Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice

Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can impact immune functions and disease outcome. Inflammation may disrupt circadian clocks in peripheral tissues and innate immune cells. However...
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Gespeichert in:

Autor*in:	Misa Hirose [verfasserIn] Alexei Leliavski [verfasserIn] Leonardo Vinícius Monteiro de Assis [verfasserIn] Olga Matveeva [verfasserIn] Ludmila Skrum [verfasserIn] Werner Solbach [verfasserIn] Henrik Oster [verfasserIn] Isabel Heyde [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	CD4 CD8 circadian clock experimental autoimmune encephalomyelitis (EAE) inflammation pertussis toxin (PTx)

Übergeordnetes Werk:	In: Cells - MDPI AG, 2012, 13(2024), 2, p 151
Übergeordnetes Werk:	volume:13 ; year:2024 ; number:2, p 151

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/cells13020151

Katalog-ID:	DOAJ096191694

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authorswithroles_txt_mv	Misa Hirose @@aut@@ Alexei Leliavski @@aut@@ Leonardo Vinícius Monteiro de Assis @@aut@@ Olga Matveeva @@aut@@ Ludmila Skrum @@aut@@ Werner Solbach @@aut@@ Henrik Oster @@aut@@ Isabel Heyde @@aut@@
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author	Misa Hirose
spellingShingle	Misa Hirose misc QH573-671 misc CD4<sup<+</sup< T cells misc CD8<sup<+</sup< T cells misc circadian clock misc experimental autoimmune encephalomyelitis (EAE) misc inflammation misc pertussis toxin (PTx) misc Cytology Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice
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topic_title	QH573-671 Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice CD4<sup<+</sup< T cells CD8<sup<+</sup< T cells circadian clock experimental autoimmune encephalomyelitis (EAE) inflammation pertussis toxin (PTx)
topic	misc QH573-671 misc CD4<sup<+</sup< T cells misc CD8<sup<+</sup< T cells misc circadian clock misc experimental autoimmune encephalomyelitis (EAE) misc inflammation misc pertussis toxin (PTx) misc Cytology
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title	Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice
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title_full	Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice
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title_sort	chronic inflammation disrupts circadian rhythms in splenic cd4+ and cd8+ t cells in mice
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title_auth	Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice
abstract	Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can impact immune functions and disease outcome. Inflammation may disrupt circadian clocks in peripheral tissues and innate immune cells. However, it remains elusive if chronic inflammation impacts adaptive immune cell clock, e.g., in CD4+ and CD8+ T lymphocytes. We studied this in the experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, as an established experimental paradigm for chronic inflammation. We analyzed splenic T cell circadian clock and immune gene expression rhythms in mice with late-stage EAE, CFA/PTx-treated, and untreated mice. In both treatment groups, clock gene expression rhythms were altered with differential effects for baseline expression and peak phase compared with control mice. Most immune cell marker genes tested in this study did not show circadian oscillations in either of the three groups, but time-of-day- independent alterations were observed in EAE and CFA/PTx compared to control mice. Notably, T cell effects were likely independent of central clock function as circadian behavioral rhythms in EAE mice remained intact. Together, chronic inflammation induced by CFA/PTx treatment and EAE immunization has lasting effects on circadian rhythms in peripheral immune cells.
abstractGer	Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can impact immune functions and disease outcome. Inflammation may disrupt circadian clocks in peripheral tissues and innate immune cells. However, it remains elusive if chronic inflammation impacts adaptive immune cell clock, e.g., in CD4+ and CD8+ T lymphocytes. We studied this in the experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, as an established experimental paradigm for chronic inflammation. We analyzed splenic T cell circadian clock and immune gene expression rhythms in mice with late-stage EAE, CFA/PTx-treated, and untreated mice. In both treatment groups, clock gene expression rhythms were altered with differential effects for baseline expression and peak phase compared with control mice. Most immune cell marker genes tested in this study did not show circadian oscillations in either of the three groups, but time-of-day- independent alterations were observed in EAE and CFA/PTx compared to control mice. Notably, T cell effects were likely independent of central clock function as circadian behavioral rhythms in EAE mice remained intact. Together, chronic inflammation induced by CFA/PTx treatment and EAE immunization has lasting effects on circadian rhythms in peripheral immune cells.
abstract_unstemmed	Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can impact immune functions and disease outcome. Inflammation may disrupt circadian clocks in peripheral tissues and innate immune cells. However, it remains elusive if chronic inflammation impacts adaptive immune cell clock, e.g., in CD4+ and CD8+ T lymphocytes. We studied this in the experimental autoimmune encephalomyelitis (EAE), a mouse model for multiple sclerosis, as an established experimental paradigm for chronic inflammation. We analyzed splenic T cell circadian clock and immune gene expression rhythms in mice with late-stage EAE, CFA/PTx-treated, and untreated mice. In both treatment groups, clock gene expression rhythms were altered with differential effects for baseline expression and peak phase compared with control mice. Most immune cell marker genes tested in this study did not show circadian oscillations in either of the three groups, but time-of-day- independent alterations were observed in EAE and CFA/PTx compared to control mice. Notably, T cell effects were likely independent of central clock function as circadian behavioral rhythms in EAE mice remained intact. Together, chronic inflammation induced by CFA/PTx treatment and EAE immunization has lasting effects on circadian rhythms in peripheral immune cells.
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title_short	Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice
url	https://doi.org/10.3390/cells13020151 https://doaj.org/article/bf7bfa4f071e44af8e4e2e94e4cdaf18 https://www.mdpi.com/2073-4409/13/2/151 https://doaj.org/toc/2073-4409
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author2	Alexei Leliavski Leonardo Vinícius Monteiro de Assis Olga Matveeva Ludmila Skrum Werner Solbach Henrik Oster Isabel Heyde
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up_date	2024-07-03T18:47:55.282Z
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Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice

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