Timing of diuretic administration effects on urine volume in hospitalized patients

Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Katie S. McCullar [verfasserIn] Sara Abbaspour [verfasserIn] Wei Wang [verfasserIn] Aaron D. Aguirre [verfasserIn] M. Brandon Westover [verfasserIn] Elizabeth B. Klerman [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	chronotherapeutic circadian medicine diuretics renal outcomes inpatients

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 14(2024)
Übergeordnetes Werk:	volume:14 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2023.1208324

Katalog-ID:	DOAJ096557028

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650		4	\|a circadian medicine
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650		4	\|a renal outcomes
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allfields	10.3389/fphys.2023.1208324 doi (DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1 DE-627 ger DE-627 rakwb eng QP1-981 Katie S. McCullar verfasserin aut Timing of diuretic administration effects on urine volume in hospitalized patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology Katie S. McCullar verfasserin aut Sara Abbaspour verfasserin aut Sara Abbaspour verfasserin aut Wei Wang verfasserin aut Wei Wang verfasserin aut Aaron D. Aguirre verfasserin aut M. Brandon Westover verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2024) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2024 https://doi.org/10.3389/fphys.2023.1208324 kostenfrei https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
spelling	10.3389/fphys.2023.1208324 doi (DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1 DE-627 ger DE-627 rakwb eng QP1-981 Katie S. McCullar verfasserin aut Timing of diuretic administration effects on urine volume in hospitalized patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology Katie S. McCullar verfasserin aut Sara Abbaspour verfasserin aut Sara Abbaspour verfasserin aut Wei Wang verfasserin aut Wei Wang verfasserin aut Aaron D. Aguirre verfasserin aut M. Brandon Westover verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2024) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2024 https://doi.org/10.3389/fphys.2023.1208324 kostenfrei https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfields_unstemmed	10.3389/fphys.2023.1208324 doi (DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1 DE-627 ger DE-627 rakwb eng QP1-981 Katie S. McCullar verfasserin aut Timing of diuretic administration effects on urine volume in hospitalized patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology Katie S. McCullar verfasserin aut Sara Abbaspour verfasserin aut Sara Abbaspour verfasserin aut Wei Wang verfasserin aut Wei Wang verfasserin aut Aaron D. Aguirre verfasserin aut M. Brandon Westover verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2024) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2024 https://doi.org/10.3389/fphys.2023.1208324 kostenfrei https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsGer	10.3389/fphys.2023.1208324 doi (DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1 DE-627 ger DE-627 rakwb eng QP1-981 Katie S. McCullar verfasserin aut Timing of diuretic administration effects on urine volume in hospitalized patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology Katie S. McCullar verfasserin aut Sara Abbaspour verfasserin aut Sara Abbaspour verfasserin aut Wei Wang verfasserin aut Wei Wang verfasserin aut Aaron D. Aguirre verfasserin aut M. Brandon Westover verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2024) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2024 https://doi.org/10.3389/fphys.2023.1208324 kostenfrei https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsSound	10.3389/fphys.2023.1208324 doi (DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1 DE-627 ger DE-627 rakwb eng QP1-981 Katie S. McCullar verfasserin aut Timing of diuretic administration effects on urine volume in hospitalized patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes. chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology Katie S. McCullar verfasserin aut Sara Abbaspour verfasserin aut Sara Abbaspour verfasserin aut Wei Wang verfasserin aut Wei Wang verfasserin aut Aaron D. Aguirre verfasserin aut M. Brandon Westover verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut Elizabeth B. Klerman verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2024) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2024 https://doi.org/10.3389/fphys.2023.1208324 kostenfrei https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
language	English
source	In Frontiers in Physiology 14(2024) volume:14 year:2024
sourceStr	In Frontiers in Physiology 14(2024) volume:14 year:2024
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topic_facet	chronotherapeutic circadian medicine diuretics renal outcomes inpatients Physiology
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container_title	Frontiers in Physiology
authorswithroles_txt_mv	Katie S. McCullar @@aut@@ Sara Abbaspour @@aut@@ Wei Wang @@aut@@ Aaron D. Aguirre @@aut@@ M. Brandon Westover @@aut@@ Elizabeth B. Klerman @@aut@@
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topic_title	QP1-981 Timing of diuretic administration effects on urine volume in hospitalized patients chronotherapeutic circadian medicine diuretics renal outcomes inpatients
topic	misc QP1-981 misc chronotherapeutic misc circadian medicine misc diuretics misc renal outcomes misc inpatients misc Physiology
topic_unstemmed	misc QP1-981 misc chronotherapeutic misc circadian medicine misc diuretics misc renal outcomes misc inpatients misc Physiology
topic_browse	misc QP1-981 misc chronotherapeutic misc circadian medicine misc diuretics misc renal outcomes misc inpatients misc Physiology
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title	Timing of diuretic administration effects on urine volume in hospitalized patients
ctrlnum	(DE-627)DOAJ096557028 (DE-599)DOAJec78e524bc2147edb20feda2ec34a4d1
title_full	Timing of diuretic administration effects on urine volume in hospitalized patients
author_sort	Katie S. McCullar
journal	Frontiers in Physiology
journalStr	Frontiers in Physiology
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author_browse	Katie S. McCullar Sara Abbaspour Wei Wang Aaron D. Aguirre M. Brandon Westover Elizabeth B. Klerman
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author-letter	Katie S. McCullar
doi_str_mv	10.3389/fphys.2023.1208324
author2-role	verfasserin
title_sort	timing of diuretic administration effects on urine volume in hospitalized patients
callnumber	QP1-981
title_auth	Timing of diuretic administration effects on urine volume in hospitalized patients
abstract	Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes.
abstractGer	Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes.
abstract_unstemmed	Importance: Some medications have effects that depend on the time of day they are given. Current knowledge of the time-of-day effects of specific medications in hospitalized patients with cardiovascular disease is very limited. In hospitalized patients, increased medication efficiency might reduce dose (and associated side effects) and/or the length of time in the Intensive Care Unit (ICU) or hospital–potentially improving patient outcomes and patient and family quality of life and reducing financial costs. We studied whether the time of day or night patients in Cardiac or Intensive Care Units receive a diuretic affects urine volume.Methods: In this observational study, data were collected from 7,685 patients (63% male, 18 to 98 years old) admitted to one hospital’s Acute Care Cardiac units, Cardiac ICUs, Cardiac Surgery ICUs, and/or Non-cardiac ICUs who received intravenous furosemide (a diuretic), had measurements of urine volume, were hospitalized for ≥3 days between January 2016 to July 2021 and were older than 18 years. The outcomes of interest were urine volume normalized by the most recent (not older than 24 h) weight or body mass index (BMI), (i) in the hour after the time of diuretic administration, and (ii) when no diuretics were administered for the previous 3 h.Results: We identified diuretic medication administration time 23:00–04:59 as a predictor of higher urine volume response. For patients without recent diuretic medication, higher urine volume was predicted 11:00–16:59 and 17:00–22:59. Other factors that affected urine volume response to the diuretic were sex, age, medication dose, creatinine concentration, diagnoses, and hospital unit.Discussion: Time-of-day of medication administration may be a factor associated with increased medication efficiency. Randomized controlled trials should be conducted to quantify the relative effect of modifiable factors, such as time of medication administration, that may affect short- and longer-term outcomes.
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title_short	Timing of diuretic administration effects on urine volume in hospitalized patients
url	https://doi.org/10.3389/fphys.2023.1208324 https://doaj.org/article/ec78e524bc2147edb20feda2ec34a4d1 https://www.frontiersin.org/articles/10.3389/fphys.2023.1208324/full https://doaj.org/toc/1664-042X
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author2	Katie S. McCullar Sara Abbaspour Wei Wang Aaron D. Aguirre M. Brandon Westover Elizabeth B. Klerman
author2Str	Katie S. McCullar Sara Abbaspour Wei Wang Aaron D. Aguirre M. Brandon Westover Elizabeth B. Klerman
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up_date	2024-07-03T20:50:10.279Z
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