SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers

At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Luigi De Maria [verfasserIn] Giuseppe Delvecchio [verfasserIn] Stefania Sponselli [verfasserIn] Francesco Cafaro [verfasserIn] Antonio Caputi [verfasserIn] Gianmarco Giannelli [verfasserIn] Pasquale Stefanizzi [verfasserIn] Francesco Paolo Bianchi [verfasserIn] Angela Stufano [verfasserIn] Silvio Tafuri [verfasserIn] Piero Lovreglio [verfasserIn] Paolo Boffetta [verfasserIn] Luigi Vimercati [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	COVID-19 SARS-CoV-2 breakthrough infections healthcare workers

Übergeordnetes Werk:	In: Journal of Clinical Medicine - MDPI AG, 2013, 12(2023), 21, p 6800
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:21, p 6800

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jcm12216800

Katalog-ID:	DOAJ095456538

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allfields	10.3390/jcm12216800 doi (DE-627)DOAJ095456538 (DE-599)DOAJa47efb246a75491d8b844b0040e61fba DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable. COVID-19 SARS-CoV-2 breakthrough infections healthcare workers Medicine R Giuseppe Delvecchio verfasserin aut Stefania Sponselli verfasserin aut Francesco Cafaro verfasserin aut Antonio Caputi verfasserin aut Gianmarco Giannelli verfasserin aut Pasquale Stefanizzi verfasserin aut Francesco Paolo Bianchi verfasserin aut Angela Stufano verfasserin aut Silvio Tafuri verfasserin aut Piero Lovreglio verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 21, p 6800 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:21, p 6800 https://doi.org/10.3390/jcm12216800 kostenfrei https://doaj.org/article/a47efb246a75491d8b844b0040e61fba kostenfrei https://www.mdpi.com/2077-0383/12/21/6800 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 21, p 6800
spelling	10.3390/jcm12216800 doi (DE-627)DOAJ095456538 (DE-599)DOAJa47efb246a75491d8b844b0040e61fba DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable. COVID-19 SARS-CoV-2 breakthrough infections healthcare workers Medicine R Giuseppe Delvecchio verfasserin aut Stefania Sponselli verfasserin aut Francesco Cafaro verfasserin aut Antonio Caputi verfasserin aut Gianmarco Giannelli verfasserin aut Pasquale Stefanizzi verfasserin aut Francesco Paolo Bianchi verfasserin aut Angela Stufano verfasserin aut Silvio Tafuri verfasserin aut Piero Lovreglio verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 21, p 6800 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:21, p 6800 https://doi.org/10.3390/jcm12216800 kostenfrei https://doaj.org/article/a47efb246a75491d8b844b0040e61fba kostenfrei https://www.mdpi.com/2077-0383/12/21/6800 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 21, p 6800
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allfieldsSound	10.3390/jcm12216800 doi (DE-627)DOAJ095456538 (DE-599)DOAJa47efb246a75491d8b844b0040e61fba DE-627 ger DE-627 rakwb eng Luigi De Maria verfasserin aut SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable. COVID-19 SARS-CoV-2 breakthrough infections healthcare workers Medicine R Giuseppe Delvecchio verfasserin aut Stefania Sponselli verfasserin aut Francesco Cafaro verfasserin aut Antonio Caputi verfasserin aut Gianmarco Giannelli verfasserin aut Pasquale Stefanizzi verfasserin aut Francesco Paolo Bianchi verfasserin aut Angela Stufano verfasserin aut Silvio Tafuri verfasserin aut Piero Lovreglio verfasserin aut Paolo Boffetta verfasserin aut Luigi Vimercati verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 12(2023), 21, p 6800 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:12 year:2023 number:21, p 6800 https://doi.org/10.3390/jcm12216800 kostenfrei https://doaj.org/article/a47efb246a75491d8b844b0040e61fba kostenfrei https://www.mdpi.com/2077-0383/12/21/6800 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 21, p 6800
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author	Luigi De Maria
spellingShingle	Luigi De Maria misc COVID-19 misc SARS-CoV-2 breakthrough infections misc healthcare workers misc Medicine misc R SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
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topic_title	SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers COVID-19 SARS-CoV-2 breakthrough infections healthcare workers
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title	SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
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title_sort	sars-cov-2 infections, re-infections and clinical characteristics: a two-year retrospective study in a large university hospital cohort of vaccinated healthcare workers
title_auth	SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
abstract	At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable.
abstractGer	At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable.
abstract_unstemmed	At the University Hospital of Bari, during the first year after the start of the mandatory vaccination campaign with BNT162b2 mRNA COVID-19 vaccine, the preliminary results of an observational study showed a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs), but no hospitalization or deaths. In the present study, we extended the observation period (January 2021–January 2023) with the aim of determining the incidence, characteristics and clinical course of SARS-CoV-2 BIs among 6213 HCWs. All HCWs were regularly monitored and screened. To allow return to work after BI, the protocol required one negative nasopharyngeal swab test followed by a medical examination certifying complete clinical recovery. We observed an overall incidence rate of SARS-CoV-2 BIs of 20.2%. Females were most affected, especially in the nurse group compared with doctors and other HCWs (<i<p</i< < 0.0001). Cardiovascular diseases were the most frequent comorbidity (<i<n</i< = 140; 11.4%). The source of infection was non-occupational in 52.4% of cases. Most cases (96.9%) showed minor symptoms and only two cases of hospitalization (one in intensive care unit), 13 cases of re-infection and no deaths were recorded. Our results confirm that SARS-CoV-2 infection can break vaccination protection but the clinical course is favorable.
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title_short	SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers
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SARS-CoV-2 Infections, Re-Infections and Clinical Characteristics: A Two-Year Retrospective Study in a Large University Hospital Cohort of Vaccinated Healthcare Workers

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