Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish indiv...
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Autor*in:	Linda Ottensmann [verfasserIn] Rubina Tabassum [verfasserIn] Sanni E. Ruotsalainen [verfasserIn] Mathias J. Gerl [verfasserIn] Christian Klose [verfasserIn] Elisabeth Widén [verfasserIn] FinnGen [verfasserIn] Kai Simons [verfasserIn] Samuli Ripatti [verfasserIn] Matti Pirinen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 14(2023), 1, Seite 15
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1 ; pages:15

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-023-42532-8

Katalog-ID:	DOAJ095329579

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allfields	10.1038/s41467-023-42532-8 doi (DE-627)DOAJ095329579 (DE-599)DOAJe64d8fe6e7a14ca697b825b469fc79d4 DE-627 ger DE-627 rakwb eng Linda Ottensmann verfasserin aut Genome-wide association analysis of plasma lipidome identifies 495 genetic associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids. Science Q Rubina Tabassum verfasserin aut Sanni E. Ruotsalainen verfasserin aut Mathias J. Gerl verfasserin aut Christian Klose verfasserin aut Elisabeth Widén verfasserin aut FinnGen verfasserin aut Kai Simons verfasserin aut Samuli Ripatti verfasserin aut Matti Pirinen verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:15 https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 kostenfrei https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 15
spelling	10.1038/s41467-023-42532-8 doi (DE-627)DOAJ095329579 (DE-599)DOAJe64d8fe6e7a14ca697b825b469fc79d4 DE-627 ger DE-627 rakwb eng Linda Ottensmann verfasserin aut Genome-wide association analysis of plasma lipidome identifies 495 genetic associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids. Science Q Rubina Tabassum verfasserin aut Sanni E. Ruotsalainen verfasserin aut Mathias J. Gerl verfasserin aut Christian Klose verfasserin aut Elisabeth Widén verfasserin aut FinnGen verfasserin aut Kai Simons verfasserin aut Samuli Ripatti verfasserin aut Matti Pirinen verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:15 https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 kostenfrei https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 15
allfields_unstemmed	10.1038/s41467-023-42532-8 doi (DE-627)DOAJ095329579 (DE-599)DOAJe64d8fe6e7a14ca697b825b469fc79d4 DE-627 ger DE-627 rakwb eng Linda Ottensmann verfasserin aut Genome-wide association analysis of plasma lipidome identifies 495 genetic associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids. Science Q Rubina Tabassum verfasserin aut Sanni E. Ruotsalainen verfasserin aut Mathias J. Gerl verfasserin aut Christian Klose verfasserin aut Elisabeth Widén verfasserin aut FinnGen verfasserin aut Kai Simons verfasserin aut Samuli Ripatti verfasserin aut Matti Pirinen verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:15 https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 kostenfrei https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 15
allfieldsGer	10.1038/s41467-023-42532-8 doi (DE-627)DOAJ095329579 (DE-599)DOAJe64d8fe6e7a14ca697b825b469fc79d4 DE-627 ger DE-627 rakwb eng Linda Ottensmann verfasserin aut Genome-wide association analysis of plasma lipidome identifies 495 genetic associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids. Science Q Rubina Tabassum verfasserin aut Sanni E. Ruotsalainen verfasserin aut Mathias J. Gerl verfasserin aut Christian Klose verfasserin aut Elisabeth Widén verfasserin aut FinnGen verfasserin aut Kai Simons verfasserin aut Samuli Ripatti verfasserin aut Matti Pirinen verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:15 https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 kostenfrei https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 15
allfieldsSound	10.1038/s41467-023-42532-8 doi (DE-627)DOAJ095329579 (DE-599)DOAJe64d8fe6e7a14ca697b825b469fc79d4 DE-627 ger DE-627 rakwb eng Linda Ottensmann verfasserin aut Genome-wide association analysis of plasma lipidome identifies 495 genetic associations 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids. Science Q Rubina Tabassum verfasserin aut Sanni E. Ruotsalainen verfasserin aut Mathias J. Gerl verfasserin aut Christian Klose verfasserin aut Elisabeth Widén verfasserin aut FinnGen verfasserin aut Kai Simons verfasserin aut Samuli Ripatti verfasserin aut Matti Pirinen verfasserin aut In Nature Communications Nature Portfolio, 2016 14(2023), 1, Seite 15 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:14 year:2023 number:1 pages:15 https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 kostenfrei https://doi.org/10.1038/s41467-023-42532-8 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1 15
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source	In Nature Communications 14(2023), 1, Seite 15 volume:14 year:2023 number:1 pages:15
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authorswithroles_txt_mv	Linda Ottensmann @@aut@@ Rubina Tabassum @@aut@@ Sanni E. Ruotsalainen @@aut@@ Mathias J. Gerl @@aut@@ Christian Klose @@aut@@ Elisabeth Widén @@aut@@ FinnGen @@aut@@ Kai Simons @@aut@@ Samuli Ripatti @@aut@@ Matti Pirinen @@aut@@
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author	Linda Ottensmann
spellingShingle	Linda Ottensmann misc Science misc Q Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
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topic_title	Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
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title	Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
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title_sort	genome-wide association analysis of plasma lipidome identifies 495 genetic associations
title_auth	Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
abstract	Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids.
abstractGer	Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids.
abstract_unstemmed	Abstract The human plasma lipidome captures risk for cardiometabolic diseases. To discover new lipid-associated variants and understand the link between lipid species and cardiometabolic disorders, we perform univariate and multivariate genome-wide analyses of 179 lipid species in 7174 Finnish individuals. We fine-map the associated loci, prioritize genes, and examine their disease links in 377,277 FinnGen participants. We identify 495 genome-trait associations in 56 genetic loci including 8 novel loci, with a considerable boost provided by the multivariate analysis. For 26 loci, fine-mapping identifies variants with a high causal probability, including 14 coding variants indicating likely causal genes. A phenome-wide analysis across 953 disease endpoints reveals disease associations for 40 lipid loci. For 11 coronary artery disease risk variants, we detect strong associations with lipid species. Our study demonstrates the power of multivariate genetic analysis in correlated lipidomics data and reveals genetic links between diseases and lipid species beyond the standard lipids.
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title_short	Genome-wide association analysis of plasma lipidome identifies 495 genetic associations
url	https://doi.org/10.1038/s41467-023-42532-8 https://doaj.org/article/e64d8fe6e7a14ca697b825b469fc79d4 https://doaj.org/toc/2041-1723
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Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

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