rakwb eng QH573-671 Efrosiniia Talalai verfasserin aut Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness. silicone breast implants autoantibodies autonomic nervous system dysautonomia G-protein coupled-receptors Cytology Denis Gorobets verfasserin aut Gilad Halpert verfasserin aut Avishai M. Tsur verfasserin aut Harald Heidecke verfasserin aut Yair Levy verfasserin aut Abdulla Watad verfasserin aut Miri Blank verfasserin aut Izhak Michaelevski verfasserin aut Yehuda Shoenfeld verfasserin aut Howard Amital verfasserin aut In Cells MDPI AG, 2012 12(2023), 11, p 1510 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:12 year:2023 number:11, p 1510 https://doi.org/10.3390/cells12111510 kostenfrei https://doaj.org/article/6dbb89bd1a114119861f1fecc72767a1 kostenfrei https://www.mdpi.com/2073-4409/12/11/1510 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1510
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allfieldsSound	10.3390/cells12111510 doi (DE-627)DOAJ094280274 (DE-599)DOAJ6dbb89bd1a114119861f1fecc72767a1 DE-627 ger DE-627 rakwb eng QH573-671 Efrosiniia Talalai verfasserin aut Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness. silicone breast implants autoantibodies autonomic nervous system dysautonomia G-protein coupled-receptors Cytology Denis Gorobets verfasserin aut Gilad Halpert verfasserin aut Avishai M. Tsur verfasserin aut Harald Heidecke verfasserin aut Yair Levy verfasserin aut Abdulla Watad verfasserin aut Miri Blank verfasserin aut Izhak Michaelevski verfasserin aut Yehuda Shoenfeld verfasserin aut Howard Amital verfasserin aut In Cells MDPI AG, 2012 12(2023), 11, p 1510 (DE-627)718622081 (DE-600)2661518-6 20734409 nnns volume:12 year:2023 number:11, p 1510 https://doi.org/10.3390/cells12111510 kostenfrei https://doaj.org/article/6dbb89bd1a114119861f1fecc72767a1 kostenfrei https://www.mdpi.com/2073-4409/12/11/1510 kostenfrei https://doaj.org/toc/2073-4409 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 11, p 1510
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callnumber-first	Q - Science
author	Efrosiniia Talalai
spellingShingle	Efrosiniia Talalai misc QH573-671 misc silicone breast implants misc autoantibodies misc autonomic nervous system misc dysautonomia misc G-protein coupled-receptors misc Cytology Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
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topic_title	QH573-671 Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants silicone breast implants autoantibodies autonomic nervous system dysautonomia G-protein coupled-receptors
topic	misc QH573-671 misc silicone breast implants misc autoantibodies misc autonomic nervous system misc dysautonomia misc G-protein coupled-receptors misc Cytology
topic_unstemmed	misc QH573-671 misc silicone breast implants misc autoantibodies misc autonomic nervous system misc dysautonomia misc G-protein coupled-receptors misc Cytology
topic_browse	misc QH573-671 misc silicone breast implants misc autoantibodies misc autonomic nervous system misc dysautonomia misc G-protein coupled-receptors misc Cytology
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title	Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
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title_full	Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
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author_browse	Efrosiniia Talalai Denis Gorobets Gilad Halpert Avishai M. Tsur Harald Heidecke Yair Levy Abdulla Watad Miri Blank Izhak Michaelevski Yehuda Shoenfeld Howard Amital
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title_sort	functional igg autoantibodies against autonomic nervous system receptors in symptomatic women with silicone breast implants
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title_auth	Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
abstract	The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness.
abstractGer	The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness.
abstract_unstemmed	The association between the clinical picture of symptomatic women with silicone breast implants (SBI) and dysregulated immunity was in dispute for decades. In the current study, we describe for the first time the functional activity of purified IgG antibodies derived from symptomatic women with SBIs (suffering from subjective/autonomic-related symptoms), both in vitro and in vivo. We found that IgGs, derived from symptomatic women with SBIs, dysregulate inflammatory cytokines (TNFα, IL-6) in activated human peripheral blood mononuclear cells, compared to healthy-women-derived IgGs. Importantly, behavioral studies conducted following intracerebroventricular injection of IgGs derived from symptomatic women with SBIs (who have dysregulated circulating level of IgG autoantibodies directed against autonomic nervous system receptors) into mice brains demonstrated a specific and transient significant increment (about 60%) in the time spent at the center of the open field arena compared with mice injected with IgG from healthy women (without SBIs). This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. Our study is the first to show the potential pathogenic activity of IgG autoantibodies in symptomatic women with SBIs, emphasizing the importance of these antibodies in SBI-related illness.
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title_short	Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants
url	https://doi.org/10.3390/cells12111510 https://doaj.org/article/6dbb89bd1a114119861f1fecc72767a1 https://www.mdpi.com/2073-4409/12/11/1510 https://doaj.org/toc/2073-4409
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author2	Denis Gorobets Gilad Halpert Avishai M. Tsur Harald Heidecke Yair Levy Abdulla Watad Miri Blank Izhak Michaelevski Yehuda Shoenfeld Howard Amital
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up_date	2024-07-03T22:17:30.231Z
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This effect was accompanied with a strong trend of reduction of the locomotor activity of the SBI-IgG treated mice, indicating an overall apathic-like behavior. 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Functional IgG Autoantibodies against Autonomic Nervous System Receptors in Symptomatic Women with Silicone Breast Implants

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