Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Myung Yoon Kim [verfasserIn] Isabelle Pellot [verfasserIn] Catherine Bresee [verfasserIn] Asma Nawaz [verfasserIn] Mario Fournier [verfasserIn] Jae Hyung Cho [verfasserIn] Eugenio Cingolani [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Journal of Molecular and Cellular Cardiology Plus ; 3(2023), Seite 100031- volume:3 ; year:2023 ; pages:100031- |
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| Links: |
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| DOI / URN: |
10.1016/j.jmccpl.2023.100031 |
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DOAJ096281014 |
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| 520 | |a Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. | ||
| 650 | 4 | |a Heart failure with preserved ejection fraction | |
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| 650 | 4 | |a Ventricular arrhythmias | |
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10.1016/j.jmccpl.2023.100031 doi (DE-627)DOAJ096281014 (DE-599)DOAJb60c141bd4034bf597f9cc18d67ef06b DE-627 ger DE-627 rakwb eng RC666-701 Myung Yoon Kim verfasserin aut Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. Heart failure with preserved ejection fraction Diet Blood pressure Diastolic function Hypertension Ventricular arrhythmias Diseases of the circulatory (Cardiovascular) system Isabelle Pellot verfasserin aut Catherine Bresee verfasserin aut Asma Nawaz verfasserin aut Mario Fournier verfasserin aut Jae Hyung Cho verfasserin aut Eugenio Cingolani verfasserin aut In Journal of Molecular and Cellular Cardiology Plus 3(2023), Seite 100031- volume:3 year:2023 pages:100031- https://doi.org/10.1016/j.jmccpl.2023.100031 kostenfrei https://doaj.org/article/b60c141bd4034bf597f9cc18d67ef06b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772976123000016 kostenfrei https://doaj.org/toc/2772-9761 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2023 100031- |
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10.1016/j.jmccpl.2023.100031 doi (DE-627)DOAJ096281014 (DE-599)DOAJb60c141bd4034bf597f9cc18d67ef06b DE-627 ger DE-627 rakwb eng RC666-701 Myung Yoon Kim verfasserin aut Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. Heart failure with preserved ejection fraction Diet Blood pressure Diastolic function Hypertension Ventricular arrhythmias Diseases of the circulatory (Cardiovascular) system Isabelle Pellot verfasserin aut Catherine Bresee verfasserin aut Asma Nawaz verfasserin aut Mario Fournier verfasserin aut Jae Hyung Cho verfasserin aut Eugenio Cingolani verfasserin aut In Journal of Molecular and Cellular Cardiology Plus 3(2023), Seite 100031- volume:3 year:2023 pages:100031- https://doi.org/10.1016/j.jmccpl.2023.100031 kostenfrei https://doaj.org/article/b60c141bd4034bf597f9cc18d67ef06b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772976123000016 kostenfrei https://doaj.org/toc/2772-9761 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2023 100031- |
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10.1016/j.jmccpl.2023.100031 doi (DE-627)DOAJ096281014 (DE-599)DOAJb60c141bd4034bf597f9cc18d67ef06b DE-627 ger DE-627 rakwb eng RC666-701 Myung Yoon Kim verfasserin aut Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. Heart failure with preserved ejection fraction Diet Blood pressure Diastolic function Hypertension Ventricular arrhythmias Diseases of the circulatory (Cardiovascular) system Isabelle Pellot verfasserin aut Catherine Bresee verfasserin aut Asma Nawaz verfasserin aut Mario Fournier verfasserin aut Jae Hyung Cho verfasserin aut Eugenio Cingolani verfasserin aut In Journal of Molecular and Cellular Cardiology Plus 3(2023), Seite 100031- volume:3 year:2023 pages:100031- https://doi.org/10.1016/j.jmccpl.2023.100031 kostenfrei https://doaj.org/article/b60c141bd4034bf597f9cc18d67ef06b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772976123000016 kostenfrei https://doaj.org/toc/2772-9761 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 3 2023 100031- |
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misc RC666-701 misc Heart failure with preserved ejection fraction misc Diet misc Blood pressure misc Diastolic function misc Hypertension misc Ventricular arrhythmias misc Diseases of the circulatory (Cardiovascular) system |
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misc RC666-701 misc Heart failure with preserved ejection fraction misc Diet misc Blood pressure misc Diastolic function misc Hypertension misc Ventricular arrhythmias misc Diseases of the circulatory (Cardiovascular) system |
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Journal of Molecular and Cellular Cardiology Plus |
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Journal of Molecular and Cellular Cardiology Plus |
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Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction |
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Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction |
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Myung Yoon Kim |
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Journal of Molecular and Cellular Cardiology Plus |
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Journal of Molecular and Cellular Cardiology Plus |
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2023 |
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100031 |
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Myung Yoon Kim Isabelle Pellot Catherine Bresee Asma Nawaz Mario Fournier Jae Hyung Cho Eugenio Cingolani |
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Myung Yoon Kim |
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10.1016/j.jmccpl.2023.100031 |
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verfasserin |
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diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction |
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RC666-701 |
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Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction |
| abstract |
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. |
| abstractGer |
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. |
| abstract_unstemmed |
Dahl Salt-Sensitive (DSS) rats develop heart failure with preserved ejection fraction (HFpEF) when fed a high-salt (8 % NaCl) diet. Hypertension-induced inflammation and subsequent ventricular fibrosis are believed to underlie the development of HFpEF. We investigated the role of diet modification in the progression of HFpEF using male DSS rats, fed either a high-salt diet from 7 weeks of age to induce HFpEF, or a normal-salt (0.3 % NaCl) diet as controls. After echocardiographic confirmation of diastolic dysfunction at 14–15 weeks of age along with HF manifestations, the HFpEF rats were randomly assigned to either continue a high-salt diet or switch to a normal-salt diet for an additional 4 weeks. HFpEF rats with diet modification showed improved diastolic function (reduced E/E′ ratio in echocardiogram), increased functional capacity (increased treadmill exercise distance), and reduced pulmonary congestions (lung/body weight ratio), compared to high-salt-fed HFpEF rats. Systolic blood pressure remained high (~200 mmHg), and ventricular hypertrophy remained unchanged. Ventricular arrhythmia inducibility (100 % inducible) and corrected QT interval (on ECG) did not change in HFpEF rats after diet modification. HFpEF rats with diet modification showed prolonged survival and reduced ventricular fibrosis (Masson's trichrome staining) compared to high-salt-fed HFpEF rats. Hence, the modification of diet (from high-salt to normal-salt diet) reversed HFpEF phenotypes without affecting blood pressure or ventricular hypertrophy. |
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Diet modification reverses diastolic dysfunction in rats with heart failure and preserved ejection fraction |
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https://doi.org/10.1016/j.jmccpl.2023.100031 https://doaj.org/article/b60c141bd4034bf597f9cc18d67ef06b http://www.sciencedirect.com/science/article/pii/S2772976123000016 https://doaj.org/toc/2772-9761 |
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Isabelle Pellot Catherine Bresee Asma Nawaz Mario Fournier Jae Hyung Cho Eugenio Cingolani |
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Isabelle Pellot Catherine Bresee Asma Nawaz Mario Fournier Jae Hyung Cho Eugenio Cingolani |
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