Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis

Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small...
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Autor*in:	Alessandra Bettiol [verfasserIn] Filippo Fagni [verfasserIn] Irene Mattioli [verfasserIn] Giacomo Bagni [verfasserIn] Gianfranco Vitiello [verfasserIn] Alessia Grassi [verfasserIn] Chiara Della Bella [verfasserIn] Marisa Benagiano [verfasserIn] Arianna Troilo [verfasserIn] Katarzyna Stella Holownia [verfasserIn] David Simon [verfasserIn] Flavia Rita Argento [verfasserIn] Jurgen Sota [verfasserIn] Claudia Fabiani [verfasserIn] Matteo Becatti [verfasserIn] Claudia Fiorillo [verfasserIn] Georg Schett [verfasserIn] Giuseppe Lopalco [verfasserIn] Luca Cantarini [verfasserIn] Domenico Prisco [verfasserIn] Elena Silvestri [verfasserIn] Giacomo Emmi [verfasserIn] Mario Milco D’Elios [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Behçet disease biomarkers cytokines interleukin 36 vasculitis

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 24(2023), 10, p 8817
Übergeordnetes Werk:	volume:24 ; year:2023 ; number:10, p 8817

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms24108817

Katalog-ID:	DOAJ094368422

Internformat


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520			\|a Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
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allfields	10.3390/ijms24108817 doi (DE-627)DOAJ094368422 (DE-599)DOAJa94c22192ea24972b0857f6558866c95 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Alessandra Bettiol verfasserin aut Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS. Behçet disease biomarkers cytokines interleukin 36 vasculitis Biology (General) Chemistry Filippo Fagni verfasserin aut Irene Mattioli verfasserin aut Giacomo Bagni verfasserin aut Gianfranco Vitiello verfasserin aut Alessia Grassi verfasserin aut Chiara Della Bella verfasserin aut Marisa Benagiano verfasserin aut Arianna Troilo verfasserin aut Katarzyna Stella Holownia verfasserin aut David Simon verfasserin aut Flavia Rita Argento verfasserin aut Jurgen Sota verfasserin aut Claudia Fabiani verfasserin aut Matteo Becatti verfasserin aut Claudia Fiorillo verfasserin aut Georg Schett verfasserin aut Giuseppe Lopalco verfasserin aut Luca Cantarini verfasserin aut Domenico Prisco verfasserin aut Elena Silvestri verfasserin aut Giacomo Emmi verfasserin aut Mario Milco D’Elios verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 10, p 8817 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:10, p 8817 https://doi.org/10.3390/ijms24108817 kostenfrei https://doaj.org/article/a94c22192ea24972b0857f6558866c95 kostenfrei https://www.mdpi.com/1422-0067/24/10/8817 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 10, p 8817
spelling	10.3390/ijms24108817 doi (DE-627)DOAJ094368422 (DE-599)DOAJa94c22192ea24972b0857f6558866c95 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Alessandra Bettiol verfasserin aut Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS. Behçet disease biomarkers cytokines interleukin 36 vasculitis Biology (General) Chemistry Filippo Fagni verfasserin aut Irene Mattioli verfasserin aut Giacomo Bagni verfasserin aut Gianfranco Vitiello verfasserin aut Alessia Grassi verfasserin aut Chiara Della Bella verfasserin aut Marisa Benagiano verfasserin aut Arianna Troilo verfasserin aut Katarzyna Stella Holownia verfasserin aut David Simon verfasserin aut Flavia Rita Argento verfasserin aut Jurgen Sota verfasserin aut Claudia Fabiani verfasserin aut Matteo Becatti verfasserin aut Claudia Fiorillo verfasserin aut Georg Schett verfasserin aut Giuseppe Lopalco verfasserin aut Luca Cantarini verfasserin aut Domenico Prisco verfasserin aut Elena Silvestri verfasserin aut Giacomo Emmi verfasserin aut Mario Milco D’Elios verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 10, p 8817 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:10, p 8817 https://doi.org/10.3390/ijms24108817 kostenfrei https://doaj.org/article/a94c22192ea24972b0857f6558866c95 kostenfrei https://www.mdpi.com/1422-0067/24/10/8817 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 10, p 8817
allfields_unstemmed	10.3390/ijms24108817 doi (DE-627)DOAJ094368422 (DE-599)DOAJa94c22192ea24972b0857f6558866c95 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Alessandra Bettiol verfasserin aut Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS. Behçet disease biomarkers cytokines interleukin 36 vasculitis Biology (General) Chemistry Filippo Fagni verfasserin aut Irene Mattioli verfasserin aut Giacomo Bagni verfasserin aut Gianfranco Vitiello verfasserin aut Alessia Grassi verfasserin aut Chiara Della Bella verfasserin aut Marisa Benagiano verfasserin aut Arianna Troilo verfasserin aut Katarzyna Stella Holownia verfasserin aut David Simon verfasserin aut Flavia Rita Argento verfasserin aut Jurgen Sota verfasserin aut Claudia Fabiani verfasserin aut Matteo Becatti verfasserin aut Claudia Fiorillo verfasserin aut Georg Schett verfasserin aut Giuseppe Lopalco verfasserin aut Luca Cantarini verfasserin aut Domenico Prisco verfasserin aut Elena Silvestri verfasserin aut Giacomo Emmi verfasserin aut Mario Milco D’Elios verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 10, p 8817 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:10, p 8817 https://doi.org/10.3390/ijms24108817 kostenfrei https://doaj.org/article/a94c22192ea24972b0857f6558866c95 kostenfrei https://www.mdpi.com/1422-0067/24/10/8817 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 10, p 8817
allfieldsGer	10.3390/ijms24108817 doi (DE-627)DOAJ094368422 (DE-599)DOAJa94c22192ea24972b0857f6558866c95 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Alessandra Bettiol verfasserin aut Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS. Behçet disease biomarkers cytokines interleukin 36 vasculitis Biology (General) Chemistry Filippo Fagni verfasserin aut Irene Mattioli verfasserin aut Giacomo Bagni verfasserin aut Gianfranco Vitiello verfasserin aut Alessia Grassi verfasserin aut Chiara Della Bella verfasserin aut Marisa Benagiano verfasserin aut Arianna Troilo verfasserin aut Katarzyna Stella Holownia verfasserin aut David Simon verfasserin aut Flavia Rita Argento verfasserin aut Jurgen Sota verfasserin aut Claudia Fabiani verfasserin aut Matteo Becatti verfasserin aut Claudia Fiorillo verfasserin aut Georg Schett verfasserin aut Giuseppe Lopalco verfasserin aut Luca Cantarini verfasserin aut Domenico Prisco verfasserin aut Elena Silvestri verfasserin aut Giacomo Emmi verfasserin aut Mario Milco D’Elios verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 24(2023), 10, p 8817 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:24 year:2023 number:10, p 8817 https://doi.org/10.3390/ijms24108817 kostenfrei https://doaj.org/article/a94c22192ea24972b0857f6558866c95 kostenfrei https://www.mdpi.com/1422-0067/24/10/8817 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2023 10, p 8817
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language	English
source	In International Journal of Molecular Sciences 24(2023), 10, p 8817 volume:24 year:2023 number:10, p 8817
sourceStr	In International Journal of Molecular Sciences 24(2023), 10, p 8817 volume:24 year:2023 number:10, p 8817
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Behçet disease biomarkers cytokines interleukin 36 vasculitis Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Alessandra Bettiol @@aut@@ Filippo Fagni @@aut@@ Irene Mattioli @@aut@@ Giacomo Bagni @@aut@@ Gianfranco Vitiello @@aut@@ Alessia Grassi @@aut@@ Chiara Della Bella @@aut@@ Marisa Benagiano @@aut@@ Arianna Troilo @@aut@@ Katarzyna Stella Holownia @@aut@@ David Simon @@aut@@ Flavia Rita Argento @@aut@@ Jurgen Sota @@aut@@ Claudia Fabiani @@aut@@ Matteo Becatti @@aut@@ Claudia Fiorillo @@aut@@ Georg Schett @@aut@@ Giuseppe Lopalco @@aut@@ Luca Cantarini @@aut@@ Domenico Prisco @@aut@@ Elena Silvestri @@aut@@ Giacomo Emmi @@aut@@ Mario Milco D’Elios @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ094368422
language_de	englisch
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callnumber-first	Q - Science
author	Alessandra Bettiol
spellingShingle	Alessandra Bettiol misc QH301-705.5 misc QD1-999 misc Behçet disease misc biomarkers misc cytokines misc interleukin 36 misc vasculitis misc Biology (General) misc Chemistry Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
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topic_title	QH301-705.5 QD1-999 Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis Behçet disease biomarkers cytokines interleukin 36 vasculitis
topic	misc QH301-705.5 misc QD1-999 misc Behçet disease misc biomarkers misc cytokines misc interleukin 36 misc vasculitis misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc Behçet disease misc biomarkers misc cytokines misc interleukin 36 misc vasculitis misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc Behçet disease misc biomarkers misc cytokines misc interleukin 36 misc vasculitis misc Biology (General) misc Chemistry
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title	Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
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title_full	Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
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author_browse	Alessandra Bettiol Filippo Fagni Irene Mattioli Giacomo Bagni Gianfranco Vitiello Alessia Grassi Chiara Della Bella Marisa Benagiano Arianna Troilo Katarzyna Stella Holownia David Simon Flavia Rita Argento Jurgen Sota Claudia Fabiani Matteo Becatti Claudia Fiorillo Georg Schett Giuseppe Lopalco Luca Cantarini Domenico Prisco Elena Silvestri Giacomo Emmi Mario Milco D’Elios
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title_sort	serum interleukin-36 α as a candidate biomarker to distinguish behçet’s syndrome and psoriatic arthritis
callnumber	QH301-705.5
title_auth	Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
abstract	Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
abstractGer	Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
abstract_unstemmed	Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
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title_short	Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
url	https://doi.org/10.3390/ijms24108817 https://doaj.org/article/a94c22192ea24972b0857f6558866c95 https://www.mdpi.com/1422-0067/24/10/8817 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2	Filippo Fagni Irene Mattioli Giacomo Bagni Gianfranco Vitiello Alessia Grassi Chiara Della Bella Marisa Benagiano Arianna Troilo Katarzyna Stella Holownia David Simon Flavia Rita Argento Jurgen Sota Claudia Fabiani Matteo Becatti Claudia Fiorillo Georg Schett Giuseppe Lopalco Luca Cantarini Domenico Prisco Elena Silvestri Giacomo Emmi Mario Milco D’Elios
author2Str	Filippo Fagni Irene Mattioli Giacomo Bagni Gianfranco Vitiello Alessia Grassi Chiara Della Bella Marisa Benagiano Arianna Troilo Katarzyna Stella Holownia David Simon Flavia Rita Argento Jurgen Sota Claudia Fabiani Matteo Becatti Claudia Fiorillo Georg Schett Giuseppe Lopalco Luca Cantarini Domenico Prisco Elena Silvestri Giacomo Emmi Mario Milco D’Elios
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