Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance

Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiologi...
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Autor*in:	Maddalena Conte [verfasserIn] Paolo Poggio [verfasserIn] Maria Monti [verfasserIn] Laura Petraglia [verfasserIn] Serena Cabaro [verfasserIn] Dario Bruzzese [verfasserIn] Giuseppe Comentale [verfasserIn] Aurelio Caruso [verfasserIn] Mariagabriella Grimaldi [verfasserIn] Emilia Zampella [verfasserIn] Annarita Gencarelli [verfasserIn] Maria Rosaria Cervasio [verfasserIn] Flora Cozzolino [verfasserIn] Vittoria Monaco [verfasserIn] Veronika Myasoedova [verfasserIn] Vincenza Valerio [verfasserIn] Adele Ferro [verfasserIn] Luigi Insabato [verfasserIn] Michele Bellino [verfasserIn] Gennaro Galasso [verfasserIn] Francesca Graziani [verfasserIn] Pietro Pucci [verfasserIn] Pietro Formisano [verfasserIn] Emanuele Pilato [verfasserIn] Alberto Cuocolo [verfasserIn] Pasquale Perrone Filardi [verfasserIn] Dario Leosco [verfasserIn] Valentina Parisi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 25(2024), 2, p 1171
Übergeordnetes Werk:	volume:25 ; year:2024 ; number:2, p 1171

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms25021171

Katalog-ID:	DOAJ096183101

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520			\|a Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology.
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allfields	10.3390/ijms25021171 doi (DE-627)DOAJ096183101 (DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Maddalena Conte verfasserin aut Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology. aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry Paolo Poggio verfasserin aut Maria Monti verfasserin aut Laura Petraglia verfasserin aut Serena Cabaro verfasserin aut Dario Bruzzese verfasserin aut Giuseppe Comentale verfasserin aut Aurelio Caruso verfasserin aut Mariagabriella Grimaldi verfasserin aut Emilia Zampella verfasserin aut Annarita Gencarelli verfasserin aut Maria Rosaria Cervasio verfasserin aut Flora Cozzolino verfasserin aut Vittoria Monaco verfasserin aut Veronika Myasoedova verfasserin aut Vincenza Valerio verfasserin aut Adele Ferro verfasserin aut Luigi Insabato verfasserin aut Michele Bellino verfasserin aut Gennaro Galasso verfasserin aut Francesca Graziani verfasserin aut Pietro Pucci verfasserin aut Pietro Formisano verfasserin aut Emanuele Pilato verfasserin aut Alberto Cuocolo verfasserin aut Pasquale Perrone Filardi verfasserin aut Dario Leosco verfasserin aut Valentina Parisi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 25(2024), 2, p 1171 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:25 year:2024 number:2, p 1171 https://doi.org/10.3390/ijms25021171 kostenfrei https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 kostenfrei https://www.mdpi.com/1422-0067/25/2/1171 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 2, p 1171
spelling	10.3390/ijms25021171 doi (DE-627)DOAJ096183101 (DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Maddalena Conte verfasserin aut Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology. aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry Paolo Poggio verfasserin aut Maria Monti verfasserin aut Laura Petraglia verfasserin aut Serena Cabaro verfasserin aut Dario Bruzzese verfasserin aut Giuseppe Comentale verfasserin aut Aurelio Caruso verfasserin aut Mariagabriella Grimaldi verfasserin aut Emilia Zampella verfasserin aut Annarita Gencarelli verfasserin aut Maria Rosaria Cervasio verfasserin aut Flora Cozzolino verfasserin aut Vittoria Monaco verfasserin aut Veronika Myasoedova verfasserin aut Vincenza Valerio verfasserin aut Adele Ferro verfasserin aut Luigi Insabato verfasserin aut Michele Bellino verfasserin aut Gennaro Galasso verfasserin aut Francesca Graziani verfasserin aut Pietro Pucci verfasserin aut Pietro Formisano verfasserin aut Emanuele Pilato verfasserin aut Alberto Cuocolo verfasserin aut Pasquale Perrone Filardi verfasserin aut Dario Leosco verfasserin aut Valentina Parisi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 25(2024), 2, p 1171 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:25 year:2024 number:2, p 1171 https://doi.org/10.3390/ijms25021171 kostenfrei https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 kostenfrei https://www.mdpi.com/1422-0067/25/2/1171 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 2, p 1171
allfields_unstemmed	10.3390/ijms25021171 doi (DE-627)DOAJ096183101 (DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Maddalena Conte verfasserin aut Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology. aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry Paolo Poggio verfasserin aut Maria Monti verfasserin aut Laura Petraglia verfasserin aut Serena Cabaro verfasserin aut Dario Bruzzese verfasserin aut Giuseppe Comentale verfasserin aut Aurelio Caruso verfasserin aut Mariagabriella Grimaldi verfasserin aut Emilia Zampella verfasserin aut Annarita Gencarelli verfasserin aut Maria Rosaria Cervasio verfasserin aut Flora Cozzolino verfasserin aut Vittoria Monaco verfasserin aut Veronika Myasoedova verfasserin aut Vincenza Valerio verfasserin aut Adele Ferro verfasserin aut Luigi Insabato verfasserin aut Michele Bellino verfasserin aut Gennaro Galasso verfasserin aut Francesca Graziani verfasserin aut Pietro Pucci verfasserin aut Pietro Formisano verfasserin aut Emanuele Pilato verfasserin aut Alberto Cuocolo verfasserin aut Pasquale Perrone Filardi verfasserin aut Dario Leosco verfasserin aut Valentina Parisi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 25(2024), 2, p 1171 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:25 year:2024 number:2, p 1171 https://doi.org/10.3390/ijms25021171 kostenfrei https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 kostenfrei https://www.mdpi.com/1422-0067/25/2/1171 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 2, p 1171
allfieldsGer	10.3390/ijms25021171 doi (DE-627)DOAJ096183101 (DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Maddalena Conte verfasserin aut Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology. aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry Paolo Poggio verfasserin aut Maria Monti verfasserin aut Laura Petraglia verfasserin aut Serena Cabaro verfasserin aut Dario Bruzzese verfasserin aut Giuseppe Comentale verfasserin aut Aurelio Caruso verfasserin aut Mariagabriella Grimaldi verfasserin aut Emilia Zampella verfasserin aut Annarita Gencarelli verfasserin aut Maria Rosaria Cervasio verfasserin aut Flora Cozzolino verfasserin aut Vittoria Monaco verfasserin aut Veronika Myasoedova verfasserin aut Vincenza Valerio verfasserin aut Adele Ferro verfasserin aut Luigi Insabato verfasserin aut Michele Bellino verfasserin aut Gennaro Galasso verfasserin aut Francesca Graziani verfasserin aut Pietro Pucci verfasserin aut Pietro Formisano verfasserin aut Emanuele Pilato verfasserin aut Alberto Cuocolo verfasserin aut Pasquale Perrone Filardi verfasserin aut Dario Leosco verfasserin aut Valentina Parisi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 25(2024), 2, p 1171 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:25 year:2024 number:2, p 1171 https://doi.org/10.3390/ijms25021171 kostenfrei https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 kostenfrei https://www.mdpi.com/1422-0067/25/2/1171 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 2, p 1171
allfieldsSound	10.3390/ijms25021171 doi (DE-627)DOAJ096183101 (DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Maddalena Conte verfasserin aut Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology. aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry Paolo Poggio verfasserin aut Maria Monti verfasserin aut Laura Petraglia verfasserin aut Serena Cabaro verfasserin aut Dario Bruzzese verfasserin aut Giuseppe Comentale verfasserin aut Aurelio Caruso verfasserin aut Mariagabriella Grimaldi verfasserin aut Emilia Zampella verfasserin aut Annarita Gencarelli verfasserin aut Maria Rosaria Cervasio verfasserin aut Flora Cozzolino verfasserin aut Vittoria Monaco verfasserin aut Veronika Myasoedova verfasserin aut Vincenza Valerio verfasserin aut Adele Ferro verfasserin aut Luigi Insabato verfasserin aut Michele Bellino verfasserin aut Gennaro Galasso verfasserin aut Francesca Graziani verfasserin aut Pietro Pucci verfasserin aut Pietro Formisano verfasserin aut Emanuele Pilato verfasserin aut Alberto Cuocolo verfasserin aut Pasquale Perrone Filardi verfasserin aut Dario Leosco verfasserin aut Valentina Parisi verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 25(2024), 2, p 1171 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:25 year:2024 number:2, p 1171 https://doi.org/10.3390/ijms25021171 kostenfrei https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 kostenfrei https://www.mdpi.com/1422-0067/25/2/1171 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 2, p 1171
language	English
source	In International Journal of Molecular Sciences 25(2024), 2, p 1171 volume:25 year:2024 number:2, p 1171
sourceStr	In International Journal of Molecular Sciences 25(2024), 2, p 1171 volume:25 year:2024 number:2, p 1171
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Maddalena Conte @@aut@@ Paolo Poggio @@aut@@ Maria Monti @@aut@@ Laura Petraglia @@aut@@ Serena Cabaro @@aut@@ Dario Bruzzese @@aut@@ Giuseppe Comentale @@aut@@ Aurelio Caruso @@aut@@ Mariagabriella Grimaldi @@aut@@ Emilia Zampella @@aut@@ Annarita Gencarelli @@aut@@ Maria Rosaria Cervasio @@aut@@ Flora Cozzolino @@aut@@ Vittoria Monaco @@aut@@ Veronika Myasoedova @@aut@@ Vincenza Valerio @@aut@@ Adele Ferro @@aut@@ Luigi Insabato @@aut@@ Michele Bellino @@aut@@ Gennaro Galasso @@aut@@ Francesca Graziani @@aut@@ Pietro Pucci @@aut@@ Pietro Formisano @@aut@@ Emanuele Pilato @@aut@@ Alberto Cuocolo @@aut@@ Pasquale Perrone Filardi @@aut@@ Dario Leosco @@aut@@ Valentina Parisi @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ096183101
language_de	englisch
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Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. 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callnumber-first	Q - Science
author	Maddalena Conte
spellingShingle	Maddalena Conte misc QH301-705.5 misc QD1-999 misc aortic stenosis misc amyloidosis misc inflammation misc aortic valve interstitial cells misc serum amyloid A misc Biology (General) misc Chemistry Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance
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topic_title	QH301-705.5 QD1-999 Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance aortic stenosis amyloidosis inflammation aortic valve interstitial cells serum amyloid A
topic	misc QH301-705.5 misc QD1-999 misc aortic stenosis misc amyloidosis misc inflammation misc aortic valve interstitial cells misc serum amyloid A misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc aortic stenosis misc amyloidosis misc inflammation misc aortic valve interstitial cells misc serum amyloid A misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc aortic stenosis misc amyloidosis misc inflammation misc aortic valve interstitial cells misc serum amyloid A misc Biology (General) misc Chemistry
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title	Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance
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title_full	Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance
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author_browse	Maddalena Conte Paolo Poggio Maria Monti Laura Petraglia Serena Cabaro Dario Bruzzese Giuseppe Comentale Aurelio Caruso Mariagabriella Grimaldi Emilia Zampella Annarita Gencarelli Maria Rosaria Cervasio Flora Cozzolino Vittoria Monaco Veronika Myasoedova Vincenza Valerio Adele Ferro Luigi Insabato Michele Bellino Gennaro Galasso Francesca Graziani Pietro Pucci Pietro Formisano Emanuele Pilato Alberto Cuocolo Pasquale Perrone Filardi Dario Leosco Valentina Parisi
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title_sort	isolated valve amyloid deposition in aortic stenosis: potential clinical and pathophysiological relevance
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title_auth	Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance
abstract	Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology.
abstractGer	Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology.
abstract_unstemmed	Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology.
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title_short	Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance
url	https://doi.org/10.3390/ijms25021171 https://doaj.org/article/8f64287c8c624b4a9485fc5f305bbdc2 https://www.mdpi.com/1422-0067/25/2/1171 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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up_date	2024-07-03T18:44:36.844Z
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ096183101</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413143645.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240413s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.3390/ijms25021171</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ096183101</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ8f64287c8c624b4a9485fc5f305bbdc2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH301-705.5</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QD1-999</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Maddalena Conte</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (<i<p</i< = 0.0082) and calcification (<i<p</i< < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, <i<p</i< = 0.02) and the AS VICs (+7.6 ± 0.5, <i<p</i< = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. 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Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance

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