Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival

BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Kendra L. Ratnapradipa [verfasserIn] Tingting Li [verfasserIn] Mei-Chin Hsieh [verfasserIn] Laura Tenner [verfasserIn] Edward S. Peters [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 14(2024)
Übergeordnetes Werk:	volume:14 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2024.1331049

Katalog-ID:	DOAJ094805377

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520			\|a BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders.
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allfields	10.3389/fonc.2024.1331049 doi (DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9 DE-627 ger DE-627 rakwb eng RC254-282 Kendra L. Ratnapradipa verfasserin aut Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tingting Li verfasserin aut Mei-Chin Hsieh verfasserin aut Laura Tenner verfasserin aut Edward S. Peters verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 14(2024) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:14 year:2024 https://doi.org/10.3389/fonc.2024.1331049 kostenfrei https://doaj.org/article/03aac268f35b4b0582920383996378a9 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
spelling	10.3389/fonc.2024.1331049 doi (DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9 DE-627 ger DE-627 rakwb eng RC254-282 Kendra L. Ratnapradipa verfasserin aut Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tingting Li verfasserin aut Mei-Chin Hsieh verfasserin aut Laura Tenner verfasserin aut Edward S. Peters verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 14(2024) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:14 year:2024 https://doi.org/10.3389/fonc.2024.1331049 kostenfrei https://doaj.org/article/03aac268f35b4b0582920383996378a9 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfields_unstemmed	10.3389/fonc.2024.1331049 doi (DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9 DE-627 ger DE-627 rakwb eng RC254-282 Kendra L. Ratnapradipa verfasserin aut Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tingting Li verfasserin aut Mei-Chin Hsieh verfasserin aut Laura Tenner verfasserin aut Edward S. Peters verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 14(2024) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:14 year:2024 https://doi.org/10.3389/fonc.2024.1331049 kostenfrei https://doaj.org/article/03aac268f35b4b0582920383996378a9 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsGer	10.3389/fonc.2024.1331049 doi (DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9 DE-627 ger DE-627 rakwb eng RC254-282 Kendra L. Ratnapradipa verfasserin aut Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tingting Li verfasserin aut Mei-Chin Hsieh verfasserin aut Laura Tenner verfasserin aut Edward S. Peters verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 14(2024) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:14 year:2024 https://doi.org/10.3389/fonc.2024.1331049 kostenfrei https://doaj.org/article/03aac268f35b4b0582920383996378a9 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsSound	10.3389/fonc.2024.1331049 doi (DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9 DE-627 ger DE-627 rakwb eng RC254-282 Kendra L. Ratnapradipa verfasserin aut Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders. Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens Tingting Li verfasserin aut Mei-Chin Hsieh verfasserin aut Laura Tenner verfasserin aut Edward S. Peters verfasserin aut In Frontiers in Oncology Frontiers Media S.A., 2012 14(2024) (DE-627)684965518 (DE-600)2649216-7 2234943X nnns volume:14 year:2024 https://doi.org/10.3389/fonc.2024.1331049 kostenfrei https://doaj.org/article/03aac268f35b4b0582920383996378a9 kostenfrei https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full kostenfrei https://doaj.org/toc/2234-943X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
language	English
source	In Frontiers in Oncology 14(2024) volume:14 year:2024
sourceStr	In Frontiers in Oncology 14(2024) volume:14 year:2024
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institution	findex.gbv.de
topic_facet	Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Kendra L. Ratnapradipa @@aut@@ Tingting Li @@aut@@ Mei-Chin Hsieh @@aut@@ Laura Tenner @@aut@@ Edward S. Peters @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
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callnumber-first	R - Medicine
author	Kendra L. Ratnapradipa
spellingShingle	Kendra L. Ratnapradipa misc RC254-282 misc Area Deprivation Index (ADI) misc hepatocellular carcinoma (HCC) misc incidence misc social determinants of health misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
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topic_title	RC254-282 Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival Area Deprivation Index (ADI) hepatocellular carcinoma (HCC) incidence social determinants of health survival
topic	misc RC254-282 misc Area Deprivation Index (ADI) misc hepatocellular carcinoma (HCC) misc incidence misc social determinants of health misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Area Deprivation Index (ADI) misc hepatocellular carcinoma (HCC) misc incidence misc social determinants of health misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Area Deprivation Index (ADI) misc hepatocellular carcinoma (HCC) misc incidence misc social determinants of health misc survival misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
ctrlnum	(DE-627)DOAJ094805377 (DE-599)DOAJ03aac268f35b4b0582920383996378a9
title_full	Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
author_sort	Kendra L. Ratnapradipa
journal	Frontiers in Oncology
journalStr	Frontiers in Oncology
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author_browse	Kendra L. Ratnapradipa Tingting Li Mei-Chin Hsieh Laura Tenner Edward S. Peters
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class	RC254-282
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author-letter	Kendra L. Ratnapradipa
doi_str_mv	10.3389/fonc.2024.1331049
author2-role	verfasserin
title_sort	most deprived louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
callnumber	RC254-282
title_auth	Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
abstract	BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders.
abstractGer	BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders.
abstract_unstemmed	BackgroundLiver cancer incidence increased in the US from 1975 through 2015 with heterogeneous rates across subpopulations. Upstream or distal area-level factors impact liver cancer risks.ObjectiveThe aim of this study was to examine the association between area-level deprivation and hepatocellular carcinoma (HCC) incidence and survival. We also explored the association between area deprivation and treatment modalities.MethodsLouisiana Tumor Registry identified 4,151 adult patients diagnosed with malignant HCC from 2011 to 2020 and linked residential address to census tract (CT)-level Area Deprivation Index (ADI) categorized into quartiles (Q1 = least deprived). ANOVA examined the association between ADI quartile and CT age-adjusted incidence rate (AAIR) per 100,000. Chi-square tested the distribution of demographic and clinical characteristics across ADI quartiles. Kaplan–Meier and proportional hazard models evaluated survival by deprivation quartile.ResultsAmong the 1,084 CTs with incident HCC, the average (SD) AAIR was 8.02 (7.05) HCC cases per 100,000 population. ADI was observed to be associated with incidence, and the mean (SD) AAIR increased from 5.80 (4.75) in Q1 to 9.26 (7.88) in Q4. ADI was also associated with receipt of surgery (p < 0.01) and radiation (p < 0.01) but not chemotherapy (p = 0.15). However, among those who received chemotherapy, people living in the least deprived areas began treatment approximately 10 days sooner than those living in other quartiles. Q4 patients experienced the worst survival with a median of 247 (95% CI 211–290) days vs. Q1 patients with a median of 474 (95% CI 407–547) days (p < 0.0001). Q4 had marginally poorer survival (HR 1.20, 1.05–1.37) than Q1 but the association became non-significant (HR 1.12, 0.96–1.30) when adjusted for rurality, liquor store density, sex, race/ethnicity, age, insurance, BMI, stage, hepatitis diagnosis, and comorbidities.ConclusionIncreasing neighborhood (CT) deprivation (ADI) was observed to be associated with increased HCC incidence and poorer HCC survival. However, the association with poorer survival becomes attenuated after adjusting for putative confounders.
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title_short	Most deprived Louisiana census tracts have higher hepatocellular carcinoma incidence and worse survival
url	https://doi.org/10.3389/fonc.2024.1331049 https://doaj.org/article/03aac268f35b4b0582920383996378a9 https://www.frontiersin.org/articles/10.3389/fonc.2024.1331049/full https://doaj.org/toc/2234-943X
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author2	Tingting Li Mei-Chin Hsieh Laura Tenner Edward S. Peters
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