T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults
IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lo...
Ausführliche Beschreibung
Autor*in: |
Bruno Salaun [verfasserIn] Jonathan De Smedt [verfasserIn] Charlotte Vernhes [verfasserIn] Annick Moureau [verfasserIn] Deniz Öner [verfasserIn] Arangassery Rosemary Bastian [verfasserIn] Michel Janssens [verfasserIn] Sunita Balla-Jhagjhoorsingh [verfasserIn] Jeroen Aerssens [verfasserIn] Christophe Lambert [verfasserIn] Samuel Coenen [verfasserIn] Christopher C. Butler [verfasserIn] Simon B. Drysdale [verfasserIn] Joanne G. Wildenbeest [verfasserIn] Andrew J. Pollard [verfasserIn] Peter J. M. Openshaw [verfasserIn] Louis Bont [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2023 |
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In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023) |
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Übergeordnetes Werk: |
volume:14 ; year:2023 |
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DOI / URN: |
10.3389/fimmu.2023.1260146 |
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Katalog-ID: |
DOAJ096755466 |
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245 | 1 | 2 | |a T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
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520 | |a IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. | ||
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650 | 4 | |a cell-mediated immunity | |
650 | 4 | |a correlate of protection | |
650 | 4 | |a interferon-gamma | |
650 | 4 | |a T-cell memory | |
650 | 4 | |a CD4+ T cell | |
653 | 0 | |a Immunologic diseases. Allergy | |
700 | 0 | |a Jonathan De Smedt |e verfasserin |4 aut | |
700 | 0 | |a Charlotte Vernhes |e verfasserin |4 aut | |
700 | 0 | |a Annick Moureau |e verfasserin |4 aut | |
700 | 0 | |a Deniz Öner |e verfasserin |4 aut | |
700 | 0 | |a Arangassery Rosemary Bastian |e verfasserin |4 aut | |
700 | 0 | |a Michel Janssens |e verfasserin |4 aut | |
700 | 0 | |a Sunita Balla-Jhagjhoorsingh |e verfasserin |4 aut | |
700 | 0 | |a Jeroen Aerssens |e verfasserin |4 aut | |
700 | 0 | |a Christophe Lambert |e verfasserin |4 aut | |
700 | 0 | |a Samuel Coenen |e verfasserin |4 aut | |
700 | 0 | |a Samuel Coenen |e verfasserin |4 aut | |
700 | 0 | |a Christopher C. Butler |e verfasserin |4 aut | |
700 | 0 | |a Simon B. Drysdale |e verfasserin |4 aut | |
700 | 0 | |a Joanne G. Wildenbeest |e verfasserin |4 aut | |
700 | 0 | |a Andrew J. Pollard |e verfasserin |4 aut | |
700 | 0 | |a Peter J. M. Openshaw |e verfasserin |4 aut | |
700 | 0 | |a Louis Bont |e verfasserin |4 aut | |
700 | 0 | |a Louis Bont |e verfasserin |4 aut | |
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10.3389/fimmu.2023.1260146 doi (DE-627)DOAJ096755466 (DE-599)DOAJ67a78a025c7a47168be51ac3c6f1535b DE-627 ger DE-627 rakwb eng RC581-607 Bruno Salaun verfasserin aut T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. respiratory syncytial virus cell-mediated immunity correlate of protection interferon-gamma T-cell memory CD4+ T cell Immunologic diseases. Allergy Jonathan De Smedt verfasserin aut Charlotte Vernhes verfasserin aut Annick Moureau verfasserin aut Deniz Öner verfasserin aut Arangassery Rosemary Bastian verfasserin aut Michel Janssens verfasserin aut Sunita Balla-Jhagjhoorsingh verfasserin aut Jeroen Aerssens verfasserin aut Christophe Lambert verfasserin aut Samuel Coenen verfasserin aut Samuel Coenen verfasserin aut Christopher C. Butler verfasserin aut Simon B. Drysdale verfasserin aut Joanne G. Wildenbeest verfasserin aut Andrew J. Pollard verfasserin aut Peter J. M. Openshaw verfasserin aut Louis Bont verfasserin aut Louis Bont verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1260146 kostenfrei https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1260146 doi (DE-627)DOAJ096755466 (DE-599)DOAJ67a78a025c7a47168be51ac3c6f1535b DE-627 ger DE-627 rakwb eng RC581-607 Bruno Salaun verfasserin aut T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. respiratory syncytial virus cell-mediated immunity correlate of protection interferon-gamma T-cell memory CD4+ T cell Immunologic diseases. Allergy Jonathan De Smedt verfasserin aut Charlotte Vernhes verfasserin aut Annick Moureau verfasserin aut Deniz Öner verfasserin aut Arangassery Rosemary Bastian verfasserin aut Michel Janssens verfasserin aut Sunita Balla-Jhagjhoorsingh verfasserin aut Jeroen Aerssens verfasserin aut Christophe Lambert verfasserin aut Samuel Coenen verfasserin aut Samuel Coenen verfasserin aut Christopher C. Butler verfasserin aut Simon B. Drysdale verfasserin aut Joanne G. Wildenbeest verfasserin aut Andrew J. Pollard verfasserin aut Peter J. M. Openshaw verfasserin aut Louis Bont verfasserin aut Louis Bont verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1260146 kostenfrei https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1260146 doi (DE-627)DOAJ096755466 (DE-599)DOAJ67a78a025c7a47168be51ac3c6f1535b DE-627 ger DE-627 rakwb eng RC581-607 Bruno Salaun verfasserin aut T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. respiratory syncytial virus cell-mediated immunity correlate of protection interferon-gamma T-cell memory CD4+ T cell Immunologic diseases. Allergy Jonathan De Smedt verfasserin aut Charlotte Vernhes verfasserin aut Annick Moureau verfasserin aut Deniz Öner verfasserin aut Arangassery Rosemary Bastian verfasserin aut Michel Janssens verfasserin aut Sunita Balla-Jhagjhoorsingh verfasserin aut Jeroen Aerssens verfasserin aut Christophe Lambert verfasserin aut Samuel Coenen verfasserin aut Samuel Coenen verfasserin aut Christopher C. Butler verfasserin aut Simon B. Drysdale verfasserin aut Joanne G. Wildenbeest verfasserin aut Andrew J. Pollard verfasserin aut Peter J. M. Openshaw verfasserin aut Louis Bont verfasserin aut Louis Bont verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1260146 kostenfrei https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1260146 doi (DE-627)DOAJ096755466 (DE-599)DOAJ67a78a025c7a47168be51ac3c6f1535b DE-627 ger DE-627 rakwb eng RC581-607 Bruno Salaun verfasserin aut T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. respiratory syncytial virus cell-mediated immunity correlate of protection interferon-gamma T-cell memory CD4+ T cell Immunologic diseases. Allergy Jonathan De Smedt verfasserin aut Charlotte Vernhes verfasserin aut Annick Moureau verfasserin aut Deniz Öner verfasserin aut Arangassery Rosemary Bastian verfasserin aut Michel Janssens verfasserin aut Sunita Balla-Jhagjhoorsingh verfasserin aut Jeroen Aerssens verfasserin aut Christophe Lambert verfasserin aut Samuel Coenen verfasserin aut Samuel Coenen verfasserin aut Christopher C. Butler verfasserin aut Simon B. Drysdale verfasserin aut Joanne G. Wildenbeest verfasserin aut Andrew J. Pollard verfasserin aut Peter J. M. Openshaw verfasserin aut Louis Bont verfasserin aut Louis Bont verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1260146 kostenfrei https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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10.3389/fimmu.2023.1260146 doi (DE-627)DOAJ096755466 (DE-599)DOAJ67a78a025c7a47168be51ac3c6f1535b DE-627 ger DE-627 rakwb eng RC581-607 Bruno Salaun verfasserin aut T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. respiratory syncytial virus cell-mediated immunity correlate of protection interferon-gamma T-cell memory CD4+ T cell Immunologic diseases. Allergy Jonathan De Smedt verfasserin aut Charlotte Vernhes verfasserin aut Annick Moureau verfasserin aut Deniz Öner verfasserin aut Arangassery Rosemary Bastian verfasserin aut Michel Janssens verfasserin aut Sunita Balla-Jhagjhoorsingh verfasserin aut Jeroen Aerssens verfasserin aut Christophe Lambert verfasserin aut Samuel Coenen verfasserin aut Samuel Coenen verfasserin aut Christopher C. Butler verfasserin aut Simon B. Drysdale verfasserin aut Joanne G. Wildenbeest verfasserin aut Andrew J. Pollard verfasserin aut Peter J. M. Openshaw verfasserin aut Louis Bont verfasserin aut Louis Bont verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1260146 kostenfrei https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023 |
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Bruno Salaun @@aut@@ Jonathan De Smedt @@aut@@ Charlotte Vernhes @@aut@@ Annick Moureau @@aut@@ Deniz Öner @@aut@@ Arangassery Rosemary Bastian @@aut@@ Michel Janssens @@aut@@ Sunita Balla-Jhagjhoorsingh @@aut@@ Jeroen Aerssens @@aut@@ Christophe Lambert @@aut@@ Samuel Coenen @@aut@@ Christopher C. Butler @@aut@@ Simon B. Drysdale @@aut@@ Joanne G. Wildenbeest @@aut@@ Andrew J. Pollard @@aut@@ Peter J. M. Openshaw @@aut@@ Louis Bont @@aut@@ |
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T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
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T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
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Bruno Salaun |
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Bruno Salaun Jonathan De Smedt Charlotte Vernhes Annick Moureau Deniz Öner Arangassery Rosemary Bastian Michel Janssens Sunita Balla-Jhagjhoorsingh Jeroen Aerssens Christophe Lambert Samuel Coenen Christopher C. Butler Simon B. Drysdale Joanne G. Wildenbeest Andrew J. Pollard Peter J. M. Openshaw Louis Bont |
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cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
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T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
abstract |
IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. |
abstractGer |
IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. |
abstract_unstemmed |
IntroductionThe immune mechanisms supporting partial protection from reinfection and disease by the respiratory syncytial virus (RSV) have not been fully characterized. In older adults, symptoms are typically mild but can be serious in patients with comorbidities when the infection extends to the lower respiratory tract.MethodsThis study formed part of the RESCEU older-adults prospective-cohort study in Northern Europe (2017–2019; NCT03621930) in which a thousand participants were followed over an RSV season. Peripheral-blood samples (taken pre-season, post-season, during illness and convalescence) were analyzed from participants who (i) had a symptomatic acute respiratory tract infection by RSV (RSV-ARTI; N=35) or (ii) asymptomatic RSV infection (RSV-Asymptomatic; N=16). These analyses included evaluations of antibody (Fc-mediated–) functional features and cell-mediated immunity, in which univariate and machine-learning (ML) models were used to explore differences between groups.ResultsPre–RSV-season peripheral-blood biomarkers were predictive of symptomatic RSV infection. T-cell data were more predictive than functional antibody data (area under receiver operating characteristic curve [AUROC] for the models were 99% and 76%, respectively). The pre-RSV season T-cell phenotypes which were selected by the ML modelling and which were more frequent in RSV-Asymptomatic group than in the RSV-ARTI group, coincided with prominent phenotypes identified during convalescence from RSV-ARTI (e.g., IFN-γ+, TNF-α+ and CD40L+ for CD4+, and IFN-γ+ and 4-1BB+ for CD8+).ConclusionThe evaluation and statistical modelling of numerous immunological parameters over the RSV season suggests a primary role of cellular immunity in preventing symptomatic RSV infections in older adults. |
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title_short |
T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults |
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https://doi.org/10.3389/fimmu.2023.1260146 https://doaj.org/article/67a78a025c7a47168be51ac3c6f1535b https://www.frontiersin.org/articles/10.3389/fimmu.2023.1260146/full https://doaj.org/toc/1664-3224 |
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Jonathan De Smedt Charlotte Vernhes Annick Moureau Deniz Öner Arangassery Rosemary Bastian Michel Janssens Sunita Balla-Jhagjhoorsingh Jeroen Aerssens Christophe Lambert Samuel Coenen Christopher C. Butler Simon B. Drysdale Joanne G. Wildenbeest Andrew J. Pollard Peter J. M. Openshaw Louis Bont |
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