Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mam...
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Autor*in:	Yana Y. Toporkova [verfasserIn] Elena O. Smirnova [verfasserIn] Svetlana S. Gorina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	fatty acid oxidation lipoxygenase cascade cytochromes P450 CYP74 clan epoxyalcohol synthase allene oxide synthase

Übergeordnetes Werk:	In: Current Issues in Molecular Biology - MDPI AG, 2021, 46(2024), 1, Seite 821-841
Übergeordnetes Werk:	volume:46 ; year:2024 ; number:1 ; pages:821-841

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/cimb46010053

Katalog-ID:	DOAJ096379480

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callnumber-first	Q - Science
author	Yana Y. Toporkova
spellingShingle	Yana Y. Toporkova misc QH301-705.5 misc fatty acid oxidation misc lipoxygenase cascade misc cytochromes P450 misc CYP74 clan misc epoxyalcohol synthase misc allene oxide synthase misc Biology (General) Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
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topic_title	QH301-705.5 Epoxyalcohol Synthase Branch of Lipoxygenase Cascade fatty acid oxidation lipoxygenase cascade cytochromes P450 CYP74 clan epoxyalcohol synthase allene oxide synthase
topic	misc QH301-705.5 misc fatty acid oxidation misc lipoxygenase cascade misc cytochromes P450 misc CYP74 clan misc epoxyalcohol synthase misc allene oxide synthase misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc fatty acid oxidation misc lipoxygenase cascade misc cytochromes P450 misc CYP74 clan misc epoxyalcohol synthase misc allene oxide synthase misc Biology (General)
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title	Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
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title_full	Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
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title_sort	epoxyalcohol synthase branch of lipoxygenase cascade
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title_auth	Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
abstract	Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mammalian eicosanoids and plant octadecanoids. In plants, the main source of oxylipins is the lipoxygenase cascade, the key enzymes of which are nonclassical cytochromes P450 of the CYP74 family, namely allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and divinyl ether synthases (DESs). The most well-studied plant oxylipins are jasmonates (AOS products) and traumatin and green leaf volatiles (HPL products), whereas other oxylipins remain outside of the focus of researchers’ attention. Among them, there is a large group of epoxy hydroxy fatty acids (epoxyalcohols), whose biosynthesis has remained unclear for a long time. In 2008, the first epoxyalcohol synthase of lancelet <i<Branchiostoma floridae</i<, BfEAS (CYP440A1), was discovered. The present review collects data on EASs discovered after BfEAS and enzymes exhibiting EAS activity along with other catalytic activities. This review also presents the results of a study on the evolutionary processes possibly occurring within the P450 superfamily as a whole.
abstractGer	Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mammalian eicosanoids and plant octadecanoids. In plants, the main source of oxylipins is the lipoxygenase cascade, the key enzymes of which are nonclassical cytochromes P450 of the CYP74 family, namely allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and divinyl ether synthases (DESs). The most well-studied plant oxylipins are jasmonates (AOS products) and traumatin and green leaf volatiles (HPL products), whereas other oxylipins remain outside of the focus of researchers’ attention. Among them, there is a large group of epoxy hydroxy fatty acids (epoxyalcohols), whose biosynthesis has remained unclear for a long time. In 2008, the first epoxyalcohol synthase of lancelet <i<Branchiostoma floridae</i<, BfEAS (CYP440A1), was discovered. The present review collects data on EASs discovered after BfEAS and enzymes exhibiting EAS activity along with other catalytic activities. This review also presents the results of a study on the evolutionary processes possibly occurring within the P450 superfamily as a whole.
abstract_unstemmed	Oxylipins are one of the most important classes of bioregulators, biosynthesized through the oxidative metabolism of unsaturated fatty acids in various aerobic organisms. Oxylipins are bioregulators that maintain homeostasis at the cellular and organismal levels. The most important oxylipins are mammalian eicosanoids and plant octadecanoids. In plants, the main source of oxylipins is the lipoxygenase cascade, the key enzymes of which are nonclassical cytochromes P450 of the CYP74 family, namely allene oxide synthases (AOSs), hydroperoxide lyases (HPLs), and divinyl ether synthases (DESs). The most well-studied plant oxylipins are jasmonates (AOS products) and traumatin and green leaf volatiles (HPL products), whereas other oxylipins remain outside of the focus of researchers’ attention. Among them, there is a large group of epoxy hydroxy fatty acids (epoxyalcohols), whose biosynthesis has remained unclear for a long time. In 2008, the first epoxyalcohol synthase of lancelet <i<Branchiostoma floridae</i<, BfEAS (CYP440A1), was discovered. The present review collects data on EASs discovered after BfEAS and enzymes exhibiting EAS activity along with other catalytic activities. This review also presents the results of a study on the evolutionary processes possibly occurring within the P450 superfamily as a whole.
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title_short	Epoxyalcohol Synthase Branch of Lipoxygenase Cascade
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Epoxyalcohol Synthase Branch of Lipoxygenase Cascade

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