The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction

G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our und...
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Autor*in:	Samuel R. Clowes [verfasserIn] Yusuf Ali [verfasserIn] Olivia R. Astley [verfasserIn] Dora M. Răsădean [verfasserIn] G. Dan Pantoş [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 21, p 7291
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:21, p 7291

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28217291

Katalog-ID:	DOAJ095450513

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520			\|a G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.
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spelling	10.3390/molecules28217291 doi (DE-627)DOAJ095450513 (DE-599)DOAJ6065ef3fb1bb46ffa0d75018f687f4f1 DE-627 ger DE-627 rakwb eng QD241-441 Samuel R. Clowes verfasserin aut The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour. circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking Organic chemistry Yusuf Ali verfasserin aut Olivia R. Astley verfasserin aut Dora M. Răsădean verfasserin aut G. Dan Pantoş verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7291 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7291 https://doi.org/10.3390/molecules28217291 kostenfrei https://doaj.org/article/6065ef3fb1bb46ffa0d75018f687f4f1 kostenfrei https://www.mdpi.com/1420-3049/28/21/7291 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7291
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allfieldsGer	10.3390/molecules28217291 doi (DE-627)DOAJ095450513 (DE-599)DOAJ6065ef3fb1bb46ffa0d75018f687f4f1 DE-627 ger DE-627 rakwb eng QD241-441 Samuel R. Clowes verfasserin aut The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour. circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking Organic chemistry Yusuf Ali verfasserin aut Olivia R. Astley verfasserin aut Dora M. Răsădean verfasserin aut G. Dan Pantoş verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7291 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7291 https://doi.org/10.3390/molecules28217291 kostenfrei https://doaj.org/article/6065ef3fb1bb46ffa0d75018f687f4f1 kostenfrei https://www.mdpi.com/1420-3049/28/21/7291 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7291
allfieldsSound	10.3390/molecules28217291 doi (DE-627)DOAJ095450513 (DE-599)DOAJ6065ef3fb1bb46ffa0d75018f687f4f1 DE-627 ger DE-627 rakwb eng QD241-441 Samuel R. Clowes verfasserin aut The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour. circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking Organic chemistry Yusuf Ali verfasserin aut Olivia R. Astley verfasserin aut Dora M. Răsădean verfasserin aut G. Dan Pantoş verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7291 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7291 https://doi.org/10.3390/molecules28217291 kostenfrei https://doaj.org/article/6065ef3fb1bb46ffa0d75018f687f4f1 kostenfrei https://www.mdpi.com/1420-3049/28/21/7291 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7291
language	English
source	In Molecules 28(2023), 21, p 7291 volume:28 year:2023 number:21, p 7291
sourceStr	In Molecules 28(2023), 21, p 7291 volume:28 year:2023 number:21, p 7291
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking Organic chemistry
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container_title	Molecules
authorswithroles_txt_mv	Samuel R. Clowes @@aut@@ Yusuf Ali @@aut@@ Olivia R. Astley @@aut@@ Dora M. Răsădean @@aut@@ G. Dan Pantoş @@aut@@
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callnumber-first	Q - Science
author	Samuel R. Clowes
spellingShingle	Samuel R. Clowes misc QD241-441 misc circular dichroism misc enantioselectivity misc G-quadruplex DNA misc chiral recognition misc docking misc Organic chemistry The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction
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topic_title	QD241-441 The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction circular dichroism enantioselectivity G-quadruplex DNA chiral recognition docking
topic	misc QD241-441 misc circular dichroism misc enantioselectivity misc G-quadruplex DNA misc chiral recognition misc docking misc Organic chemistry
topic_unstemmed	misc QD241-441 misc circular dichroism misc enantioselectivity misc G-quadruplex DNA misc chiral recognition misc docking misc Organic chemistry
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title	The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction
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title_sort	influence of chirality on the β-amino-acid naphthalenediimides/g-quadruplex dna interaction
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title_auth	The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction
abstract	G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.
abstractGer	G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.
abstract_unstemmed	G-quadruplexes (G4s) have been identified as a potential alternative chemotherapy target. A series of eight β-amino acid derived naphthalenediimides (NDI) were screened against a series of oncogenic G4 sequences: c-KIT1, h-TELO, and TBA. Three sets of enantiomers were investigated to further our understanding of the effect of point chirality on G4 stabilisation. Enantioselective binding behaviour was observed with both c-KIT1 and h-TELO. Docking studies using GNINA and UV-vis titrations were employed to better understand this selective binding behaviour.
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title_short	The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction
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The Influence of Chirality on the β-Amino-Acid Naphthalenediimides/G-Quadruplex DNA Interaction

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