Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context
Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention target...
Ausführliche Beschreibung
Gespeichert in:
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2024 |
|---|
| Schlagwörter: |
|---|
| Übergeordnetes Werk: |
In: EBioMedicine - Elsevier, 2015, 100(2024), Seite 104991- |
|---|---|
| Übergeordnetes Werk: |
volume:100 ; year:2024 ; pages:104991- |
| Links: |
|---|
| DOI / URN: |
10.1016/j.ebiom.2024.104991 |
|---|
| Katalog-ID: |
DOAJ096058870 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | DOAJ096058870 | ||
| 003 | DE-627 | ||
| 005 | 20240413140923.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240413s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ebiom.2024.104991 |2 doi | |
| 035 | |a (DE-627)DOAJ096058870 | ||
| 035 | |a (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 050 | 0 | |a R5-920 | |
| 100 | 0 | |a James Yarmolinsky |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). | ||
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Mendelian randomization | |
| 650 | 4 | |a Genetic epidemiology | |
| 653 | 0 | |a Medicine | |
| 653 | 0 | |a R | |
| 653 | 0 | |a Medicine (General) | |
| 700 | 0 | |a Jamie W. Robinson |e verfasserin |4 aut | |
| 700 | 0 | |a Daniela Mariosa |e verfasserin |4 aut | |
| 700 | 0 | |a Ville Karhunen |e verfasserin |4 aut | |
| 700 | 0 | |a Jian Huang |e verfasserin |4 aut | |
| 700 | 0 | |a Niki Dimou |e verfasserin |4 aut | |
| 700 | 0 | |a Neil Murphy |e verfasserin |4 aut | |
| 700 | 0 | |a Kimberley Burrows |e verfasserin |4 aut | |
| 700 | 0 | |a Emmanouil Bouras |e verfasserin |4 aut | |
| 700 | 0 | |a Karl Smith-Byrne |e verfasserin |4 aut | |
| 700 | 0 | |a Sarah J. Lewis |e verfasserin |4 aut | |
| 700 | 0 | |a Tessel E. Galesloot |e verfasserin |4 aut | |
| 700 | 0 | |a Lambertus A. Kiemeney |e verfasserin |4 aut | |
| 700 | 0 | |a Sita Vermeulen |e verfasserin |4 aut | |
| 700 | 0 | |a Paul Martin |e verfasserin |4 aut | |
| 700 | 0 | |a Demetrius Albanes |e verfasserin |4 aut | |
| 700 | 0 | |a Lifang Hou |e verfasserin |4 aut | |
| 700 | 0 | |a Polly A. Newcomb |e verfasserin |4 aut | |
| 700 | 0 | |a Emily White |e verfasserin |4 aut | |
| 700 | 0 | |a Alicja Wolk |e verfasserin |4 aut | |
| 700 | 0 | |a Anna H. Wu |e verfasserin |4 aut | |
| 700 | 0 | |a Loïc Le Marchand |e verfasserin |4 aut | |
| 700 | 0 | |a Amanda I. Phipps |e verfasserin |4 aut | |
| 700 | 0 | |a Daniel D. Buchanan |e verfasserin |4 aut | |
| 700 | 0 | |a Sizheng Steven Zhao |e verfasserin |4 aut | |
| 700 | 0 | |a Dipender Gill |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen J. Chanock |e verfasserin |4 aut | |
| 700 | 0 | |a Mark P. Purdue |e verfasserin |4 aut | |
| 700 | 0 | |a George Davey Smith |e verfasserin |4 aut | |
| 700 | 0 | |a Paul Brennan |e verfasserin |4 aut | |
| 700 | 0 | |a Karl-Heinz Herzig |e verfasserin |4 aut | |
| 700 | 0 | |a Marjo-Riitta Järvelin |e verfasserin |4 aut | |
| 700 | 0 | |a Chris I. Amos |e verfasserin |4 aut | |
| 700 | 0 | |a Rayjean J. Hung |e verfasserin |4 aut | |
| 700 | 0 | |a Abbas Dehghan |e verfasserin |4 aut | |
| 700 | 0 | |a Mattias Johansson |e verfasserin |4 aut | |
| 700 | 0 | |a Marc J. Gunter |e verfasserin |4 aut | |
| 700 | 0 | |a Kostas K. Tsilidis |e verfasserin |4 aut | |
| 700 | 0 | |a Richard M. Martin |e verfasserin |4 aut | |
| 700 | 0 | |a Maria Teresa Landi |e verfasserin |4 aut | |
| 700 | 0 | |a Victoria Stevens |e verfasserin |4 aut | |
| 700 | 0 | |a Ying Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Demetrios Albanes |e verfasserin |4 aut | |
| 700 | 0 | |a Neil Caporaso |e verfasserin |4 aut | |
| 700 | 0 | |a Paul Brennan |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher I. Amos |e verfasserin |4 aut | |
| 700 | 0 | |a Sanjay Shete |e verfasserin |4 aut | |
| 700 | 0 | |a Rayjean J. Hung |e verfasserin |4 aut | |
| 700 | 0 | |a Heike Bickeböller |e verfasserin |4 aut | |
| 700 | 0 | |a Angela Risch |e verfasserin |4 aut | |
| 700 | 0 | |a Richard Houlston |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen Lam |e verfasserin |4 aut | |
| 700 | 0 | |a Adonina Tardon |e verfasserin |4 aut | |
| 700 | 0 | |a Chu Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Stig E. Bojesen |e verfasserin |4 aut | |
| 700 | 0 | |a Mattias Johansson |e verfasserin |4 aut | |
| 700 | 0 | |a H-Erich Wichmann |e verfasserin |4 aut | |
| 700 | 0 | |a David Christiani |e verfasserin |4 aut | |
| 700 | 0 | |a Gadi Rennert |e verfasserin |4 aut | |
| 700 | 0 | |a Susanne Arnold |e verfasserin |4 aut | |
| 700 | 0 | |a John K. Field |e verfasserin |4 aut | |
| 700 | 0 | |a Loic Le Marchand |e verfasserin |4 aut | |
| 700 | 0 | |a Olle Melander |e verfasserin |4 aut | |
| 700 | 0 | |a Hans Brunnström |e verfasserin |4 aut | |
| 700 | 0 | |a Geoffrey Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Angeline Andrew |e verfasserin |4 aut | |
| 700 | 0 | |a Lambertus A. Kiemeney |e verfasserin |4 aut | |
| 700 | 0 | |a Hongbing Shen |e verfasserin |4 aut | |
| 700 | 0 | |a Shan Zienolddiny |e verfasserin |4 aut | |
| 700 | 0 | |a Kjell Grankvist |e verfasserin |4 aut | |
| 700 | 0 | |a Mikael Johansson |e verfasserin |4 aut | |
| 700 | 0 | |a M. Dawn Teare |e verfasserin |4 aut | |
| 700 | 0 | |a Yun-Chul Hong |e verfasserin |4 aut | |
| 700 | 0 | |a Jian-Min Yuan |e verfasserin |4 aut | |
| 700 | 0 | |a Philip Lazarus |e verfasserin |4 aut | |
| 700 | 0 | |a Matthew B. Schabath |e verfasserin |4 aut | |
| 700 | 0 | |a Melinda C. Aldrich |e verfasserin |4 aut | |
| 700 | 0 | |a Rosalind A. Eeles |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher A. Haiman |e verfasserin |4 aut | |
| 700 | 0 | |a Zsofia Kote-Jarai |e verfasserin |4 aut | |
| 700 | 0 | |a Fredrick R. Schumacher |e verfasserin |4 aut | |
| 700 | 0 | |a Sara Benlloch |e verfasserin |4 aut | |
| 700 | 0 | |a Ali Amin Al Olama |e verfasserin |4 aut | |
| 700 | 0 | |a Kenneth R. Muir |e verfasserin |4 aut | |
| 700 | 0 | |a Sonja I. Berndt |e verfasserin |4 aut | |
| 700 | 0 | |a David V. Conti |e verfasserin |4 aut | |
| 700 | 0 | |a Fredrik Wiklund |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen Chanock |e verfasserin |4 aut | |
| 700 | 0 | |a Ying Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Catherine M. Tangen |e verfasserin |4 aut | |
| 700 | 0 | |a Jyotsna Batra |e verfasserin |4 aut | |
| 700 | 0 | |a Judith A. Clements |e verfasserin |4 aut | |
| 700 | 0 | |a Henrik Grönberg |e verfasserin |4 aut | |
| 700 | 0 | |a Nora Pashayan |e verfasserin |4 aut | |
| 700 | 0 | |a Johanna Schleutker |e verfasserin |4 aut | |
| 700 | 0 | |a Demetrius Albanes |e verfasserin |4 aut | |
| 700 | 0 | |a Stephanie J. Weinstein |e verfasserin |4 aut | |
| 700 | 0 | |a Alicja Wolk |e verfasserin |4 aut | |
| 700 | 0 | |a Catharine M.L. West |e verfasserin |4 aut | |
| 700 | 0 | |a Lorelei A. Mucci |e verfasserin |4 aut | |
| 700 | 0 | |a Géraldine Cancel-Tassin |e verfasserin |4 aut | |
| 700 | 0 | |a Stella Koutros |e verfasserin |4 aut | |
| 700 | 0 | |a Karina Dalsgaard Sørensen |e verfasserin |4 aut | |
| 700 | 0 | |a Eli Marie Grindedal |e verfasserin |4 aut | |
| 700 | 0 | |a David E. Neal |e verfasserin |4 aut | |
| 700 | 0 | |a Freddie C. Hamdy |e verfasserin |4 aut | |
| 700 | 0 | |a Jenny L. Donovan |e verfasserin |4 aut | |
| 700 | 0 | |a Ruth C. Travis |e verfasserin |4 aut | |
| 700 | 0 | |a Robert J. Hamilton |e verfasserin |4 aut | |
| 700 | 0 | |a Sue Ann Ingles |e verfasserin |4 aut | |
| 700 | 0 | |a Barry S. Rosenstein |e verfasserin |4 aut | |
| 700 | 0 | |a Yong-Jie Lu |e verfasserin |4 aut | |
| 700 | 0 | |a Graham G. Giles |e verfasserin |4 aut | |
| 700 | 0 | |a Robert J. MacInnis |e verfasserin |4 aut | |
| 700 | 0 | |a Adam S. Kibel |e verfasserin |4 aut | |
| 700 | 0 | |a Ana Vega |e verfasserin |4 aut | |
| 700 | 0 | |a Manolis Kogevinas |e verfasserin |4 aut | |
| 700 | 0 | |a Kathryn L. Penney |e verfasserin |4 aut | |
| 700 | 0 | |a Jong Y. Park |e verfasserin |4 aut | |
| 700 | 0 | |a Janet L. Stanfrod |e verfasserin |4 aut | |
| 700 | 0 | |a Cezary Cybulski |e verfasserin |4 aut | |
| 700 | 0 | |a Børge G. Nordestgaard |e verfasserin |4 aut | |
| 700 | 0 | |a Sune F. Nielsen |e verfasserin |4 aut | |
| 700 | 0 | |a Hermann Brenner |e verfasserin |4 aut | |
| 700 | 0 | |a Christiane Maier |e verfasserin |4 aut | |
| 700 | 0 | |a Christopher J. Logothetis |e verfasserin |4 aut | |
| 700 | 0 | |a Esther M. John |e verfasserin |4 aut | |
| 700 | 0 | |a Manuel R. Teixeira |e verfasserin |4 aut | |
| 700 | 0 | |a Susan L. Neuhausen |e verfasserin |4 aut | |
| 700 | 0 | |a Kim De Ruyck |e verfasserin |4 aut | |
| 700 | 0 | |a Azad Razack |e verfasserin |4 aut | |
| 700 | 0 | |a Lisa F. Newcomb |e verfasserin |4 aut | |
| 700 | 0 | |a Davor Lessel |e verfasserin |4 aut | |
| 700 | 0 | |a Radka Kaneva |e verfasserin |4 aut | |
| 700 | 0 | |a Nawaid Usmani |e verfasserin |4 aut | |
| 700 | 0 | |a Frank Claessens |e verfasserin |4 aut | |
| 700 | 0 | |a Paul A. Townsend |e verfasserin |4 aut | |
| 700 | 0 | |a Jose Esteban Castelao |e verfasserin |4 aut | |
| 700 | 0 | |a Monique J. Roobol |e verfasserin |4 aut | |
| 700 | 0 | |a Florence Menegaux |e verfasserin |4 aut | |
| 700 | 0 | |a Kay-Tee Khaw |e verfasserin |4 aut | |
| 700 | 0 | |a Lisa Cannon-Albright |e verfasserin |4 aut | |
| 700 | 0 | |a Hardev Pandha |e verfasserin |4 aut | |
| 700 | 0 | |a Stephen N. Thibodeau |e verfasserin |4 aut | |
| 700 | 0 | |a David J. Hunter |e verfasserin |4 aut | |
| 700 | 0 | |a Peter Kraft |e verfasserin |4 aut | |
| 700 | 0 | |a William J. Blot |e verfasserin |4 aut | |
| 700 | 0 | |a Elio Riboli |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i In |t EBioMedicine |d Elsevier, 2015 |g 100(2024), Seite 104991- |w (DE-627)802540074 |w (DE-600)2799017-5 |x 23523964 |7 nnns |
| 773 | 1 | 8 | |g volume:100 |g year:2024 |g pages:104991- |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ebiom.2024.104991 |z kostenfrei |
| 856 | 4 | 0 | |u https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 |z kostenfrei |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S2352396424000264 |z kostenfrei |
| 856 | 4 | 2 | |u https://doaj.org/toc/2352-3964 |y Journal toc |z kostenfrei |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_DOAJ | ||
| 912 | |a GBV_ILN_20 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_23 | ||
| 912 | |a GBV_ILN_24 | ||
| 912 | |a GBV_ILN_31 | ||
| 912 | |a GBV_ILN_39 | ||
| 912 | |a GBV_ILN_40 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_62 | ||
| 912 | |a GBV_ILN_63 | ||
| 912 | |a GBV_ILN_65 | ||
| 912 | |a GBV_ILN_69 | ||
| 912 | |a GBV_ILN_73 | ||
| 912 | |a GBV_ILN_74 | ||
| 912 | |a GBV_ILN_95 | ||
| 912 | |a GBV_ILN_105 | ||
| 912 | |a GBV_ILN_110 | ||
| 912 | |a GBV_ILN_151 | ||
| 912 | |a GBV_ILN_161 | ||
| 912 | |a GBV_ILN_170 | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_213 | ||
| 912 | |a GBV_ILN_230 | ||
| 912 | |a GBV_ILN_285 | ||
| 912 | |a GBV_ILN_293 | ||
| 912 | |a GBV_ILN_602 | ||
| 912 | |a GBV_ILN_2001 | ||
| 912 | |a GBV_ILN_2003 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2006 | ||
| 912 | |a GBV_ILN_2007 | ||
| 912 | |a GBV_ILN_2008 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2010 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2014 | ||
| 912 | |a GBV_ILN_2015 | ||
| 912 | |a GBV_ILN_2020 | ||
| 912 | |a GBV_ILN_2021 | ||
| 912 | |a GBV_ILN_2025 | ||
| 912 | |a GBV_ILN_2026 | ||
| 912 | |a GBV_ILN_2027 | ||
| 912 | |a GBV_ILN_2038 | ||
| 912 | |a GBV_ILN_2044 | ||
| 912 | |a GBV_ILN_2048 | ||
| 912 | |a GBV_ILN_2049 | ||
| 912 | |a GBV_ILN_2050 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2059 | ||
| 912 | |a GBV_ILN_2061 | ||
| 912 | |a GBV_ILN_2064 | ||
| 912 | |a GBV_ILN_2068 | ||
| 912 | |a GBV_ILN_2088 | ||
| 912 | |a GBV_ILN_2110 | ||
| 912 | |a GBV_ILN_2112 | ||
| 912 | |a GBV_ILN_2129 | ||
| 912 | |a GBV_ILN_2143 | ||
| 912 | |a GBV_ILN_2153 | ||
| 912 | |a GBV_ILN_2190 | ||
| 912 | |a GBV_ILN_2336 | ||
| 912 | |a GBV_ILN_2470 | ||
| 912 | |a GBV_ILN_2507 | ||
| 912 | |a GBV_ILN_4012 | ||
| 912 | |a GBV_ILN_4035 | ||
| 912 | |a GBV_ILN_4037 | ||
| 912 | |a GBV_ILN_4112 | ||
| 912 | |a GBV_ILN_4125 | ||
| 912 | |a GBV_ILN_4126 | ||
| 912 | |a GBV_ILN_4249 | ||
| 912 | |a GBV_ILN_4251 | ||
| 912 | |a GBV_ILN_4305 | ||
| 912 | |a GBV_ILN_4306 | ||
| 912 | |a GBV_ILN_4307 | ||
| 912 | |a GBV_ILN_4313 | ||
| 912 | |a GBV_ILN_4322 | ||
| 912 | |a GBV_ILN_4323 | ||
| 912 | |a GBV_ILN_4324 | ||
| 912 | |a GBV_ILN_4325 | ||
| 912 | |a GBV_ILN_4326 | ||
| 912 | |a GBV_ILN_4333 | ||
| 912 | |a GBV_ILN_4338 | ||
| 912 | |a GBV_ILN_4367 | ||
| 912 | |a GBV_ILN_4393 | ||
| 912 | |a GBV_ILN_4700 | ||
| 951 | |a AR | ||
| 952 | |d 100 |j 2024 |h 104991- | ||
| author_variant |
j y jy j w r jwr d m dm v k vk j h jh n d nd n m nm k b kb e b eb k s b ksb s j l sjl t e g teg l a k lak s v sv p m pm d a da l h lh p a n pan e w ew a w aw a h w ahw l l m llm a i p aip d d b ddb s s z ssz d g dg s j c sjc m p p mpp g d s gds p b pb k h h khh m r j mrj c i a cia r j h rjh a d ad m j mj m j g mjg k k t kkt r m m rmm m t l mtl v s vs y w yw d a da n c nc p b pb c i a cia s s ss r j h rjh h b hb a r ar r h rh s l sl a t at c c cc s e b seb m j mj h e w hew d c dc g r gr s a sa j k f jkf l l m llm o m om h b hb g l gl a a aa l a k lak h s hs s z sz k g kg m j mj m d t mdt y c h ych j m y jmy p l pl m b s mbs m c a mca r a e rae c a h cah z k j zkj f r s frs s b sb a a a o aaao k r m krm s i b sib d v c dvc f w fw s c sc y w yw c m t cmt j b jb j a c jac h g hg n p np j s js d a da s j w sjw a w aw c m w cmw l a m lam g c t gct s k sk k d s kds e m g emg d e n den f c h fch j l d jld r c t rct r j h rjh s a i sai b s r bsr y j l yjl g g g ggg r j m rjm a s k ask a v av m k mk k l p klp j y p jyp j l s jls c c cc b g n bgn s f n sfn h b hb c m cm c j l cjl e m j emj m r t mrt s l n sln k d r kdr a r ar l f n lfn d l dl r k rk n u nu f c fc p a t pat j e c jec m j r mjr f m fm k t k ktk l c a lca h p hp s n t snt d j h djh p k pk w j b wjb e r er |
|---|---|
| matchkey_str |
article:23523964:2024----::soitobtenicltnifamtrmresnautacrikmneinadmz |
| hierarchy_sort_str |
2024 |
| callnumber-subject-code |
R |
| publishDate |
2024 |
| allfields |
10.1016/j.ebiom.2024.104991 doi (DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 DE-627 ger DE-627 rakwb eng R5-920 James Yarmolinsky verfasserin aut Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) Jamie W. Robinson verfasserin aut Daniela Mariosa verfasserin aut Ville Karhunen verfasserin aut Jian Huang verfasserin aut Niki Dimou verfasserin aut Neil Murphy verfasserin aut Kimberley Burrows verfasserin aut Emmanouil Bouras verfasserin aut Karl Smith-Byrne verfasserin aut Sarah J. Lewis verfasserin aut Tessel E. Galesloot verfasserin aut Lambertus A. Kiemeney verfasserin aut Sita Vermeulen verfasserin aut Paul Martin verfasserin aut Demetrius Albanes verfasserin aut Lifang Hou verfasserin aut Polly A. Newcomb verfasserin aut Emily White verfasserin aut Alicja Wolk verfasserin aut Anna H. Wu verfasserin aut Loïc Le Marchand verfasserin aut Amanda I. Phipps verfasserin aut Daniel D. Buchanan verfasserin aut Sizheng Steven Zhao verfasserin aut Dipender Gill verfasserin aut Stephen J. Chanock verfasserin aut Mark P. Purdue verfasserin aut George Davey Smith verfasserin aut Paul Brennan verfasserin aut Karl-Heinz Herzig verfasserin aut Marjo-Riitta Järvelin verfasserin aut Chris I. Amos verfasserin aut Rayjean J. Hung verfasserin aut Abbas Dehghan verfasserin aut Mattias Johansson verfasserin aut Marc J. Gunter verfasserin aut Kostas K. Tsilidis verfasserin aut Richard M. Martin verfasserin aut Maria Teresa Landi verfasserin aut Victoria Stevens verfasserin aut Ying Wang verfasserin aut Demetrios Albanes verfasserin aut Neil Caporaso verfasserin aut Paul Brennan verfasserin aut Christopher I. Amos verfasserin aut Sanjay Shete verfasserin aut Rayjean J. Hung verfasserin aut Heike Bickeböller verfasserin aut Angela Risch verfasserin aut Richard Houlston verfasserin aut Stephen Lam verfasserin aut Adonina Tardon verfasserin aut Chu Chen verfasserin aut Stig E. Bojesen verfasserin aut Mattias Johansson verfasserin aut H-Erich Wichmann verfasserin aut David Christiani verfasserin aut Gadi Rennert verfasserin aut Susanne Arnold verfasserin aut John K. Field verfasserin aut Loic Le Marchand verfasserin aut Olle Melander verfasserin aut Hans Brunnström verfasserin aut Geoffrey Liu verfasserin aut Angeline Andrew verfasserin aut Lambertus A. Kiemeney verfasserin aut Hongbing Shen verfasserin aut Shan Zienolddiny verfasserin aut Kjell Grankvist verfasserin aut Mikael Johansson verfasserin aut M. Dawn Teare verfasserin aut Yun-Chul Hong verfasserin aut Jian-Min Yuan verfasserin aut Philip Lazarus verfasserin aut Matthew B. Schabath verfasserin aut Melinda C. Aldrich verfasserin aut Rosalind A. Eeles verfasserin aut Christopher A. Haiman verfasserin aut Zsofia Kote-Jarai verfasserin aut Fredrick R. Schumacher verfasserin aut Sara Benlloch verfasserin aut Ali Amin Al Olama verfasserin aut Kenneth R. Muir verfasserin aut Sonja I. Berndt verfasserin aut David V. Conti verfasserin aut Fredrik Wiklund verfasserin aut Stephen Chanock verfasserin aut Ying Wang verfasserin aut Catherine M. Tangen verfasserin aut Jyotsna Batra verfasserin aut Judith A. Clements verfasserin aut Henrik Grönberg verfasserin aut Nora Pashayan verfasserin aut Johanna Schleutker verfasserin aut Demetrius Albanes verfasserin aut Stephanie J. Weinstein verfasserin aut Alicja Wolk verfasserin aut Catharine M.L. West verfasserin aut Lorelei A. Mucci verfasserin aut Géraldine Cancel-Tassin verfasserin aut Stella Koutros verfasserin aut Karina Dalsgaard Sørensen verfasserin aut Eli Marie Grindedal verfasserin aut David E. Neal verfasserin aut Freddie C. Hamdy verfasserin aut Jenny L. Donovan verfasserin aut Ruth C. Travis verfasserin aut Robert J. Hamilton verfasserin aut Sue Ann Ingles verfasserin aut Barry S. Rosenstein verfasserin aut Yong-Jie Lu verfasserin aut Graham G. Giles verfasserin aut Robert J. MacInnis verfasserin aut Adam S. Kibel verfasserin aut Ana Vega verfasserin aut Manolis Kogevinas verfasserin aut Kathryn L. Penney verfasserin aut Jong Y. Park verfasserin aut Janet L. Stanfrod verfasserin aut Cezary Cybulski verfasserin aut Børge G. Nordestgaard verfasserin aut Sune F. Nielsen verfasserin aut Hermann Brenner verfasserin aut Christiane Maier verfasserin aut Christopher J. Logothetis verfasserin aut Esther M. John verfasserin aut Manuel R. Teixeira verfasserin aut Susan L. Neuhausen verfasserin aut Kim De Ruyck verfasserin aut Azad Razack verfasserin aut Lisa F. Newcomb verfasserin aut Davor Lessel verfasserin aut Radka Kaneva verfasserin aut Nawaid Usmani verfasserin aut Frank Claessens verfasserin aut Paul A. Townsend verfasserin aut Jose Esteban Castelao verfasserin aut Monique J. Roobol verfasserin aut Florence Menegaux verfasserin aut Kay-Tee Khaw verfasserin aut Lisa Cannon-Albright verfasserin aut Hardev Pandha verfasserin aut Stephen N. Thibodeau verfasserin aut David J. Hunter verfasserin aut Peter Kraft verfasserin aut William J. Blot verfasserin aut Elio Riboli verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104991- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104991- https://doi.org/10.1016/j.ebiom.2024.104991 kostenfrei https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000264 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104991- |
| spelling |
10.1016/j.ebiom.2024.104991 doi (DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 DE-627 ger DE-627 rakwb eng R5-920 James Yarmolinsky verfasserin aut Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) Jamie W. Robinson verfasserin aut Daniela Mariosa verfasserin aut Ville Karhunen verfasserin aut Jian Huang verfasserin aut Niki Dimou verfasserin aut Neil Murphy verfasserin aut Kimberley Burrows verfasserin aut Emmanouil Bouras verfasserin aut Karl Smith-Byrne verfasserin aut Sarah J. Lewis verfasserin aut Tessel E. Galesloot verfasserin aut Lambertus A. Kiemeney verfasserin aut Sita Vermeulen verfasserin aut Paul Martin verfasserin aut Demetrius Albanes verfasserin aut Lifang Hou verfasserin aut Polly A. Newcomb verfasserin aut Emily White verfasserin aut Alicja Wolk verfasserin aut Anna H. Wu verfasserin aut Loïc Le Marchand verfasserin aut Amanda I. Phipps verfasserin aut Daniel D. Buchanan verfasserin aut Sizheng Steven Zhao verfasserin aut Dipender Gill verfasserin aut Stephen J. Chanock verfasserin aut Mark P. Purdue verfasserin aut George Davey Smith verfasserin aut Paul Brennan verfasserin aut Karl-Heinz Herzig verfasserin aut Marjo-Riitta Järvelin verfasserin aut Chris I. Amos verfasserin aut Rayjean J. Hung verfasserin aut Abbas Dehghan verfasserin aut Mattias Johansson verfasserin aut Marc J. Gunter verfasserin aut Kostas K. Tsilidis verfasserin aut Richard M. Martin verfasserin aut Maria Teresa Landi verfasserin aut Victoria Stevens verfasserin aut Ying Wang verfasserin aut Demetrios Albanes verfasserin aut Neil Caporaso verfasserin aut Paul Brennan verfasserin aut Christopher I. Amos verfasserin aut Sanjay Shete verfasserin aut Rayjean J. Hung verfasserin aut Heike Bickeböller verfasserin aut Angela Risch verfasserin aut Richard Houlston verfasserin aut Stephen Lam verfasserin aut Adonina Tardon verfasserin aut Chu Chen verfasserin aut Stig E. Bojesen verfasserin aut Mattias Johansson verfasserin aut H-Erich Wichmann verfasserin aut David Christiani verfasserin aut Gadi Rennert verfasserin aut Susanne Arnold verfasserin aut John K. Field verfasserin aut Loic Le Marchand verfasserin aut Olle Melander verfasserin aut Hans Brunnström verfasserin aut Geoffrey Liu verfasserin aut Angeline Andrew verfasserin aut Lambertus A. Kiemeney verfasserin aut Hongbing Shen verfasserin aut Shan Zienolddiny verfasserin aut Kjell Grankvist verfasserin aut Mikael Johansson verfasserin aut M. Dawn Teare verfasserin aut Yun-Chul Hong verfasserin aut Jian-Min Yuan verfasserin aut Philip Lazarus verfasserin aut Matthew B. Schabath verfasserin aut Melinda C. Aldrich verfasserin aut Rosalind A. Eeles verfasserin aut Christopher A. Haiman verfasserin aut Zsofia Kote-Jarai verfasserin aut Fredrick R. Schumacher verfasserin aut Sara Benlloch verfasserin aut Ali Amin Al Olama verfasserin aut Kenneth R. Muir verfasserin aut Sonja I. Berndt verfasserin aut David V. Conti verfasserin aut Fredrik Wiklund verfasserin aut Stephen Chanock verfasserin aut Ying Wang verfasserin aut Catherine M. Tangen verfasserin aut Jyotsna Batra verfasserin aut Judith A. Clements verfasserin aut Henrik Grönberg verfasserin aut Nora Pashayan verfasserin aut Johanna Schleutker verfasserin aut Demetrius Albanes verfasserin aut Stephanie J. Weinstein verfasserin aut Alicja Wolk verfasserin aut Catharine M.L. West verfasserin aut Lorelei A. Mucci verfasserin aut Géraldine Cancel-Tassin verfasserin aut Stella Koutros verfasserin aut Karina Dalsgaard Sørensen verfasserin aut Eli Marie Grindedal verfasserin aut David E. Neal verfasserin aut Freddie C. Hamdy verfasserin aut Jenny L. Donovan verfasserin aut Ruth C. Travis verfasserin aut Robert J. Hamilton verfasserin aut Sue Ann Ingles verfasserin aut Barry S. Rosenstein verfasserin aut Yong-Jie Lu verfasserin aut Graham G. Giles verfasserin aut Robert J. MacInnis verfasserin aut Adam S. Kibel verfasserin aut Ana Vega verfasserin aut Manolis Kogevinas verfasserin aut Kathryn L. Penney verfasserin aut Jong Y. Park verfasserin aut Janet L. Stanfrod verfasserin aut Cezary Cybulski verfasserin aut Børge G. Nordestgaard verfasserin aut Sune F. Nielsen verfasserin aut Hermann Brenner verfasserin aut Christiane Maier verfasserin aut Christopher J. Logothetis verfasserin aut Esther M. John verfasserin aut Manuel R. Teixeira verfasserin aut Susan L. Neuhausen verfasserin aut Kim De Ruyck verfasserin aut Azad Razack verfasserin aut Lisa F. Newcomb verfasserin aut Davor Lessel verfasserin aut Radka Kaneva verfasserin aut Nawaid Usmani verfasserin aut Frank Claessens verfasserin aut Paul A. Townsend verfasserin aut Jose Esteban Castelao verfasserin aut Monique J. Roobol verfasserin aut Florence Menegaux verfasserin aut Kay-Tee Khaw verfasserin aut Lisa Cannon-Albright verfasserin aut Hardev Pandha verfasserin aut Stephen N. Thibodeau verfasserin aut David J. Hunter verfasserin aut Peter Kraft verfasserin aut William J. Blot verfasserin aut Elio Riboli verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104991- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104991- https://doi.org/10.1016/j.ebiom.2024.104991 kostenfrei https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000264 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104991- |
| allfields_unstemmed |
10.1016/j.ebiom.2024.104991 doi (DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 DE-627 ger DE-627 rakwb eng R5-920 James Yarmolinsky verfasserin aut Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) Jamie W. Robinson verfasserin aut Daniela Mariosa verfasserin aut Ville Karhunen verfasserin aut Jian Huang verfasserin aut Niki Dimou verfasserin aut Neil Murphy verfasserin aut Kimberley Burrows verfasserin aut Emmanouil Bouras verfasserin aut Karl Smith-Byrne verfasserin aut Sarah J. Lewis verfasserin aut Tessel E. Galesloot verfasserin aut Lambertus A. Kiemeney verfasserin aut Sita Vermeulen verfasserin aut Paul Martin verfasserin aut Demetrius Albanes verfasserin aut Lifang Hou verfasserin aut Polly A. Newcomb verfasserin aut Emily White verfasserin aut Alicja Wolk verfasserin aut Anna H. Wu verfasserin aut Loïc Le Marchand verfasserin aut Amanda I. Phipps verfasserin aut Daniel D. Buchanan verfasserin aut Sizheng Steven Zhao verfasserin aut Dipender Gill verfasserin aut Stephen J. Chanock verfasserin aut Mark P. Purdue verfasserin aut George Davey Smith verfasserin aut Paul Brennan verfasserin aut Karl-Heinz Herzig verfasserin aut Marjo-Riitta Järvelin verfasserin aut Chris I. Amos verfasserin aut Rayjean J. Hung verfasserin aut Abbas Dehghan verfasserin aut Mattias Johansson verfasserin aut Marc J. Gunter verfasserin aut Kostas K. Tsilidis verfasserin aut Richard M. Martin verfasserin aut Maria Teresa Landi verfasserin aut Victoria Stevens verfasserin aut Ying Wang verfasserin aut Demetrios Albanes verfasserin aut Neil Caporaso verfasserin aut Paul Brennan verfasserin aut Christopher I. Amos verfasserin aut Sanjay Shete verfasserin aut Rayjean J. Hung verfasserin aut Heike Bickeböller verfasserin aut Angela Risch verfasserin aut Richard Houlston verfasserin aut Stephen Lam verfasserin aut Adonina Tardon verfasserin aut Chu Chen verfasserin aut Stig E. Bojesen verfasserin aut Mattias Johansson verfasserin aut H-Erich Wichmann verfasserin aut David Christiani verfasserin aut Gadi Rennert verfasserin aut Susanne Arnold verfasserin aut John K. Field verfasserin aut Loic Le Marchand verfasserin aut Olle Melander verfasserin aut Hans Brunnström verfasserin aut Geoffrey Liu verfasserin aut Angeline Andrew verfasserin aut Lambertus A. Kiemeney verfasserin aut Hongbing Shen verfasserin aut Shan Zienolddiny verfasserin aut Kjell Grankvist verfasserin aut Mikael Johansson verfasserin aut M. Dawn Teare verfasserin aut Yun-Chul Hong verfasserin aut Jian-Min Yuan verfasserin aut Philip Lazarus verfasserin aut Matthew B. Schabath verfasserin aut Melinda C. Aldrich verfasserin aut Rosalind A. Eeles verfasserin aut Christopher A. Haiman verfasserin aut Zsofia Kote-Jarai verfasserin aut Fredrick R. Schumacher verfasserin aut Sara Benlloch verfasserin aut Ali Amin Al Olama verfasserin aut Kenneth R. Muir verfasserin aut Sonja I. Berndt verfasserin aut David V. Conti verfasserin aut Fredrik Wiklund verfasserin aut Stephen Chanock verfasserin aut Ying Wang verfasserin aut Catherine M. Tangen verfasserin aut Jyotsna Batra verfasserin aut Judith A. Clements verfasserin aut Henrik Grönberg verfasserin aut Nora Pashayan verfasserin aut Johanna Schleutker verfasserin aut Demetrius Albanes verfasserin aut Stephanie J. Weinstein verfasserin aut Alicja Wolk verfasserin aut Catharine M.L. West verfasserin aut Lorelei A. Mucci verfasserin aut Géraldine Cancel-Tassin verfasserin aut Stella Koutros verfasserin aut Karina Dalsgaard Sørensen verfasserin aut Eli Marie Grindedal verfasserin aut David E. Neal verfasserin aut Freddie C. Hamdy verfasserin aut Jenny L. Donovan verfasserin aut Ruth C. Travis verfasserin aut Robert J. Hamilton verfasserin aut Sue Ann Ingles verfasserin aut Barry S. Rosenstein verfasserin aut Yong-Jie Lu verfasserin aut Graham G. Giles verfasserin aut Robert J. MacInnis verfasserin aut Adam S. Kibel verfasserin aut Ana Vega verfasserin aut Manolis Kogevinas verfasserin aut Kathryn L. Penney verfasserin aut Jong Y. Park verfasserin aut Janet L. Stanfrod verfasserin aut Cezary Cybulski verfasserin aut Børge G. Nordestgaard verfasserin aut Sune F. Nielsen verfasserin aut Hermann Brenner verfasserin aut Christiane Maier verfasserin aut Christopher J. Logothetis verfasserin aut Esther M. John verfasserin aut Manuel R. Teixeira verfasserin aut Susan L. Neuhausen verfasserin aut Kim De Ruyck verfasserin aut Azad Razack verfasserin aut Lisa F. Newcomb verfasserin aut Davor Lessel verfasserin aut Radka Kaneva verfasserin aut Nawaid Usmani verfasserin aut Frank Claessens verfasserin aut Paul A. Townsend verfasserin aut Jose Esteban Castelao verfasserin aut Monique J. Roobol verfasserin aut Florence Menegaux verfasserin aut Kay-Tee Khaw verfasserin aut Lisa Cannon-Albright verfasserin aut Hardev Pandha verfasserin aut Stephen N. Thibodeau verfasserin aut David J. Hunter verfasserin aut Peter Kraft verfasserin aut William J. Blot verfasserin aut Elio Riboli verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104991- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104991- https://doi.org/10.1016/j.ebiom.2024.104991 kostenfrei https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000264 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104991- |
| allfieldsGer |
10.1016/j.ebiom.2024.104991 doi (DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 DE-627 ger DE-627 rakwb eng R5-920 James Yarmolinsky verfasserin aut Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) Jamie W. Robinson verfasserin aut Daniela Mariosa verfasserin aut Ville Karhunen verfasserin aut Jian Huang verfasserin aut Niki Dimou verfasserin aut Neil Murphy verfasserin aut Kimberley Burrows verfasserin aut Emmanouil Bouras verfasserin aut Karl Smith-Byrne verfasserin aut Sarah J. Lewis verfasserin aut Tessel E. Galesloot verfasserin aut Lambertus A. Kiemeney verfasserin aut Sita Vermeulen verfasserin aut Paul Martin verfasserin aut Demetrius Albanes verfasserin aut Lifang Hou verfasserin aut Polly A. Newcomb verfasserin aut Emily White verfasserin aut Alicja Wolk verfasserin aut Anna H. Wu verfasserin aut Loïc Le Marchand verfasserin aut Amanda I. Phipps verfasserin aut Daniel D. Buchanan verfasserin aut Sizheng Steven Zhao verfasserin aut Dipender Gill verfasserin aut Stephen J. Chanock verfasserin aut Mark P. Purdue verfasserin aut George Davey Smith verfasserin aut Paul Brennan verfasserin aut Karl-Heinz Herzig verfasserin aut Marjo-Riitta Järvelin verfasserin aut Chris I. Amos verfasserin aut Rayjean J. Hung verfasserin aut Abbas Dehghan verfasserin aut Mattias Johansson verfasserin aut Marc J. Gunter verfasserin aut Kostas K. Tsilidis verfasserin aut Richard M. Martin verfasserin aut Maria Teresa Landi verfasserin aut Victoria Stevens verfasserin aut Ying Wang verfasserin aut Demetrios Albanes verfasserin aut Neil Caporaso verfasserin aut Paul Brennan verfasserin aut Christopher I. Amos verfasserin aut Sanjay Shete verfasserin aut Rayjean J. Hung verfasserin aut Heike Bickeböller verfasserin aut Angela Risch verfasserin aut Richard Houlston verfasserin aut Stephen Lam verfasserin aut Adonina Tardon verfasserin aut Chu Chen verfasserin aut Stig E. Bojesen verfasserin aut Mattias Johansson verfasserin aut H-Erich Wichmann verfasserin aut David Christiani verfasserin aut Gadi Rennert verfasserin aut Susanne Arnold verfasserin aut John K. Field verfasserin aut Loic Le Marchand verfasserin aut Olle Melander verfasserin aut Hans Brunnström verfasserin aut Geoffrey Liu verfasserin aut Angeline Andrew verfasserin aut Lambertus A. Kiemeney verfasserin aut Hongbing Shen verfasserin aut Shan Zienolddiny verfasserin aut Kjell Grankvist verfasserin aut Mikael Johansson verfasserin aut M. Dawn Teare verfasserin aut Yun-Chul Hong verfasserin aut Jian-Min Yuan verfasserin aut Philip Lazarus verfasserin aut Matthew B. Schabath verfasserin aut Melinda C. Aldrich verfasserin aut Rosalind A. Eeles verfasserin aut Christopher A. Haiman verfasserin aut Zsofia Kote-Jarai verfasserin aut Fredrick R. Schumacher verfasserin aut Sara Benlloch verfasserin aut Ali Amin Al Olama verfasserin aut Kenneth R. Muir verfasserin aut Sonja I. Berndt verfasserin aut David V. Conti verfasserin aut Fredrik Wiklund verfasserin aut Stephen Chanock verfasserin aut Ying Wang verfasserin aut Catherine M. Tangen verfasserin aut Jyotsna Batra verfasserin aut Judith A. Clements verfasserin aut Henrik Grönberg verfasserin aut Nora Pashayan verfasserin aut Johanna Schleutker verfasserin aut Demetrius Albanes verfasserin aut Stephanie J. Weinstein verfasserin aut Alicja Wolk verfasserin aut Catharine M.L. West verfasserin aut Lorelei A. Mucci verfasserin aut Géraldine Cancel-Tassin verfasserin aut Stella Koutros verfasserin aut Karina Dalsgaard Sørensen verfasserin aut Eli Marie Grindedal verfasserin aut David E. Neal verfasserin aut Freddie C. Hamdy verfasserin aut Jenny L. Donovan verfasserin aut Ruth C. Travis verfasserin aut Robert J. Hamilton verfasserin aut Sue Ann Ingles verfasserin aut Barry S. Rosenstein verfasserin aut Yong-Jie Lu verfasserin aut Graham G. Giles verfasserin aut Robert J. MacInnis verfasserin aut Adam S. Kibel verfasserin aut Ana Vega verfasserin aut Manolis Kogevinas verfasserin aut Kathryn L. Penney verfasserin aut Jong Y. Park verfasserin aut Janet L. Stanfrod verfasserin aut Cezary Cybulski verfasserin aut Børge G. Nordestgaard verfasserin aut Sune F. Nielsen verfasserin aut Hermann Brenner verfasserin aut Christiane Maier verfasserin aut Christopher J. Logothetis verfasserin aut Esther M. John verfasserin aut Manuel R. Teixeira verfasserin aut Susan L. Neuhausen verfasserin aut Kim De Ruyck verfasserin aut Azad Razack verfasserin aut Lisa F. Newcomb verfasserin aut Davor Lessel verfasserin aut Radka Kaneva verfasserin aut Nawaid Usmani verfasserin aut Frank Claessens verfasserin aut Paul A. Townsend verfasserin aut Jose Esteban Castelao verfasserin aut Monique J. Roobol verfasserin aut Florence Menegaux verfasserin aut Kay-Tee Khaw verfasserin aut Lisa Cannon-Albright verfasserin aut Hardev Pandha verfasserin aut Stephen N. Thibodeau verfasserin aut David J. Hunter verfasserin aut Peter Kraft verfasserin aut William J. Blot verfasserin aut Elio Riboli verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104991- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104991- https://doi.org/10.1016/j.ebiom.2024.104991 kostenfrei https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000264 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104991- |
| allfieldsSound |
10.1016/j.ebiom.2024.104991 doi (DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 DE-627 ger DE-627 rakwb eng R5-920 James Yarmolinsky verfasserin aut Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) Jamie W. Robinson verfasserin aut Daniela Mariosa verfasserin aut Ville Karhunen verfasserin aut Jian Huang verfasserin aut Niki Dimou verfasserin aut Neil Murphy verfasserin aut Kimberley Burrows verfasserin aut Emmanouil Bouras verfasserin aut Karl Smith-Byrne verfasserin aut Sarah J. Lewis verfasserin aut Tessel E. Galesloot verfasserin aut Lambertus A. Kiemeney verfasserin aut Sita Vermeulen verfasserin aut Paul Martin verfasserin aut Demetrius Albanes verfasserin aut Lifang Hou verfasserin aut Polly A. Newcomb verfasserin aut Emily White verfasserin aut Alicja Wolk verfasserin aut Anna H. Wu verfasserin aut Loïc Le Marchand verfasserin aut Amanda I. Phipps verfasserin aut Daniel D. Buchanan verfasserin aut Sizheng Steven Zhao verfasserin aut Dipender Gill verfasserin aut Stephen J. Chanock verfasserin aut Mark P. Purdue verfasserin aut George Davey Smith verfasserin aut Paul Brennan verfasserin aut Karl-Heinz Herzig verfasserin aut Marjo-Riitta Järvelin verfasserin aut Chris I. Amos verfasserin aut Rayjean J. Hung verfasserin aut Abbas Dehghan verfasserin aut Mattias Johansson verfasserin aut Marc J. Gunter verfasserin aut Kostas K. Tsilidis verfasserin aut Richard M. Martin verfasserin aut Maria Teresa Landi verfasserin aut Victoria Stevens verfasserin aut Ying Wang verfasserin aut Demetrios Albanes verfasserin aut Neil Caporaso verfasserin aut Paul Brennan verfasserin aut Christopher I. Amos verfasserin aut Sanjay Shete verfasserin aut Rayjean J. Hung verfasserin aut Heike Bickeböller verfasserin aut Angela Risch verfasserin aut Richard Houlston verfasserin aut Stephen Lam verfasserin aut Adonina Tardon verfasserin aut Chu Chen verfasserin aut Stig E. Bojesen verfasserin aut Mattias Johansson verfasserin aut H-Erich Wichmann verfasserin aut David Christiani verfasserin aut Gadi Rennert verfasserin aut Susanne Arnold verfasserin aut John K. Field verfasserin aut Loic Le Marchand verfasserin aut Olle Melander verfasserin aut Hans Brunnström verfasserin aut Geoffrey Liu verfasserin aut Angeline Andrew verfasserin aut Lambertus A. Kiemeney verfasserin aut Hongbing Shen verfasserin aut Shan Zienolddiny verfasserin aut Kjell Grankvist verfasserin aut Mikael Johansson verfasserin aut M. Dawn Teare verfasserin aut Yun-Chul Hong verfasserin aut Jian-Min Yuan verfasserin aut Philip Lazarus verfasserin aut Matthew B. Schabath verfasserin aut Melinda C. Aldrich verfasserin aut Rosalind A. Eeles verfasserin aut Christopher A. Haiman verfasserin aut Zsofia Kote-Jarai verfasserin aut Fredrick R. Schumacher verfasserin aut Sara Benlloch verfasserin aut Ali Amin Al Olama verfasserin aut Kenneth R. Muir verfasserin aut Sonja I. Berndt verfasserin aut David V. Conti verfasserin aut Fredrik Wiklund verfasserin aut Stephen Chanock verfasserin aut Ying Wang verfasserin aut Catherine M. Tangen verfasserin aut Jyotsna Batra verfasserin aut Judith A. Clements verfasserin aut Henrik Grönberg verfasserin aut Nora Pashayan verfasserin aut Johanna Schleutker verfasserin aut Demetrius Albanes verfasserin aut Stephanie J. Weinstein verfasserin aut Alicja Wolk verfasserin aut Catharine M.L. West verfasserin aut Lorelei A. Mucci verfasserin aut Géraldine Cancel-Tassin verfasserin aut Stella Koutros verfasserin aut Karina Dalsgaard Sørensen verfasserin aut Eli Marie Grindedal verfasserin aut David E. Neal verfasserin aut Freddie C. Hamdy verfasserin aut Jenny L. Donovan verfasserin aut Ruth C. Travis verfasserin aut Robert J. Hamilton verfasserin aut Sue Ann Ingles verfasserin aut Barry S. Rosenstein verfasserin aut Yong-Jie Lu verfasserin aut Graham G. Giles verfasserin aut Robert J. MacInnis verfasserin aut Adam S. Kibel verfasserin aut Ana Vega verfasserin aut Manolis Kogevinas verfasserin aut Kathryn L. Penney verfasserin aut Jong Y. Park verfasserin aut Janet L. Stanfrod verfasserin aut Cezary Cybulski verfasserin aut Børge G. Nordestgaard verfasserin aut Sune F. Nielsen verfasserin aut Hermann Brenner verfasserin aut Christiane Maier verfasserin aut Christopher J. Logothetis verfasserin aut Esther M. John verfasserin aut Manuel R. Teixeira verfasserin aut Susan L. Neuhausen verfasserin aut Kim De Ruyck verfasserin aut Azad Razack verfasserin aut Lisa F. Newcomb verfasserin aut Davor Lessel verfasserin aut Radka Kaneva verfasserin aut Nawaid Usmani verfasserin aut Frank Claessens verfasserin aut Paul A. Townsend verfasserin aut Jose Esteban Castelao verfasserin aut Monique J. Roobol verfasserin aut Florence Menegaux verfasserin aut Kay-Tee Khaw verfasserin aut Lisa Cannon-Albright verfasserin aut Hardev Pandha verfasserin aut Stephen N. Thibodeau verfasserin aut David J. Hunter verfasserin aut Peter Kraft verfasserin aut William J. Blot verfasserin aut Elio Riboli verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104991- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104991- https://doi.org/10.1016/j.ebiom.2024.104991 kostenfrei https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000264 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104991- |
| language |
English |
| source |
In EBioMedicine 100(2024), Seite 104991- volume:100 year:2024 pages:104991- |
| sourceStr |
In EBioMedicine 100(2024), Seite 104991- volume:100 year:2024 pages:104991- |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Inflammation Cancer Mendelian randomization Genetic epidemiology Medicine R Medicine (General) |
| isfreeaccess_bool |
true |
| container_title |
EBioMedicine |
| authorswithroles_txt_mv |
James Yarmolinsky @@aut@@ Jamie W. Robinson @@aut@@ Daniela Mariosa @@aut@@ Ville Karhunen @@aut@@ Jian Huang @@aut@@ Niki Dimou @@aut@@ Neil Murphy @@aut@@ Kimberley Burrows @@aut@@ Emmanouil Bouras @@aut@@ Karl Smith-Byrne @@aut@@ Sarah J. Lewis @@aut@@ Tessel E. Galesloot @@aut@@ Lambertus A. Kiemeney @@aut@@ Sita Vermeulen @@aut@@ Paul Martin @@aut@@ Demetrius Albanes @@aut@@ Lifang Hou @@aut@@ Polly A. Newcomb @@aut@@ Emily White @@aut@@ Alicja Wolk @@aut@@ Anna H. Wu @@aut@@ Loïc Le Marchand @@aut@@ Amanda I. Phipps @@aut@@ Daniel D. Buchanan @@aut@@ Sizheng Steven Zhao @@aut@@ Dipender Gill @@aut@@ Stephen J. Chanock @@aut@@ Mark P. Purdue @@aut@@ George Davey Smith @@aut@@ Paul Brennan @@aut@@ Karl-Heinz Herzig @@aut@@ Marjo-Riitta Järvelin @@aut@@ Chris I. Amos @@aut@@ Rayjean J. Hung @@aut@@ Abbas Dehghan @@aut@@ Mattias Johansson @@aut@@ Marc J. Gunter @@aut@@ Kostas K. Tsilidis @@aut@@ Richard M. Martin @@aut@@ Maria Teresa Landi @@aut@@ Victoria Stevens @@aut@@ Ying Wang @@aut@@ Demetrios Albanes @@aut@@ Neil Caporaso @@aut@@ Christopher I. Amos @@aut@@ Sanjay Shete @@aut@@ Heike Bickeböller @@aut@@ Angela Risch @@aut@@ Richard Houlston @@aut@@ Stephen Lam @@aut@@ Adonina Tardon @@aut@@ Chu Chen @@aut@@ Stig E. Bojesen @@aut@@ H-Erich Wichmann @@aut@@ David Christiani @@aut@@ Gadi Rennert @@aut@@ Susanne Arnold @@aut@@ John K. Field @@aut@@ Loic Le Marchand @@aut@@ Olle Melander @@aut@@ Hans Brunnström @@aut@@ Geoffrey Liu @@aut@@ Angeline Andrew @@aut@@ Hongbing Shen @@aut@@ Shan Zienolddiny @@aut@@ Kjell Grankvist @@aut@@ Mikael Johansson @@aut@@ M. Dawn Teare @@aut@@ Yun-Chul Hong @@aut@@ Jian-Min Yuan @@aut@@ Philip Lazarus @@aut@@ Matthew B. Schabath @@aut@@ Melinda C. Aldrich @@aut@@ Rosalind A. Eeles @@aut@@ Christopher A. Haiman @@aut@@ Zsofia Kote-Jarai @@aut@@ Fredrick R. Schumacher @@aut@@ Sara Benlloch @@aut@@ Ali Amin Al Olama @@aut@@ Kenneth R. Muir @@aut@@ Sonja I. Berndt @@aut@@ David V. Conti @@aut@@ Fredrik Wiklund @@aut@@ Stephen Chanock @@aut@@ Catherine M. Tangen @@aut@@ Jyotsna Batra @@aut@@ Judith A. Clements @@aut@@ Henrik Grönberg @@aut@@ Nora Pashayan @@aut@@ Johanna Schleutker @@aut@@ Stephanie J. Weinstein @@aut@@ Catharine M.L. West @@aut@@ Lorelei A. Mucci @@aut@@ Géraldine Cancel-Tassin @@aut@@ Stella Koutros @@aut@@ Karina Dalsgaard Sørensen @@aut@@ Eli Marie Grindedal @@aut@@ David E. Neal @@aut@@ Freddie C. Hamdy @@aut@@ Jenny L. Donovan @@aut@@ Ruth C. Travis @@aut@@ Robert J. Hamilton @@aut@@ Sue Ann Ingles @@aut@@ Barry S. Rosenstein @@aut@@ Yong-Jie Lu @@aut@@ Graham G. Giles @@aut@@ Robert J. MacInnis @@aut@@ Adam S. Kibel @@aut@@ Ana Vega @@aut@@ Manolis Kogevinas @@aut@@ Kathryn L. Penney @@aut@@ Jong Y. Park @@aut@@ Janet L. Stanfrod @@aut@@ Cezary Cybulski @@aut@@ Børge G. Nordestgaard @@aut@@ Sune F. Nielsen @@aut@@ Hermann Brenner @@aut@@ Christiane Maier @@aut@@ Christopher J. Logothetis @@aut@@ Esther M. John @@aut@@ Manuel R. Teixeira @@aut@@ Susan L. Neuhausen @@aut@@ Kim De Ruyck @@aut@@ Azad Razack @@aut@@ Lisa F. Newcomb @@aut@@ Davor Lessel @@aut@@ Radka Kaneva @@aut@@ Nawaid Usmani @@aut@@ Frank Claessens @@aut@@ Paul A. Townsend @@aut@@ Jose Esteban Castelao @@aut@@ Monique J. Roobol @@aut@@ Florence Menegaux @@aut@@ Kay-Tee Khaw @@aut@@ Lisa Cannon-Albright @@aut@@ Hardev Pandha @@aut@@ Stephen N. Thibodeau @@aut@@ David J. Hunter @@aut@@ Peter Kraft @@aut@@ William J. Blot @@aut@@ Elio Riboli @@aut@@ |
| publishDateDaySort_date |
2024-01-01T00:00:00Z |
| hierarchy_top_id |
802540074 |
| id |
DOAJ096058870 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ096058870</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413140923.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240413s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ebiom.2024.104991</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ096058870</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">James Yarmolinsky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mendelian randomization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic epidemiology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jamie W. Robinson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Mariosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ville Karhunen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jian Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Niki Dimou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Neil Murphy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kimberley Burrows</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Bouras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karl Smith-Byrne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarah J. Lewis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tessel E. Galesloot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lambertus A. Kiemeney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sita Vermeulen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Martin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrius Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lifang Hou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Polly A. Newcomb</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily White</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicja Wolk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna H. Wu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loïc Le Marchand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amanda I. Phipps</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel D. Buchanan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sizheng Steven Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dipender Gill</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen J. Chanock</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mark P. Purdue</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">George Davey Smith</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Brennan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karl-Heinz Herzig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marjo-Riitta Järvelin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chris I. Amos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayjean J. Hung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abbas Dehghan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mattias Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marc J. Gunter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kostas K. Tsilidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard M. Martin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Teresa Landi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Victoria Stevens</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ying Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrios Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Neil Caporaso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Brennan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher I. Amos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sanjay Shete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayjean J. Hung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Heike Bickeböller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angela Risch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard Houlston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen Lam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adonina Tardon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chu Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stig E. Bojesen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mattias Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">H-Erich Wichmann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Christiani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gadi Rennert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susanne Arnold</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John K. Field</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loic Le Marchand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olle Melander</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hans Brunnström</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Geoffrey Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angeline Andrew</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lambertus A. Kiemeney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hongbing Shen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shan Zienolddiny</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kjell Grankvist</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mikael Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">M. Dawn Teare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yun-Chul Hong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jian-Min Yuan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philip Lazarus</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew B. Schabath</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Melinda C. Aldrich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rosalind A. Eeles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher A. Haiman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zsofia Kote-Jarai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fredrick R. Schumacher</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sara Benlloch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Amin Al Olama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenneth R. Muir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sonja I. Berndt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David V. Conti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fredrik Wiklund</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen Chanock</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ying Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Catherine M. Tangen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jyotsna Batra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Judith A. Clements</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Henrik Grönberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nora Pashayan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Johanna Schleutker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrius Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie J. Weinstein</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicja Wolk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Catharine M.L. West</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorelei A. Mucci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Géraldine Cancel-Tassin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stella Koutros</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karina Dalsgaard Sørensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eli Marie Grindedal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David E. Neal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Freddie C. Hamdy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jenny L. Donovan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruth C. Travis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert J. Hamilton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sue Ann Ingles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Barry S. Rosenstein</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yong-Jie Lu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graham G. Giles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert J. MacInnis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam S. Kibel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Vega</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manolis Kogevinas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kathryn L. Penney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jong Y. Park</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Janet L. Stanfrod</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cezary Cybulski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Børge G. Nordestgaard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sune F. Nielsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hermann Brenner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christiane Maier</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher J. Logothetis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Esther M. John</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manuel R. Teixeira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan L. Neuhausen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kim De Ruyck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azad Razack</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa F. Newcomb</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Davor Lessel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Radka Kaneva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nawaid Usmani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Frank Claessens</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul A. Townsend</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Esteban Castelao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monique J. Roobol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Florence Menegaux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kay-Tee Khaw</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Cannon-Albright</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hardev Pandha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen N. Thibodeau</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Hunter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Peter Kraft</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">William J. Blot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elio Riboli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">EBioMedicine</subfield><subfield code="d">Elsevier, 2015</subfield><subfield code="g">100(2024), Seite 104991-</subfield><subfield code="w">(DE-627)802540074</subfield><subfield code="w">(DE-600)2799017-5</subfield><subfield code="x">23523964</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:100</subfield><subfield code="g">year:2024</subfield><subfield code="g">pages:104991-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ebiom.2024.104991</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2352396424000264</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2352-3964</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">100</subfield><subfield code="j">2024</subfield><subfield code="h">104991-</subfield></datafield></record></collection>
|
| callnumber-first |
R - Medicine |
| author |
James Yarmolinsky |
| spellingShingle |
James Yarmolinsky misc R5-920 misc Inflammation misc Cancer misc Mendelian randomization misc Genetic epidemiology misc Medicine misc R misc Medicine (General) Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| authorStr |
James Yarmolinsky |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)802540074 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
| collection |
DOAJ |
| remote_str |
true |
| callnumber-label |
R5-920 |
| illustrated |
Not Illustrated |
| issn |
23523964 |
| topic_title |
R5-920 Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context Inflammation Cancer Mendelian randomization Genetic epidemiology |
| topic |
misc R5-920 misc Inflammation misc Cancer misc Mendelian randomization misc Genetic epidemiology misc Medicine misc R misc Medicine (General) |
| topic_unstemmed |
misc R5-920 misc Inflammation misc Cancer misc Mendelian randomization misc Genetic epidemiology misc Medicine misc R misc Medicine (General) |
| topic_browse |
misc R5-920 misc Inflammation misc Cancer misc Mendelian randomization misc Genetic epidemiology misc Medicine misc R misc Medicine (General) |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
EBioMedicine |
| hierarchy_parent_id |
802540074 |
| hierarchy_top_title |
EBioMedicine |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)802540074 (DE-600)2799017-5 |
| title |
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| ctrlnum |
(DE-627)DOAJ096058870 (DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4 |
| title_full |
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| author_sort |
James Yarmolinsky |
| journal |
EBioMedicine |
| journalStr |
EBioMedicine |
| callnumber-first-code |
R |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2024 |
| contenttype_str_mv |
txt |
| container_start_page |
104991 |
| author_browse |
James Yarmolinsky Jamie W. Robinson Daniela Mariosa Ville Karhunen Jian Huang Niki Dimou Neil Murphy Kimberley Burrows Emmanouil Bouras Karl Smith-Byrne Sarah J. Lewis Tessel E. Galesloot Lambertus A. Kiemeney Sita Vermeulen Paul Martin Demetrius Albanes Lifang Hou Polly A. Newcomb Emily White Alicja Wolk Anna H. Wu Loïc Le Marchand Amanda I. Phipps Daniel D. Buchanan Sizheng Steven Zhao Dipender Gill Stephen J. Chanock Mark P. Purdue George Davey Smith Paul Brennan Karl-Heinz Herzig Marjo-Riitta Järvelin Chris I. Amos Rayjean J. Hung Abbas Dehghan Mattias Johansson Marc J. Gunter Kostas K. Tsilidis Richard M. Martin Maria Teresa Landi Victoria Stevens Ying Wang Demetrios Albanes Neil Caporaso Christopher I. Amos Sanjay Shete Heike Bickeböller Angela Risch Richard Houlston Stephen Lam Adonina Tardon Chu Chen Stig E. Bojesen H-Erich Wichmann David Christiani Gadi Rennert Susanne Arnold John K. Field Loic Le Marchand Olle Melander Hans Brunnström Geoffrey Liu Angeline Andrew Hongbing Shen Shan Zienolddiny Kjell Grankvist Mikael Johansson M. Dawn Teare Yun-Chul Hong Jian-Min Yuan Philip Lazarus Matthew B. Schabath Melinda C. Aldrich Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Sara Benlloch Ali Amin Al Olama Kenneth R. Muir Sonja I. Berndt David V. Conti Fredrik Wiklund Stephen Chanock Catherine M. Tangen Jyotsna Batra Judith A. Clements Henrik Grönberg Nora Pashayan Johanna Schleutker Stephanie J. Weinstein Catharine M.L. West Lorelei A. Mucci Géraldine Cancel-Tassin Stella Koutros Karina Dalsgaard Sørensen Eli Marie Grindedal David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Sue Ann Ingles Barry S. Rosenstein Yong-Jie Lu Graham G. Giles Robert J. MacInnis Adam S. Kibel Ana Vega Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanfrod Cezary Cybulski Børge G. Nordestgaard Sune F. Nielsen Hermann Brenner Christiane Maier Christopher J. Logothetis Esther M. John Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Jose Esteban Castelao Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Stephen N. Thibodeau David J. Hunter Peter Kraft William J. Blot Elio Riboli |
| container_volume |
100 |
| class |
R5-920 |
| format_se |
Elektronische Aufsätze |
| author-letter |
James Yarmolinsky |
| doi_str_mv |
10.1016/j.ebiom.2024.104991 |
| author2-role |
verfasserin |
| title_sort |
association between circulating inflammatory markers and adult cancer risk: a mendelian randomization analysisresearch in context |
| callnumber |
R5-920 |
| title_auth |
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| abstract |
Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). |
| abstractGer |
Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). |
| abstract_unstemmed |
Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654). |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 |
| title_short |
Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context |
| url |
https://doi.org/10.1016/j.ebiom.2024.104991 https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4 http://www.sciencedirect.com/science/article/pii/S2352396424000264 https://doaj.org/toc/2352-3964 |
| remote_bool |
true |
| author2 |
Jamie W. Robinson Daniela Mariosa Ville Karhunen Jian Huang Niki Dimou Neil Murphy Kimberley Burrows Emmanouil Bouras Karl Smith-Byrne Sarah J. Lewis Tessel E. Galesloot Lambertus A. Kiemeney Sita Vermeulen Paul Martin Demetrius Albanes Lifang Hou Polly A. Newcomb Emily White Alicja Wolk Anna H. Wu Loïc Le Marchand Amanda I. Phipps Daniel D. Buchanan Sizheng Steven Zhao Dipender Gill Stephen J. Chanock Mark P. Purdue George Davey Smith Paul Brennan Karl-Heinz Herzig Marjo-Riitta Järvelin Chris I. Amos Rayjean J. Hung Abbas Dehghan Mattias Johansson Marc J. Gunter Kostas K. Tsilidis Richard M. Martin Maria Teresa Landi Victoria Stevens Ying Wang Demetrios Albanes Neil Caporaso Christopher I. Amos Sanjay Shete Heike Bickeböller Angela Risch Richard Houlston Stephen Lam Adonina Tardon Chu Chen Stig E. Bojesen H-Erich Wichmann David Christiani Gadi Rennert Susanne Arnold John K. Field Loic Le Marchand Olle Melander Hans Brunnström Geoffrey Liu Angeline Andrew Hongbing Shen Shan Zienolddiny Kjell Grankvist Mikael Johansson M. Dawn Teare Yun-Chul Hong Jian-Min Yuan Philip Lazarus Matthew B. Schabath Melinda C. Aldrich Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Sara Benlloch Ali Amin Al Olama Kenneth R. Muir Sonja I. Berndt David V. Conti Fredrik Wiklund Stephen Chanock Catherine M. Tangen Jyotsna Batra Judith A. Clements Henrik Grönberg Nora Pashayan Johanna Schleutker Stephanie J. Weinstein Catharine M.L. West Lorelei A. Mucci Géraldine Cancel-Tassin Stella Koutros Karina Dalsgaard Sørensen Eli Marie Grindedal David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Sue Ann Ingles Barry S. Rosenstein Yong-Jie Lu Graham G. Giles Robert J. MacInnis Adam S. Kibel Ana Vega Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanfrod Cezary Cybulski Børge G. Nordestgaard Sune F. Nielsen Hermann Brenner Christiane Maier Christopher J. Logothetis Esther M. John Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Jose Esteban Castelao Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Stephen N. Thibodeau David J. Hunter Peter Kraft William J. Blot Elio Riboli |
| author2Str |
Jamie W. Robinson Daniela Mariosa Ville Karhunen Jian Huang Niki Dimou Neil Murphy Kimberley Burrows Emmanouil Bouras Karl Smith-Byrne Sarah J. Lewis Tessel E. Galesloot Lambertus A. Kiemeney Sita Vermeulen Paul Martin Demetrius Albanes Lifang Hou Polly A. Newcomb Emily White Alicja Wolk Anna H. Wu Loïc Le Marchand Amanda I. Phipps Daniel D. Buchanan Sizheng Steven Zhao Dipender Gill Stephen J. Chanock Mark P. Purdue George Davey Smith Paul Brennan Karl-Heinz Herzig Marjo-Riitta Järvelin Chris I. Amos Rayjean J. Hung Abbas Dehghan Mattias Johansson Marc J. Gunter Kostas K. Tsilidis Richard M. Martin Maria Teresa Landi Victoria Stevens Ying Wang Demetrios Albanes Neil Caporaso Christopher I. Amos Sanjay Shete Heike Bickeböller Angela Risch Richard Houlston Stephen Lam Adonina Tardon Chu Chen Stig E. Bojesen H-Erich Wichmann David Christiani Gadi Rennert Susanne Arnold John K. Field Loic Le Marchand Olle Melander Hans Brunnström Geoffrey Liu Angeline Andrew Hongbing Shen Shan Zienolddiny Kjell Grankvist Mikael Johansson M. Dawn Teare Yun-Chul Hong Jian-Min Yuan Philip Lazarus Matthew B. Schabath Melinda C. Aldrich Rosalind A. Eeles Christopher A. Haiman Zsofia Kote-Jarai Fredrick R. Schumacher Sara Benlloch Ali Amin Al Olama Kenneth R. Muir Sonja I. Berndt David V. Conti Fredrik Wiklund Stephen Chanock Catherine M. Tangen Jyotsna Batra Judith A. Clements Henrik Grönberg Nora Pashayan Johanna Schleutker Stephanie J. Weinstein Catharine M.L. West Lorelei A. Mucci Géraldine Cancel-Tassin Stella Koutros Karina Dalsgaard Sørensen Eli Marie Grindedal David E. Neal Freddie C. Hamdy Jenny L. Donovan Ruth C. Travis Robert J. Hamilton Sue Ann Ingles Barry S. Rosenstein Yong-Jie Lu Graham G. Giles Robert J. MacInnis Adam S. Kibel Ana Vega Manolis Kogevinas Kathryn L. Penney Jong Y. Park Janet L. Stanfrod Cezary Cybulski Børge G. Nordestgaard Sune F. Nielsen Hermann Brenner Christiane Maier Christopher J. Logothetis Esther M. John Manuel R. Teixeira Susan L. Neuhausen Kim De Ruyck Azad Razack Lisa F. Newcomb Davor Lessel Radka Kaneva Nawaid Usmani Frank Claessens Paul A. Townsend Jose Esteban Castelao Monique J. Roobol Florence Menegaux Kay-Tee Khaw Lisa Cannon-Albright Hardev Pandha Stephen N. Thibodeau David J. Hunter Peter Kraft William J. Blot Elio Riboli |
| ppnlink |
802540074 |
| callnumber-subject |
R - General Medicine |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1016/j.ebiom.2024.104991 |
| callnumber-a |
R5-920 |
| up_date |
2024-07-03T18:05:08.611Z |
| _version_ |
1803582081459027968 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ096058870</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413140923.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240413s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.ebiom.2024.104991</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ096058870</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ76559893532a492cbb3d1275b22f7ce4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">R5-920</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">James Yarmolinsky</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysisResearch in context</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary: Background: Tumour-promoting inflammation is a “hallmark” of cancer and conventional epidemiological studies have reported links between various inflammatory markers and cancer risk. The causal nature of these relationships and, thus, the suitability of these markers as intervention targets for cancer prevention is unclear. Methods: We meta-analysed 6 genome-wide association studies of circulating inflammatory markers comprising 59,969 participants of European ancestry. We then used combined cis-Mendelian randomization and colocalisation analysis to evaluate the causal role of 66 circulating inflammatory markers in risk of 30 adult cancers in 338,294 cancer cases and up to 1,238,345 controls. Genetic instruments for inflammatory markers were constructed using genome-wide significant (P < 5.0 × 10−8) cis-acting SNPs (i.e., in or ±250 kb from the gene encoding the relevant protein) in weak linkage disequilibrium (LD, r2 < 0.10). Effect estimates were generated using inverse-variance weighted random-effects models and standard errors were inflated to account for weak LD between variants with reference to the 1000 Genomes Phase 3 CEU panel. A false discovery rate (FDR)-corrected P-value (“q-value”) <0.05 was used as a threshold to define “strong evidence” to support associations and 0.05 ≤ q-value < 0.20 to define “suggestive evidence”. A colocalisation posterior probability (PPH4) <70% was employed to indicate support for shared causal variants across inflammatory markers and cancer outcomes. Findings were replicated in the FinnGen study and then pooled using meta-analysis. Findings: We found strong evidence to support an association of genetically-proxied circulating pro-adrenomedullin concentrations with increased breast cancer risk (OR: 1.19, 95% CI: 1.10–1.29, q-value = 0.033, PPH4 = 84.3%) and suggestive evidence to support associations of interleukin-23 receptor concentrations with increased pancreatic cancer risk (OR: 1.42, 95% CI: 1.20–1.69, q-value = 0.055, PPH4 = 73.9%), prothrombin concentrations with decreased basal cell carcinoma risk (OR: 0.66, 95% CI: 0.53–0.81, q-value = 0.067, PPH4 = 81.8%), and interleukin-1 receptor-like 1 concentrations with decreased triple-negative breast cancer risk (OR: 0.92, 95% CI: 0.88–0.97, q-value = 0.15, PPH4 = 85.6%). These findings were replicated in pooled analyses with the FinnGen study. Though suggestive evidence was found to support an association of macrophage migration inhibitory factor concentrations with increased bladder cancer risk (OR: 2.46, 95% CI: 1.48–4.10, q-value = 0.072, PPH4 = 76.1%), this finding was not replicated when pooled with the FinnGen study. For 22 of 30 cancer outcomes examined, there was little evidence (q-value ≥0.20) that any of the 66 circulating inflammatory markers examined were associated with cancer risk. Interpretation: Our comprehensive joint Mendelian randomization and colocalisation analysis of the role of circulating inflammatory markers in cancer risk identified potential roles for 4 circulating inflammatory markers in risk of 4 site-specific cancers. Contrary to reports from some prior conventional epidemiological studies, we found little evidence of association of circulating inflammatory markers with the majority of site-specific cancers evaluated. Funding: Cancer Research UK (C68933/A28534, C18281/A29019, PPRCPJT∖100005), World Cancer Research Fund (IIG_FULL_2020_022), National Institute for Health Research (NIHR202411, BRC-1215-20011), Medical Research Council (MC_UU_00011/1, MC_UU_00011/3, MC_UU_00011/6, and MC_UU_00011/4), Academy of Finland Project 326291, European Union's Horizon 2020 grant agreement no. 848158 (EarlyCause), French National Cancer Institute (INCa SHSESP20, 2020-076), Versus Arthritis (21173, 21754, 21755), National Institutes of Health (U19 CA203654), National Cancer Institute (U19CA203654).</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mendelian randomization</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic epidemiology</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">R</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Medicine (General)</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jamie W. Robinson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniela Mariosa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ville Karhunen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jian Huang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Niki Dimou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Neil Murphy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kimberley Burrows</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emmanouil Bouras</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karl Smith-Byrne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sarah J. Lewis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tessel E. Galesloot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lambertus A. Kiemeney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sita Vermeulen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Martin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrius Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lifang Hou</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Polly A. Newcomb</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Emily White</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicja Wolk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Anna H. Wu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loïc Le Marchand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Amanda I. Phipps</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Daniel D. Buchanan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sizheng Steven Zhao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Dipender Gill</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen J. Chanock</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mark P. Purdue</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">George Davey Smith</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Brennan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karl-Heinz Herzig</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marjo-Riitta Järvelin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chris I. Amos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayjean J. Hung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Abbas Dehghan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mattias Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Marc J. Gunter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kostas K. Tsilidis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard M. Martin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Maria Teresa Landi</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Victoria Stevens</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ying Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrios Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Neil Caporaso</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul Brennan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher I. Amos</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sanjay Shete</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rayjean J. Hung</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Heike Bickeböller</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angela Risch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Richard Houlston</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen Lam</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adonina Tardon</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Chu Chen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stig E. Bojesen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mattias Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">H-Erich Wichmann</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David Christiani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Gadi Rennert</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susanne Arnold</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">John K. Field</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Loic Le Marchand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Olle Melander</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hans Brunnström</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Geoffrey Liu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Angeline Andrew</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lambertus A. Kiemeney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hongbing Shen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Shan Zienolddiny</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kjell Grankvist</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Mikael Johansson</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">M. Dawn Teare</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yun-Chul Hong</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jian-Min Yuan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Philip Lazarus</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Matthew B. Schabath</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Melinda C. Aldrich</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Rosalind A. Eeles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher A. Haiman</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Zsofia Kote-Jarai</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fredrick R. Schumacher</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sara Benlloch</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ali Amin Al Olama</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kenneth R. Muir</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sonja I. Berndt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David V. Conti</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Fredrik Wiklund</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen Chanock</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ying Wang</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Catherine M. Tangen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jyotsna Batra</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Judith A. Clements</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Henrik Grönberg</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nora Pashayan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Johanna Schleutker</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Demetrius Albanes</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie J. Weinstein</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Alicja Wolk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Catharine M.L. West</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lorelei A. Mucci</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Géraldine Cancel-Tassin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stella Koutros</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Karina Dalsgaard Sørensen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Eli Marie Grindedal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David E. Neal</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Freddie C. Hamdy</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jenny L. Donovan</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ruth C. Travis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert J. Hamilton</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sue Ann Ingles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Barry S. Rosenstein</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Yong-Jie Lu</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Graham G. Giles</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Robert J. MacInnis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Adam S. Kibel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Ana Vega</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manolis Kogevinas</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kathryn L. Penney</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jong Y. Park</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Janet L. Stanfrod</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Cezary Cybulski</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Børge G. Nordestgaard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Sune F. Nielsen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hermann Brenner</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christiane Maier</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Christopher J. Logothetis</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Esther M. John</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Manuel R. Teixeira</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Susan L. Neuhausen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kim De Ruyck</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Azad Razack</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa F. Newcomb</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Davor Lessel</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Radka Kaneva</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Nawaid Usmani</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Frank Claessens</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Paul A. Townsend</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Jose Esteban Castelao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Monique J. Roobol</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Florence Menegaux</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Kay-Tee Khaw</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Lisa Cannon-Albright</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hardev Pandha</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephen N. Thibodeau</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">David J. Hunter</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Peter Kraft</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">William J. Blot</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Elio Riboli</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">EBioMedicine</subfield><subfield code="d">Elsevier, 2015</subfield><subfield code="g">100(2024), Seite 104991-</subfield><subfield code="w">(DE-627)802540074</subfield><subfield code="w">(DE-600)2799017-5</subfield><subfield code="x">23523964</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:100</subfield><subfield code="g">year:2024</subfield><subfield code="g">pages:104991-</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.ebiom.2024.104991</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/76559893532a492cbb3d1275b22f7ce4</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/article/pii/S2352396424000264</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="u">https://doaj.org/toc/2352-3964</subfield><subfield code="y">Journal toc</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_DOAJ</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2001</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2006</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2007</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2008</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2010</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2015</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2020</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2021</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2025</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2026</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2027</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2038</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2044</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2048</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2049</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2059</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2061</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2064</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2068</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2088</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2129</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2143</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2153</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2190</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2336</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2470</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2507</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4035</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4251</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4326</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4333</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4393</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">100</subfield><subfield code="j">2024</subfield><subfield code="h">104991-</subfield></datafield></record></collection>
|
| score |
7.401602 |