Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission

IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a poss...
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Autor*in:	Giovanna Elisiana Carpagnano [verfasserIn] Andrea Portacci [verfasserIn] Santi Nolasco [verfasserIn] Aikaterini Detoraki [verfasserIn] Alessandro Vatrella [verfasserIn] Cecilia Calabrese [verfasserIn] Corrado Pelaia [verfasserIn] Francesca Montagnolo [verfasserIn] Giulia Scioscia [verfasserIn] Giuseppe Valenti [verfasserIn] Maria D’Amato [verfasserIn] Maria Filomena Caiaffa [verfasserIn] Massimo Triggiani [verfasserIn] Nicola Scichilone [verfasserIn] Claudia Crimi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 15(2024)
Übergeordnetes Werk:	volume:15 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2024.1343362

Katalog-ID:	DOAJ096555211

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520			\|a IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items.
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allfields	10.3389/fimmu.2024.1343362 doi (DE-627)DOAJ096555211 (DE-599)DOAJ0c7c9e26d5744c2e93df0d4eb67ad39d DE-627 ger DE-627 rakwb eng RC581-607 Giovanna Elisiana Carpagnano verfasserin aut Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items. severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy Andrea Portacci verfasserin aut Santi Nolasco verfasserin aut Santi Nolasco verfasserin aut Aikaterini Detoraki verfasserin aut Alessandro Vatrella verfasserin aut Cecilia Calabrese verfasserin aut Corrado Pelaia verfasserin aut Francesca Montagnolo verfasserin aut Giulia Scioscia verfasserin aut Giuseppe Valenti verfasserin aut Maria D’Amato verfasserin aut Maria Filomena Caiaffa verfasserin aut Massimo Triggiani verfasserin aut Nicola Scichilone verfasserin aut Claudia Crimi verfasserin aut Claudia Crimi verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 15(2024) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:15 year:2024 https://doi.org/10.3389/fimmu.2024.1343362 kostenfrei https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
spelling	10.3389/fimmu.2024.1343362 doi (DE-627)DOAJ096555211 (DE-599)DOAJ0c7c9e26d5744c2e93df0d4eb67ad39d DE-627 ger DE-627 rakwb eng RC581-607 Giovanna Elisiana Carpagnano verfasserin aut Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items. severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy Andrea Portacci verfasserin aut Santi Nolasco verfasserin aut Santi Nolasco verfasserin aut Aikaterini Detoraki verfasserin aut Alessandro Vatrella verfasserin aut Cecilia Calabrese verfasserin aut Corrado Pelaia verfasserin aut Francesca Montagnolo verfasserin aut Giulia Scioscia verfasserin aut Giuseppe Valenti verfasserin aut Maria D’Amato verfasserin aut Maria Filomena Caiaffa verfasserin aut Massimo Triggiani verfasserin aut Nicola Scichilone verfasserin aut Claudia Crimi verfasserin aut Claudia Crimi verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 15(2024) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:15 year:2024 https://doi.org/10.3389/fimmu.2024.1343362 kostenfrei https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
allfields_unstemmed	10.3389/fimmu.2024.1343362 doi (DE-627)DOAJ096555211 (DE-599)DOAJ0c7c9e26d5744c2e93df0d4eb67ad39d DE-627 ger DE-627 rakwb eng RC581-607 Giovanna Elisiana Carpagnano verfasserin aut Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items. severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy Andrea Portacci verfasserin aut Santi Nolasco verfasserin aut Santi Nolasco verfasserin aut Aikaterini Detoraki verfasserin aut Alessandro Vatrella verfasserin aut Cecilia Calabrese verfasserin aut Corrado Pelaia verfasserin aut Francesca Montagnolo verfasserin aut Giulia Scioscia verfasserin aut Giuseppe Valenti verfasserin aut Maria D’Amato verfasserin aut Maria Filomena Caiaffa verfasserin aut Massimo Triggiani verfasserin aut Nicola Scichilone verfasserin aut Claudia Crimi verfasserin aut Claudia Crimi verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 15(2024) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:15 year:2024 https://doi.org/10.3389/fimmu.2024.1343362 kostenfrei https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
allfieldsGer	10.3389/fimmu.2024.1343362 doi (DE-627)DOAJ096555211 (DE-599)DOAJ0c7c9e26d5744c2e93df0d4eb67ad39d DE-627 ger DE-627 rakwb eng RC581-607 Giovanna Elisiana Carpagnano verfasserin aut Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items. severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy Andrea Portacci verfasserin aut Santi Nolasco verfasserin aut Santi Nolasco verfasserin aut Aikaterini Detoraki verfasserin aut Alessandro Vatrella verfasserin aut Cecilia Calabrese verfasserin aut Corrado Pelaia verfasserin aut Francesca Montagnolo verfasserin aut Giulia Scioscia verfasserin aut Giuseppe Valenti verfasserin aut Maria D’Amato verfasserin aut Maria Filomena Caiaffa verfasserin aut Massimo Triggiani verfasserin aut Nicola Scichilone verfasserin aut Claudia Crimi verfasserin aut Claudia Crimi verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 15(2024) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:15 year:2024 https://doi.org/10.3389/fimmu.2024.1343362 kostenfrei https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
allfieldsSound	10.3389/fimmu.2024.1343362 doi (DE-627)DOAJ096555211 (DE-599)DOAJ0c7c9e26d5744c2e93df0d4eb67ad39d DE-627 ger DE-627 rakwb eng RC581-607 Giovanna Elisiana Carpagnano verfasserin aut Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items. severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy Andrea Portacci verfasserin aut Santi Nolasco verfasserin aut Santi Nolasco verfasserin aut Aikaterini Detoraki verfasserin aut Alessandro Vatrella verfasserin aut Cecilia Calabrese verfasserin aut Corrado Pelaia verfasserin aut Francesca Montagnolo verfasserin aut Giulia Scioscia verfasserin aut Giuseppe Valenti verfasserin aut Maria D’Amato verfasserin aut Maria Filomena Caiaffa verfasserin aut Massimo Triggiani verfasserin aut Nicola Scichilone verfasserin aut Claudia Crimi verfasserin aut Claudia Crimi verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 15(2024) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:15 year:2024 https://doi.org/10.3389/fimmu.2024.1343362 kostenfrei https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024
language	English
source	In Frontiers in Immunology 15(2024) volume:15 year:2024
sourceStr	In Frontiers in Immunology 15(2024) volume:15 year:2024
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1 Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	Frontiers in Immunology
authorswithroles_txt_mv	Giovanna Elisiana Carpagnano @@aut@@ Andrea Portacci @@aut@@ Santi Nolasco @@aut@@ Aikaterini Detoraki @@aut@@ Alessandro Vatrella @@aut@@ Cecilia Calabrese @@aut@@ Corrado Pelaia @@aut@@ Francesca Montagnolo @@aut@@ Giulia Scioscia @@aut@@ Giuseppe Valenti @@aut@@ Maria D’Amato @@aut@@ Maria Filomena Caiaffa @@aut@@ Massimo Triggiani @@aut@@ Nicola Scichilone @@aut@@ Claudia Crimi @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	657998354
id	DOAJ096555211
language_de	englisch
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Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. 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callnumber-first	R - Medicine
author	Giovanna Elisiana Carpagnano
spellingShingle	Giovanna Elisiana Carpagnano misc RC581-607 misc severe asthma misc anti-IL5 misc anti-IL5 receptor misc clinical remission misc biologics misc FEV1 misc Immunologic diseases. Allergy Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission
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topic_title	RC581-607 Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission severe asthma anti-IL5 anti-IL5 receptor clinical remission biologics FEV1
topic	misc RC581-607 misc severe asthma misc anti-IL5 misc anti-IL5 receptor misc clinical remission misc biologics misc FEV1 misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc severe asthma misc anti-IL5 misc anti-IL5 receptor misc clinical remission misc biologics misc FEV1 misc Immunologic diseases. Allergy
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title	Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission
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title_full	Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission
author_sort	Giovanna Elisiana Carpagnano
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author_browse	Giovanna Elisiana Carpagnano Andrea Portacci Santi Nolasco Aikaterini Detoraki Alessandro Vatrella Cecilia Calabrese Corrado Pelaia Francesca Montagnolo Giulia Scioscia Giuseppe Valenti Maria D’Amato Maria Filomena Caiaffa Massimo Triggiani Nicola Scichilone Claudia Crimi
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doi_str_mv	10.3389/fimmu.2024.1343362
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title_sort	features of severe asthma response to anti-il5/il5r therapies: identikit of clinical remission
callnumber	RC581-607
title_auth	Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission
abstract	IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items.
abstractGer	IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items.
abstract_unstemmed	IntroductionClinical remission (CliR) achievement has been recognized as a new potential outcome in severe asthma. Nevertheless, we still lack a detailed profile of what features could better identify patients undergoing clinical remission. In this study, we aim to address this issue, tracing a possible identikit of patients fulfilling remission criteria.MethodsWe enrolled 266 patients with severe eosinophilic asthma (SEA) treated with a 12-month course of anti-IL5/IL5 receptor (IL5r) monoclonal antibodies. Patients with no exacerbation, OCS withdrawal, ACT ≥ 20 and FEV1 ≥ 80% after 1 year of biologic treatment were classified as in clinical remission.Results30.5% of the enrolled patients achieved remission after biologic administration. CliR group showed a lower number of baseline asthma exacerbations and better lung function parameters, with a trend for higher ACT scores and a less frequent history of a positive skin prick test. CliR achievement was unlikely in presence of a higher BMI, a positive skin prick test, an increased number of asthma exacerbations before biologic treatment, anti-muscarinic administration, and a previous diagnosis of EGPA, bronchiectasis or osteoporosis. In contrast, a better lung function, an increased blood eosinophilic count, the presence of chronic rhinosinusitis with nasal polyps and a more frequent use of reliever therapy predicts remission development. Changes in exacerbations number, OCS use, ACT scores and FEV1% between remittent and non-remittent patients arise at specific follow up timepoints and are positively associated with CliR achievement.Discussionanti-IL5/IL5r biologics can induce CliR in a proportion of patients with SEA. Patients achieving remission demonstrate specific clinical, functional and inflammatory features, as well as a specific moment of improvement in all the CliR items.
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title_short	Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission
url	https://doi.org/10.3389/fimmu.2024.1343362 https://doaj.org/article/0c7c9e26d5744c2e93df0d4eb67ad39d https://www.frontiersin.org/articles/10.3389/fimmu.2024.1343362/full https://doaj.org/toc/1664-3224
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author2	Andrea Portacci Santi Nolasco Aikaterini Detoraki Alessandro Vatrella Cecilia Calabrese Corrado Pelaia Francesca Montagnolo Giulia Scioscia Giuseppe Valenti Maria D’Amato Maria Filomena Caiaffa Massimo Triggiani Nicola Scichilone Claudia Crimi
author2Str	Andrea Portacci Santi Nolasco Aikaterini Detoraki Alessandro Vatrella Cecilia Calabrese Corrado Pelaia Francesca Montagnolo Giulia Scioscia Giuseppe Valenti Maria D’Amato Maria Filomena Caiaffa Massimo Triggiani Nicola Scichilone Claudia Crimi
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up_date	2024-07-03T20:49:22.252Z
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Features of severe asthma response to anti-IL5/IL5r therapies: identikit of clinical remission

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