Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial

Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a mu...
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Autor*in:	Matteo Donadon [verfasserIn] Angela Palmisano [verfasserIn] Mariano Bizzarri [verfasserIn] Roberto Ceriani [verfasserIn] Luigi Veneroni [verfasserIn] Gabriele Donati [verfasserIn] Davide Tassinari [verfasserIn] Massimo Giuseppe Viola [verfasserIn] Emiliano Tamburini [verfasserIn] Guido Torzilli [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 10, p 2809
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:10, p 2809

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15102809

Katalog-ID:	DOAJ094405190

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520			\|a Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence.
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653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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allfields	10.3390/cancers15102809 doi (DE-627)DOAJ094405190 (DE-599)DOAJf3da35e5d8f9420da2853734ad70a08c DE-627 ger DE-627 rakwb eng RC254-282 Matteo Donadon verfasserin aut Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence. oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Angela Palmisano verfasserin aut Mariano Bizzarri verfasserin aut Roberto Ceriani verfasserin aut Luigi Veneroni verfasserin aut Gabriele Donati verfasserin aut Davide Tassinari verfasserin aut Massimo Giuseppe Viola verfasserin aut Emiliano Tamburini verfasserin aut Guido Torzilli verfasserin aut In Cancers MDPI AG, 2010 15(2023), 10, p 2809 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:10, p 2809 https://doi.org/10.3390/cancers15102809 kostenfrei https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c kostenfrei https://www.mdpi.com/2072-6694/15/10/2809 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 10, p 2809
spelling	10.3390/cancers15102809 doi (DE-627)DOAJ094405190 (DE-599)DOAJf3da35e5d8f9420da2853734ad70a08c DE-627 ger DE-627 rakwb eng RC254-282 Matteo Donadon verfasserin aut Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence. oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Angela Palmisano verfasserin aut Mariano Bizzarri verfasserin aut Roberto Ceriani verfasserin aut Luigi Veneroni verfasserin aut Gabriele Donati verfasserin aut Davide Tassinari verfasserin aut Massimo Giuseppe Viola verfasserin aut Emiliano Tamburini verfasserin aut Guido Torzilli verfasserin aut In Cancers MDPI AG, 2010 15(2023), 10, p 2809 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:10, p 2809 https://doi.org/10.3390/cancers15102809 kostenfrei https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c kostenfrei https://www.mdpi.com/2072-6694/15/10/2809 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 10, p 2809
allfields_unstemmed	10.3390/cancers15102809 doi (DE-627)DOAJ094405190 (DE-599)DOAJf3da35e5d8f9420da2853734ad70a08c DE-627 ger DE-627 rakwb eng RC254-282 Matteo Donadon verfasserin aut Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence. oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Angela Palmisano verfasserin aut Mariano Bizzarri verfasserin aut Roberto Ceriani verfasserin aut Luigi Veneroni verfasserin aut Gabriele Donati verfasserin aut Davide Tassinari verfasserin aut Massimo Giuseppe Viola verfasserin aut Emiliano Tamburini verfasserin aut Guido Torzilli verfasserin aut In Cancers MDPI AG, 2010 15(2023), 10, p 2809 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:10, p 2809 https://doi.org/10.3390/cancers15102809 kostenfrei https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c kostenfrei https://www.mdpi.com/2072-6694/15/10/2809 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 10, p 2809
allfieldsGer	10.3390/cancers15102809 doi (DE-627)DOAJ094405190 (DE-599)DOAJf3da35e5d8f9420da2853734ad70a08c DE-627 ger DE-627 rakwb eng RC254-282 Matteo Donadon verfasserin aut Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence. oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Angela Palmisano verfasserin aut Mariano Bizzarri verfasserin aut Roberto Ceriani verfasserin aut Luigi Veneroni verfasserin aut Gabriele Donati verfasserin aut Davide Tassinari verfasserin aut Massimo Giuseppe Viola verfasserin aut Emiliano Tamburini verfasserin aut Guido Torzilli verfasserin aut In Cancers MDPI AG, 2010 15(2023), 10, p 2809 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:10, p 2809 https://doi.org/10.3390/cancers15102809 kostenfrei https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c kostenfrei https://www.mdpi.com/2072-6694/15/10/2809 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 10, p 2809
allfieldsSound	10.3390/cancers15102809 doi (DE-627)DOAJ094405190 (DE-599)DOAJf3da35e5d8f9420da2853734ad70a08c DE-627 ger DE-627 rakwb eng RC254-282 Matteo Donadon verfasserin aut Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence. oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery Neoplasms. Tumors. Oncology. Including cancer and carcinogens Angela Palmisano verfasserin aut Mariano Bizzarri verfasserin aut Roberto Ceriani verfasserin aut Luigi Veneroni verfasserin aut Gabriele Donati verfasserin aut Davide Tassinari verfasserin aut Massimo Giuseppe Viola verfasserin aut Emiliano Tamburini verfasserin aut Guido Torzilli verfasserin aut In Cancers MDPI AG, 2010 15(2023), 10, p 2809 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:10, p 2809 https://doi.org/10.3390/cancers15102809 kostenfrei https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c kostenfrei https://www.mdpi.com/2072-6694/15/10/2809 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 10, p 2809
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authorswithroles_txt_mv	Matteo Donadon @@aut@@ Angela Palmisano @@aut@@ Mariano Bizzarri @@aut@@ Roberto Ceriani @@aut@@ Luigi Veneroni @@aut@@ Gabriele Donati @@aut@@ Davide Tassinari @@aut@@ Massimo Giuseppe Viola @@aut@@ Emiliano Tamburini @@aut@@ Guido Torzilli @@aut@@
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callnumber-first	R - Medicine
author	Matteo Donadon
spellingShingle	Matteo Donadon misc RC254-282 misc oocyte extract misc quality of life misc hepatocellular carcinoma misc cholangiocarcinoma misc liver surgery misc postoperative recovery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial
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topic_title	RC254-282 Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial oocyte extract quality of life hepatocellular carcinoma cholangiocarcinoma liver surgery postoperative recovery
topic	misc RC254-282 misc oocyte extract misc quality of life misc hepatocellular carcinoma misc cholangiocarcinoma misc liver surgery misc postoperative recovery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc oocyte extract misc quality of life misc hepatocellular carcinoma misc cholangiocarcinoma misc liver surgery misc postoperative recovery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc oocyte extract misc quality of life misc hepatocellular carcinoma misc cholangiocarcinoma misc liver surgery misc postoperative recovery misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial
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title_full	Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial
author_sort	Matteo Donadon
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author_browse	Matteo Donadon Angela Palmisano Mariano Bizzarri Roberto Ceriani Luigi Veneroni Gabriele Donati Davide Tassinari Massimo Giuseppe Viola Emiliano Tamburini Guido Torzilli
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author-letter	Matteo Donadon
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title_sort	impact of oocyte extract supplement on quality of life after hepatectomy for liver tumours: a prospective, multicentre, double-blind randomized clinical trial
callnumber	RC254-282
title_auth	Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial
abstract	Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence.
abstractGer	Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence.
abstract_unstemmed	Background: Previous studies on oocyte extract supplementation showed benefits in patients with liver tumours. In this trial, we hypothesized that the oocyte extract supplement impacted the QoL after hepatectomy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Methods: This was a multicentre, double-blind, randomized clinical trial designed to assess the QoL of patients receiving a supplement of oocyte extract or placebo postoperatively. QoL was assessed using the Short Form-36 questionnaire in participants randomly assigned to treatment (Synchrolevels) or placebo. All study personnel and participants were masked to treatment assignment. The endpoint was the change in the QoL score. Results: Between June 2018 and September 2022, 66 of 128 expected patients were considered as per interim analysis, of which 33 were assigned to the treatment and 33 to the placebo group. Baseline and clinicopathological characteristics were similar between the two groups. In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. Further in-depth studies are required to confirm this evidence.
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title_short	Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial
url	https://doi.org/10.3390/cancers15102809 https://doaj.org/article/f3da35e5d8f9420da2853734ad70a08c https://www.mdpi.com/2072-6694/15/10/2809 https://doaj.org/toc/2072-6694
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author2	Angela Palmisano Mariano Bizzarri Roberto Ceriani Luigi Veneroni Gabriele Donati Davide Tassinari Massimo Giuseppe Viola Emiliano Tamburini Guido Torzilli
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up_date	2024-07-03T22:58:43.921Z
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In the treatment group, the health, mental and psychological status improved for many of the items considered, reaching statistical significance, while in the placebo group, those items either did not change or were impaired in comparison with the corresponding baseline. Conclusions: Supplementation with oocyte extract modifies QoL after liver surgery by enhancing functional recovery. 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Impact of Oocyte Extract Supplement on Quality of Life after Hepatectomy for Liver Tumours: A Prospective, Multicentre, Double-Blind Randomized Clinical Trial

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