The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies

STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating oppo...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Weiyuan Wang [verfasserIn] Melanie Cristina Lopez McDonald [verfasserIn] Christine Kim [verfasserIn] Mirielle Ma [verfasserIn] Zetao (Tommy) Pan [verfasserIn] Charlotte Kaufmann [verfasserIn] David A. Frank [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	cancer oncology transcription factors signal transduction tumor immunology protein phosphorylation

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2023.1265818

Katalog-ID:	DOAJ096961538

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allfieldsSound	10.3389/fimmu.2023.1265818 doi (DE-627)DOAJ096961538 (DE-599)DOAJ2ac65bb4e95345bf9fb32aa27da84719 DE-627 ger DE-627 rakwb eng RC581-607 Weiyuan Wang verfasserin aut The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity. cancer oncology transcription factors signal transduction tumor immunology protein phosphorylation Immunologic diseases. Allergy Melanie Cristina Lopez McDonald verfasserin aut Christine Kim verfasserin aut Mirielle Ma verfasserin aut Zetao (Tommy) Pan verfasserin aut Charlotte Kaufmann verfasserin aut David A. Frank verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 14(2023) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:14 year:2023 https://doi.org/10.3389/fimmu.2023.1265818 kostenfrei https://doaj.org/article/2ac65bb4e95345bf9fb32aa27da84719 kostenfrei https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265818/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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topic_facet	cancer oncology transcription factors signal transduction tumor immunology protein phosphorylation Immunologic diseases. Allergy
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authorswithroles_txt_mv	Weiyuan Wang @@aut@@ Melanie Cristina Lopez McDonald @@aut@@ Christine Kim @@aut@@ Mirielle Ma @@aut@@ Zetao (Tommy) Pan @@aut@@ Charlotte Kaufmann @@aut@@ David A. Frank @@aut@@
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callnumber-first	R - Medicine
author	Weiyuan Wang
spellingShingle	Weiyuan Wang misc RC581-607 misc cancer misc oncology misc transcription factors misc signal transduction misc tumor immunology misc protein phosphorylation misc Immunologic diseases. Allergy The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
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topic_title	RC581-607 The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies cancer oncology transcription factors signal transduction tumor immunology protein phosphorylation
topic	misc RC581-607 misc cancer misc oncology misc transcription factors misc signal transduction misc tumor immunology misc protein phosphorylation misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc cancer misc oncology misc transcription factors misc signal transduction misc tumor immunology misc protein phosphorylation misc Immunologic diseases. Allergy
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title	The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
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title_full	The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
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title_sort	complementary roles of stat3 and stat1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
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title_auth	The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
abstract	STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity.
abstractGer	STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity.
abstract_unstemmed	STATs are a family of transcription factors that regulate many critical cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of STATs is frequently observed in tumors and can directly drive cancer pathogenesis. STAT1 and STAT3 are generally viewed as mediating opposite roles in cancer development, with STAT1 suppressing tumorigenesis and STAT3 promoting oncogenesis. In this review, we investigate the specific roles of STAT1 and STAT3 in normal physiology and cancer biology, explore their interactions with each other, and offer insights into therapeutic strategies through modulating their transcriptional activity.
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title_short	The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies
url	https://doi.org/10.3389/fimmu.2023.1265818 https://doaj.org/article/2ac65bb4e95345bf9fb32aa27da84719 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1265818/full https://doaj.org/toc/1664-3224
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