Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study

The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyz...
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Autor*in:	Bin Xu [verfasserIn] Xueru Wang [verfasserIn] Zhaogen Wu [verfasserIn] Chengbi Cui [verfasserIn] Xin Qi [verfasserIn] Yan Yu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway

Übergeordnetes Werk:	In: Journal of Functional Foods - Elsevier, 2021, 116(2024), Seite 106083-
Übergeordnetes Werk:	volume:116 ; year:2024 ; pages:106083-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.jff.2024.106083

Katalog-ID:	DOAJ095706267

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allfields	10.1016/j.jff.2024.106083 doi (DE-627)DOAJ095706267 (DE-599)DOAJ42f3d6768d854a8d87dee42bc378fd97 DE-627 ger DE-627 rakwb eng TX341-641 Bin Xu verfasserin aut Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources. Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway Nutrition. Foods and food supply Xueru Wang verfasserin aut Zhaogen Wu verfasserin aut Chengbi Cui verfasserin aut Xin Qi verfasserin aut Yan Yu verfasserin aut In Journal of Functional Foods Elsevier, 2021 116(2024), Seite 106083- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:116 year:2024 pages:106083- https://doi.org/10.1016/j.jff.2024.106083 kostenfrei https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000859 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 116 2024 106083-
spelling	10.1016/j.jff.2024.106083 doi (DE-627)DOAJ095706267 (DE-599)DOAJ42f3d6768d854a8d87dee42bc378fd97 DE-627 ger DE-627 rakwb eng TX341-641 Bin Xu verfasserin aut Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources. Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway Nutrition. Foods and food supply Xueru Wang verfasserin aut Zhaogen Wu verfasserin aut Chengbi Cui verfasserin aut Xin Qi verfasserin aut Yan Yu verfasserin aut In Journal of Functional Foods Elsevier, 2021 116(2024), Seite 106083- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:116 year:2024 pages:106083- https://doi.org/10.1016/j.jff.2024.106083 kostenfrei https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000859 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 116 2024 106083-
allfields_unstemmed	10.1016/j.jff.2024.106083 doi (DE-627)DOAJ095706267 (DE-599)DOAJ42f3d6768d854a8d87dee42bc378fd97 DE-627 ger DE-627 rakwb eng TX341-641 Bin Xu verfasserin aut Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources. Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway Nutrition. Foods and food supply Xueru Wang verfasserin aut Zhaogen Wu verfasserin aut Chengbi Cui verfasserin aut Xin Qi verfasserin aut Yan Yu verfasserin aut In Journal of Functional Foods Elsevier, 2021 116(2024), Seite 106083- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:116 year:2024 pages:106083- https://doi.org/10.1016/j.jff.2024.106083 kostenfrei https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000859 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 116 2024 106083-
allfieldsGer	10.1016/j.jff.2024.106083 doi (DE-627)DOAJ095706267 (DE-599)DOAJ42f3d6768d854a8d87dee42bc378fd97 DE-627 ger DE-627 rakwb eng TX341-641 Bin Xu verfasserin aut Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources. Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway Nutrition. Foods and food supply Xueru Wang verfasserin aut Zhaogen Wu verfasserin aut Chengbi Cui verfasserin aut Xin Qi verfasserin aut Yan Yu verfasserin aut In Journal of Functional Foods Elsevier, 2021 116(2024), Seite 106083- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:116 year:2024 pages:106083- https://doi.org/10.1016/j.jff.2024.106083 kostenfrei https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000859 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 116 2024 106083-
allfieldsSound	10.1016/j.jff.2024.106083 doi (DE-627)DOAJ095706267 (DE-599)DOAJ42f3d6768d854a8d87dee42bc378fd97 DE-627 ger DE-627 rakwb eng TX341-641 Bin Xu verfasserin aut Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources. Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway Nutrition. Foods and food supply Xueru Wang verfasserin aut Zhaogen Wu verfasserin aut Chengbi Cui verfasserin aut Xin Qi verfasserin aut Yan Yu verfasserin aut In Journal of Functional Foods Elsevier, 2021 116(2024), Seite 106083- (DE-627)587138432 (DE-600)2467241-5 22149414 nnns volume:116 year:2024 pages:106083- https://doi.org/10.1016/j.jff.2024.106083 kostenfrei https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 kostenfrei http://www.sciencedirect.com/science/article/pii/S1756464624000859 kostenfrei https://doaj.org/toc/1756-4646 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 116 2024 106083-
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callnumber-first	T - Technology
author	Bin Xu
spellingShingle	Bin Xu misc TX341-641 misc Network pharmacology misc Adventitious root of ginseng misc Ginsenoside misc Inflammation misc Oxidative stress misc PI3K/AKT/mTOR signaling pathway misc Nutrition. Foods and food supply Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study
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topic_title	TX341-641 Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study Network pharmacology Adventitious root of ginseng Ginsenoside Inflammation Oxidative stress PI3K/AKT/mTOR signaling pathway
topic	misc TX341-641 misc Network pharmacology misc Adventitious root of ginseng misc Ginsenoside misc Inflammation misc Oxidative stress misc PI3K/AKT/mTOR signaling pathway misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc Network pharmacology misc Adventitious root of ginseng misc Ginsenoside misc Inflammation misc Oxidative stress misc PI3K/AKT/mTOR signaling pathway misc Nutrition. Foods and food supply
topic_browse	misc TX341-641 misc Network pharmacology misc Adventitious root of ginseng misc Ginsenoside misc Inflammation misc Oxidative stress misc PI3K/AKT/mTOR signaling pathway misc Nutrition. Foods and food supply
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title	Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study
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title_full	Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study
author_sort	Bin Xu
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author_browse	Bin Xu Xueru Wang Zhaogen Wu Chengbi Cui Xin Qi Yan Yu
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title_sort	identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on t1dm mice: a network pharmacology and animal experiment study
callnumber	TX341-641
title_auth	Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study
abstract	The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources.
abstractGer	The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources.
abstract_unstemmed	The aim of this study was to investigate the effects and mechanisms of action of extract of Adventitious Root of Ginseng (GARE) on a mouse model of Type 1 diabetes mellitus (T1DM). Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. These findings suggest that GARE may have potential therapeutic effects for T1DM and provide a theoretical basis for the development and utilization of adventitious root of ginseng (GAR) resources.
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title_short	Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study
url	https://doi.org/10.1016/j.jff.2024.106083 https://doaj.org/article/42f3d6768d854a8d87dee42bc378fd97 http://www.sciencedirect.com/science/article/pii/S1756464624000859 https://doaj.org/toc/1756-4646
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author2	Xueru Wang Zhaogen Wu Chengbi Cui Xin Qi Yan Yu
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doi_str	10.1016/j.jff.2024.106083
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up_date	2024-07-03T16:07:23.769Z
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Firstly, using network pharmacology methods to predict relevant targets. The main active components of GARE were analyzed using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS). Mice were then divided into multiple experimental groups and a T1DM model was established. The results showed that GARE significantly reduced blood glucose levels in mice, while also decreasing the levels of total cholesterol (TC), triglycerides (TG), and glycosylated hemoglobin (GHb). GARE increased the activity of antioxidant enzymes and reduced the expression of inflammatory factors in the liver. Furthermore, GARE exerted its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway. 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Identification of ginsenoside components from adventitious root of ginseng and their hypoglycemic effects on T1DM mice: A network pharmacology and animal experiment study

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