Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biologica...
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Autor*in:	Pei-Ying Wu [verfasserIn] Michelle Van Scoyk [verfasserIn] Stephanie S. McHale [verfasserIn] Chu-Fang Chou [verfasserIn] Gregory Riddick [verfasserIn] Kamran Farouq [verfasserIn] Bin Hu [verfasserIn] Vita Kraskauskiene [verfasserIn] Jennifer Koblinski [verfasserIn] Charles Lyons [verfasserIn] Arjun Rijal [verfasserIn] Vignesh Vudatha [verfasserIn] Dongyu Zhang [verfasserIn] Jose G. Trevino [verfasserIn] Rachit D. Shah [verfasserIn] Patrick Nana-Sinkam [verfasserIn] Yong Huang [verfasserIn] Shwu-Fan Ma [verfasserIn] Imre Noth [verfasserIn] Chanita Hughes-Halbert [verfasserIn] Victoria L. Seewaldt [verfasserIn] Ching-Yi Chen [verfasserIn] Robert A. Winn [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Health disparity Molecular biology Cancer

Übergeordnetes Werk:	In: iScience - Elsevier, 2019, 27(2024), 2, Seite 108858-
Übergeordnetes Werk:	volume:27 ; year:2024 ; number:2 ; pages:108858-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.isci.2024.108858

Katalog-ID:	DOAJ096556102

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520			\|a Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
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allfields	10.1016/j.isci.2024.108858 doi (DE-627)DOAJ096556102 (DE-599)DOAJ2b1b617e9e464c16a2b0c6f8fca1416f DE-627 ger DE-627 rakwb eng Pei-Ying Wu verfasserin aut Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities. Health disparity Molecular biology Cancer Science Q Michelle Van Scoyk verfasserin aut Stephanie S. McHale verfasserin aut Chu-Fang Chou verfasserin aut Gregory Riddick verfasserin aut Kamran Farouq verfasserin aut Bin Hu verfasserin aut Vita Kraskauskiene verfasserin aut Jennifer Koblinski verfasserin aut Charles Lyons verfasserin aut Arjun Rijal verfasserin aut Vignesh Vudatha verfasserin aut Dongyu Zhang verfasserin aut Jose G. Trevino verfasserin aut Rachit D. Shah verfasserin aut Patrick Nana-Sinkam verfasserin aut Yong Huang verfasserin aut Shwu-Fan Ma verfasserin aut Imre Noth verfasserin aut Chanita Hughes-Halbert verfasserin aut Victoria L. Seewaldt verfasserin aut Ching-Yi Chen verfasserin aut Robert A. Winn verfasserin aut In iScience Elsevier, 2019 27(2024), 2, Seite 108858- (DE-627)1019532106 25890042 nnns volume:27 year:2024 number:2 pages:108858- https://doi.org/10.1016/j.isci.2024.108858 kostenfrei https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004224000798 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2024 2 108858-
spelling	10.1016/j.isci.2024.108858 doi (DE-627)DOAJ096556102 (DE-599)DOAJ2b1b617e9e464c16a2b0c6f8fca1416f DE-627 ger DE-627 rakwb eng Pei-Ying Wu verfasserin aut Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities. Health disparity Molecular biology Cancer Science Q Michelle Van Scoyk verfasserin aut Stephanie S. McHale verfasserin aut Chu-Fang Chou verfasserin aut Gregory Riddick verfasserin aut Kamran Farouq verfasserin aut Bin Hu verfasserin aut Vita Kraskauskiene verfasserin aut Jennifer Koblinski verfasserin aut Charles Lyons verfasserin aut Arjun Rijal verfasserin aut Vignesh Vudatha verfasserin aut Dongyu Zhang verfasserin aut Jose G. Trevino verfasserin aut Rachit D. Shah verfasserin aut Patrick Nana-Sinkam verfasserin aut Yong Huang verfasserin aut Shwu-Fan Ma verfasserin aut Imre Noth verfasserin aut Chanita Hughes-Halbert verfasserin aut Victoria L. Seewaldt verfasserin aut Ching-Yi Chen verfasserin aut Robert A. Winn verfasserin aut In iScience Elsevier, 2019 27(2024), 2, Seite 108858- (DE-627)1019532106 25890042 nnns volume:27 year:2024 number:2 pages:108858- https://doi.org/10.1016/j.isci.2024.108858 kostenfrei https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004224000798 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2024 2 108858-
allfields_unstemmed	10.1016/j.isci.2024.108858 doi (DE-627)DOAJ096556102 (DE-599)DOAJ2b1b617e9e464c16a2b0c6f8fca1416f DE-627 ger DE-627 rakwb eng Pei-Ying Wu verfasserin aut Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities. Health disparity Molecular biology Cancer Science Q Michelle Van Scoyk verfasserin aut Stephanie S. McHale verfasserin aut Chu-Fang Chou verfasserin aut Gregory Riddick verfasserin aut Kamran Farouq verfasserin aut Bin Hu verfasserin aut Vita Kraskauskiene verfasserin aut Jennifer Koblinski verfasserin aut Charles Lyons verfasserin aut Arjun Rijal verfasserin aut Vignesh Vudatha verfasserin aut Dongyu Zhang verfasserin aut Jose G. Trevino verfasserin aut Rachit D. Shah verfasserin aut Patrick Nana-Sinkam verfasserin aut Yong Huang verfasserin aut Shwu-Fan Ma verfasserin aut Imre Noth verfasserin aut Chanita Hughes-Halbert verfasserin aut Victoria L. Seewaldt verfasserin aut Ching-Yi Chen verfasserin aut Robert A. Winn verfasserin aut In iScience Elsevier, 2019 27(2024), 2, Seite 108858- (DE-627)1019532106 25890042 nnns volume:27 year:2024 number:2 pages:108858- https://doi.org/10.1016/j.isci.2024.108858 kostenfrei https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004224000798 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2024 2 108858-
allfieldsGer	10.1016/j.isci.2024.108858 doi (DE-627)DOAJ096556102 (DE-599)DOAJ2b1b617e9e464c16a2b0c6f8fca1416f DE-627 ger DE-627 rakwb eng Pei-Ying Wu verfasserin aut Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities. Health disparity Molecular biology Cancer Science Q Michelle Van Scoyk verfasserin aut Stephanie S. McHale verfasserin aut Chu-Fang Chou verfasserin aut Gregory Riddick verfasserin aut Kamran Farouq verfasserin aut Bin Hu verfasserin aut Vita Kraskauskiene verfasserin aut Jennifer Koblinski verfasserin aut Charles Lyons verfasserin aut Arjun Rijal verfasserin aut Vignesh Vudatha verfasserin aut Dongyu Zhang verfasserin aut Jose G. Trevino verfasserin aut Rachit D. Shah verfasserin aut Patrick Nana-Sinkam verfasserin aut Yong Huang verfasserin aut Shwu-Fan Ma verfasserin aut Imre Noth verfasserin aut Chanita Hughes-Halbert verfasserin aut Victoria L. Seewaldt verfasserin aut Ching-Yi Chen verfasserin aut Robert A. Winn verfasserin aut In iScience Elsevier, 2019 27(2024), 2, Seite 108858- (DE-627)1019532106 25890042 nnns volume:27 year:2024 number:2 pages:108858- https://doi.org/10.1016/j.isci.2024.108858 kostenfrei https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004224000798 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2024 2 108858-
allfieldsSound	10.1016/j.isci.2024.108858 doi (DE-627)DOAJ096556102 (DE-599)DOAJ2b1b617e9e464c16a2b0c6f8fca1416f DE-627 ger DE-627 rakwb eng Pei-Ying Wu verfasserin aut Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities. Health disparity Molecular biology Cancer Science Q Michelle Van Scoyk verfasserin aut Stephanie S. McHale verfasserin aut Chu-Fang Chou verfasserin aut Gregory Riddick verfasserin aut Kamran Farouq verfasserin aut Bin Hu verfasserin aut Vita Kraskauskiene verfasserin aut Jennifer Koblinski verfasserin aut Charles Lyons verfasserin aut Arjun Rijal verfasserin aut Vignesh Vudatha verfasserin aut Dongyu Zhang verfasserin aut Jose G. Trevino verfasserin aut Rachit D. Shah verfasserin aut Patrick Nana-Sinkam verfasserin aut Yong Huang verfasserin aut Shwu-Fan Ma verfasserin aut Imre Noth verfasserin aut Chanita Hughes-Halbert verfasserin aut Victoria L. Seewaldt verfasserin aut Ching-Yi Chen verfasserin aut Robert A. Winn verfasserin aut In iScience Elsevier, 2019 27(2024), 2, Seite 108858- (DE-627)1019532106 25890042 nnns volume:27 year:2024 number:2 pages:108858- https://doi.org/10.1016/j.isci.2024.108858 kostenfrei https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f kostenfrei http://www.sciencedirect.com/science/article/pii/S2589004224000798 kostenfrei https://doaj.org/toc/2589-0042 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 27 2024 2 108858-
language	English
source	In iScience 27(2024), 2, Seite 108858- volume:27 year:2024 number:2 pages:108858-
sourceStr	In iScience 27(2024), 2, Seite 108858- volume:27 year:2024 number:2 pages:108858-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Health disparity Molecular biology Cancer Science Q
isfreeaccess_bool	true
container_title	iScience
authorswithroles_txt_mv	Pei-Ying Wu @@aut@@ Michelle Van Scoyk @@aut@@ Stephanie S. McHale @@aut@@ Chu-Fang Chou @@aut@@ Gregory Riddick @@aut@@ Kamran Farouq @@aut@@ Bin Hu @@aut@@ Vita Kraskauskiene @@aut@@ Jennifer Koblinski @@aut@@ Charles Lyons @@aut@@ Arjun Rijal @@aut@@ Vignesh Vudatha @@aut@@ Dongyu Zhang @@aut@@ Jose G. Trevino @@aut@@ Rachit D. Shah @@aut@@ Patrick Nana-Sinkam @@aut@@ Yong Huang @@aut@@ Shwu-Fan Ma @@aut@@ Imre Noth @@aut@@ Chanita Hughes-Halbert @@aut@@ Victoria L. Seewaldt @@aut@@ Ching-Yi Chen @@aut@@ Robert A. Winn @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	1019532106
id	DOAJ096556102
language_de	englisch
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author	Pei-Ying Wu
spellingShingle	Pei-Ying Wu misc Health disparity misc Molecular biology misc Cancer misc Science misc Q Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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topic_title	Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men Health disparity Molecular biology Cancer
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title	Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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title_full	Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
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author_browse	Pei-Ying Wu Michelle Van Scoyk Stephanie S. McHale Chu-Fang Chou Gregory Riddick Kamran Farouq Bin Hu Vita Kraskauskiene Jennifer Koblinski Charles Lyons Arjun Rijal Vignesh Vudatha Dongyu Zhang Jose G. Trevino Rachit D. Shah Patrick Nana-Sinkam Yong Huang Shwu-Fan Ma Imre Noth Chanita Hughes-Halbert Victoria L. Seewaldt Ching-Yi Chen Robert A. Winn
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title_sort	cooperation between prmt1 and prmt6 drives lung cancer health disparities among black/african american men
title_auth	Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
abstract	Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
abstractGer	Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
abstract_unstemmed	Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
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title_short	Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
url	https://doi.org/10.1016/j.isci.2024.108858 https://doaj.org/article/2b1b617e9e464c16a2b0c6f8fca1416f http://www.sciencedirect.com/science/article/pii/S2589004224000798 https://doaj.org/toc/2589-0042
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doi_str	10.1016/j.isci.2024.108858
up_date	2024-07-03T20:49:46.196Z
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Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Health disparity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Molecular biology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cancer</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Science</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Q</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Michelle Van Scoyk</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Stephanie S. 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Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men

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