B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients

ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses pos...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Younes Bathish [verfasserIn] Neta Tuvia [verfasserIn] Elizabeth Eshel [verfasserIn] Tali Tal Lange [verfasserIn] Christiane Sigrid Eberhardt [verfasserIn] Michael Edelstein [verfasserIn] Kamal Abu-Jabal [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine

Übergeordnetes Werk:	In: Human Vaccines & Immunotherapeutics - Taylor & Francis Group, 2022, 20(2024), 1
Übergeordnetes Werk:	volume:20 ; year:2024 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21645515.2023.2292376

Katalog-ID:	DOAJ096545712

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520			\|a ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group.
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allfields	10.1080/21645515.2023.2292376 doi (DE-627)DOAJ096545712 (DE-599)DOAJ11e4972170684f7da931320abcf061b9 DE-627 ger DE-627 rakwb eng RC581-607 RM1-950 Younes Bathish verfasserin aut B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group. B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine Immunologic diseases. Allergy Therapeutics. Pharmacology Neta Tuvia verfasserin aut Elizabeth Eshel verfasserin aut Tali Tal Lange verfasserin aut Christiane Sigrid Eberhardt verfasserin aut Michael Edelstein verfasserin aut Kamal Abu-Jabal verfasserin aut In Human Vaccines & Immunotherapeutics Taylor & Francis Group, 2022 20(2024), 1 (DE-627)718665929 (DE-600)2664177-X 2164554X nnns volume:20 year:2024 number:1 https://doi.org/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/article/11e4972170684f7da931320abcf061b9 kostenfrei https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/toc/2164-5515 Journal toc kostenfrei https://doaj.org/toc/2164-554X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2024 1
spelling	10.1080/21645515.2023.2292376 doi (DE-627)DOAJ096545712 (DE-599)DOAJ11e4972170684f7da931320abcf061b9 DE-627 ger DE-627 rakwb eng RC581-607 RM1-950 Younes Bathish verfasserin aut B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group. B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine Immunologic diseases. Allergy Therapeutics. Pharmacology Neta Tuvia verfasserin aut Elizabeth Eshel verfasserin aut Tali Tal Lange verfasserin aut Christiane Sigrid Eberhardt verfasserin aut Michael Edelstein verfasserin aut Kamal Abu-Jabal verfasserin aut In Human Vaccines & Immunotherapeutics Taylor & Francis Group, 2022 20(2024), 1 (DE-627)718665929 (DE-600)2664177-X 2164554X nnns volume:20 year:2024 number:1 https://doi.org/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/article/11e4972170684f7da931320abcf061b9 kostenfrei https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/toc/2164-5515 Journal toc kostenfrei https://doaj.org/toc/2164-554X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2024 1
allfields_unstemmed	10.1080/21645515.2023.2292376 doi (DE-627)DOAJ096545712 (DE-599)DOAJ11e4972170684f7da931320abcf061b9 DE-627 ger DE-627 rakwb eng RC581-607 RM1-950 Younes Bathish verfasserin aut B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group. B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine Immunologic diseases. Allergy Therapeutics. Pharmacology Neta Tuvia verfasserin aut Elizabeth Eshel verfasserin aut Tali Tal Lange verfasserin aut Christiane Sigrid Eberhardt verfasserin aut Michael Edelstein verfasserin aut Kamal Abu-Jabal verfasserin aut In Human Vaccines & Immunotherapeutics Taylor & Francis Group, 2022 20(2024), 1 (DE-627)718665929 (DE-600)2664177-X 2164554X nnns volume:20 year:2024 number:1 https://doi.org/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/article/11e4972170684f7da931320abcf061b9 kostenfrei https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/toc/2164-5515 Journal toc kostenfrei https://doaj.org/toc/2164-554X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2024 1
allfieldsGer	10.1080/21645515.2023.2292376 doi (DE-627)DOAJ096545712 (DE-599)DOAJ11e4972170684f7da931320abcf061b9 DE-627 ger DE-627 rakwb eng RC581-607 RM1-950 Younes Bathish verfasserin aut B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group. B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine Immunologic diseases. Allergy Therapeutics. Pharmacology Neta Tuvia verfasserin aut Elizabeth Eshel verfasserin aut Tali Tal Lange verfasserin aut Christiane Sigrid Eberhardt verfasserin aut Michael Edelstein verfasserin aut Kamal Abu-Jabal verfasserin aut In Human Vaccines & Immunotherapeutics Taylor & Francis Group, 2022 20(2024), 1 (DE-627)718665929 (DE-600)2664177-X 2164554X nnns volume:20 year:2024 number:1 https://doi.org/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/article/11e4972170684f7da931320abcf061b9 kostenfrei https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/toc/2164-5515 Journal toc kostenfrei https://doaj.org/toc/2164-554X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2024 1
allfieldsSound	10.1080/21645515.2023.2292376 doi (DE-627)DOAJ096545712 (DE-599)DOAJ11e4972170684f7da931320abcf061b9 DE-627 ger DE-627 rakwb eng RC581-607 RM1-950 Younes Bathish verfasserin aut B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group. B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine Immunologic diseases. Allergy Therapeutics. Pharmacology Neta Tuvia verfasserin aut Elizabeth Eshel verfasserin aut Tali Tal Lange verfasserin aut Christiane Sigrid Eberhardt verfasserin aut Michael Edelstein verfasserin aut Kamal Abu-Jabal verfasserin aut In Human Vaccines & Immunotherapeutics Taylor & Francis Group, 2022 20(2024), 1 (DE-627)718665929 (DE-600)2664177-X 2164554X nnns volume:20 year:2024 number:1 https://doi.org/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/article/11e4972170684f7da931320abcf061b9 kostenfrei https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 kostenfrei https://doaj.org/toc/2164-5515 Journal toc kostenfrei https://doaj.org/toc/2164-554X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2024 1
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author	Younes Bathish
spellingShingle	Younes Bathish misc RC581-607 misc RM1-950 misc B cells misc COVID-19 misc dialysis misc SARS-CoV-2 misc T cells misc vaccine misc Immunologic diseases. Allergy misc Therapeutics. Pharmacology B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients
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topic_title	RC581-607 RM1-950 B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients B cells COVID-19 dialysis SARS-CoV-2 T cells vaccine
topic	misc RC581-607 misc RM1-950 misc B cells misc COVID-19 misc dialysis misc SARS-CoV-2 misc T cells misc vaccine misc Immunologic diseases. Allergy misc Therapeutics. Pharmacology
topic_unstemmed	misc RC581-607 misc RM1-950 misc B cells misc COVID-19 misc dialysis misc SARS-CoV-2 misc T cells misc vaccine misc Immunologic diseases. Allergy misc Therapeutics. Pharmacology
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title	B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients
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title_full	B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients
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title_sort	b and t cell responses to the 3rd and 4th dose of the bnt162b2 vaccine in dialysis patients
callnumber	RC581-607
title_auth	B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients
abstract	ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group.
abstractGer	ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group.
abstract_unstemmed	ABSTRACTPatients on dialysis (PoD) are at high risk of severe morbidity and mortality from COVID-19. Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. Our results suggest that standard BNT162b2 vaccination is suitable for this group.
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title_short	B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients
url	https://doi.org/10.1080/21645515.2023.2292376 https://doaj.org/article/11e4972170684f7da931320abcf061b9 https://www.tandfonline.com/doi/10.1080/21645515.2023.2292376 https://doaj.org/toc/2164-5515 https://doaj.org/toc/2164-554X
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author2	Neta Tuvia Elizabeth Eshel Tali Tal Lange Christiane Sigrid Eberhardt Michael Edelstein Kamal Abu-Jabal
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Characterizing long-term vaccine immune responses in these patients will help optimize vaccine schedule for PoD. This study aimed to determine whether long-term humoral and B and T cell-responses post 3rd and 4th dose of the BNT162b2 vaccine differed between PoD and controls. Non-infected PoD and controls vaccinated with BNT162b2 were recruited in Ziv Medical Center, Israel, between 2021 and 2022. Specimens were collected 1–2 months pre 3rd dose; 1–3 months post 3rd dose; 4–5 months post 3rd dose and 3–5 months post the 4th dose. Anti-SARS-CoV-2 spike (spike) specific antibodies, spike specific memory B cells, and spike specific CD154+ T cells as well as cytokines producing CD4+/CD8+ T cells were measured using standardized assays and compared between PoD and controls at each time point using Mann Whitney and Fisher’s exact tests. We recruited 22 PoD and 20 controls. Antibody levels in PoD were lower compared to controls pre 3rd dose but not post 3rd and 4th doses. Frequencies of spike specific memory B cell populations were similar between PoD and controls overall. Frequencies of spike specific T cells, including those producing IFNγ and TNFα, were not lower in PoD. B and T cell mediated immune response in PoD following a 3rd and a 4th dose of the BNT162b2 vaccine was not inferior to controls up to 5 months post vaccination. 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B and T cell responses to the 3rd and 4th dose of the BNT162b2 vaccine in dialysis patients

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