Knowns and unknowns of TiLV-associated neuronal disease

ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detect...
Ausführliche Beschreibung

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Autor*in:	Japhette E. Kembou-Ringert [verfasserIn] Fortune N. Hotio [verfasserIn] Dieter Steinhagen [verfasserIn] Kim D. Thompson [verfasserIn] Win Surachetpong [verfasserIn] Krzysztof Rakus [verfasserIn] Janet M. Daly [verfasserIn] Niluka Goonawardane [verfasserIn] Mikolaj Adamek [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Tilapia lake virus fish nervous system neurotropic viral infection neurotropism neuroinflammation neuropathogenesis

Übergeordnetes Werk:	In: Virulence - Taylor & Francis Group, 2018, 15(2024), 1
Übergeordnetes Werk:	volume:15 ; year:2024 ; number:1

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21505594.2024.2329568

Katalog-ID:	DOAJ097283266

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520			\|a ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field.
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allfieldsSound	10.1080/21505594.2024.2329568 doi (DE-627)DOAJ097283266 (DE-599)DOAJ35e72643187b44de933542572557d61f DE-627 ger DE-627 rakwb eng RC109-216 Japhette E. Kembou-Ringert verfasserin aut Knowns and unknowns of TiLV-associated neuronal disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field. Tilapia lake virus fish nervous system neurotropic viral infection neurotropism neuroinflammation neuropathogenesis Infectious and parasitic diseases Fortune N. Hotio verfasserin aut Dieter Steinhagen verfasserin aut Kim D. Thompson verfasserin aut Win Surachetpong verfasserin aut Krzysztof Rakus verfasserin aut Janet M. Daly verfasserin aut Niluka Goonawardane verfasserin aut Mikolaj Adamek verfasserin aut In Virulence Taylor & Francis Group, 2018 15(2024), 1 (DE-627)689717296 (DE-600)2657572-3 21505608 nnns volume:15 year:2024 number:1 https://doi.org/10.1080/21505594.2024.2329568 kostenfrei https://doaj.org/article/35e72643187b44de933542572557d61f kostenfrei https://www.tandfonline.com/doi/10.1080/21505594.2024.2329568 kostenfrei https://doaj.org/toc/2150-5594 Journal toc kostenfrei https://doaj.org/toc/2150-5608 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 1
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topic_facet	Tilapia lake virus fish nervous system neurotropic viral infection neurotropism neuroinflammation neuropathogenesis Infectious and parasitic diseases
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authorswithroles_txt_mv	Japhette E. Kembou-Ringert @@aut@@ Fortune N. Hotio @@aut@@ Dieter Steinhagen @@aut@@ Kim D. Thompson @@aut@@ Win Surachetpong @@aut@@ Krzysztof Rakus @@aut@@ Janet M. Daly @@aut@@ Niluka Goonawardane @@aut@@ Mikolaj Adamek @@aut@@
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callnumber-first	R - Medicine
author	Japhette E. Kembou-Ringert
spellingShingle	Japhette E. Kembou-Ringert misc RC109-216 misc Tilapia lake virus misc fish nervous system misc neurotropic viral infection misc neurotropism misc neuroinflammation misc neuropathogenesis misc Infectious and parasitic diseases Knowns and unknowns of TiLV-associated neuronal disease
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topic_title	RC109-216 Knowns and unknowns of TiLV-associated neuronal disease Tilapia lake virus fish nervous system neurotropic viral infection neurotropism neuroinflammation neuropathogenesis
topic	misc RC109-216 misc Tilapia lake virus misc fish nervous system misc neurotropic viral infection misc neurotropism misc neuroinflammation misc neuropathogenesis misc Infectious and parasitic diseases
topic_unstemmed	misc RC109-216 misc Tilapia lake virus misc fish nervous system misc neurotropic viral infection misc neurotropism misc neuroinflammation misc neuropathogenesis misc Infectious and parasitic diseases
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title	Knowns and unknowns of TiLV-associated neuronal disease
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title_full	Knowns and unknowns of TiLV-associated neuronal disease
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title_sort	knowns and unknowns of tilv-associated neuronal disease
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title_auth	Knowns and unknowns of TiLV-associated neuronal disease
abstract	ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field.
abstractGer	ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field.
abstract_unstemmed	ABSTRACTTilapia Lake Virus (TiLV) is associated with pathological changes in the brain of infected fish, but the mechanisms driving the virus’s neuropathogenesis remain poorly characterized. TiLV establishes a persistent infection in the brain of infected fish even when the virus is no longer detectable in the peripheral organs, rendering therapeutic interventions and disease management challenging. Moreover, the persistence of the virus in the brain may pose a risk for viral reinfection and spread and contribute to ongoing tissue damage and neuroinflammatory processes. In this review, we explore TiLV-associated neurological disease. We discuss the possible mechanism(s) used by TiLV to enter the central nervous system (CNS) and examine TiLV-induced neuroinflammation and brain immune responses. Lastly, we discuss future research questions and knowledge gaps to be addressed to significantly advance this field.
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title_short	Knowns and unknowns of TiLV-associated neuronal disease
url	https://doi.org/10.1080/21505594.2024.2329568 https://doaj.org/article/35e72643187b44de933542572557d61f https://www.tandfonline.com/doi/10.1080/21505594.2024.2329568 https://doaj.org/toc/2150-5594 https://doaj.org/toc/2150-5608
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Knowns and unknowns of TiLV-associated neuronal disease

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