Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation
Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last fo...
Ausführliche Beschreibung
Autor*in: |
Umit M. Sahiner [verfasserIn] Mattia Giovannini [verfasserIn] Maria M. Escribese [verfasserIn] Giovanni Paoletti [verfasserIn] Enrico Heffler [verfasserIn] Montserrat Alvaro Lozano [verfasserIn] Domingo Barber [verfasserIn] Giorgio Walter Canonica [verfasserIn] Oliver Pfaar [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Journal of Personalized Medicine - MDPI AG, 2012, 13(2023), 5, p 845 |
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Übergeordnetes Werk: |
volume:13 ; year:2023 ; number:5, p 845 |
Links: |
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DOI / URN: |
10.3390/jpm13050845 |
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Katalog-ID: |
DOAJ09435491X |
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10.3390/jpm13050845 doi (DE-627)DOAJ09435491X (DE-599)DOAJ80fadd2723cd4f35aa3a7806d4643b0c DE-627 ger DE-627 rakwb eng Umit M. Sahiner verfasserin aut Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. allergen immunotherapy mechanisms biomarkers clinical evaluation personalized medicine Medicine R Mattia Giovannini verfasserin aut Maria M. Escribese verfasserin aut Giovanni Paoletti verfasserin aut Enrico Heffler verfasserin aut Montserrat Alvaro Lozano verfasserin aut Domingo Barber verfasserin aut Giorgio Walter Canonica verfasserin aut Oliver Pfaar verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 5, p 845 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:5, p 845 https://doi.org/10.3390/jpm13050845 kostenfrei https://doaj.org/article/80fadd2723cd4f35aa3a7806d4643b0c kostenfrei https://www.mdpi.com/2075-4426/13/5/845 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 5, p 845 |
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10.3390/jpm13050845 doi (DE-627)DOAJ09435491X (DE-599)DOAJ80fadd2723cd4f35aa3a7806d4643b0c DE-627 ger DE-627 rakwb eng Umit M. Sahiner verfasserin aut Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. allergen immunotherapy mechanisms biomarkers clinical evaluation personalized medicine Medicine R Mattia Giovannini verfasserin aut Maria M. Escribese verfasserin aut Giovanni Paoletti verfasserin aut Enrico Heffler verfasserin aut Montserrat Alvaro Lozano verfasserin aut Domingo Barber verfasserin aut Giorgio Walter Canonica verfasserin aut Oliver Pfaar verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 5, p 845 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:5, p 845 https://doi.org/10.3390/jpm13050845 kostenfrei https://doaj.org/article/80fadd2723cd4f35aa3a7806d4643b0c kostenfrei https://www.mdpi.com/2075-4426/13/5/845 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 5, p 845 |
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10.3390/jpm13050845 doi (DE-627)DOAJ09435491X (DE-599)DOAJ80fadd2723cd4f35aa3a7806d4643b0c DE-627 ger DE-627 rakwb eng Umit M. Sahiner verfasserin aut Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. allergen immunotherapy mechanisms biomarkers clinical evaluation personalized medicine Medicine R Mattia Giovannini verfasserin aut Maria M. Escribese verfasserin aut Giovanni Paoletti verfasserin aut Enrico Heffler verfasserin aut Montserrat Alvaro Lozano verfasserin aut Domingo Barber verfasserin aut Giorgio Walter Canonica verfasserin aut Oliver Pfaar verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 5, p 845 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:5, p 845 https://doi.org/10.3390/jpm13050845 kostenfrei https://doaj.org/article/80fadd2723cd4f35aa3a7806d4643b0c kostenfrei https://www.mdpi.com/2075-4426/13/5/845 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 5, p 845 |
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10.3390/jpm13050845 doi (DE-627)DOAJ09435491X (DE-599)DOAJ80fadd2723cd4f35aa3a7806d4643b0c DE-627 ger DE-627 rakwb eng Umit M. Sahiner verfasserin aut Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. allergen immunotherapy mechanisms biomarkers clinical evaluation personalized medicine Medicine R Mattia Giovannini verfasserin aut Maria M. Escribese verfasserin aut Giovanni Paoletti verfasserin aut Enrico Heffler verfasserin aut Montserrat Alvaro Lozano verfasserin aut Domingo Barber verfasserin aut Giorgio Walter Canonica verfasserin aut Oliver Pfaar verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 5, p 845 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:5, p 845 https://doi.org/10.3390/jpm13050845 kostenfrei https://doaj.org/article/80fadd2723cd4f35aa3a7806d4643b0c kostenfrei https://www.mdpi.com/2075-4426/13/5/845 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 5, p 845 |
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10.3390/jpm13050845 doi (DE-627)DOAJ09435491X (DE-599)DOAJ80fadd2723cd4f35aa3a7806d4643b0c DE-627 ger DE-627 rakwb eng Umit M. Sahiner verfasserin aut Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. allergen immunotherapy mechanisms biomarkers clinical evaluation personalized medicine Medicine R Mattia Giovannini verfasserin aut Maria M. Escribese verfasserin aut Giovanni Paoletti verfasserin aut Enrico Heffler verfasserin aut Montserrat Alvaro Lozano verfasserin aut Domingo Barber verfasserin aut Giorgio Walter Canonica verfasserin aut Oliver Pfaar verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 5, p 845 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:5, p 845 https://doi.org/10.3390/jpm13050845 kostenfrei https://doaj.org/article/80fadd2723cd4f35aa3a7806d4643b0c kostenfrei https://www.mdpi.com/2075-4426/13/5/845 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 5, p 845 |
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Mechanisms of Allergen Immunotherapy and Potential Biomarkers for Clinical Evaluation |
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Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. |
abstractGer |
Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. |
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Allergen-immunotherapy (AIT) is an efficacious and disease-modifying treatment option for IgE-mediated diseases. Among these allergic rhinitis, insect venom allergy, food allergy, and allergic asthma are the most common candidates for AIT. AIT gives rise to clinical immunotolerance which may last for years after the treatment cessation. Mechanisms of AIT include suppression of allergic inflammation in target tissues and stimulation of the production of blocking antibodies, especially IgG4 and IgA. These mechanisms are followed by a reduction of underlying allergen-specific Th2 cell-driven responses to the allergens. Tolerance induction takes place through the desensitization of effector cells and stimulation of regulatory T cells that show their effects by mechanisms involving cell-cell cross-talk, but also other mechanisms, e.g., by the production of immunomodulatory cytokines such as, e.g., IL-10 and TGF-beta. From a personalized medical perspective, there is a need for clinical biomarkers of value in selecting responders and optimizing patient care during AIT. Also, a deeper understanding of underlying mechanistic processes will improve AIT’s future outcomes. In this paper, the current knowledge of mechanisms in AIT is reviewed with a special focus on biomarkers of this therapy. |
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7.400629 |