An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management

Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the curre...
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Autor*in:	Farid Khallouki [verfasserIn] Lhoussain Hajji [verfasserIn] Somayya Saber [verfasserIn] Toufik Bouddine [verfasserIn] Mouad Edderkaoui [verfasserIn] Mohammed Bourhia [verfasserIn] Nora Mir [verfasserIn] Adrian Lim [verfasserIn] Adil El Midaoui [verfasserIn] John P. Giesy [verfasserIn] Mourad A. M. Aboul-Soud [verfasserIn] Sandrine Silvente-Poirot [verfasserIn] Marc Poirot [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	tamoxifen estrogen receptor AEBS ChEH cholesterol metabolism cholesterol biosynthesis

Übergeordnetes Werk:	In: Journal of Personalized Medicine - MDPI AG, 2012, 13(2023), 5, p 754
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:5, p 754

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jpm13050754

Katalog-ID:	DOAJ094355789

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authorswithroles_txt_mv	Farid Khallouki @@aut@@ Lhoussain Hajji @@aut@@ Somayya Saber @@aut@@ Toufik Bouddine @@aut@@ Mouad Edderkaoui @@aut@@ Mohammed Bourhia @@aut@@ Nora Mir @@aut@@ Adrian Lim @@aut@@ Adil El Midaoui @@aut@@ John P. Giesy @@aut@@ Mourad A. M. Aboul-Soud @@aut@@ Sandrine Silvente-Poirot @@aut@@ Marc Poirot @@aut@@
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author	Farid Khallouki
spellingShingle	Farid Khallouki misc tamoxifen misc estrogen receptor misc AEBS misc ChEH misc cholesterol metabolism misc cholesterol biosynthesis misc Medicine misc R An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
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topic_title	An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management tamoxifen estrogen receptor AEBS ChEH cholesterol metabolism cholesterol biosynthesis
topic	misc tamoxifen misc estrogen receptor misc AEBS misc ChEH misc cholesterol metabolism misc cholesterol biosynthesis misc Medicine misc R
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title	An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
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title_full	An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
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author_browse	Farid Khallouki Lhoussain Hajji Somayya Saber Toufik Bouddine Mouad Edderkaoui Mohammed Bourhia Nora Mir Adrian Lim Adil El Midaoui John P. Giesy Mourad A. M. Aboul-Soud Sandrine Silvente-Poirot Marc Poirot
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title_sort	update on tamoxifen and the chemo-preventive potential of vitamin e in breast cancer management
title_auth	An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
abstract	Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.
abstractGer	Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.
abstract_unstemmed	Breast cancer (BC) is the most common female cancer in terms of incidence and mortality worldwide. Tamoxifen (Nolvadex) is a widely prescribed, oral anti-estrogen drug for the hormonal treatment of estrogen-receptor-positive BC, which represents 70% of all BC subtypes. This review assesses the current knowledge on the molecular pharmacology of tamoxifen in terms of its anticancer and chemo-preventive actions. Due to the importance of vitamin E compounds, which are widely taken as a supplementary dietary component, the review focuses only on the potential importance of vitamin E in BC chemo-prevention. The chemo-preventive and onco-protective effects of tamoxifen combined with the potential effects of vitamin E can alter the anticancer actions of tamoxifen. Therefore, methods involving an individually designed, nutritional intervention for patients with BC warrant further consideration. These data are of great importance for tamoxifen chemo-prevention strategies in future epidemiological studies.
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title_short	An Update on Tamoxifen and the Chemo-Preventive Potential of Vitamin E in Breast Cancer Management
url	https://doi.org/10.3390/jpm13050754 https://doaj.org/article/43c8b2d1684f4a99aac662c90ec85797 https://www.mdpi.com/2075-4426/13/5/754 https://doaj.org/toc/2075-4426
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author2Str	Lhoussain Hajji Somayya Saber Toufik Bouddine Mouad Edderkaoui Mohammed Bourhia Nora Mir Adrian Lim Adil El Midaoui John P. Giesy Mourad A. M. Aboul-Soud Sandrine Silvente-Poirot Marc Poirot
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