Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods

Recent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices...
Ausführliche Beschreibung

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Autor*in:	Yusuf Aslan [verfasserIn] Maryam Atabay [verfasserIn] Hussain Kawsar Chowdhury [verfasserIn] Ilgım Göktürk [verfasserIn] Yeşeren Saylan [verfasserIn] Fatih Inci [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	aptamer aptasensor biosensor computational methods nanomaterials point-of-care

Übergeordnetes Werk:	In: Biosensors - MDPI AG, 2012, 13(2023), 5, p 569
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:5, p 569

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/bios13050569

Katalog-ID:	DOAJ094410674

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language	English
source	In Biosensors 13(2023), 5, p 569 volume:13 year:2023 number:5, p 569
sourceStr	In Biosensors 13(2023), 5, p 569 volume:13 year:2023 number:5, p 569
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institution	findex.gbv.de
topic_facet	aptamer aptasensor biosensor computational methods nanomaterials point-of-care Biotechnology
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authorswithroles_txt_mv	Yusuf Aslan @@aut@@ Maryam Atabay @@aut@@ Hussain Kawsar Chowdhury @@aut@@ Ilgım Göktürk @@aut@@ Yeşeren Saylan @@aut@@ Fatih Inci @@aut@@
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callnumber-first	T - Technology
author	Yusuf Aslan
spellingShingle	Yusuf Aslan misc TP248.13-248.65 misc aptamer misc aptasensor misc biosensor misc computational methods misc nanomaterials misc point-of-care misc Biotechnology Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods
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title_sort	aptamer-based point-of-care devices: emerging technologies and integration of computational methods
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title_auth	Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods
abstract	Recent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices is currently limited due to obstacles associated with cost and production, impeding its widespread adoption. One promising alternative, on the other hand, is aptamer integration, i.e., short sequences of single-stranded DNA and RNA structures. The advantageous properties of these molecules are as follows: small molecular size, amenability to chemical modification, low- or nonimmunogenic characteristics, and their reproducibility within a short generation time. The utilization of these aforementioned features is critical in developing sensitive and portable POC systems. Furthermore, the deficiencies related to past experimental efforts to improve biosensor schematics, including the design of biorecognition elements, can be tackled with the integration of computational tools. These complementary tools enable the prediction of the reliability and functionality of the molecular structure of aptamers. In this review, we have overviewed the usage of aptamers in the development of novel and portable POC devices, in addition to highlighting the insights that simulations and other computational methods can provide into the use of aptamer modeling for POC integration.
abstractGer	Recent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices is currently limited due to obstacles associated with cost and production, impeding its widespread adoption. One promising alternative, on the other hand, is aptamer integration, i.e., short sequences of single-stranded DNA and RNA structures. The advantageous properties of these molecules are as follows: small molecular size, amenability to chemical modification, low- or nonimmunogenic characteristics, and their reproducibility within a short generation time. The utilization of these aforementioned features is critical in developing sensitive and portable POC systems. Furthermore, the deficiencies related to past experimental efforts to improve biosensor schematics, including the design of biorecognition elements, can be tackled with the integration of computational tools. These complementary tools enable the prediction of the reliability and functionality of the molecular structure of aptamers. In this review, we have overviewed the usage of aptamers in the development of novel and portable POC devices, in addition to highlighting the insights that simulations and other computational methods can provide into the use of aptamer modeling for POC integration.
abstract_unstemmed	Recent innovations in point-of-care (POC) diagnostic technologies have paved a critical road for the improved application of biomedicine through the deployment of accurate and affordable programs into resource-scarce settings. The utilization of antibodies as a bio-recognition element in POC devices is currently limited due to obstacles associated with cost and production, impeding its widespread adoption. One promising alternative, on the other hand, is aptamer integration, i.e., short sequences of single-stranded DNA and RNA structures. The advantageous properties of these molecules are as follows: small molecular size, amenability to chemical modification, low- or nonimmunogenic characteristics, and their reproducibility within a short generation time. The utilization of these aforementioned features is critical in developing sensitive and portable POC systems. Furthermore, the deficiencies related to past experimental efforts to improve biosensor schematics, including the design of biorecognition elements, can be tackled with the integration of computational tools. These complementary tools enable the prediction of the reliability and functionality of the molecular structure of aptamers. In this review, we have overviewed the usage of aptamers in the development of novel and portable POC devices, in addition to highlighting the insights that simulations and other computational methods can provide into the use of aptamer modeling for POC integration.
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title_short	Aptamer-Based Point-of-Care Devices: Emerging Technologies and Integration of Computational Methods
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