Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds

The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jinfeng Yang [verfasserIn] Joo Seok Kim [verfasserIn] Yong Soo Kwon [verfasserIn] Eun Soo Seong [verfasserIn] Myong Jo Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	antioxidant activity antiproliferative flavonoids

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 21, p 7354
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:21, p 7354

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28217354

Katalog-ID:	DOAJ095449825

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520			\|a The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds.
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allfields	10.3390/molecules28217354 doi (DE-627)DOAJ095449825 (DE-599)DOAJfbb96067c3eb48dd870b6e0db2ee3f01 DE-627 ger DE-627 rakwb eng QD241-441 Jinfeng Yang verfasserin aut Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds. <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids Organic chemistry Joo Seok Kim verfasserin aut Yong Soo Kwon verfasserin aut Eun Soo Seong verfasserin aut Myong Jo Kim verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7354 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7354 https://doi.org/10.3390/molecules28217354 kostenfrei https://doaj.org/article/fbb96067c3eb48dd870b6e0db2ee3f01 kostenfrei https://www.mdpi.com/1420-3049/28/21/7354 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7354
spelling	10.3390/molecules28217354 doi (DE-627)DOAJ095449825 (DE-599)DOAJfbb96067c3eb48dd870b6e0db2ee3f01 DE-627 ger DE-627 rakwb eng QD241-441 Jinfeng Yang verfasserin aut Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds. <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids Organic chemistry Joo Seok Kim verfasserin aut Yong Soo Kwon verfasserin aut Eun Soo Seong verfasserin aut Myong Jo Kim verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7354 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7354 https://doi.org/10.3390/molecules28217354 kostenfrei https://doaj.org/article/fbb96067c3eb48dd870b6e0db2ee3f01 kostenfrei https://www.mdpi.com/1420-3049/28/21/7354 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7354
allfields_unstemmed	10.3390/molecules28217354 doi (DE-627)DOAJ095449825 (DE-599)DOAJfbb96067c3eb48dd870b6e0db2ee3f01 DE-627 ger DE-627 rakwb eng QD241-441 Jinfeng Yang verfasserin aut Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds. <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids Organic chemistry Joo Seok Kim verfasserin aut Yong Soo Kwon verfasserin aut Eun Soo Seong verfasserin aut Myong Jo Kim verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7354 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7354 https://doi.org/10.3390/molecules28217354 kostenfrei https://doaj.org/article/fbb96067c3eb48dd870b6e0db2ee3f01 kostenfrei https://www.mdpi.com/1420-3049/28/21/7354 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7354
allfieldsGer	10.3390/molecules28217354 doi (DE-627)DOAJ095449825 (DE-599)DOAJfbb96067c3eb48dd870b6e0db2ee3f01 DE-627 ger DE-627 rakwb eng QD241-441 Jinfeng Yang verfasserin aut Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds. <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids Organic chemistry Joo Seok Kim verfasserin aut Yong Soo Kwon verfasserin aut Eun Soo Seong verfasserin aut Myong Jo Kim verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7354 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7354 https://doi.org/10.3390/molecules28217354 kostenfrei https://doaj.org/article/fbb96067c3eb48dd870b6e0db2ee3f01 kostenfrei https://www.mdpi.com/1420-3049/28/21/7354 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7354
allfieldsSound	10.3390/molecules28217354 doi (DE-627)DOAJ095449825 (DE-599)DOAJfbb96067c3eb48dd870b6e0db2ee3f01 DE-627 ger DE-627 rakwb eng QD241-441 Jinfeng Yang verfasserin aut Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds. <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids Organic chemistry Joo Seok Kim verfasserin aut Yong Soo Kwon verfasserin aut Eun Soo Seong verfasserin aut Myong Jo Kim verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7354 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7354 https://doi.org/10.3390/molecules28217354 kostenfrei https://doaj.org/article/fbb96067c3eb48dd870b6e0db2ee3f01 kostenfrei https://www.mdpi.com/1420-3049/28/21/7354 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7354
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source	In Molecules 28(2023), 21, p 7354 volume:28 year:2023 number:21, p 7354
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callnumber-first	Q - Science
author	Jinfeng Yang
spellingShingle	Jinfeng Yang misc QD241-441 misc <i<Eclipta prostrata</i< (L.) L. misc antioxidant activity misc antiproliferative misc flavonoids misc Organic chemistry Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds
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topic_title	QD241-441 Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds <i<Eclipta prostrata</i< (L.) L. antioxidant activity antiproliferative flavonoids
topic	misc QD241-441 misc <i<Eclipta prostrata</i< (L.) L. misc antioxidant activity misc antiproliferative misc flavonoids misc Organic chemistry
topic_unstemmed	misc QD241-441 misc <i<Eclipta prostrata</i< (L.) L. misc antioxidant activity misc antiproliferative misc flavonoids misc Organic chemistry
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title	Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds
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title_full	Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds
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title_sort	antioxidant and antiproliferative activities of <i<eclipta prostrata</i< (l.) l. extract and isolated compounds
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title_auth	Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds
abstract	The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds.
abstractGer	The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds.
abstract_unstemmed	The primary objective of this study was to elucidate the chemical composition, antioxidant properties, and antiproliferative activities of <i<Eclipta prostrata</i< extracts. Two flavonoids, 3′-O-methylorobol and apigenin 7-sulfate, were isolated from the ethyl acetate (EtOAc) extract of <i<E. prostrata</i<. The total phenolic and flavonoid contents of the <i<E. prostrata</i< extracts, as well as their overall antioxidant activities as measured using the 2,2-diphenyl-1-picrylhydrazyl and reducing power assays, were investigated. The <i<E. prostrata</i< EtOAc extract exhibited significantly greater antioxidant activities in both assays and higher phenol and flavonoid contents than the other extracts. The potential antiproliferative properties of the <i<E. prostrata</i< extracts and isolated compounds were investigated in vitro against the AGS, A549, and HT-29 cancer cell lines and the normal human HEK-293 cell line using the MTT assay. Annexin V-FITC/PI staining analysis and quantitative real-time PCR were used to assess AGS cell apoptosis. At a concentration of 100 µg/mL, the EtOAc extract of <i<E. prostrata</i< reduced AGS cell viability and proliferation by inducing apoptosis through the alteration of gene expression in the apoptotic cascade. These results highlight <i<E. prostrata</i< as a promising source of anticancer compounds.
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title_short	Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds
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Antioxidant and Antiproliferative Activities of <i<Eclipta prostrata</i< (L.) L. Extract and Isolated Compounds

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