Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response

<b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vishnupriyadevi Parvathareddy [verfasserIn] Umut Selamet [verfasserIn] Aditi A. Sen [verfasserIn] Omar Mamlouk [verfasserIn] Juhee Song [verfasserIn] Valda D. Page [verfasserIn] Maen Abdelrahim [verfasserIn] Adi Diab [verfasserIn] Noha Abdel-Wahab [verfasserIn] Ala Abudayyeh [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	acute kidney injury immune checkpoint inhibitor cancer progression

Übergeordnetes Werk:	In: Cancers - MDPI AG, 2010, 15(2023), 21, p 5181
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:21, p 5181

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cancers15215181

Katalog-ID:	DOAJ095472991

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allfields	10.3390/cancers15215181 doi (DE-627)DOAJ095472991 (DE-599)DOAJc9b625fa8c6c420f86b9bc1193e9a875 DE-627 ger DE-627 rakwb eng RC254-282 Vishnupriyadevi Parvathareddy verfasserin aut Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umut Selamet verfasserin aut Aditi A. Sen verfasserin aut Omar Mamlouk verfasserin aut Juhee Song verfasserin aut Valda D. Page verfasserin aut Maen Abdelrahim verfasserin aut Adi Diab verfasserin aut Noha Abdel-Wahab verfasserin aut Ala Abudayyeh verfasserin aut In Cancers MDPI AG, 2010 15(2023), 21, p 5181 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:21, p 5181 https://doi.org/10.3390/cancers15215181 kostenfrei https://doaj.org/article/c9b625fa8c6c420f86b9bc1193e9a875 kostenfrei https://www.mdpi.com/2072-6694/15/21/5181 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 21, p 5181
spelling	10.3390/cancers15215181 doi (DE-627)DOAJ095472991 (DE-599)DOAJc9b625fa8c6c420f86b9bc1193e9a875 DE-627 ger DE-627 rakwb eng RC254-282 Vishnupriyadevi Parvathareddy verfasserin aut Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umut Selamet verfasserin aut Aditi A. Sen verfasserin aut Omar Mamlouk verfasserin aut Juhee Song verfasserin aut Valda D. Page verfasserin aut Maen Abdelrahim verfasserin aut Adi Diab verfasserin aut Noha Abdel-Wahab verfasserin aut Ala Abudayyeh verfasserin aut In Cancers MDPI AG, 2010 15(2023), 21, p 5181 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:21, p 5181 https://doi.org/10.3390/cancers15215181 kostenfrei https://doaj.org/article/c9b625fa8c6c420f86b9bc1193e9a875 kostenfrei https://www.mdpi.com/2072-6694/15/21/5181 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 21, p 5181
allfields_unstemmed	10.3390/cancers15215181 doi (DE-627)DOAJ095472991 (DE-599)DOAJc9b625fa8c6c420f86b9bc1193e9a875 DE-627 ger DE-627 rakwb eng RC254-282 Vishnupriyadevi Parvathareddy verfasserin aut Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umut Selamet verfasserin aut Aditi A. Sen verfasserin aut Omar Mamlouk verfasserin aut Juhee Song verfasserin aut Valda D. Page verfasserin aut Maen Abdelrahim verfasserin aut Adi Diab verfasserin aut Noha Abdel-Wahab verfasserin aut Ala Abudayyeh verfasserin aut In Cancers MDPI AG, 2010 15(2023), 21, p 5181 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:21, p 5181 https://doi.org/10.3390/cancers15215181 kostenfrei https://doaj.org/article/c9b625fa8c6c420f86b9bc1193e9a875 kostenfrei https://www.mdpi.com/2072-6694/15/21/5181 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 21, p 5181
allfieldsGer	10.3390/cancers15215181 doi (DE-627)DOAJ095472991 (DE-599)DOAJc9b625fa8c6c420f86b9bc1193e9a875 DE-627 ger DE-627 rakwb eng RC254-282 Vishnupriyadevi Parvathareddy verfasserin aut Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umut Selamet verfasserin aut Aditi A. Sen verfasserin aut Omar Mamlouk verfasserin aut Juhee Song verfasserin aut Valda D. Page verfasserin aut Maen Abdelrahim verfasserin aut Adi Diab verfasserin aut Noha Abdel-Wahab verfasserin aut Ala Abudayyeh verfasserin aut In Cancers MDPI AG, 2010 15(2023), 21, p 5181 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:21, p 5181 https://doi.org/10.3390/cancers15215181 kostenfrei https://doaj.org/article/c9b625fa8c6c420f86b9bc1193e9a875 kostenfrei https://www.mdpi.com/2072-6694/15/21/5181 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 21, p 5181
allfieldsSound	10.3390/cancers15215181 doi (DE-627)DOAJ095472991 (DE-599)DOAJc9b625fa8c6c420f86b9bc1193e9a875 DE-627 ger DE-627 rakwb eng RC254-282 Vishnupriyadevi Parvathareddy verfasserin aut Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers. acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens Umut Selamet verfasserin aut Aditi A. Sen verfasserin aut Omar Mamlouk verfasserin aut Juhee Song verfasserin aut Valda D. Page verfasserin aut Maen Abdelrahim verfasserin aut Adi Diab verfasserin aut Noha Abdel-Wahab verfasserin aut Ala Abudayyeh verfasserin aut In Cancers MDPI AG, 2010 15(2023), 21, p 5181 (DE-627)614095670 (DE-600)2527080-1 20726694 nnns volume:15 year:2023 number:21, p 5181 https://doi.org/10.3390/cancers15215181 kostenfrei https://doaj.org/article/c9b625fa8c6c420f86b9bc1193e9a875 kostenfrei https://www.mdpi.com/2072-6694/15/21/5181 kostenfrei https://doaj.org/toc/2072-6694 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 21, p 5181
language	English
source	In Cancers 15(2023), 21, p 5181 volume:15 year:2023 number:21, p 5181
sourceStr	In Cancers 15(2023), 21, p 5181 volume:15 year:2023 number:21, p 5181
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	acute kidney injury immune checkpoint inhibitor cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Cancers
authorswithroles_txt_mv	Vishnupriyadevi Parvathareddy @@aut@@ Umut Selamet @@aut@@ Aditi A. Sen @@aut@@ Omar Mamlouk @@aut@@ Juhee Song @@aut@@ Valda D. Page @@aut@@ Maen Abdelrahim @@aut@@ Adi Diab @@aut@@ Noha Abdel-Wahab @@aut@@ Ala Abudayyeh @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	614095670
id	DOAJ095472991
language_de	englisch
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Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. 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callnumber-first	R - Medicine
author	Vishnupriyadevi Parvathareddy
spellingShingle	Vishnupriyadevi Parvathareddy misc RC254-282 misc acute kidney injury misc immune checkpoint inhibitor misc cancer progression misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response
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topic_title	RC254-282 Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response acute kidney injury immune checkpoint inhibitor cancer progression
topic	misc RC254-282 misc acute kidney injury misc immune checkpoint inhibitor misc cancer progression misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc acute kidney injury misc immune checkpoint inhibitor misc cancer progression misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc acute kidney injury misc immune checkpoint inhibitor misc cancer progression misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response
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title_full	Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response
author_sort	Vishnupriyadevi Parvathareddy
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author_browse	Vishnupriyadevi Parvathareddy Umut Selamet Aditi A. Sen Omar Mamlouk Juhee Song Valda D. Page Maen Abdelrahim Adi Diab Noha Abdel-Wahab Ala Abudayyeh
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author-letter	Vishnupriyadevi Parvathareddy
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author2-role	verfasserin
title_sort	infliximab for treatment of immune adverse events and its impact on tumor response
callnumber	RC254-282
title_auth	Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response
abstract	<b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers.
abstractGer	<b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers.
abstract_unstemmed	<b<Background:</b< Immune-related adverse events (irAEs) challenge the use of immune checkpoint inhibitors (ICIs). We performed a retrospective study to evaluate response to infliximab for immune-related adverse event management, and infliximab’s effect on progression-free survival (PFS) and overall survival (OS) with a focus on melanoma and genitourinary cancers. <b<Methods:</b< We retrospectively reviewed records of all cancer patients exposed to infliximab after immune checkpoint inhibitor (ICI) treatment from 2004 to 2021 at the MD Anderson Cancer Center. Survival was assessed utilizing the Kaplan–Meier method. Univariate and multivariate logistic regression was utilized to evaluate predictors of infliximab response, OS, and PFS. <b<Results:</b< We identified 185 cancer patients (93 melanoma and 37 genitourinary cancers) treated with ICI and who received infliximab to treat irAEs. Within 3 months of treatment initiation, 71% of the patients responded to infliximab, 27% had no response, and 2% had unknown response. Among different irAEs, colitis was associated with increased response to infliximab at 3 months, irrespective of the type of malignancy. We evaluated best tumor response before and after infliximab in the entire cohort and again in the melanoma and genitourinary (GU); the findings were similar in the melanoma cohort and the entire cohort, where best tumor response before and after infliximab was not significantly different. In the melanoma cohort, acute kidney injury (AKI) was associated with increased risk of death, <i<p</i< = 0.0109, and having response to infliximab was associated with decreased risk of death, <i<p</i< = 0.0383. Interestingly in GU cancer patients, myositis was associated with increased risk of death, <i<p</i< = 0.0041, and having a response to infliximab was marginally associated with decreased risk of death, <i<p</i< = 0.0992. As regards PFS, in a multivariate Cox regression model, having a history of cardiovascular disease remained significantly associated with shorter PFS in the melanoma cohort. For patients with GU cancers, response to infliximab was associated with longer PFS. <b<Conclusions:</b< Our study is among the largest retrospective analyses of infliximab use for irAE management. Patients with colitis were the best responders to infliximab. AKI before initiation of infliximab in the melanoma subcohort and myositis in GU subcohort are associated with higher risk of death. Our results indicate no association between infliximab and cancer progression with the exception of genitourinary cancers.
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title_short	Infliximab for Treatment of Immune Adverse Events and Its Impact on Tumor Response
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