Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics
Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adapt...
Ausführliche Beschreibung
Autor*in: |
Alina Szewczuk [verfasserIn] Zbigniew M. Wawrzyniak [verfasserIn] Jacek P. Szaflik [verfasserIn] Anna Zaleska-Żmijewska [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Übergeordnetes Werk: |
In: Journal of Clinical Medicine - MDPI AG, 2013, 13(2024), 2, p 478 |
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Übergeordnetes Werk: |
volume:13 ; year:2024 ; number:2, p 478 |
Links: |
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DOI / URN: |
10.3390/jcm13020478 |
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Katalog-ID: |
DOAJ096179384 |
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520 | |a Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. | ||
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10.3390/jcm13020478 doi (DE-627)DOAJ096179384 (DE-599)DOAJ5398801618064317b9161ae8c2a3a303 DE-627 ger DE-627 rakwb eng Alina Szewczuk verfasserin aut Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. ocular vascular disease glaucoma adaptive optics Medicine R Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 2, p 478 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:2, p 478 https://doi.org/10.3390/jcm13020478 kostenfrei https://doaj.org/article/5398801618064317b9161ae8c2a3a303 kostenfrei https://www.mdpi.com/2077-0383/13/2/478 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2, p 478 |
spelling |
10.3390/jcm13020478 doi (DE-627)DOAJ096179384 (DE-599)DOAJ5398801618064317b9161ae8c2a3a303 DE-627 ger DE-627 rakwb eng Alina Szewczuk verfasserin aut Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. ocular vascular disease glaucoma adaptive optics Medicine R Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 2, p 478 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:2, p 478 https://doi.org/10.3390/jcm13020478 kostenfrei https://doaj.org/article/5398801618064317b9161ae8c2a3a303 kostenfrei https://www.mdpi.com/2077-0383/13/2/478 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2, p 478 |
allfields_unstemmed |
10.3390/jcm13020478 doi (DE-627)DOAJ096179384 (DE-599)DOAJ5398801618064317b9161ae8c2a3a303 DE-627 ger DE-627 rakwb eng Alina Szewczuk verfasserin aut Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. ocular vascular disease glaucoma adaptive optics Medicine R Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 2, p 478 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:2, p 478 https://doi.org/10.3390/jcm13020478 kostenfrei https://doaj.org/article/5398801618064317b9161ae8c2a3a303 kostenfrei https://www.mdpi.com/2077-0383/13/2/478 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2, p 478 |
allfieldsGer |
10.3390/jcm13020478 doi (DE-627)DOAJ096179384 (DE-599)DOAJ5398801618064317b9161ae8c2a3a303 DE-627 ger DE-627 rakwb eng Alina Szewczuk verfasserin aut Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. ocular vascular disease glaucoma adaptive optics Medicine R Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 2, p 478 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:2, p 478 https://doi.org/10.3390/jcm13020478 kostenfrei https://doaj.org/article/5398801618064317b9161ae8c2a3a303 kostenfrei https://www.mdpi.com/2077-0383/13/2/478 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2, p 478 |
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10.3390/jcm13020478 doi (DE-627)DOAJ096179384 (DE-599)DOAJ5398801618064317b9161ae8c2a3a303 DE-627 ger DE-627 rakwb eng Alina Szewczuk verfasserin aut Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. ocular vascular disease glaucoma adaptive optics Medicine R Zbigniew M. Wawrzyniak verfasserin aut Jacek P. Szaflik verfasserin aut Anna Zaleska-Żmijewska verfasserin aut In Journal of Clinical Medicine MDPI AG, 2013 13(2024), 2, p 478 (DE-627)718632478 (DE-600)2662592-1 20770383 nnns volume:13 year:2024 number:2, p 478 https://doi.org/10.3390/jcm13020478 kostenfrei https://doaj.org/article/5398801618064317b9161ae8c2a3a303 kostenfrei https://www.mdpi.com/2077-0383/13/2/478 kostenfrei https://doaj.org/toc/2077-0383 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2024 2, p 478 |
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is primary open-angle glaucoma a vascular disease? assessment of the relationship between retinal arteriolar morphology and glaucoma severity using adaptive optics |
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Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics |
abstract |
Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. |
abstractGer |
Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. |
abstract_unstemmed |
Background: Retinal vascular abnormalities may be associated with glaucomatous damage. Adaptive optics (AO) is a new technology that enables the analysis of retinal vasculature at the cellular level in vivo. The purpose of this study was to evaluate retinal arteriolar parameters using the rtx1 adaptive optics fundus camera (AO-FC) in patients with primary open-angle glaucoma (POAG) at different stages and to investigate the relationship between these parameters and changes in spectral-domain optical coherence tomography (SD-OCT) and perimetry. Methods: Parameters of the retinal supratemporal and infratemporal arterioles (wall thickness (WT), lumen diameter (LD), total diameter (TD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall (WCSA)) were analysed with the rtx1 in 111 POAG eyes, which were divided into three groups according to the severity of the disease, and 70 healthy eyes. The associations between RTX1 values and the cup-to-disk ratio, SD-OCT parameters, and visual field parameters were assessed. Results: Compared with the control group, the POAG groups showed significantly smaller TD and LD values (<i<p</i< < 0.05) and significantly higher WLR and WT values (<i<p</i< < 0.05) for the supratemporal and infratemporal arterioles. TD was significantly positively correlated with the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) (<i<p</i< < 0.05). LD was significantly positively correlated with the RNFL, GCC, and rim area (<i<p</i< < 0.05). The WLR was significantly negatively correlated with the RNFL, GCC, rim area, and MD (<i<p</i< < 0.05), while it was significantly positively correlated with the cup-to-disc ratio and PSD (<i<p</i< < 0.05). Conclusions: The results suggest that vascular dysfunction is present in POAG, even at a very early stage of glaucoma, and increases with the severity of the disease. |
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Is Primary Open-Angle Glaucoma a Vascular Disease? Assessment of the Relationship between Retinal Arteriolar Morphology and Glaucoma Severity Using Adaptive Optics |
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https://doi.org/10.3390/jcm13020478 https://doaj.org/article/5398801618064317b9161ae8c2a3a303 https://www.mdpi.com/2077-0383/13/2/478 https://doaj.org/toc/2077-0383 |
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Zbigniew M. Wawrzyniak Jacek P. Szaflik Anna Zaleska-Żmijewska |
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