Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers

Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons, evolved as a powerful method for the high-resolution structural investigation of proteins that are critical for human health, thus advancing drug discovery and novel therapies. However, a critical barrie...
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Autor*in:	Lars Paulson [verfasserIn] Sankar Raju Narayanasamy [verfasserIn] Megan L. Shelby [verfasserIn] Matthias Frank [verfasserIn] Martin Trebbin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Übergeordnetes Werk:	In: Structural Dynamics - AIP Publishing LLC and ACA, 2016, 11(2024), 1, Seite 011101-011101-8
Übergeordnetes Werk:	volume:11 ; year:2024 ; number:1 ; pages:011101-011101-8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1063/4.0000229

Katalog-ID:	DOAJ095573860

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language	English
source	In Structural Dynamics 11(2024), 1, Seite 011101-011101-8 volume:11 year:2024 number:1 pages:011101-011101-8
sourceStr	In Structural Dynamics 11(2024), 1, Seite 011101-011101-8 volume:11 year:2024 number:1 pages:011101-011101-8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Crystallography
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container_title	Structural Dynamics
authorswithroles_txt_mv	Lars Paulson @@aut@@ Sankar Raju Narayanasamy @@aut@@ Megan L. Shelby @@aut@@ Matthias Frank @@aut@@ Martin Trebbin @@aut@@
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topic_title	QD901-999 Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers
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title	Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers
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title_sort	advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers
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title_auth	Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers
abstract	Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons, evolved as a powerful method for the high-resolution structural investigation of proteins that are critical for human health, thus advancing drug discovery and novel therapies. However, a critical barrier to successful serial crystallography experiments lies in the efficient handling of the protein microcrystals and solutions at microscales. Microfluidics are the obvious approach for any high-throughput, nano-to-microliter sample handling, that also requires design flexibility and rapid prototyping to deal with the variable shapes, sizes, and density of crystals. Here, we discuss recent advances in polymer 3D printing for microfluidics-based serial crystallography research and present a demonstration of emerging, large-scale, nano-3D printing approaches leading into the future of 3D sample environment and delivery device fabrication from liquid jet gas-dynamic virtual nozzles devices to fixed-target sample environment technology.
abstractGer	Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons, evolved as a powerful method for the high-resolution structural investigation of proteins that are critical for human health, thus advancing drug discovery and novel therapies. However, a critical barrier to successful serial crystallography experiments lies in the efficient handling of the protein microcrystals and solutions at microscales. Microfluidics are the obvious approach for any high-throughput, nano-to-microliter sample handling, that also requires design flexibility and rapid prototyping to deal with the variable shapes, sizes, and density of crystals. Here, we discuss recent advances in polymer 3D printing for microfluidics-based serial crystallography research and present a demonstration of emerging, large-scale, nano-3D printing approaches leading into the future of 3D sample environment and delivery device fabrication from liquid jet gas-dynamic virtual nozzles devices to fixed-target sample environment technology.
abstract_unstemmed	Serial crystallography at large facilities, such as x-ray free-electron lasers and synchrotrons, evolved as a powerful method for the high-resolution structural investigation of proteins that are critical for human health, thus advancing drug discovery and novel therapies. However, a critical barrier to successful serial crystallography experiments lies in the efficient handling of the protein microcrystals and solutions at microscales. Microfluidics are the obvious approach for any high-throughput, nano-to-microliter sample handling, that also requires design flexibility and rapid prototyping to deal with the variable shapes, sizes, and density of crystals. Here, we discuss recent advances in polymer 3D printing for microfluidics-based serial crystallography research and present a demonstration of emerging, large-scale, nano-3D printing approaches leading into the future of 3D sample environment and delivery device fabrication from liquid jet gas-dynamic virtual nozzles devices to fixed-target sample environment technology.
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title_short	Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers
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score	7.400075

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Advanced manufacturing provides tailor-made solutions for crystallography with x-ray free-electron lasers

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