Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context
Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of choles...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rory Taylor [verfasserIn] Chengyuan Zhang [verfasserIn] Deslit George [verfasserIn] Sarah Kotecha [verfasserIn] Mariam Abdelghaffar [verfasserIn] Thorsten Forster [verfasserIn] Patricia Dos Santos Rodrigues [verfasserIn] Alexander C. Reisinger [verfasserIn] Daniel White [verfasserIn] Fergus Hamilton [verfasserIn] W. John Watkins [verfasserIn] David M. Griffith [verfasserIn] Peter Ghazal [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: EBioMedicine - Elsevier, 2015, 100(2024), Seite 104981- |
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| Übergeordnetes Werk: |
volume:100 ; year:2024 ; pages:104981- |
| Links: |
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| DOI / URN: |
10.1016/j.ebiom.2024.104981 |
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| Katalog-ID: |
DOAJ096109807 |
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| 245 | 1 | 0 | |a Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
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| 520 | |a Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). | ||
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a Critical illness | |
| 650 | 4 | |a Lipids | |
| 650 | 4 | |a Cholesterol | |
| 650 | 4 | |a Immunometabolism | |
| 653 | 0 | |a Medicine | |
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| 700 | 0 | |a Chengyuan Zhang |e verfasserin |4 aut | |
| 700 | 0 | |a Deslit George |e verfasserin |4 aut | |
| 700 | 0 | |a Sarah Kotecha |e verfasserin |4 aut | |
| 700 | 0 | |a Mariam Abdelghaffar |e verfasserin |4 aut | |
| 700 | 0 | |a Thorsten Forster |e verfasserin |4 aut | |
| 700 | 0 | |a Patricia Dos Santos Rodrigues |e verfasserin |4 aut | |
| 700 | 0 | |a Alexander C. Reisinger |e verfasserin |4 aut | |
| 700 | 0 | |a Daniel White |e verfasserin |4 aut | |
| 700 | 0 | |a Fergus Hamilton |e verfasserin |4 aut | |
| 700 | 0 | |a W. John Watkins |e verfasserin |4 aut | |
| 700 | 0 | |a David M. Griffith |e verfasserin |4 aut | |
| 700 | 0 | |a Peter Ghazal |e verfasserin |4 aut | |
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10.1016/j.ebiom.2024.104981 doi (DE-627)DOAJ096109807 (DE-599)DOAJc4ca1ee0b24e424d8cba2b2e11ad2989 DE-627 ger DE-627 rakwb eng R5-920 Rory Taylor verfasserin aut Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). Sepsis Critical illness Lipids Cholesterol Immunometabolism Medicine R Medicine (General) Chengyuan Zhang verfasserin aut Deslit George verfasserin aut Sarah Kotecha verfasserin aut Mariam Abdelghaffar verfasserin aut Thorsten Forster verfasserin aut Patricia Dos Santos Rodrigues verfasserin aut Alexander C. Reisinger verfasserin aut Daniel White verfasserin aut Fergus Hamilton verfasserin aut W. John Watkins verfasserin aut David M. Griffith verfasserin aut Peter Ghazal verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104981- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104981- https://doi.org/10.1016/j.ebiom.2024.104981 kostenfrei https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000161 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104981- |
| spelling |
10.1016/j.ebiom.2024.104981 doi (DE-627)DOAJ096109807 (DE-599)DOAJc4ca1ee0b24e424d8cba2b2e11ad2989 DE-627 ger DE-627 rakwb eng R5-920 Rory Taylor verfasserin aut Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). Sepsis Critical illness Lipids Cholesterol Immunometabolism Medicine R Medicine (General) Chengyuan Zhang verfasserin aut Deslit George verfasserin aut Sarah Kotecha verfasserin aut Mariam Abdelghaffar verfasserin aut Thorsten Forster verfasserin aut Patricia Dos Santos Rodrigues verfasserin aut Alexander C. Reisinger verfasserin aut Daniel White verfasserin aut Fergus Hamilton verfasserin aut W. John Watkins verfasserin aut David M. Griffith verfasserin aut Peter Ghazal verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104981- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104981- https://doi.org/10.1016/j.ebiom.2024.104981 kostenfrei https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000161 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104981- |
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10.1016/j.ebiom.2024.104981 doi (DE-627)DOAJ096109807 (DE-599)DOAJc4ca1ee0b24e424d8cba2b2e11ad2989 DE-627 ger DE-627 rakwb eng R5-920 Rory Taylor verfasserin aut Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). Sepsis Critical illness Lipids Cholesterol Immunometabolism Medicine R Medicine (General) Chengyuan Zhang verfasserin aut Deslit George verfasserin aut Sarah Kotecha verfasserin aut Mariam Abdelghaffar verfasserin aut Thorsten Forster verfasserin aut Patricia Dos Santos Rodrigues verfasserin aut Alexander C. Reisinger verfasserin aut Daniel White verfasserin aut Fergus Hamilton verfasserin aut W. John Watkins verfasserin aut David M. Griffith verfasserin aut Peter Ghazal verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104981- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104981- https://doi.org/10.1016/j.ebiom.2024.104981 kostenfrei https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000161 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104981- |
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10.1016/j.ebiom.2024.104981 doi (DE-627)DOAJ096109807 (DE-599)DOAJc4ca1ee0b24e424d8cba2b2e11ad2989 DE-627 ger DE-627 rakwb eng R5-920 Rory Taylor verfasserin aut Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). Sepsis Critical illness Lipids Cholesterol Immunometabolism Medicine R Medicine (General) Chengyuan Zhang verfasserin aut Deslit George verfasserin aut Sarah Kotecha verfasserin aut Mariam Abdelghaffar verfasserin aut Thorsten Forster verfasserin aut Patricia Dos Santos Rodrigues verfasserin aut Alexander C. Reisinger verfasserin aut Daniel White verfasserin aut Fergus Hamilton verfasserin aut W. John Watkins verfasserin aut David M. Griffith verfasserin aut Peter Ghazal verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104981- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104981- https://doi.org/10.1016/j.ebiom.2024.104981 kostenfrei https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000161 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104981- |
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10.1016/j.ebiom.2024.104981 doi (DE-627)DOAJ096109807 (DE-599)DOAJc4ca1ee0b24e424d8cba2b2e11ad2989 DE-627 ger DE-627 rakwb eng R5-920 Rory Taylor verfasserin aut Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). Sepsis Critical illness Lipids Cholesterol Immunometabolism Medicine R Medicine (General) Chengyuan Zhang verfasserin aut Deslit George verfasserin aut Sarah Kotecha verfasserin aut Mariam Abdelghaffar verfasserin aut Thorsten Forster verfasserin aut Patricia Dos Santos Rodrigues verfasserin aut Alexander C. Reisinger verfasserin aut Daniel White verfasserin aut Fergus Hamilton verfasserin aut W. John Watkins verfasserin aut David M. Griffith verfasserin aut Peter Ghazal verfasserin aut In EBioMedicine Elsevier, 2015 100(2024), Seite 104981- (DE-627)802540074 (DE-600)2799017-5 23523964 nnns volume:100 year:2024 pages:104981- https://doi.org/10.1016/j.ebiom.2024.104981 kostenfrei https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 kostenfrei http://www.sciencedirect.com/science/article/pii/S2352396424000161 kostenfrei https://doaj.org/toc/2352-3964 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 100 2024 104981- |
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In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. 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Rory Taylor |
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Rory Taylor misc R5-920 misc Sepsis misc Critical illness misc Lipids misc Cholesterol misc Immunometabolism misc Medicine misc R misc Medicine (General) Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
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R5-920 Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context Sepsis Critical illness Lipids Cholesterol Immunometabolism |
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Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
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Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
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low circulatory levels of total cholesterol, hdl-c and ldl-c are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesresearch in context |
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Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
| abstract |
Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). |
| abstractGer |
Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). |
| abstract_unstemmed |
Summary: Background: Mechanistic studies have established a biological role of sterol metabolism in infection and immunity with clinical data linking deranged cholesterol metabolism during sepsis with poorer outcomes. In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. Funding: EU-ERDF-Welsh Government Ser Cymru programme, BBSRC, and EU-FP7 ClouDx-i project (PG). |
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Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context |
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https://doi.org/10.1016/j.ebiom.2024.104981 https://doaj.org/article/c4ca1ee0b24e424d8cba2b2e11ad2989 http://www.sciencedirect.com/science/article/pii/S2352396424000161 https://doaj.org/toc/2352-3964 |
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Chengyuan Zhang Deslit George Sarah Kotecha Mariam Abdelghaffar Thorsten Forster Patricia Dos Santos Rodrigues Alexander C. Reisinger Daniel White Fergus Hamilton W. John Watkins David M. Griffith Peter Ghazal |
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Chengyuan Zhang Deslit George Sarah Kotecha Mariam Abdelghaffar Thorsten Forster Patricia Dos Santos Rodrigues Alexander C. Reisinger Daniel White Fergus Hamilton W. John Watkins David M. Griffith Peter Ghazal |
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10.1016/j.ebiom.2024.104981 |
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2024-07-03T18:21:01.610Z |
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In this systematic review we assess the relationship between biomarkers of cholesterol homeostasis and mortality in critical illness. Methods: We identified articles by searching a total of seven electronic databases from inception to October 2023. Prospective observational cohort studies included those subjects who had systemic cholesterol (Total Cholesterol (TC), HDL-C or LDL-C) levels assessed on the first day of ICU admission and short-term mortality recorded. Meta-analysis and meta-regression were used to evaluate overall mean differences in serum cholesterol levels between survivors and non-survivors. Study quality was assessed using the Newcastle–Ottawa Scale. Findings: From 6469 studies identified by searches, 24 studies with 2542 participants were included in meta-analysis. Non-survivors had distinctly lower HDL-C at ICU admission −7.06 mg/dL (95% CI −9.21 to −4.91, p < 0.0001) in comparison with survivors. Corresponding differences were also seen less robustly for TC −21.86 mg/dL (95% CI −31.23 to −12.49, p < 0.0001) and LDL-C −8.79 mg/dL (95% CI, −13.74 to −3.83, p = 0.0005). Interpretation: Systemic cholesterol levels (TC, HDL-C and LDL-C) on admission to critical care are inversely related to mortality. This finding is consistent with the notion that inflammatory and metabolic setpoints are coupled, such that the maladaptive-setpoint changes of cholesterol in critical illness are related to underlying inflammatory processes. We highlight the potential of HDL-biomarkers as early predictors of severity of illness and emphasise that future research should consider the metabolic and functional heterogeneity of HDLs. 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