The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment
Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Reg...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Winfried März [verfasserIn] Nina Schmidt [verfasserIn] Ira an Haack [verfasserIn] Alexander Dressel [verfasserIn] Tanja B. Grammer [verfasserIn] Marcus E. Kleber [verfasserIn] Andrea Baessler [verfasserIn] F. Ulrich Beil [verfasserIn] Ioanna Gouni-Berthold [verfasserIn] Ulrich Julius [verfasserIn] Ursula Kassner [verfasserIn] Julius L. Katzmann [verfasserIn] Gerald Klose [verfasserIn] Christel König [verfasserIn] Wolfgang Koenig [verfasserIn] Ann-Cathrin Koschker [verfasserIn] Ulrich Laufs [verfasserIn] Martin Merkel [verfasserIn] Britta Otte [verfasserIn] Klaus G. Parhofer [verfasserIn] Wibke Hengstenberg [verfasserIn] Heribert Schunkert [verfasserIn] Ksenija Stach-Jablonski [verfasserIn] Elisabeth Steinhagen-Thiessen [verfasserIn] Christoph B. Olivier [verfasserIn] Harry Hahmann [verfasserIn] Stefan Krzossok [verfasserIn] Anja Vogt [verfasserIn] Dirk Müller-Wieland [verfasserIn] Ulrike Schatz [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Atherosclerosis Plus - Elsevier, 2021, 53(2023), Seite 6-15 |
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| Übergeordnetes Werk: |
volume:53 ; year:2023 ; pages:6-15 |
| Links: |
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| DOI / URN: |
10.1016/j.athplu.2023.06.001 |
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| Katalog-ID: |
DOAJ096656034 |
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| 245 | 1 | 4 | |a The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment |
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| 520 | |a Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. | ||
| 650 | 4 | |a Familial hypercholesterolemia | |
| 650 | 4 | |a Cascade screening | |
| 650 | 4 | |a Patient registry | |
| 650 | 4 | |a Low-density lipoproteins | |
| 650 | 4 | |a Cardiovascular risk | |
| 650 | 4 | |a Treatment | |
| 653 | 0 | |a Diseases of the circulatory (Cardiovascular) system | |
| 700 | 0 | |a Nina Schmidt |e verfasserin |4 aut | |
| 700 | 0 | |a Ira an Haack |e verfasserin |4 aut | |
| 700 | 0 | |a Alexander Dressel |e verfasserin |4 aut | |
| 700 | 0 | |a Tanja B. Grammer |e verfasserin |4 aut | |
| 700 | 0 | |a Marcus E. Kleber |e verfasserin |4 aut | |
| 700 | 0 | |a Andrea Baessler |e verfasserin |4 aut | |
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| 700 | 0 | |a Julius L. Katzmann |e verfasserin |4 aut | |
| 700 | 0 | |a Gerald Klose |e verfasserin |4 aut | |
| 700 | 0 | |a Christel König |e verfasserin |4 aut | |
| 700 | 0 | |a Wolfgang Koenig |e verfasserin |4 aut | |
| 700 | 0 | |a Ann-Cathrin Koschker |e verfasserin |4 aut | |
| 700 | 0 | |a Ulrich Laufs |e verfasserin |4 aut | |
| 700 | 0 | |a Martin Merkel |e verfasserin |4 aut | |
| 700 | 0 | |a Britta Otte |e verfasserin |4 aut | |
| 700 | 0 | |a Klaus G. Parhofer |e verfasserin |4 aut | |
| 700 | 0 | |a Wibke Hengstenberg |e verfasserin |4 aut | |
| 700 | 0 | |a Heribert Schunkert |e verfasserin |4 aut | |
| 700 | 0 | |a Ksenija Stach-Jablonski |e verfasserin |4 aut | |
| 700 | 0 | |a Elisabeth Steinhagen-Thiessen |e verfasserin |4 aut | |
| 700 | 0 | |a Christoph B. Olivier |e verfasserin |4 aut | |
| 700 | 0 | |a Harry Hahmann |e verfasserin |4 aut | |
| 700 | 0 | |a Stefan Krzossok |e verfasserin |4 aut | |
| 700 | 0 | |a Anja Vogt |e verfasserin |4 aut | |
| 700 | 0 | |a Dirk Müller-Wieland |e verfasserin |4 aut | |
| 700 | 0 | |a Ulrike Schatz |e verfasserin |4 aut | |
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10.1016/j.athplu.2023.06.001 doi (DE-627)DOAJ096656034 (DE-599)DOAJ44abb781f75e4c768e1caf7b413b15bf DE-627 ger DE-627 rakwb eng RC666-701 Winfried März verfasserin aut The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment Diseases of the circulatory (Cardiovascular) system Nina Schmidt verfasserin aut Ira an Haack verfasserin aut Alexander Dressel verfasserin aut Tanja B. Grammer verfasserin aut Marcus E. Kleber verfasserin aut Andrea Baessler verfasserin aut F. Ulrich Beil verfasserin aut Ioanna Gouni-Berthold verfasserin aut Ulrich Julius verfasserin aut Ursula Kassner verfasserin aut Julius L. Katzmann verfasserin aut Gerald Klose verfasserin aut Christel König verfasserin aut Wolfgang Koenig verfasserin aut Ann-Cathrin Koschker verfasserin aut Ulrich Laufs verfasserin aut Martin Merkel verfasserin aut Britta Otte verfasserin aut Klaus G. Parhofer verfasserin aut Wibke Hengstenberg verfasserin aut Heribert Schunkert verfasserin aut Ksenija Stach-Jablonski verfasserin aut Elisabeth Steinhagen-Thiessen verfasserin aut Christoph B. Olivier verfasserin aut Harry Hahmann verfasserin aut Stefan Krzossok verfasserin aut Anja Vogt verfasserin aut Dirk Müller-Wieland verfasserin aut Ulrike Schatz verfasserin aut In Atherosclerosis Plus Elsevier, 2021 53(2023), Seite 6-15 (DE-627)178447987X 26670895 nnns volume:53 year:2023 pages:6-15 https://doi.org/10.1016/j.athplu.2023.06.001 kostenfrei https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf kostenfrei http://www.sciencedirect.com/science/article/pii/S2667089523000093 kostenfrei https://doaj.org/toc/2667-0895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 53 2023 6-15 |
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10.1016/j.athplu.2023.06.001 doi (DE-627)DOAJ096656034 (DE-599)DOAJ44abb781f75e4c768e1caf7b413b15bf DE-627 ger DE-627 rakwb eng RC666-701 Winfried März verfasserin aut The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment Diseases of the circulatory (Cardiovascular) system Nina Schmidt verfasserin aut Ira an Haack verfasserin aut Alexander Dressel verfasserin aut Tanja B. Grammer verfasserin aut Marcus E. Kleber verfasserin aut Andrea Baessler verfasserin aut F. Ulrich Beil verfasserin aut Ioanna Gouni-Berthold verfasserin aut Ulrich Julius verfasserin aut Ursula Kassner verfasserin aut Julius L. Katzmann verfasserin aut Gerald Klose verfasserin aut Christel König verfasserin aut Wolfgang Koenig verfasserin aut Ann-Cathrin Koschker verfasserin aut Ulrich Laufs verfasserin aut Martin Merkel verfasserin aut Britta Otte verfasserin aut Klaus G. Parhofer verfasserin aut Wibke Hengstenberg verfasserin aut Heribert Schunkert verfasserin aut Ksenija Stach-Jablonski verfasserin aut Elisabeth Steinhagen-Thiessen verfasserin aut Christoph B. Olivier verfasserin aut Harry Hahmann verfasserin aut Stefan Krzossok verfasserin aut Anja Vogt verfasserin aut Dirk Müller-Wieland verfasserin aut Ulrike Schatz verfasserin aut In Atherosclerosis Plus Elsevier, 2021 53(2023), Seite 6-15 (DE-627)178447987X 26670895 nnns volume:53 year:2023 pages:6-15 https://doi.org/10.1016/j.athplu.2023.06.001 kostenfrei https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf kostenfrei http://www.sciencedirect.com/science/article/pii/S2667089523000093 kostenfrei https://doaj.org/toc/2667-0895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 53 2023 6-15 |
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10.1016/j.athplu.2023.06.001 doi (DE-627)DOAJ096656034 (DE-599)DOAJ44abb781f75e4c768e1caf7b413b15bf DE-627 ger DE-627 rakwb eng RC666-701 Winfried März verfasserin aut The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment Diseases of the circulatory (Cardiovascular) system Nina Schmidt verfasserin aut Ira an Haack verfasserin aut Alexander Dressel verfasserin aut Tanja B. Grammer verfasserin aut Marcus E. Kleber verfasserin aut Andrea Baessler verfasserin aut F. Ulrich Beil verfasserin aut Ioanna Gouni-Berthold verfasserin aut Ulrich Julius verfasserin aut Ursula Kassner verfasserin aut Julius L. Katzmann verfasserin aut Gerald Klose verfasserin aut Christel König verfasserin aut Wolfgang Koenig verfasserin aut Ann-Cathrin Koschker verfasserin aut Ulrich Laufs verfasserin aut Martin Merkel verfasserin aut Britta Otte verfasserin aut Klaus G. Parhofer verfasserin aut Wibke Hengstenberg verfasserin aut Heribert Schunkert verfasserin aut Ksenija Stach-Jablonski verfasserin aut Elisabeth Steinhagen-Thiessen verfasserin aut Christoph B. Olivier verfasserin aut Harry Hahmann verfasserin aut Stefan Krzossok verfasserin aut Anja Vogt verfasserin aut Dirk Müller-Wieland verfasserin aut Ulrike Schatz verfasserin aut In Atherosclerosis Plus Elsevier, 2021 53(2023), Seite 6-15 (DE-627)178447987X 26670895 nnns volume:53 year:2023 pages:6-15 https://doi.org/10.1016/j.athplu.2023.06.001 kostenfrei https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf kostenfrei http://www.sciencedirect.com/science/article/pii/S2667089523000093 kostenfrei https://doaj.org/toc/2667-0895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 53 2023 6-15 |
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10.1016/j.athplu.2023.06.001 doi (DE-627)DOAJ096656034 (DE-599)DOAJ44abb781f75e4c768e1caf7b413b15bf DE-627 ger DE-627 rakwb eng RC666-701 Winfried März verfasserin aut The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment Diseases of the circulatory (Cardiovascular) system Nina Schmidt verfasserin aut Ira an Haack verfasserin aut Alexander Dressel verfasserin aut Tanja B. Grammer verfasserin aut Marcus E. Kleber verfasserin aut Andrea Baessler verfasserin aut F. Ulrich Beil verfasserin aut Ioanna Gouni-Berthold verfasserin aut Ulrich Julius verfasserin aut Ursula Kassner verfasserin aut Julius L. Katzmann verfasserin aut Gerald Klose verfasserin aut Christel König verfasserin aut Wolfgang Koenig verfasserin aut Ann-Cathrin Koschker verfasserin aut Ulrich Laufs verfasserin aut Martin Merkel verfasserin aut Britta Otte verfasserin aut Klaus G. Parhofer verfasserin aut Wibke Hengstenberg verfasserin aut Heribert Schunkert verfasserin aut Ksenija Stach-Jablonski verfasserin aut Elisabeth Steinhagen-Thiessen verfasserin aut Christoph B. Olivier verfasserin aut Harry Hahmann verfasserin aut Stefan Krzossok verfasserin aut Anja Vogt verfasserin aut Dirk Müller-Wieland verfasserin aut Ulrike Schatz verfasserin aut In Atherosclerosis Plus Elsevier, 2021 53(2023), Seite 6-15 (DE-627)178447987X 26670895 nnns volume:53 year:2023 pages:6-15 https://doi.org/10.1016/j.athplu.2023.06.001 kostenfrei https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf kostenfrei http://www.sciencedirect.com/science/article/pii/S2667089523000093 kostenfrei https://doaj.org/toc/2667-0895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 53 2023 6-15 |
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10.1016/j.athplu.2023.06.001 doi (DE-627)DOAJ096656034 (DE-599)DOAJ44abb781f75e4c768e1caf7b413b15bf DE-627 ger DE-627 rakwb eng RC666-701 Winfried März verfasserin aut The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment Diseases of the circulatory (Cardiovascular) system Nina Schmidt verfasserin aut Ira an Haack verfasserin aut Alexander Dressel verfasserin aut Tanja B. Grammer verfasserin aut Marcus E. Kleber verfasserin aut Andrea Baessler verfasserin aut F. Ulrich Beil verfasserin aut Ioanna Gouni-Berthold verfasserin aut Ulrich Julius verfasserin aut Ursula Kassner verfasserin aut Julius L. Katzmann verfasserin aut Gerald Klose verfasserin aut Christel König verfasserin aut Wolfgang Koenig verfasserin aut Ann-Cathrin Koschker verfasserin aut Ulrich Laufs verfasserin aut Martin Merkel verfasserin aut Britta Otte verfasserin aut Klaus G. Parhofer verfasserin aut Wibke Hengstenberg verfasserin aut Heribert Schunkert verfasserin aut Ksenija Stach-Jablonski verfasserin aut Elisabeth Steinhagen-Thiessen verfasserin aut Christoph B. Olivier verfasserin aut Harry Hahmann verfasserin aut Stefan Krzossok verfasserin aut Anja Vogt verfasserin aut Dirk Müller-Wieland verfasserin aut Ulrike Schatz verfasserin aut In Atherosclerosis Plus Elsevier, 2021 53(2023), Seite 6-15 (DE-627)178447987X 26670895 nnns volume:53 year:2023 pages:6-15 https://doi.org/10.1016/j.athplu.2023.06.001 kostenfrei https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf kostenfrei http://www.sciencedirect.com/science/article/pii/S2667089523000093 kostenfrei https://doaj.org/toc/2667-0895 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 53 2023 6-15 |
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Winfried März @@aut@@ Nina Schmidt @@aut@@ Ira an Haack @@aut@@ Alexander Dressel @@aut@@ Tanja B. Grammer @@aut@@ Marcus E. Kleber @@aut@@ Andrea Baessler @@aut@@ F. Ulrich Beil @@aut@@ Ioanna Gouni-Berthold @@aut@@ Ulrich Julius @@aut@@ Ursula Kassner @@aut@@ Julius L. Katzmann @@aut@@ Gerald Klose @@aut@@ Christel König @@aut@@ Wolfgang Koenig @@aut@@ Ann-Cathrin Koschker @@aut@@ Ulrich Laufs @@aut@@ Martin Merkel @@aut@@ Britta Otte @@aut@@ Klaus G. Parhofer @@aut@@ Wibke Hengstenberg @@aut@@ Heribert Schunkert @@aut@@ Ksenija Stach-Jablonski @@aut@@ Elisabeth Steinhagen-Thiessen @@aut@@ Christoph B. Olivier @@aut@@ Harry Hahmann @@aut@@ Stefan Krzossok @@aut@@ Anja Vogt @@aut@@ Dirk Müller-Wieland @@aut@@ Ulrike Schatz @@aut@@ |
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However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. 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R - Medicine |
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Winfried März |
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Winfried März misc RC666-701 misc Familial hypercholesterolemia misc Cascade screening misc Patient registry misc Low-density lipoproteins misc Cardiovascular risk misc Treatment misc Diseases of the circulatory (Cardiovascular) system The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment |
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RC666-701 The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment Familial hypercholesterolemia Cascade screening Patient registry Low-density lipoproteins Cardiovascular risk Treatment |
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misc RC666-701 misc Familial hypercholesterolemia misc Cascade screening misc Patient registry misc Low-density lipoproteins misc Cardiovascular risk misc Treatment misc Diseases of the circulatory (Cardiovascular) system |
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The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment |
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Winfried März |
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Winfried März Nina Schmidt Ira an Haack Alexander Dressel Tanja B. Grammer Marcus E. Kleber Andrea Baessler F. Ulrich Beil Ioanna Gouni-Berthold Ulrich Julius Ursula Kassner Julius L. Katzmann Gerald Klose Christel König Wolfgang Koenig Ann-Cathrin Koschker Ulrich Laufs Martin Merkel Britta Otte Klaus G. Parhofer Wibke Hengstenberg Heribert Schunkert Ksenija Stach-Jablonski Elisabeth Steinhagen-Thiessen Christoph B. Olivier Harry Hahmann Stefan Krzossok Anja Vogt Dirk Müller-Wieland Ulrike Schatz |
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german care high registry for familial hypercholesterolemia – sex differences, treatment strategies, and target value attainment |
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RC666-701 |
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The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment |
| abstract |
Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. |
| abstractGer |
Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. |
| abstract_unstemmed |
Background and aims: Familial hypercholesterolemia (FH) is among the most common genetic disorders in primary care. However, only 15% or less of patients are diagnosed, and few achieve the goals for low-density lipoprotein cholesterol (LDL-C). In this analysis of the German Cascade Screening and Registry for High Cholesterol (CaRe High), we examined the status of lipid management, treatment strategies, and LDL-C goal attainment according to the ESC/EAS dyslipidemia guidelines. Methods: We evaluated consolidated datasets from 1501 FH patients diagnosed clinically and seen either by lipid specialists or general practitioners and internists. We conducted a questionnaire survey of both the recruiting physicians and patients. Results: Among the 1501 patients, 86% regularly received lipid-lowering drugs. LDL-C goals were achieved by 26% and 10% of patients with atherosclerotic cardiovascular disease (ASCVD) according to the 2016 and 2019 ESC/EAS dyslipidemia guidelines, respectively. High intensity lipid-lowering was administered more often in men than in women, in patients with ASCVD, at higher LDL-C and in patients with a genetic diagnosis of FH. Conclusions: FH is under-treated in Germany compared to guideline recommendations. Male gender, genetic proof of FH, treatment by a specialist, and presence of ASCVD appear to be associated with increased treatment intensity. Achieving the LDL-C goals of the 2019 ESC/EAS dyslipidemia guidelines remains challenging if pre-treatment LDL-C is very high. |
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| title_short |
The German CaRe high registry for familial hypercholesterolemia – Sex differences, treatment strategies, and target value attainment |
| url |
https://doi.org/10.1016/j.athplu.2023.06.001 https://doaj.org/article/44abb781f75e4c768e1caf7b413b15bf http://www.sciencedirect.com/science/article/pii/S2667089523000093 https://doaj.org/toc/2667-0895 |
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true |
| author2 |
Nina Schmidt Ira an Haack Alexander Dressel Tanja B. Grammer Marcus E. Kleber Andrea Baessler F. Ulrich Beil Ioanna Gouni-Berthold Ulrich Julius Ursula Kassner Julius L. Katzmann Gerald Klose Christel König Wolfgang Koenig Ann-Cathrin Koschker Ulrich Laufs Martin Merkel Britta Otte Klaus G. Parhofer Wibke Hengstenberg Heribert Schunkert Ksenija Stach-Jablonski Elisabeth Steinhagen-Thiessen Christoph B. Olivier Harry Hahmann Stefan Krzossok Anja Vogt Dirk Müller-Wieland Ulrike Schatz |
| author2Str |
Nina Schmidt Ira an Haack Alexander Dressel Tanja B. Grammer Marcus E. Kleber Andrea Baessler F. Ulrich Beil Ioanna Gouni-Berthold Ulrich Julius Ursula Kassner Julius L. Katzmann Gerald Klose Christel König Wolfgang Koenig Ann-Cathrin Koschker Ulrich Laufs Martin Merkel Britta Otte Klaus G. Parhofer Wibke Hengstenberg Heribert Schunkert Ksenija Stach-Jablonski Elisabeth Steinhagen-Thiessen Christoph B. Olivier Harry Hahmann Stefan Krzossok Anja Vogt Dirk Müller-Wieland Ulrike Schatz |
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178447987X |
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RC - Internal Medicine |
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c |
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true |
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| doi_str |
10.1016/j.athplu.2023.06.001 |
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RC666-701 |
| up_date |
2024-07-03T21:22:16.970Z |
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| score |
7.399703 |