Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study

Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel i...
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Autor*in:	Sezgi Kaçar [verfasserIn] Danko Coric [verfasserIn] Giovanni Ometto [verfasserIn] Giovanni Montesano [verfasserIn] Alastair K. Denniston [verfasserIn] Pearse A. Keane [verfasserIn] Bernard M. J. Uitdehaag [verfasserIn] David P. Crabb [verfasserIn] Menno M. Schoonheim [verfasserIn] Axel Petzold [verfasserIn] Eva M. M. Strijbis [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze

Übergeordnetes Werk:	In: Brain Sciences - MDPI AG, 2012, 14(2023), 1, p 36
Übergeordnetes Werk:	volume:14 ; year:2023 ; number:1, p 36

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/brainsci14010036

Katalog-ID:	DOAJ09638588X

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520			\|a Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy.
650		4	\|a glymphatic system
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allfields	10.3390/brainsci14010036 doi (DE-627)DOAJ09638588X (DE-599)DOAJ709d0031c41c410a95b2c622875e7d3c DE-627 ger DE-627 rakwb eng RC321-571 Sezgi Kaçar verfasserin aut Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry Danko Coric verfasserin aut Giovanni Ometto verfasserin aut Giovanni Montesano verfasserin aut Alastair K. Denniston verfasserin aut Pearse A. Keane verfasserin aut Bernard M. J. Uitdehaag verfasserin aut David P. Crabb verfasserin aut Menno M. Schoonheim verfasserin aut Axel Petzold verfasserin aut Eva M. M. Strijbis verfasserin aut In Brain Sciences MDPI AG, 2012 14(2023), 1, p 36 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2023 number:1, p 36 https://doi.org/10.3390/brainsci14010036 kostenfrei https://doaj.org/article/709d0031c41c410a95b2c622875e7d3c kostenfrei https://www.mdpi.com/2076-3425/14/1/36 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 36
spelling	10.3390/brainsci14010036 doi (DE-627)DOAJ09638588X (DE-599)DOAJ709d0031c41c410a95b2c622875e7d3c DE-627 ger DE-627 rakwb eng RC321-571 Sezgi Kaçar verfasserin aut Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry Danko Coric verfasserin aut Giovanni Ometto verfasserin aut Giovanni Montesano verfasserin aut Alastair K. Denniston verfasserin aut Pearse A. Keane verfasserin aut Bernard M. J. Uitdehaag verfasserin aut David P. Crabb verfasserin aut Menno M. Schoonheim verfasserin aut Axel Petzold verfasserin aut Eva M. M. Strijbis verfasserin aut In Brain Sciences MDPI AG, 2012 14(2023), 1, p 36 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2023 number:1, p 36 https://doi.org/10.3390/brainsci14010036 kostenfrei https://doaj.org/article/709d0031c41c410a95b2c622875e7d3c kostenfrei https://www.mdpi.com/2076-3425/14/1/36 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 36
allfields_unstemmed	10.3390/brainsci14010036 doi (DE-627)DOAJ09638588X (DE-599)DOAJ709d0031c41c410a95b2c622875e7d3c DE-627 ger DE-627 rakwb eng RC321-571 Sezgi Kaçar verfasserin aut Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry Danko Coric verfasserin aut Giovanni Ometto verfasserin aut Giovanni Montesano verfasserin aut Alastair K. Denniston verfasserin aut Pearse A. Keane verfasserin aut Bernard M. J. Uitdehaag verfasserin aut David P. Crabb verfasserin aut Menno M. Schoonheim verfasserin aut Axel Petzold verfasserin aut Eva M. M. Strijbis verfasserin aut In Brain Sciences MDPI AG, 2012 14(2023), 1, p 36 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2023 number:1, p 36 https://doi.org/10.3390/brainsci14010036 kostenfrei https://doaj.org/article/709d0031c41c410a95b2c622875e7d3c kostenfrei https://www.mdpi.com/2076-3425/14/1/36 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 36
allfieldsGer	10.3390/brainsci14010036 doi (DE-627)DOAJ09638588X (DE-599)DOAJ709d0031c41c410a95b2c622875e7d3c DE-627 ger DE-627 rakwb eng RC321-571 Sezgi Kaçar verfasserin aut Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry Danko Coric verfasserin aut Giovanni Ometto verfasserin aut Giovanni Montesano verfasserin aut Alastair K. Denniston verfasserin aut Pearse A. Keane verfasserin aut Bernard M. J. Uitdehaag verfasserin aut David P. Crabb verfasserin aut Menno M. Schoonheim verfasserin aut Axel Petzold verfasserin aut Eva M. M. Strijbis verfasserin aut In Brain Sciences MDPI AG, 2012 14(2023), 1, p 36 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2023 number:1, p 36 https://doi.org/10.3390/brainsci14010036 kostenfrei https://doaj.org/article/709d0031c41c410a95b2c622875e7d3c kostenfrei https://www.mdpi.com/2076-3425/14/1/36 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 36
allfieldsSound	10.3390/brainsci14010036 doi (DE-627)DOAJ09638588X (DE-599)DOAJ709d0031c41c410a95b2c622875e7d3c DE-627 ger DE-627 rakwb eng RC321-571 Sezgi Kaçar verfasserin aut Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy. glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry Danko Coric verfasserin aut Giovanni Ometto verfasserin aut Giovanni Montesano verfasserin aut Alastair K. Denniston verfasserin aut Pearse A. Keane verfasserin aut Bernard M. J. Uitdehaag verfasserin aut David P. Crabb verfasserin aut Menno M. Schoonheim verfasserin aut Axel Petzold verfasserin aut Eva M. M. Strijbis verfasserin aut In Brain Sciences MDPI AG, 2012 14(2023), 1, p 36 (DE-627)687718139 (DE-600)2651993-8 20763425 nnns volume:14 year:2023 number:1, p 36 https://doi.org/10.3390/brainsci14010036 kostenfrei https://doaj.org/article/709d0031c41c410a95b2c622875e7d3c kostenfrei https://www.mdpi.com/2076-3425/14/1/36 kostenfrei https://doaj.org/toc/2076-3425 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 1, p 36
language	English
source	In Brain Sciences 14(2023), 1, p 36 volume:14 year:2023 number:1, p 36
sourceStr	In Brain Sciences 14(2023), 1, p 36 volume:14 year:2023 number:1, p 36
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Brain Sciences
authorswithroles_txt_mv	Sezgi Kaçar @@aut@@ Danko Coric @@aut@@ Giovanni Ometto @@aut@@ Giovanni Montesano @@aut@@ Alastair K. Denniston @@aut@@ Pearse A. Keane @@aut@@ Bernard M. J. Uitdehaag @@aut@@ David P. Crabb @@aut@@ Menno M. Schoonheim @@aut@@ Axel Petzold @@aut@@ Eva M. M. Strijbis @@aut@@
publishDateDaySort_date	2023-01-01T00:00:00Z
hierarchy_top_id	687718139
id	DOAJ09638588X
language_de	englisch
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The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. 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callnumber-first	R - Medicine
author	Sezgi Kaçar
spellingShingle	Sezgi Kaçar misc RC321-571 misc glymphatic system misc multiple sclerosis misc neurodegeneration misc optical coherence tomography misc vitreous haze misc Neurosciences. Biological psychiatry. Neuropsychiatry Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
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topic_title	RC321-571 Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study glymphatic system multiple sclerosis neurodegeneration optical coherence tomography vitreous haze
topic	misc RC321-571 misc glymphatic system misc multiple sclerosis misc neurodegeneration misc optical coherence tomography misc vitreous haze misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc glymphatic system misc multiple sclerosis misc neurodegeneration misc optical coherence tomography misc vitreous haze misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
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title_full	Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
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journal	Brain Sciences
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author_browse	Sezgi Kaçar Danko Coric Giovanni Ometto Giovanni Montesano Alastair K. Denniston Pearse A. Keane Bernard M. J. Uitdehaag David P. Crabb Menno M. Schoonheim Axel Petzold Eva M. M. Strijbis
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doi_str_mv	10.3390/brainsci14010036
author2-role	verfasserin
title_sort	exploring vitreous haze as a potential biomarker for accelerated glymphatic outflow and neurodegeneration in multiple sclerosis: a cross-sectional study
callnumber	RC321-571
title_auth	Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
abstract	Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy.
abstractGer	Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy.
abstract_unstemmed	Background: The glymphatic system removes neurodegenerative debris. The ocular glymphatic outflow is from the eye to the proximal optic nerve. In multiple sclerosis (MS), atrophy of the optic nerve increases the glymphatic outflow space. Here, we tested whether vitreous haze (VH) can provide novel insights into the relationship between neurodegeneration and the ocular glymphatic system in MS. Methods: This cross-sectional study comprised 315 persons with MS and 87 healthy controls (HCs). VH was quantified from optical coherence tomography (OCT) volume scans. Neurodegeneration was determined on three-dimensional T1 (3DT1) MRI, lesion detection on fluid-attenuated inversion (FLAIR), and layer thickness on OCT. Generalized estimating equations, corrected for age, were used to analyze associations between VH and metrics for neurodegeneration, demographics, and clinical scales. Group differences were determined between mild, moderate, and severe disability. Results: On the group level, VH scores were comparable between MS and control (<i<p</i< = 0.629). In MS, VH scores declined with disease duration (β = −0.009, <i<p</i< = 0.004) and age (β = −0.007, <i<p</i< = 0.001). There was no relation between VH scores and higher age in HCs. In MS patients, VH was related to normalized gray (NGMV, β = 0.001, <i<p</i< = 0.011) and white matter volume (NWMV, β = 0.001, <i<p</i< = 0.003), macular ganglion cell–inner plexiform layer thickness (mGCIPL, β = 0.006, <i<p</i< < 0.001), and peripapillary retinal nerve fiber layer thickness (pRNFL, β = 0.004, <i<p</i< = 0.008). VH was significantly lower in severe compared to mild disability (mean difference −28.86%, <i<p</i< = 0.058). Conclusions: There is a correlation between VH on OCT and disease duration, more severe disability and lower brain volumes in MS. Biologically, these relationships suggest accelerated glymphatic clearance with disease-related atrophy.
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title_short	Exploring Vitreous Haze as a Potential Biomarker for Accelerated Glymphatic Outflow and Neurodegeneration in Multiple Sclerosis: A Cross-Sectional Study
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