Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan

Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degre...
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Autor*in:	Usama M. Abdelaal* [verfasserIn] Mohammed E. Mahmoud [verfasserIn] Ali Taha Ali [verfasserIn] Amal Khalifa Ahmed [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	viral load hepatitis b transient elastography liver stiffness

Übergeordnetes Werk:	In: SVU - International Journal of Medical Sciences - South Valley University, Faculty of Medicine, 2021, 6(2023), 2, Seite 799-807
Übergeordnetes Werk:	volume:6 ; year:2023 ; number:2 ; pages:799-807

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ094653461

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100	0		\|a Usama M. Abdelaal* \|e verfasserin \|4 aut
245	1	0	\|a Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
264		1	\|c 2023
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520			\|a Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point.
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700	0		\|a Ali Taha Ali \|e verfasserin \|4 aut
700	0		\|a Amal Khalifa Ahmed \|e verfasserin \|4 aut
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912			\|a GBV_USEFLAG_A
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912			\|a GBV_ILN_20
912			\|a GBV_ILN_22
912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4037
912			\|a GBV_ILN_4112
912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4338
912			\|a GBV_ILN_4367
912			\|a GBV_ILN_4700
951			\|a AR
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allfields	(DE-627)DOAJ094653461 (DE-599)DOAJ0c401f1083144f0c8b95c0db9db0e2f2 DE-627 ger DE-627 rakwb eng Usama M. Abdelaal* verfasserin aut Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point. viral load hepatitis b transient elastography liver stiffness Medicine R Mohammed E. Mahmoud verfasserin aut Ali Taha Ali verfasserin aut Amal Khalifa Ahmed verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 6(2023), 2, Seite 799-807 (DE-627)1761094386 26363402 nnns volume:6 year:2023 number:2 pages:799-807 https://doi.org/10.21608/svuijm.2023.210886.1584 kostenfrei https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 kostenfrei https://svuijm.journals.ekb.eg/article_320257.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2023 2 799-807
spelling	(DE-627)DOAJ094653461 (DE-599)DOAJ0c401f1083144f0c8b95c0db9db0e2f2 DE-627 ger DE-627 rakwb eng Usama M. Abdelaal* verfasserin aut Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point. viral load hepatitis b transient elastography liver stiffness Medicine R Mohammed E. Mahmoud verfasserin aut Ali Taha Ali verfasserin aut Amal Khalifa Ahmed verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 6(2023), 2, Seite 799-807 (DE-627)1761094386 26363402 nnns volume:6 year:2023 number:2 pages:799-807 https://doi.org/10.21608/svuijm.2023.210886.1584 kostenfrei https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 kostenfrei https://svuijm.journals.ekb.eg/article_320257.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2023 2 799-807
allfields_unstemmed	(DE-627)DOAJ094653461 (DE-599)DOAJ0c401f1083144f0c8b95c0db9db0e2f2 DE-627 ger DE-627 rakwb eng Usama M. Abdelaal* verfasserin aut Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point. viral load hepatitis b transient elastography liver stiffness Medicine R Mohammed E. Mahmoud verfasserin aut Ali Taha Ali verfasserin aut Amal Khalifa Ahmed verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 6(2023), 2, Seite 799-807 (DE-627)1761094386 26363402 nnns volume:6 year:2023 number:2 pages:799-807 https://doi.org/10.21608/svuijm.2023.210886.1584 kostenfrei https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 kostenfrei https://svuijm.journals.ekb.eg/article_320257.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2023 2 799-807
allfieldsGer	(DE-627)DOAJ094653461 (DE-599)DOAJ0c401f1083144f0c8b95c0db9db0e2f2 DE-627 ger DE-627 rakwb eng Usama M. Abdelaal* verfasserin aut Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point. viral load hepatitis b transient elastography liver stiffness Medicine R Mohammed E. Mahmoud verfasserin aut Ali Taha Ali verfasserin aut Amal Khalifa Ahmed verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 6(2023), 2, Seite 799-807 (DE-627)1761094386 26363402 nnns volume:6 year:2023 number:2 pages:799-807 https://doi.org/10.21608/svuijm.2023.210886.1584 kostenfrei https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 kostenfrei https://svuijm.journals.ekb.eg/article_320257.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2023 2 799-807
allfieldsSound	(DE-627)DOAJ094653461 (DE-599)DOAJ0c401f1083144f0c8b95c0db9db0e2f2 DE-627 ger DE-627 rakwb eng Usama M. Abdelaal* verfasserin aut Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point. viral load hepatitis b transient elastography liver stiffness Medicine R Mohammed E. Mahmoud verfasserin aut Ali Taha Ali verfasserin aut Amal Khalifa Ahmed verfasserin aut In SVU - International Journal of Medical Sciences South Valley University, Faculty of Medicine, 2021 6(2023), 2, Seite 799-807 (DE-627)1761094386 26363402 nnns volume:6 year:2023 number:2 pages:799-807 https://doi.org/10.21608/svuijm.2023.210886.1584 kostenfrei https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 kostenfrei https://svuijm.journals.ekb.eg/article_320257.html kostenfrei https://doaj.org/toc/2735-427X Journal toc kostenfrei https://doaj.org/toc/2636-3402 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2023 2 799-807
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author	Usama M. Abdelaal*
spellingShingle	Usama M. Abdelaal* misc viral load hepatitis b transient elastography liver stiffness misc Medicine misc R Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
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topic_title	Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan viral load hepatitis b transient elastography liver stiffness
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title	Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
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title_full	Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
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author_browse	Usama M. Abdelaal* Mohammed E. Mahmoud Ali Taha Ali Amal Khalifa Ahmed
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title_sort	effect of viral load on hepatic fibrosis in patients with chronic hepatitis b patients: assessed by fibroscan
title_auth	Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
abstract	Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point.
abstractGer	Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point.
abstract_unstemmed	Background: Hepatitis B virus (HBV) infection is a severe worldwide health problem and a primary cause of chronic hepatitis, hepatic fibrosis, cirrhosis, and hepatocellular cancer. In Egypt, the prevalence of HBsAg is of intermediate endemicity (2–8%). It has been known that the viral load and degree of hepatic fibrosis are considered independent factors that predict clinical outcomes after persistent HBV infection. However, the exact relationship between viral load and hepatic fibrosis is not well studied. Objectives: Our objective was to investigate the clinical effects of viral load on the severity of hepatic fibrosis. Patients and methods: Sixty patients with evident chronic HBV infection were enrolled. Using transient elastography, the patients were divided into two groups. Group 1: low fibrosis stage F1–2, and Group 2: high or significant fibrosis stage (F3–F4). Both groups were statistically compared for HBV-DNA viremia (PCR), clinical, and laboratory tests. Results: Serum bilirubin (p = 0.048), international normalised ratio (p 0.0001), and albumin (p = 0.01) were significantly increased in patients with higher grades of liver fibrosis on top of CHB. In addition, the viral load was found to be considerably greater in individuals who had higher grades of liver fibrosis and cirrhosis (P = 0.03). Conclusions: During follow-up, an obvious increase in the viraemia level may indicate significant hepatic fibrosis in patients with chronic HBV infection. Our results could influence the decision about liver biopsy or treatment at that point.
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title_short	Effect of viral load on hepatic fibrosis in patients with chronic hepatitis B patients: assessed by fibroscan
url	https://doi.org/10.21608/svuijm.2023.210886.1584 https://doaj.org/article/0c401f1083144f0c8b95c0db9db0e2f2 https://svuijm.journals.ekb.eg/article_320257.html https://doaj.org/toc/2735-427X https://doaj.org/toc/2636-3402
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