Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway

Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination...
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Autor*in:	Tianming Lu [verfasserIn] Lirun Zhou [verfasserIn] Zheng Chu [verfasserIn] Yang Song [verfasserIn] Qixin Wang [verfasserIn] Minghong Zhao [verfasserIn] Chuanhao Dai [verfasserIn] Lin Chen [verfasserIn] Guangqing Cheng [verfasserIn] Jigang Wang [verfasserIn] Qiuyan Guo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics

Übergeordnetes Werk:	In: Chinese Medicine - BMC, 2006, 19(2024), 1, Seite 14
Übergeordnetes Werk:	volume:19 ; year:2024 ; number:1 ; pages:14

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s13020-024-00895-0

Katalog-ID:	DOAJ097258253

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520			\|a Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway.
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allfields	10.1186/s13020-024-00895-0 doi (DE-627)DOAJ097258253 (DE-599)DOAJ8efdef8686cf4f37ad1ebdb6886e65ce DE-627 ger DE-627 rakwb eng RZ201-999 Tianming Lu verfasserin aut Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway. Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics Other systems of medicine Lirun Zhou verfasserin aut Zheng Chu verfasserin aut Yang Song verfasserin aut Qixin Wang verfasserin aut Minghong Zhao verfasserin aut Chuanhao Dai verfasserin aut Lin Chen verfasserin aut Guangqing Cheng verfasserin aut Jigang Wang verfasserin aut Qiuyan Guo verfasserin aut In Chinese Medicine BMC, 2006 19(2024), 1, Seite 14 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:19 year:2024 number:1 pages:14 https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce kostenfrei https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 14
spelling	10.1186/s13020-024-00895-0 doi (DE-627)DOAJ097258253 (DE-599)DOAJ8efdef8686cf4f37ad1ebdb6886e65ce DE-627 ger DE-627 rakwb eng RZ201-999 Tianming Lu verfasserin aut Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway. Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics Other systems of medicine Lirun Zhou verfasserin aut Zheng Chu verfasserin aut Yang Song verfasserin aut Qixin Wang verfasserin aut Minghong Zhao verfasserin aut Chuanhao Dai verfasserin aut Lin Chen verfasserin aut Guangqing Cheng verfasserin aut Jigang Wang verfasserin aut Qiuyan Guo verfasserin aut In Chinese Medicine BMC, 2006 19(2024), 1, Seite 14 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:19 year:2024 number:1 pages:14 https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce kostenfrei https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 14
allfields_unstemmed	10.1186/s13020-024-00895-0 doi (DE-627)DOAJ097258253 (DE-599)DOAJ8efdef8686cf4f37ad1ebdb6886e65ce DE-627 ger DE-627 rakwb eng RZ201-999 Tianming Lu verfasserin aut Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway. Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics Other systems of medicine Lirun Zhou verfasserin aut Zheng Chu verfasserin aut Yang Song verfasserin aut Qixin Wang verfasserin aut Minghong Zhao verfasserin aut Chuanhao Dai verfasserin aut Lin Chen verfasserin aut Guangqing Cheng verfasserin aut Jigang Wang verfasserin aut Qiuyan Guo verfasserin aut In Chinese Medicine BMC, 2006 19(2024), 1, Seite 14 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:19 year:2024 number:1 pages:14 https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce kostenfrei https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 14
allfieldsGer	10.1186/s13020-024-00895-0 doi (DE-627)DOAJ097258253 (DE-599)DOAJ8efdef8686cf4f37ad1ebdb6886e65ce DE-627 ger DE-627 rakwb eng RZ201-999 Tianming Lu verfasserin aut Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway. Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics Other systems of medicine Lirun Zhou verfasserin aut Zheng Chu verfasserin aut Yang Song verfasserin aut Qixin Wang verfasserin aut Minghong Zhao verfasserin aut Chuanhao Dai verfasserin aut Lin Chen verfasserin aut Guangqing Cheng verfasserin aut Jigang Wang verfasserin aut Qiuyan Guo verfasserin aut In Chinese Medicine BMC, 2006 19(2024), 1, Seite 14 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:19 year:2024 number:1 pages:14 https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce kostenfrei https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 14
allfieldsSound	10.1186/s13020-024-00895-0 doi (DE-627)DOAJ097258253 (DE-599)DOAJ8efdef8686cf4f37ad1ebdb6886e65ce DE-627 ger DE-627 rakwb eng RZ201-999 Tianming Lu verfasserin aut Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway. Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics Other systems of medicine Lirun Zhou verfasserin aut Zheng Chu verfasserin aut Yang Song verfasserin aut Qixin Wang verfasserin aut Minghong Zhao verfasserin aut Chuanhao Dai verfasserin aut Lin Chen verfasserin aut Guangqing Cheng verfasserin aut Jigang Wang verfasserin aut Qiuyan Guo verfasserin aut In Chinese Medicine BMC, 2006 19(2024), 1, Seite 14 (DE-627)521457025 (DE-600)2260322-0 17498546 nnns volume:19 year:2024 number:1 pages:14 https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce kostenfrei https://doi.org/10.1186/s13020-024-00895-0 kostenfrei https://doaj.org/toc/1749-8546 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2024 1 14
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Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. 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callnumber-first	R - Medicine
author	Tianming Lu
spellingShingle	Tianming Lu misc RZ201-999 misc Cordyceps Sinensis misc NSCLC misc MAPK pathway misc Transcriptomics misc Proteomics misc Other systems of medicine Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
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topic_title	RZ201-999 Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway Cordyceps Sinensis NSCLC MAPK pathway Transcriptomics Proteomics
topic	misc RZ201-999 misc Cordyceps Sinensis misc NSCLC misc MAPK pathway misc Transcriptomics misc Proteomics misc Other systems of medicine
topic_unstemmed	misc RZ201-999 misc Cordyceps Sinensis misc NSCLC misc MAPK pathway misc Transcriptomics misc Proteomics misc Other systems of medicine
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title	Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
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title_full	Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
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title_sort	cordyceps sinensis relieves non-small cell lung cancer by inhibiting the mapk pathway
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title_auth	Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
abstract	Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway.
abstractGer	Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway.
abstract_unstemmed	Abstract Objective To determine the pharmacodynamic mechanism underlying Cordyceps sinensis relief in a murine model of non-small cell lung cancer (NSCLC). Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. Conclusions Based on our preclinical study, C. sinensis was shown to exert a protective effect on NSCLC, primarily by inhibiting the MAPK pathway.
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title_short	Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway
url	https://doi.org/10.1186/s13020-024-00895-0 https://doaj.org/article/8efdef8686cf4f37ad1ebdb6886e65ce https://doaj.org/toc/1749-8546
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author2	Lirun Zhou Zheng Chu Yang Song Qixin Wang Minghong Zhao Chuanhao Dai Lin Chen Guangqing Cheng Jigang Wang Qiuyan Guo
author2Str	Lirun Zhou Zheng Chu Yang Song Qixin Wang Minghong Zhao Chuanhao Dai Lin Chen Guangqing Cheng Jigang Wang Qiuyan Guo
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up_date	2024-07-04T00:27:15.114Z
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Methods We created a murine model of NSCLC and studied the potential molecular mechanism by which C. sinensis relieved NSCLC using a combination of transcriptomics, proteomics, and experimental validation. Results C. sinensis markedly suppressed the fluorescence values in mice with NSCLC, improved the pathologic morphology of lung tissue, ameliorated inflammatory cytokines (tumor necrosis factor-alpha, interleukin-6, interleukin-10, and the oxidative stress indicators superoxide dismutase, malondialdehyde, and glutathione peroxidase). Transcriptomics results showed that the therapeutic effect of C. sinensis was primarily involved in the differentiation and activation of T cells. Based on the proteomic results, C. sinensis likely exerted a protective effect by recruiting immune cells and suppressing tumor cell proliferation via the MAPK pathway. Finally, the experimental validation results indicated that C. sinensis significantly decreased the VEGF and Ki67 expression, downregulated RhoA, Raf-1, and c-fos expression, which are related to cell migration and invasion, increased the serum concentration of hematopoietic factors (EPO and GM-CSF), and improved the percentage of immune cells (natural killer cells, dendritic cells, and CD4+ and CD8+ lymphocytes), which enhanced immune function. 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Cordyceps sinensis relieves non-small cell lung cancer by inhibiting the MAPK pathway

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