Triggered contraction of self-assembled micron-scale DNA nanotube rings

Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as syntheti...
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Autor*in:	Maja Illig [verfasserIn] Kevin Jahnke [verfasserIn] Lukas P. Weise [verfasserIn] Marlene Scheffold [verfasserIn] Ulrike Mersdorf [verfasserIn] Hauke Drechsler [verfasserIn] Yixin Zhang [verfasserIn] Stefan Diez [verfasserIn] Jan Kierfeld [verfasserIn] Kerstin Göpfrich [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 15(2024), 1, Seite 12
Übergeordnetes Werk:	volume:15 ; year:2024 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-024-46339-z

Katalog-ID:	DOAJ095656235

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520			\|a Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.
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allfields	10.1038/s41467-024-46339-z doi (DE-627)DOAJ095656235 (DE-599)DOAJ30ce568fa6c54126b64c8ce23d3efdb0 DE-627 ger DE-627 rakwb eng Maja Illig verfasserin aut Triggered contraction of self-assembled micron-scale DNA nanotube rings 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. Science Q Kevin Jahnke verfasserin aut Lukas P. Weise verfasserin aut Marlene Scheffold verfasserin aut Ulrike Mersdorf verfasserin aut Hauke Drechsler verfasserin aut Yixin Zhang verfasserin aut Stefan Diez verfasserin aut Jan Kierfeld verfasserin aut Kerstin Göpfrich verfasserin aut In Nature Communications Nature Portfolio, 2016 15(2024), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:15 year:2024 number:1 pages:12 https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/article/30ce568fa6c54126b64c8ce23d3efdb0 kostenfrei https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 12
spelling	10.1038/s41467-024-46339-z doi (DE-627)DOAJ095656235 (DE-599)DOAJ30ce568fa6c54126b64c8ce23d3efdb0 DE-627 ger DE-627 rakwb eng Maja Illig verfasserin aut Triggered contraction of self-assembled micron-scale DNA nanotube rings 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. Science Q Kevin Jahnke verfasserin aut Lukas P. Weise verfasserin aut Marlene Scheffold verfasserin aut Ulrike Mersdorf verfasserin aut Hauke Drechsler verfasserin aut Yixin Zhang verfasserin aut Stefan Diez verfasserin aut Jan Kierfeld verfasserin aut Kerstin Göpfrich verfasserin aut In Nature Communications Nature Portfolio, 2016 15(2024), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:15 year:2024 number:1 pages:12 https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/article/30ce568fa6c54126b64c8ce23d3efdb0 kostenfrei https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 12
allfields_unstemmed	10.1038/s41467-024-46339-z doi (DE-627)DOAJ095656235 (DE-599)DOAJ30ce568fa6c54126b64c8ce23d3efdb0 DE-627 ger DE-627 rakwb eng Maja Illig verfasserin aut Triggered contraction of self-assembled micron-scale DNA nanotube rings 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. Science Q Kevin Jahnke verfasserin aut Lukas P. Weise verfasserin aut Marlene Scheffold verfasserin aut Ulrike Mersdorf verfasserin aut Hauke Drechsler verfasserin aut Yixin Zhang verfasserin aut Stefan Diez verfasserin aut Jan Kierfeld verfasserin aut Kerstin Göpfrich verfasserin aut In Nature Communications Nature Portfolio, 2016 15(2024), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:15 year:2024 number:1 pages:12 https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/article/30ce568fa6c54126b64c8ce23d3efdb0 kostenfrei https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 12
allfieldsGer	10.1038/s41467-024-46339-z doi (DE-627)DOAJ095656235 (DE-599)DOAJ30ce568fa6c54126b64c8ce23d3efdb0 DE-627 ger DE-627 rakwb eng Maja Illig verfasserin aut Triggered contraction of self-assembled micron-scale DNA nanotube rings 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. Science Q Kevin Jahnke verfasserin aut Lukas P. Weise verfasserin aut Marlene Scheffold verfasserin aut Ulrike Mersdorf verfasserin aut Hauke Drechsler verfasserin aut Yixin Zhang verfasserin aut Stefan Diez verfasserin aut Jan Kierfeld verfasserin aut Kerstin Göpfrich verfasserin aut In Nature Communications Nature Portfolio, 2016 15(2024), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:15 year:2024 number:1 pages:12 https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/article/30ce568fa6c54126b64c8ce23d3efdb0 kostenfrei https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 12
allfieldsSound	10.1038/s41467-024-46339-z doi (DE-627)DOAJ095656235 (DE-599)DOAJ30ce568fa6c54126b64c8ce23d3efdb0 DE-627 ger DE-627 rakwb eng Maja Illig verfasserin aut Triggered contraction of self-assembled micron-scale DNA nanotube rings 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials. Science Q Kevin Jahnke verfasserin aut Lukas P. Weise verfasserin aut Marlene Scheffold verfasserin aut Ulrike Mersdorf verfasserin aut Hauke Drechsler verfasserin aut Yixin Zhang verfasserin aut Stefan Diez verfasserin aut Jan Kierfeld verfasserin aut Kerstin Göpfrich verfasserin aut In Nature Communications Nature Portfolio, 2016 15(2024), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:15 year:2024 number:1 pages:12 https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/article/30ce568fa6c54126b64c8ce23d3efdb0 kostenfrei https://doi.org/10.1038/s41467-024-46339-z kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1 12
language	English
source	In Nature Communications 15(2024), 1, Seite 12 volume:15 year:2024 number:1 pages:12
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author	Maja Illig
spellingShingle	Maja Illig misc Science misc Q Triggered contraction of self-assembled micron-scale DNA nanotube rings
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topic_title	Triggered contraction of self-assembled micron-scale DNA nanotube rings
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title	Triggered contraction of self-assembled micron-scale DNA nanotube rings
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title_full	Triggered contraction of self-assembled micron-scale DNA nanotube rings
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title_sort	triggered contraction of self-assembled micron-scale dna nanotube rings
title_auth	Triggered contraction of self-assembled micron-scale DNA nanotube rings
abstract	Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.
abstractGer	Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.
abstract_unstemmed	Abstract Contractile rings are formed from cytoskeletal filaments during cell division. Ring formation is induced by specific crosslinkers, while contraction is typically associated with motor protein activity. Here, we engineer DNA nanotubes and peptide-functionalized starPEG constructs as synthetic crosslinkers to mimic this process. The crosslinker induces bundling of ten to hundred DNA nanotubes into closed micron-scale rings in a one-pot self-assembly process yielding several thousand rings per microliter. Molecular dynamics simulations reproduce the detailed architectural properties of the DNA rings observed in electron microscopy. Theory and simulations predict DNA ring contraction – without motor proteins – providing mechanistic insights into the parameter space relevant for efficient nanotube sliding. In agreement between simulation and experiment, we obtain ring contraction to less than half of the initial ring diameter. DNA-based contractile rings hold promise for an artificial division machinery or contractile muscle-like materials.
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title_short	Triggered contraction of self-assembled micron-scale DNA nanotube rings
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Triggered contraction of self-assembled micron-scale DNA nanotube rings

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