Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles

Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with sing...
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Autor*in:	Gerard Wong [verfasserIn] Kothandaraman Narasimhan [verfasserIn] Wei Fun Cheong [verfasserIn] Sharon Ng [verfasserIn] Izzuddin M. Aris [verfasserIn] See Ling Loy [verfasserIn] Anne K. Bendt [verfasserIn] Kok Hian Tan [verfasserIn] Fabian K. P. Yap [verfasserIn] Lynette P. Shek [verfasserIn] Yap Seng Chong [verfasserIn] Peter D. Gluckman [verfasserIn] Keith M. Godfrey [verfasserIn] Yung Seng Lee [verfasserIn] Markus R. Wenk [verfasserIn] Neerja Karnani [verfasserIn] Shiao-Yng Chan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 16(2024), 2, p 274
Übergeordnetes Werk:	volume:16 ; year:2024 ; number:2, p 274

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu16020274

Katalog-ID:	DOAJ09617062X

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650		4	\|a umbilical cord blood
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700	0		\|a Wei Fun Cheong \|e verfasserin \|4 aut
700	0		\|a Sharon Ng \|e verfasserin \|4 aut
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allfields	10.3390/nu16020274 doi (DE-627)DOAJ09617062X (DE-599)DOAJb47fa868d8ce4d6da4429b55f67d6d72 DE-627 ger DE-627 rakwb eng TX341-641 Gerard Wong verfasserin aut Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established. umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply Kothandaraman Narasimhan verfasserin aut Wei Fun Cheong verfasserin aut Sharon Ng verfasserin aut Izzuddin M. Aris verfasserin aut See Ling Loy verfasserin aut Anne K. Bendt verfasserin aut Kok Hian Tan verfasserin aut Fabian K. P. Yap verfasserin aut Lynette P. Shek verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Keith M. Godfrey verfasserin aut Yung Seng Lee verfasserin aut Markus R. Wenk verfasserin aut Neerja Karnani verfasserin aut Shiao-Yng Chan verfasserin aut In Nutrients MDPI AG, 2009 16(2024), 2, p 274 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:16 year:2024 number:2, p 274 https://doi.org/10.3390/nu16020274 kostenfrei https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72 kostenfrei https://www.mdpi.com/2072-6643/16/2/274 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 274
spelling	10.3390/nu16020274 doi (DE-627)DOAJ09617062X (DE-599)DOAJb47fa868d8ce4d6da4429b55f67d6d72 DE-627 ger DE-627 rakwb eng TX341-641 Gerard Wong verfasserin aut Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established. umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply Kothandaraman Narasimhan verfasserin aut Wei Fun Cheong verfasserin aut Sharon Ng verfasserin aut Izzuddin M. Aris verfasserin aut See Ling Loy verfasserin aut Anne K. Bendt verfasserin aut Kok Hian Tan verfasserin aut Fabian K. P. Yap verfasserin aut Lynette P. Shek verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Keith M. Godfrey verfasserin aut Yung Seng Lee verfasserin aut Markus R. Wenk verfasserin aut Neerja Karnani verfasserin aut Shiao-Yng Chan verfasserin aut In Nutrients MDPI AG, 2009 16(2024), 2, p 274 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:16 year:2024 number:2, p 274 https://doi.org/10.3390/nu16020274 kostenfrei https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72 kostenfrei https://www.mdpi.com/2072-6643/16/2/274 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 274
allfields_unstemmed	10.3390/nu16020274 doi (DE-627)DOAJ09617062X (DE-599)DOAJb47fa868d8ce4d6da4429b55f67d6d72 DE-627 ger DE-627 rakwb eng TX341-641 Gerard Wong verfasserin aut Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established. umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply Kothandaraman Narasimhan verfasserin aut Wei Fun Cheong verfasserin aut Sharon Ng verfasserin aut Izzuddin M. Aris verfasserin aut See Ling Loy verfasserin aut Anne K. Bendt verfasserin aut Kok Hian Tan verfasserin aut Fabian K. P. Yap verfasserin aut Lynette P. Shek verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Keith M. Godfrey verfasserin aut Yung Seng Lee verfasserin aut Markus R. Wenk verfasserin aut Neerja Karnani verfasserin aut Shiao-Yng Chan verfasserin aut In Nutrients MDPI AG, 2009 16(2024), 2, p 274 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:16 year:2024 number:2, p 274 https://doi.org/10.3390/nu16020274 kostenfrei https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72 kostenfrei https://www.mdpi.com/2072-6643/16/2/274 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 274
allfieldsGer	10.3390/nu16020274 doi (DE-627)DOAJ09617062X (DE-599)DOAJb47fa868d8ce4d6da4429b55f67d6d72 DE-627 ger DE-627 rakwb eng TX341-641 Gerard Wong verfasserin aut Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established. umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply Kothandaraman Narasimhan verfasserin aut Wei Fun Cheong verfasserin aut Sharon Ng verfasserin aut Izzuddin M. Aris verfasserin aut See Ling Loy verfasserin aut Anne K. Bendt verfasserin aut Kok Hian Tan verfasserin aut Fabian K. P. Yap verfasserin aut Lynette P. Shek verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Keith M. Godfrey verfasserin aut Yung Seng Lee verfasserin aut Markus R. Wenk verfasserin aut Neerja Karnani verfasserin aut Shiao-Yng Chan verfasserin aut In Nutrients MDPI AG, 2009 16(2024), 2, p 274 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:16 year:2024 number:2, p 274 https://doi.org/10.3390/nu16020274 kostenfrei https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72 kostenfrei https://www.mdpi.com/2072-6643/16/2/274 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 274
allfieldsSound	10.3390/nu16020274 doi (DE-627)DOAJ09617062X (DE-599)DOAJb47fa868d8ce4d6da4429b55f67d6d72 DE-627 ger DE-627 rakwb eng TX341-641 Gerard Wong verfasserin aut Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established. umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply Kothandaraman Narasimhan verfasserin aut Wei Fun Cheong verfasserin aut Sharon Ng verfasserin aut Izzuddin M. Aris verfasserin aut See Ling Loy verfasserin aut Anne K. Bendt verfasserin aut Kok Hian Tan verfasserin aut Fabian K. P. Yap verfasserin aut Lynette P. Shek verfasserin aut Yap Seng Chong verfasserin aut Peter D. Gluckman verfasserin aut Keith M. Godfrey verfasserin aut Yung Seng Lee verfasserin aut Markus R. Wenk verfasserin aut Neerja Karnani verfasserin aut Shiao-Yng Chan verfasserin aut In Nutrients MDPI AG, 2009 16(2024), 2, p 274 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:16 year:2024 number:2, p 274 https://doi.org/10.3390/nu16020274 kostenfrei https://doaj.org/article/b47fa868d8ce4d6da4429b55f67d6d72 kostenfrei https://www.mdpi.com/2072-6643/16/2/274 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 16 2024 2, p 274
language	English
source	In Nutrients 16(2024), 2, p 274 volume:16 year:2024 number:2, p 274
sourceStr	In Nutrients 16(2024), 2, p 274 volume:16 year:2024 number:2, p 274
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO Nutrition. Foods and food supply
isfreeaccess_bool	true
container_title	Nutrients
authorswithroles_txt_mv	Gerard Wong @@aut@@ Kothandaraman Narasimhan @@aut@@ Wei Fun Cheong @@aut@@ Sharon Ng @@aut@@ Izzuddin M. Aris @@aut@@ See Ling Loy @@aut@@ Anne K. Bendt @@aut@@ Kok Hian Tan @@aut@@ Fabian K. P. Yap @@aut@@ Lynette P. Shek @@aut@@ Yap Seng Chong @@aut@@ Peter D. Gluckman @@aut@@ Keith M. Godfrey @@aut@@ Yung Seng Lee @@aut@@ Markus R. Wenk @@aut@@ Neerja Karnani @@aut@@ Shiao-Yng Chan @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	610604155
id	DOAJ09617062X
language_de	englisch
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callnumber-first	T - Technology
author	Gerard Wong
spellingShingle	Gerard Wong misc TX341-641 misc umbilical cord blood misc lysophosphatidylcholine misc triacylglycerol misc lipidomics misc fetal growth misc GUSTO misc Nutrition. Foods and food supply Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
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topic_title	TX341-641 Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles umbilical cord blood lysophosphatidylcholine triacylglycerol lipidomics fetal growth GUSTO
topic	misc TX341-641 misc umbilical cord blood misc lysophosphatidylcholine misc triacylglycerol misc lipidomics misc fetal growth misc GUSTO misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc umbilical cord blood misc lysophosphatidylcholine misc triacylglycerol misc lipidomics misc fetal growth misc GUSTO misc Nutrition. Foods and food supply
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title	Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
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title_full	Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
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author_browse	Gerard Wong Kothandaraman Narasimhan Wei Fun Cheong Sharon Ng Izzuddin M. Aris See Ling Loy Anne K. Bendt Kok Hian Tan Fabian K. P. Yap Lynette P. Shek Yap Seng Chong Peter D. Gluckman Keith M. Godfrey Yung Seng Lee Markus R. Wenk Neerja Karnani Shiao-Yng Chan
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title_sort	umbilical cord plasma lysophospholipids and triacylglycerols associated with birthweight percentiles
callnumber	TX341-641
title_auth	Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
abstract	Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established.
abstractGer	Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established.
abstract_unstemmed	Dysregulated transplacental lipid transfer and fetal–placental lipid metabolism affect birthweight, as does maternal hyperglycemia. As the mechanisms are unclear, we aimed to identify the lipids in umbilical cord plasma that were most associated with birthweight. Seventy-five Chinese women with singleton pregnancies recruited into the GUSTO mother–offspring cohort were selected from across the glycemic range based on a mid-gestation 75 g oral glucose tolerance test, excluding pre-existing diabetes. Cord plasma samples collected at term delivery were analyzed using targeted liquid-chromatography tandem mass-spectrometry to determine the concentrations of 404 lipid species across 17 lipid classes. The birthweights were standardized for sex and gestational age by local references, and regression analyses were adjusted for the maternal age, BMI, parity, mode of delivery, insulin treatment, and fasting/2 h glucose, with a false discovery-corrected <i<p</i< < 0.05 considered significant. Ten lysophosphatidylcholines (LPCs) and two lysophosphatidylethanolamines were positively associated with the birthweight percentiles, while twenty-four triacylglycerols were negatively associated with the birthweight percentiles. The topmost associated lipid was LPC 20:2 [21.28 (95%CI 12.70, 29.87) percentile increase in the standardized birthweight with each SD-unit increase in log<sub<10</sub<-transformed concentration]. Within these same regression models, maternal glycemia did not significantly associate with the birthweight percentiles. Specific fetal circulating lysophospholipids and triacylglycerols associate with birthweight independently of maternal glycemia, but a causal relationship remains to be established.
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title_short	Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles
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Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles

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