Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3

Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of growth factors from CGFs is rapid. RADA16, a self-assembling peptide, can form a scaffold that is similar to the extracellular matrix. Based on the properties of RADA16 and CGF, we hypothesized that...
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Autor*in:	Renjie Yang [verfasserIn] Jiali Chen [verfasserIn] Dingjie Wang [verfasserIn] Yichen Xu [verfasserIn] Guomin Ou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	alveolar bone cleft alveolar bone grafting RADA16 CGFs osteogenesis

Übergeordnetes Werk:	In: Journal of Functional Biomaterials - MDPI AG, 2011, 14(2023), 5, p 260
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:5, p 260

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jfb14050260

Katalog-ID:	DOAJ094359997

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language	English
source	In Journal of Functional Biomaterials 14(2023), 5, p 260 volume:14 year:2023 number:5, p 260
sourceStr	In Journal of Functional Biomaterials 14(2023), 5, p 260 volume:14 year:2023 number:5, p 260
format_phy_str_mv	Article
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topic_facet	alveolar bone cleft alveolar bone grafting RADA16 CGFs osteogenesis Biotechnology Medicine (General)
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container_title	Journal of Functional Biomaterials
authorswithroles_txt_mv	Renjie Yang @@aut@@ Jiali Chen @@aut@@ Dingjie Wang @@aut@@ Yichen Xu @@aut@@ Guomin Ou @@aut@@
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callnumber-first	T - Technology
author	Renjie Yang
spellingShingle	Renjie Yang misc TP248.13-248.65 misc R5-920 misc alveolar bone cleft misc alveolar bone grafting misc RADA16 misc CGFs misc osteogenesis misc Biotechnology misc Medicine (General) Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
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topic_title	TP248.13-248.65 R5-920 Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3 alveolar bone cleft alveolar bone grafting RADA16 CGFs osteogenesis
topic	misc TP248.13-248.65 misc R5-920 misc alveolar bone cleft misc alveolar bone grafting misc RADA16 misc CGFs misc osteogenesis misc Biotechnology misc Medicine (General)
topic_unstemmed	misc TP248.13-248.65 misc R5-920 misc alveolar bone cleft misc alveolar bone grafting misc RADA16 misc CGFs misc osteogenesis misc Biotechnology misc Medicine (General)
topic_browse	misc TP248.13-248.65 misc R5-920 misc alveolar bone cleft misc alveolar bone grafting misc RADA16 misc CGFs misc osteogenesis misc Biotechnology misc Medicine (General)
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title	Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
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title_full	Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
author_sort	Renjie Yang
journal	Journal of Functional Biomaterials
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author_browse	Renjie Yang Jiali Chen Dingjie Wang Yichen Xu Guomin Ou
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title_sort	self-assembling peptide rada16 nanofiber scaffold hydrogel-wrapped concentrated growth factors in osteogenesis of mc3t3
callnumber	TP248.13-248.65
title_auth	Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
abstract	Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of growth factors from CGFs is rapid. RADA16, a self-assembling peptide, can form a scaffold that is similar to the extracellular matrix. Based on the properties of RADA16 and CGF, we hypothesized that the RADA16 nanofiber scaffold hydrogel could enhance the function of CGFs and that the RADA16 nanofiber scaffold hydrogel-wrapped CGFs (RADA16-CGFs) would perform a good osteoinductive function. This study aimed to investigate the osteoinductive function of RADA16-CGFs. Scanning electron microscopy, rheometry, and ELISA were performed, and MC3T3-E1 cells were used to test cell adhesion, cytotoxicity, and mineralization after administration with RADA16-CGFs. We found that RADA16 endowed with the sustained release of growth factors from CGFs, which can help maximize the function of CGFs in osteoinduction. The application of the atoxic RADA16 nanofiber scaffold hydrogel with CGFs can be a new therapeutic strategy for the treatment of alveolar bone loss and other problems that require bone regeneration.
abstractGer	Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of growth factors from CGFs is rapid. RADA16, a self-assembling peptide, can form a scaffold that is similar to the extracellular matrix. Based on the properties of RADA16 and CGF, we hypothesized that the RADA16 nanofiber scaffold hydrogel could enhance the function of CGFs and that the RADA16 nanofiber scaffold hydrogel-wrapped CGFs (RADA16-CGFs) would perform a good osteoinductive function. This study aimed to investigate the osteoinductive function of RADA16-CGFs. Scanning electron microscopy, rheometry, and ELISA were performed, and MC3T3-E1 cells were used to test cell adhesion, cytotoxicity, and mineralization after administration with RADA16-CGFs. We found that RADA16 endowed with the sustained release of growth factors from CGFs, which can help maximize the function of CGFs in osteoinduction. The application of the atoxic RADA16 nanofiber scaffold hydrogel with CGFs can be a new therapeutic strategy for the treatment of alveolar bone loss and other problems that require bone regeneration.
abstract_unstemmed	Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of growth factors from CGFs is rapid. RADA16, a self-assembling peptide, can form a scaffold that is similar to the extracellular matrix. Based on the properties of RADA16 and CGF, we hypothesized that the RADA16 nanofiber scaffold hydrogel could enhance the function of CGFs and that the RADA16 nanofiber scaffold hydrogel-wrapped CGFs (RADA16-CGFs) would perform a good osteoinductive function. This study aimed to investigate the osteoinductive function of RADA16-CGFs. Scanning electron microscopy, rheometry, and ELISA were performed, and MC3T3-E1 cells were used to test cell adhesion, cytotoxicity, and mineralization after administration with RADA16-CGFs. We found that RADA16 endowed with the sustained release of growth factors from CGFs, which can help maximize the function of CGFs in osteoinduction. The application of the atoxic RADA16 nanofiber scaffold hydrogel with CGFs can be a new therapeutic strategy for the treatment of alveolar bone loss and other problems that require bone regeneration.
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title_short	Self-Assembling Peptide RADA16 Nanofiber Scaffold Hydrogel-Wrapped Concentrated Growth Factors in Osteogenesis of MC3T3
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author2	Jiali Chen Dingjie Wang Yichen Xu Guomin Ou
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