Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery

ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive...
Ausführliche Beschreibung

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Autor*in:	Sonja Boatman [verfasserIn] Thomas Kaiser [verfasserIn] Harika Nalluri-Butz [verfasserIn] Mohammad Haneef Khan [verfasserIn] Matthew Dietz [verfasserIn] Julia Kohn [verfasserIn] Abigail J Johnson [verfasserIn] Wolfgang B Gaertner [verfasserIn] Christopher Staley [verfasserIn] Cyrus Jahansouz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Gut microbiota Colon surgery anastomotic leak mouse model diet fecal microbiota transplantation

Übergeordnetes Werk:	In: Gut Microbes - Taylor & Francis Group, 2020, 15(2023), 2
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:2

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/19490976.2023.2283147

Katalog-ID:	DOAJ094729239

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allfields	10.1080/19490976.2023.2283147 doi (DE-627)DOAJ094729239 (DE-599)DOAJ7558d315e00649b8aec1744443086607 DE-627 ger DE-627 rakwb eng RC799-869 Sonja Boatman verfasserin aut Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by increased levels of Bacteroides and Akkermansia. We identified several key taxa that were associated with leak formation, and developed an index based on the ratio of bacteria associated with the absence and presence of leak. We also highlight a modifiable connection between diet, microbiota, and anastomotic healing, potentially paving the way for perioperative modulation by microbiota-targeted therapeutics to reduce AL. Gut microbiota Colon surgery anastomotic leak mouse model diet fecal microbiota transplantation Diseases of the digestive system. Gastroenterology Thomas Kaiser verfasserin aut Harika Nalluri-Butz verfasserin aut Mohammad Haneef Khan verfasserin aut Matthew Dietz verfasserin aut Julia Kohn verfasserin aut Abigail J Johnson verfasserin aut Wolfgang B Gaertner verfasserin aut Christopher Staley verfasserin aut Cyrus Jahansouz verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2283147 kostenfrei https://doaj.org/article/7558d315e00649b8aec1744443086607 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2283147 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2
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allfieldsSound	10.1080/19490976.2023.2283147 doi (DE-627)DOAJ094729239 (DE-599)DOAJ7558d315e00649b8aec1744443086607 DE-627 ger DE-627 rakwb eng RC799-869 Sonja Boatman verfasserin aut Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by increased levels of Bacteroides and Akkermansia. We identified several key taxa that were associated with leak formation, and developed an index based on the ratio of bacteria associated with the absence and presence of leak. We also highlight a modifiable connection between diet, microbiota, and anastomotic healing, potentially paving the way for perioperative modulation by microbiota-targeted therapeutics to reduce AL. Gut microbiota Colon surgery anastomotic leak mouse model diet fecal microbiota transplantation Diseases of the digestive system. Gastroenterology Thomas Kaiser verfasserin aut Harika Nalluri-Butz verfasserin aut Mohammad Haneef Khan verfasserin aut Matthew Dietz verfasserin aut Julia Kohn verfasserin aut Abigail J Johnson verfasserin aut Wolfgang B Gaertner verfasserin aut Christopher Staley verfasserin aut Cyrus Jahansouz verfasserin aut In Gut Microbes Taylor & Francis Group, 2020 15(2023), 2 (DE-627)635932830 (DE-600)2575755-6 19490984 nnns volume:15 year:2023 number:2 https://doi.org/10.1080/19490976.2023.2283147 kostenfrei https://doaj.org/article/7558d315e00649b8aec1744443086607 kostenfrei https://www.tandfonline.com/doi/10.1080/19490976.2023.2283147 kostenfrei https://doaj.org/toc/1949-0976 Journal toc kostenfrei https://doaj.org/toc/1949-0984 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 2
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callnumber-first	R - Medicine
author	Sonja Boatman
spellingShingle	Sonja Boatman misc RC799-869 misc Gut microbiota misc Colon surgery misc anastomotic leak misc mouse model misc diet misc fecal microbiota transplantation misc Diseases of the digestive system. Gastroenterology Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
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topic_title	RC799-869 Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery Gut microbiota Colon surgery anastomotic leak mouse model diet fecal microbiota transplantation
topic	misc RC799-869 misc Gut microbiota misc Colon surgery misc anastomotic leak misc mouse model misc diet misc fecal microbiota transplantation misc Diseases of the digestive system. Gastroenterology
topic_unstemmed	misc RC799-869 misc Gut microbiota misc Colon surgery misc anastomotic leak misc mouse model misc diet misc fecal microbiota transplantation misc Diseases of the digestive system. Gastroenterology
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title	Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
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title_full	Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
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title_sort	diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
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title_auth	Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
abstract	ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by increased levels of Bacteroides and Akkermansia. We identified several key taxa that were associated with leak formation, and developed an index based on the ratio of bacteria associated with the absence and presence of leak. We also highlight a modifiable connection between diet, microbiota, and anastomotic healing, potentially paving the way for perioperative modulation by microbiota-targeted therapeutics to reduce AL.
abstractGer	ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by increased levels of Bacteroides and Akkermansia. We identified several key taxa that were associated with leak formation, and developed an index based on the ratio of bacteria associated with the absence and presence of leak. We also highlight a modifiable connection between diet, microbiota, and anastomotic healing, potentially paving the way for perioperative modulation by microbiota-targeted therapeutics to reduce AL.
abstract_unstemmed	ABSTRACTHost diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) impacted the intestinal microbiota and if a predictive signature for AL could be determined. We hypothesized that a Western diet (WD) would impact gut microbial composition and that the resulting dysbiosis would correlate with increased rates of AL, while FMT from healthy, lean diet (LD) donors would reduce the risk of AL. Furthermore, we predicted that surgical outcomes would allow for the development of a microbial preclinical translational tool to identify AL. Here, we show that AL is associated with a dysbiotic microbial community characterized by increased levels of Bacteroides and Akkermansia. We identified several key taxa that were associated with leak formation, and developed an index based on the ratio of bacteria associated with the absence and presence of leak. We also highlight a modifiable connection between diet, microbiota, and anastomotic healing, potentially paving the way for perioperative modulation by microbiota-targeted therapeutics to reduce AL.
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title_short	Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery
url	https://doi.org/10.1080/19490976.2023.2283147 https://doaj.org/article/7558d315e00649b8aec1744443086607 https://www.tandfonline.com/doi/10.1080/19490976.2023.2283147 https://doaj.org/toc/1949-0976 https://doaj.org/toc/1949-0984
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author2	Thomas Kaiser Harika Nalluri-Butz Mohammad Haneef Khan Matthew Dietz Julia Kohn Abigail J Johnson Wolfgang B Gaertner Christopher Staley Cyrus Jahansouz
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Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery

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