Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)

<i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides name...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shi-Hui Lu [verfasserIn] Xiu-Xia Li [verfasserIn] Hao-Jiang Zuo [verfasserIn] Wei-Neng Li [verfasserIn] Jia-Ping Pan [verfasserIn] Jing Huang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 28(2023), 21, p 7274
Übergeordnetes Werk:	volume:28 ; year:2023 ; number:21, p 7274

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules28217274

Katalog-ID:	DOAJ09545067X

Internformat


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520			\|a <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications.
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allfields	10.3390/molecules28217274 doi (DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b DE-627 ger DE-627 rakwb eng QD241-441 Shi-Hui Lu verfasserin aut Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications. <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry Xiu-Xia Li verfasserin aut Hao-Jiang Zuo verfasserin aut Wei-Neng Li verfasserin aut Jia-Ping Pan verfasserin aut Jing Huang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7274 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7274 https://doi.org/10.3390/molecules28217274 kostenfrei https://doaj.org/article/30ea53230c6a439aa55bbed5c336a82b kostenfrei https://www.mdpi.com/1420-3049/28/21/7274 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7274
spelling	10.3390/molecules28217274 doi (DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b DE-627 ger DE-627 rakwb eng QD241-441 Shi-Hui Lu verfasserin aut Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications. <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry Xiu-Xia Li verfasserin aut Hao-Jiang Zuo verfasserin aut Wei-Neng Li verfasserin aut Jia-Ping Pan verfasserin aut Jing Huang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7274 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7274 https://doi.org/10.3390/molecules28217274 kostenfrei https://doaj.org/article/30ea53230c6a439aa55bbed5c336a82b kostenfrei https://www.mdpi.com/1420-3049/28/21/7274 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7274
allfields_unstemmed	10.3390/molecules28217274 doi (DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b DE-627 ger DE-627 rakwb eng QD241-441 Shi-Hui Lu verfasserin aut Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications. <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry Xiu-Xia Li verfasserin aut Hao-Jiang Zuo verfasserin aut Wei-Neng Li verfasserin aut Jia-Ping Pan verfasserin aut Jing Huang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7274 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7274 https://doi.org/10.3390/molecules28217274 kostenfrei https://doaj.org/article/30ea53230c6a439aa55bbed5c336a82b kostenfrei https://www.mdpi.com/1420-3049/28/21/7274 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7274
allfieldsGer	10.3390/molecules28217274 doi (DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b DE-627 ger DE-627 rakwb eng QD241-441 Shi-Hui Lu verfasserin aut Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications. <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry Xiu-Xia Li verfasserin aut Hao-Jiang Zuo verfasserin aut Wei-Neng Li verfasserin aut Jia-Ping Pan verfasserin aut Jing Huang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7274 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7274 https://doi.org/10.3390/molecules28217274 kostenfrei https://doaj.org/article/30ea53230c6a439aa55bbed5c336a82b kostenfrei https://www.mdpi.com/1420-3049/28/21/7274 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7274
allfieldsSound	10.3390/molecules28217274 doi (DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b DE-627 ger DE-627 rakwb eng QD241-441 Shi-Hui Lu verfasserin aut Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications. <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry Xiu-Xia Li verfasserin aut Hao-Jiang Zuo verfasserin aut Wei-Neng Li verfasserin aut Jia-Ping Pan verfasserin aut Jing Huang verfasserin aut In Molecules MDPI AG, 2003 28(2023), 21, p 7274 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:28 year:2023 number:21, p 7274 https://doi.org/10.3390/molecules28217274 kostenfrei https://doaj.org/article/30ea53230c6a439aa55bbed5c336a82b kostenfrei https://www.mdpi.com/1420-3049/28/21/7274 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 28 2023 21, p 7274
language	English
source	In Molecules 28(2023), 21, p 7274 volume:28 year:2023 number:21, p 7274
sourceStr	In Molecules 28(2023), 21, p 7274 volume:28 year:2023 number:21, p 7274
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	<i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes Organic chemistry
isfreeaccess_bool	true
container_title	Molecules
authorswithroles_txt_mv	Shi-Hui Lu @@aut@@ Xiu-Xia Li @@aut@@ Hao-Jiang Zuo @@aut@@ Wei-Neng Li @@aut@@ Jia-Ping Pan @@aut@@ Jing Huang @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	311313132
id	DOAJ09545067X
language_de	englisch
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callnumber-first	Q - Science
author	Shi-Hui Lu
spellingShingle	Shi-Hui Lu misc QD241-441 misc <i<Ligustrum robustum</i< misc monoterpenoid glycoside misc FAS misc α-glucosidase misc antioxidant misc anti-diabetes misc Organic chemistry Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)
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topic_title	QD241-441 Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II) <i<Ligustrum robustum</i< monoterpenoid glycoside FAS α-glucosidase antioxidant anti-diabetes
topic	misc QD241-441 misc <i<Ligustrum robustum</i< misc monoterpenoid glycoside misc FAS misc α-glucosidase misc antioxidant misc anti-diabetes misc Organic chemistry
topic_unstemmed	misc QD241-441 misc <i<Ligustrum robustum</i< misc monoterpenoid glycoside misc FAS misc α-glucosidase misc antioxidant misc anti-diabetes misc Organic chemistry
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title	Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)
ctrlnum	(DE-627)DOAJ09545067X (DE-599)DOAJ30ea53230c6a439aa55bbed5c336a82b
title_full	Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)
author_sort	Shi-Hui Lu
journal	Molecules
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author_browse	Shi-Hui Lu Xiu-Xia Li Hao-Jiang Zuo Wei-Neng Li Jia-Ping Pan Jing Huang
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title_sort	monoterpenoid glycosides from the leaves of <i<ligustrum robustum</i< and their bioactivities (ii)
callnumber	QD241-441
title_auth	Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)
abstract	<i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications.
abstractGer	<i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications.
abstract_unstemmed	<i<Ligustrum robustum</i< has been not only used as a heat-clearing and detoxicating functional tea (Ku-Ding-Cha) but also consumed as a hypotensive, anti-diabetic, and weight-reducing folk medicine. From the leaves of <i<L. robustum</i<, ten new monoterpenoid glycosides named ligurobustosides T<sub<10</sub< (<b<1a</b<), T<sub<11</sub< (<b<1b</b<), T<sub<12</sub< (<b<2a</b<), T<sub<13</sub< (<b<2b</b<), T<sub<14</sub< (<b<3a</b<), T<sub<15</sub< (<b<3b</b<), F<sub<1</sub< (<b<4b</b<), T<sub<16</sub< (<b<5a</b<), T<sub<17</sub< (<b<5b</b<), and E<sub<1</sub< (<b<6b</b<), together with five known ones (<b<4a</b<, <b<6a</b<, <b<7</b<, <b<8a</b<, <b<8b</b<), were separated and identified using the spectroscopic method and chemical method in this research. The results of biological tests exhibited that the fatty acid synthase (FAS) inhibitory action of compound <b<5</b< (IC<sub<50</sub<: 4.38 ± 0.11 μM) was as strong as orlistat (IC<sub<50</sub<: 4.46 ± 0.13 μM), a positive control; the α-glucosidase inhibitory actions of compounds <b<1</b<–<b<4</b< and <b<7</b<–<b<8</b<, and the α-amylase inhibitory actions of compounds <b<1</b<–<b<8</b< were medium; the ABTS radical scavenging capacities of compounds <b<1</b<–<b<3</b< and <b<5</b<–<b<8</b< (IC<sub<50</sub<: 6.27 ± 0.23 ~ 8.59 ± 0.09 μM) were stronger than <span style="font-variant: small-caps;"<l</span<-(+)-ascorbic acid (IC<sub<50</sub<: 10.06 ± 0.19 μM) served as a positive control. This research offered a theoretical foundation for the leaves of <i<L. robustum</i< to prevent diabetes and its complications.
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title_short	Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)
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Monoterpenoid Glycosides from the Leaves of <i<Ligustrum robustum</i< and Their Bioactivities (II)

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