Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols

Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement...
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Autor*in:	Kai-Yen Chang [verfasserIn] Martin Tik [verfasserIn] Yuki Mizutani-Tiebel [verfasserIn] Anna-Lisa Schuler [verfasserIn] Paul Taylor [verfasserIn] Mattia Campana [verfasserIn] Ulrike Vogelmann [verfasserIn] Barbara Huber [verfasserIn] Esther Dechantsreiter [verfasserIn] Axel Thielscher [verfasserIn] Lucia Bulubas [verfasserIn] Frank Padberg [verfasserIn] Daniel Keeser [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation

Übergeordnetes Werk:	In: NeuroImage - Elsevier, 2020, 291(2024), Seite 120596-
Übergeordnetes Werk:	volume:291 ; year:2024 ; pages:120596-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.neuroimage.2024.120596

Katalog-ID:	DOAJ095831746

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520			\|a Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action.
650		4	\|a Functional MRI (fMRI)
650		4	\|a Transcranial magnetic stimulation (TMS)
650		4	\|a Concurrent TMS-fMRI
650		4	\|a Interleaved iTBS-fMRI
650		4	\|a Non-invasive brain stimulation
650		4	\|a Neuromodulation
653		0	\|a Neurosciences. Biological psychiatry. Neuropsychiatry
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allfields	10.1016/j.neuroimage.2024.120596 doi (DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc DE-627 ger DE-627 rakwb eng RC321-571 Kai-Yen Chang verfasserin aut Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action. Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry Martin Tik verfasserin aut Yuki Mizutani-Tiebel verfasserin aut Anna-Lisa Schuler verfasserin aut Paul Taylor verfasserin aut Mattia Campana verfasserin aut Ulrike Vogelmann verfasserin aut Barbara Huber verfasserin aut Esther Dechantsreiter verfasserin aut Axel Thielscher verfasserin aut Lucia Bulubas verfasserin aut Frank Padberg verfasserin aut Daniel Keeser verfasserin aut In NeuroImage Elsevier, 2020 291(2024), Seite 120596- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:291 year:2024 pages:120596- https://doi.org/10.1016/j.neuroimage.2024.120596 kostenfrei https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811924000910 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 291 2024 120596-
spelling	10.1016/j.neuroimage.2024.120596 doi (DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc DE-627 ger DE-627 rakwb eng RC321-571 Kai-Yen Chang verfasserin aut Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action. Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry Martin Tik verfasserin aut Yuki Mizutani-Tiebel verfasserin aut Anna-Lisa Schuler verfasserin aut Paul Taylor verfasserin aut Mattia Campana verfasserin aut Ulrike Vogelmann verfasserin aut Barbara Huber verfasserin aut Esther Dechantsreiter verfasserin aut Axel Thielscher verfasserin aut Lucia Bulubas verfasserin aut Frank Padberg verfasserin aut Daniel Keeser verfasserin aut In NeuroImage Elsevier, 2020 291(2024), Seite 120596- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:291 year:2024 pages:120596- https://doi.org/10.1016/j.neuroimage.2024.120596 kostenfrei https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811924000910 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 291 2024 120596-
allfields_unstemmed	10.1016/j.neuroimage.2024.120596 doi (DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc DE-627 ger DE-627 rakwb eng RC321-571 Kai-Yen Chang verfasserin aut Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action. Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry Martin Tik verfasserin aut Yuki Mizutani-Tiebel verfasserin aut Anna-Lisa Schuler verfasserin aut Paul Taylor verfasserin aut Mattia Campana verfasserin aut Ulrike Vogelmann verfasserin aut Barbara Huber verfasserin aut Esther Dechantsreiter verfasserin aut Axel Thielscher verfasserin aut Lucia Bulubas verfasserin aut Frank Padberg verfasserin aut Daniel Keeser verfasserin aut In NeuroImage Elsevier, 2020 291(2024), Seite 120596- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:291 year:2024 pages:120596- https://doi.org/10.1016/j.neuroimage.2024.120596 kostenfrei https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811924000910 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 291 2024 120596-
allfieldsGer	10.1016/j.neuroimage.2024.120596 doi (DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc DE-627 ger DE-627 rakwb eng RC321-571 Kai-Yen Chang verfasserin aut Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action. Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry Martin Tik verfasserin aut Yuki Mizutani-Tiebel verfasserin aut Anna-Lisa Schuler verfasserin aut Paul Taylor verfasserin aut Mattia Campana verfasserin aut Ulrike Vogelmann verfasserin aut Barbara Huber verfasserin aut Esther Dechantsreiter verfasserin aut Axel Thielscher verfasserin aut Lucia Bulubas verfasserin aut Frank Padberg verfasserin aut Daniel Keeser verfasserin aut In NeuroImage Elsevier, 2020 291(2024), Seite 120596- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:291 year:2024 pages:120596- https://doi.org/10.1016/j.neuroimage.2024.120596 kostenfrei https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811924000910 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 291 2024 120596-
allfieldsSound	10.1016/j.neuroimage.2024.120596 doi (DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc DE-627 ger DE-627 rakwb eng RC321-571 Kai-Yen Chang verfasserin aut Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action. Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry Martin Tik verfasserin aut Yuki Mizutani-Tiebel verfasserin aut Anna-Lisa Schuler verfasserin aut Paul Taylor verfasserin aut Mattia Campana verfasserin aut Ulrike Vogelmann verfasserin aut Barbara Huber verfasserin aut Esther Dechantsreiter verfasserin aut Axel Thielscher verfasserin aut Lucia Bulubas verfasserin aut Frank Padberg verfasserin aut Daniel Keeser verfasserin aut In NeuroImage Elsevier, 2020 291(2024), Seite 120596- (DE-627)268125503 (DE-600)1471418-8 10959572 nnns volume:291 year:2024 pages:120596- https://doi.org/10.1016/j.neuroimage.2024.120596 kostenfrei https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc kostenfrei http://www.sciencedirect.com/science/article/pii/S1053811924000910 kostenfrei https://doaj.org/toc/1095-9572 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_165 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2008 GBV_ILN_2014 GBV_ILN_2034 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2064 GBV_ILN_2106 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 291 2024 120596-
language	English
source	In NeuroImage 291(2024), Seite 120596- volume:291 year:2024 pages:120596-
sourceStr	In NeuroImage 291(2024), Seite 120596- volume:291 year:2024 pages:120596-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	NeuroImage
authorswithroles_txt_mv	Kai-Yen Chang @@aut@@ Martin Tik @@aut@@ Yuki Mizutani-Tiebel @@aut@@ Anna-Lisa Schuler @@aut@@ Paul Taylor @@aut@@ Mattia Campana @@aut@@ Ulrike Vogelmann @@aut@@ Barbara Huber @@aut@@ Esther Dechantsreiter @@aut@@ Axel Thielscher @@aut@@ Lucia Bulubas @@aut@@ Frank Padberg @@aut@@ Daniel Keeser @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	268125503
id	DOAJ095831746
language_de	englisch
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callnumber-first	R - Medicine
author	Kai-Yen Chang
spellingShingle	Kai-Yen Chang misc RC321-571 misc Functional MRI (fMRI) misc Transcranial magnetic stimulation (TMS) misc Concurrent TMS-fMRI misc Interleaved iTBS-fMRI misc Non-invasive brain stimulation misc Neuromodulation misc Neurosciences. Biological psychiatry. Neuropsychiatry Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols
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topic_title	RC321-571 Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols Functional MRI (fMRI) Transcranial magnetic stimulation (TMS) Concurrent TMS-fMRI Interleaved iTBS-fMRI Non-invasive brain stimulation Neuromodulation
topic	misc RC321-571 misc Functional MRI (fMRI) misc Transcranial magnetic stimulation (TMS) misc Concurrent TMS-fMRI misc Interleaved iTBS-fMRI misc Non-invasive brain stimulation misc Neuromodulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Functional MRI (fMRI) misc Transcranial magnetic stimulation (TMS) misc Concurrent TMS-fMRI misc Interleaved iTBS-fMRI misc Non-invasive brain stimulation misc Neuromodulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_browse	misc RC321-571 misc Functional MRI (fMRI) misc Transcranial magnetic stimulation (TMS) misc Concurrent TMS-fMRI misc Interleaved iTBS-fMRI misc Non-invasive brain stimulation misc Neuromodulation misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols
ctrlnum	(DE-627)DOAJ095831746 (DE-599)DOAJ4fdc07453c7b432eaaf4acd054885fdc
title_full	Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols
author_sort	Kai-Yen Chang
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author_browse	Kai-Yen Chang Martin Tik Yuki Mizutani-Tiebel Anna-Lisa Schuler Paul Taylor Mattia Campana Ulrike Vogelmann Barbara Huber Esther Dechantsreiter Axel Thielscher Lucia Bulubas Frank Padberg Daniel Keeser
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author-letter	Kai-Yen Chang
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title_sort	neural response during prefrontal theta burst stimulation: interleaved tms-fmri of full itbs protocols
callnumber	RC321-571
title_auth	Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols
abstract	Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action.
abstractGer	Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action.
abstract_unstemmed	Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions. Objective/hypothesis: In our effort to explore interleaved iTBS-fMRI feasibility, we hypothesize that TMS will induce acute BOLD signal changes in both the stimulated area and interconnected neural regions. Methods: Concurrent TMS-fMRI with full sessions of neuronavigated iTBS (i.e. 600 pulses) of the left dorsolateral prefrontal cortex (DLPFC) was investigated in 18 healthy participants. In addition, we conducted four TMS-fMRI sessions in a single patient on long-term maintenance iTBS for bipolar depression to test the transfer to clinical cases. Results: Concurrent TMS-fMRI was feasible for iTBS sequences with 600 pulses. During interleaved iTBS-fMRI, an increase of the BOLD signal was observed in a network including bilateral DLPFC regions. In the clinical case, a reduced BOLD response was found in the left DLPFC and the subgenual anterior cingulate cortex, with high variability across individual sessions. Conclusions: Full iTBS sessions as applied for the treatment of depressive disorders can be established in the interleaved iTBS-fMRI paradigm. In the future, this experimental approach could be valuable in clinical samples, for demonstrating target engagement by iTBS protocols and investigating their mechanisms of therapeutic action.
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title_short	Neural response during prefrontal theta burst stimulation: Interleaved TMS-fMRI of full iTBS protocols
url	https://doi.org/10.1016/j.neuroimage.2024.120596 https://doaj.org/article/4fdc07453c7b432eaaf4acd054885fdc http://www.sciencedirect.com/science/article/pii/S1053811924000910 https://doaj.org/toc/1095-9572
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