Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents
Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in...
Ausführliche Beschreibung
Autor*in: |
Dong Z [verfasserIn] Zhang X [verfasserIn] Zhang Q [verfasserIn] Tangthianchaichana J [verfasserIn] Guo M [verfasserIn] Du S [verfasserIn] Lu Y [verfasserIn] |
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2024 |
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In: International Journal of Nanomedicine - Dove Medical Press, 2018, (2024), Seite 1017-1039 |
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year:2024 ; pages:1017-1039 |
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DOAJ096000252 |
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520 | |a Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents | ||
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(DE-627)DOAJ096000252 (DE-599)DOAJ8f7e4f0264664fa695200707cf7a31fc DE-627 ger DE-627 rakwb eng R5-920 Dong Z verfasserin aut Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents antimicrobial peptides anticancer mechanisms drug combination anticancer application peptide nano agents. Medicine (General) Zhang X verfasserin aut Zhang Q verfasserin aut Tangthianchaichana J verfasserin aut Guo M verfasserin aut Du S verfasserin aut Lu Y verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2024), Seite 1017-1039 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2024 pages:1017-1039 https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc kostenfrei https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 1017-1039 |
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(DE-627)DOAJ096000252 (DE-599)DOAJ8f7e4f0264664fa695200707cf7a31fc DE-627 ger DE-627 rakwb eng R5-920 Dong Z verfasserin aut Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents antimicrobial peptides anticancer mechanisms drug combination anticancer application peptide nano agents. Medicine (General) Zhang X verfasserin aut Zhang Q verfasserin aut Tangthianchaichana J verfasserin aut Guo M verfasserin aut Du S verfasserin aut Lu Y verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2024), Seite 1017-1039 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2024 pages:1017-1039 https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc kostenfrei https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 1017-1039 |
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(DE-627)DOAJ096000252 (DE-599)DOAJ8f7e4f0264664fa695200707cf7a31fc DE-627 ger DE-627 rakwb eng R5-920 Dong Z verfasserin aut Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents antimicrobial peptides anticancer mechanisms drug combination anticancer application peptide nano agents. Medicine (General) Zhang X verfasserin aut Zhang Q verfasserin aut Tangthianchaichana J verfasserin aut Guo M verfasserin aut Du S verfasserin aut Lu Y verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2024), Seite 1017-1039 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2024 pages:1017-1039 https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc kostenfrei https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 1017-1039 |
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(DE-627)DOAJ096000252 (DE-599)DOAJ8f7e4f0264664fa695200707cf7a31fc DE-627 ger DE-627 rakwb eng R5-920 Dong Z verfasserin aut Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents antimicrobial peptides anticancer mechanisms drug combination anticancer application peptide nano agents. Medicine (General) Zhang X verfasserin aut Zhang Q verfasserin aut Tangthianchaichana J verfasserin aut Guo M verfasserin aut Du S verfasserin aut Lu Y verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2024), Seite 1017-1039 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2024 pages:1017-1039 https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc kostenfrei https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 1017-1039 |
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(DE-627)DOAJ096000252 (DE-599)DOAJ8f7e4f0264664fa695200707cf7a31fc DE-627 ger DE-627 rakwb eng R5-920 Dong Z verfasserin aut Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents antimicrobial peptides anticancer mechanisms drug combination anticancer application peptide nano agents. Medicine (General) Zhang X verfasserin aut Zhang Q verfasserin aut Tangthianchaichana J verfasserin aut Guo M verfasserin aut Du S verfasserin aut Lu Y verfasserin aut In International Journal of Nanomedicine Dove Medical Press, 2018 (2024), Seite 1017-1039 (DE-627)537879560 (DE-600)2377464-2 11782013 nnns year:2024 pages:1017-1039 https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc kostenfrei https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN kostenfrei https://doaj.org/toc/1178-2013 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2024 1017-1039 |
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Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents |
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Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents |
abstract_unstemmed |
Ziyi Dong,1,2 Xinyu Zhang,1 Qing Zhang,1 Jakkree Tangthianchaichana,1,3 Mingxue Guo,1 Shouying Du,1 Yang Lu1 1Laboratory of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Research and Development Centre in Beijing, CSPC Pharmaceutical Group Limited, Beijing, People’s Republic of China; 3Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, ThailandCorrespondence: Yang Lu; Shouying Du, Beijing University of Chinese Medicine, Number 11 East Section of the North Third Ring Road, Beijing, 100029, People’s Republic of China, Tel + 86-10-84738615, Email luyangbucm.edu.cn; dumenzidi123@163.comAbstract: Traditional chemotherapy is one of the main methods of cancer treatment, which is largely limited by severe side effects and frequent development of multi-drug resistance by cancer cells. Antimicrobial peptides (AMPs) with high efficiency and low toxicity, as one of the most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting the attention of worldwide researchers. AMPs are natural-source small peptides from the innate immune system, and certain AMPs can selectively kill a broad spectrum of cancer cells while exhibiting less damage to normal cells. Although it involves intracellular mechanisms, AMPs exert their anti-cancer effects mainly through membrane destruction effect; thus, AMPs also hold unique advantages in fighting drug-resistant cancer cells. However, the poor stability and hemolytic toxicity of peptides limit their clinical application. Fortunately, functionalized nanoparticles have many possibilities in overcoming the shortcomings of AMPs, which provides a huge prospect for better application of AMPs. In this paper, we briefly introduce the characteristics and different sources of AMPs, review and summarize the mechanisms of action and the research status of AMPs used as an anticancer therapy, and finally focus on the further use of AMPs nano agents in the anti-cancer direction. Keywords: antimicrobial peptides, anticancer mechanisms, drug combination, anticancer application, peptide nano agents |
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Anticancer Mechanisms and Potential Anticancer Applications of Antimicrobial Peptides and Their Nano Agents |
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https://doaj.org/article/8f7e4f0264664fa695200707cf7a31fc https://www.dovepress.com/anticancer-mechanisms-and-potential-anticancer-applications-of-antimic-peer-reviewed-fulltext-article-IJN https://doaj.org/toc/1178-2013 |
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