Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis

Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yaru Zhang [verfasserIn] Tingyu Yang [verfasserIn] Yuqiong He [verfasserIn] Fanchao Meng [verfasserIn] Kun Zhang [verfasserIn] Xingyue Jin [verfasserIn] Xilong Cui [verfasserIn] Xuerong Luo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Children and adolescents electroencephalogram N2 oscillations psychosis

Übergeordnetes Werk:	In: BJPsych Open - Cambridge University Press, 2018, 10(2024)
Übergeordnetes Werk:	volume:10 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1192/bjo.2024.32

Katalog-ID:	DOAJ097234567

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520			\|a Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.
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allfields	10.1192/bjo.2024.32 doi (DE-627)DOAJ097234567 (DE-599)DOAJc94a985f33f1459080ec64cf86808554 DE-627 ger DE-627 rakwb eng RC435-571 Yaru Zhang verfasserin aut Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis. Children and adolescents electroencephalogram N2 oscillations psychosis Psychiatry Tingyu Yang verfasserin aut Yuqiong He verfasserin aut Fanchao Meng verfasserin aut Kun Zhang verfasserin aut Xingyue Jin verfasserin aut Xilong Cui verfasserin aut Xuerong Luo verfasserin aut In BJPsych Open Cambridge University Press, 2018 10(2024) (DE-627)832781878 (DE-600)2829557-2 20564724 nnns volume:10 year:2024 https://doi.org/10.1192/bjo.2024.32 kostenfrei https://doaj.org/article/c94a985f33f1459080ec64cf86808554 kostenfrei https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article kostenfrei https://doaj.org/toc/2056-4724 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
spelling	10.1192/bjo.2024.32 doi (DE-627)DOAJ097234567 (DE-599)DOAJc94a985f33f1459080ec64cf86808554 DE-627 ger DE-627 rakwb eng RC435-571 Yaru Zhang verfasserin aut Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis. Children and adolescents electroencephalogram N2 oscillations psychosis Psychiatry Tingyu Yang verfasserin aut Yuqiong He verfasserin aut Fanchao Meng verfasserin aut Kun Zhang verfasserin aut Xingyue Jin verfasserin aut Xilong Cui verfasserin aut Xuerong Luo verfasserin aut In BJPsych Open Cambridge University Press, 2018 10(2024) (DE-627)832781878 (DE-600)2829557-2 20564724 nnns volume:10 year:2024 https://doi.org/10.1192/bjo.2024.32 kostenfrei https://doaj.org/article/c94a985f33f1459080ec64cf86808554 kostenfrei https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article kostenfrei https://doaj.org/toc/2056-4724 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfields_unstemmed	10.1192/bjo.2024.32 doi (DE-627)DOAJ097234567 (DE-599)DOAJc94a985f33f1459080ec64cf86808554 DE-627 ger DE-627 rakwb eng RC435-571 Yaru Zhang verfasserin aut Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis. Children and adolescents electroencephalogram N2 oscillations psychosis Psychiatry Tingyu Yang verfasserin aut Yuqiong He verfasserin aut Fanchao Meng verfasserin aut Kun Zhang verfasserin aut Xingyue Jin verfasserin aut Xilong Cui verfasserin aut Xuerong Luo verfasserin aut In BJPsych Open Cambridge University Press, 2018 10(2024) (DE-627)832781878 (DE-600)2829557-2 20564724 nnns volume:10 year:2024 https://doi.org/10.1192/bjo.2024.32 kostenfrei https://doaj.org/article/c94a985f33f1459080ec64cf86808554 kostenfrei https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article kostenfrei https://doaj.org/toc/2056-4724 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfieldsGer	10.1192/bjo.2024.32 doi (DE-627)DOAJ097234567 (DE-599)DOAJc94a985f33f1459080ec64cf86808554 DE-627 ger DE-627 rakwb eng RC435-571 Yaru Zhang verfasserin aut Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis. Children and adolescents electroencephalogram N2 oscillations psychosis Psychiatry Tingyu Yang verfasserin aut Yuqiong He verfasserin aut Fanchao Meng verfasserin aut Kun Zhang verfasserin aut Xingyue Jin verfasserin aut Xilong Cui verfasserin aut Xuerong Luo verfasserin aut In BJPsych Open Cambridge University Press, 2018 10(2024) (DE-627)832781878 (DE-600)2829557-2 20564724 nnns volume:10 year:2024 https://doi.org/10.1192/bjo.2024.32 kostenfrei https://doaj.org/article/c94a985f33f1459080ec64cf86808554 kostenfrei https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article kostenfrei https://doaj.org/toc/2056-4724 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
allfieldsSound	10.1192/bjo.2024.32 doi (DE-627)DOAJ097234567 (DE-599)DOAJc94a985f33f1459080ec64cf86808554 DE-627 ger DE-627 rakwb eng RC435-571 Yaru Zhang verfasserin aut Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis. Children and adolescents electroencephalogram N2 oscillations psychosis Psychiatry Tingyu Yang verfasserin aut Yuqiong He verfasserin aut Fanchao Meng verfasserin aut Kun Zhang verfasserin aut Xingyue Jin verfasserin aut Xilong Cui verfasserin aut Xuerong Luo verfasserin aut In BJPsych Open Cambridge University Press, 2018 10(2024) (DE-627)832781878 (DE-600)2829557-2 20564724 nnns volume:10 year:2024 https://doi.org/10.1192/bjo.2024.32 kostenfrei https://doaj.org/article/c94a985f33f1459080ec64cf86808554 kostenfrei https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article kostenfrei https://doaj.org/toc/2056-4724 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_374 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2024
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The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. 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callnumber-first	R - Medicine
author	Yaru Zhang
spellingShingle	Yaru Zhang misc RC435-571 misc Children and adolescents misc electroencephalogram misc N2 misc oscillations misc psychosis misc Psychiatry Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
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topic_title	RC435-571 Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis Children and adolescents electroencephalogram N2 oscillations psychosis
topic	misc RC435-571 misc Children and adolescents misc electroencephalogram misc N2 misc oscillations misc psychosis misc Psychiatry
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title	Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
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title_full	Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
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author_browse	Yaru Zhang Tingyu Yang Yuqiong He Fanchao Meng Kun Zhang Xingyue Jin Xilong Cui Xuerong Luo
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title_sort	abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
callnumber	RC435-571
title_auth	Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
abstract	Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.
abstractGer	Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.
abstract_unstemmed	Background Cognitive control deficits are one of the main symptoms of psychosis. The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.
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title_short	Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis
url	https://doi.org/10.1192/bjo.2024.32 https://doaj.org/article/c94a985f33f1459080ec64cf86808554 https://www.cambridge.org/core/product/identifier/S2056472424000322/type/journal_article https://doaj.org/toc/2056-4724
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author2	Tingyu Yang Yuqiong He Fanchao Meng Kun Zhang Xingyue Jin Xilong Cui Xuerong Luo
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doi_str	10.1192/bjo.2024.32
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up_date	2024-07-04T00:20:31.534Z
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The basic neural oscillation patterns associated with cognitive control are already present in early adolescence. However, as previous studies have focused on adults with psychosis, it is unclear whether neurobiological impairments in cognitive control are present in children and adolescents with first-episode psychosis (FEP) or clinical high-risk (CHR) state for psychosis. Aims To explore the deficits of electroencephalogram related to cognitive control tasks in children and adolescents with FEP and CHR. Method Electroencephalogram was recorded in untreated 48 patients with FEP, 24 patients with CHR and 42 healthy controls aged 10–17 years, while performing the visual oddball task. The N2 amplitude, theta and alpha oscillations were then analysed and compared between groups. Results There was no significant group difference in N2 amplitude (P = 0.099). All groups showed increased theta and alpha oscillations relative to baseline before the stimulus in the frontal, central, left fronto-central and right fronto-central areas. These changes differed significantly between groups, with the FEP group showing significantly smaller theta (P < 0.001) and alpha (P < 0.01) oscillation than healthy controls. Theta and alpha oscillations in the CHR group did not differ significantly from the FEP group and healthy controls. Conclusions These results suggest that neural damage has already occurred in the early stage of psychosis, and that abnormal rhythmic activity of neurons may constitute the pathophysiological mechanism of cognitive dysfunction related to early-onset psychosis.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Children and adolescents</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">electroencephalogram</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">N2</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">oscillations</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">psychosis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Psychiatry</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Tingyu Yang</subfield><subfield code="e">verfasserin</subfield><subfield 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code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">BJPsych Open</subfield><subfield code="d">Cambridge University Press, 2018</subfield><subfield code="g">10(2024)</subfield><subfield code="w">(DE-627)832781878</subfield><subfield code="w">(DE-600)2829557-2</subfield><subfield code="x">20564724</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:2024</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1192/bjo.2024.32</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doaj.org/article/c94a985f33f1459080ec64cf86808554</subfield><subfield code="z">kostenfrei</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield 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Abnormal theta and alpha oscillations in children and adolescents with first-episode psychosis and clinical high-risk psychosis

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