Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease
Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chuchu Shao [verfasserIn] Xinxin Zhi [verfasserIn] Shiqi Mao [verfasserIn] Leilei Wu [verfasserIn] Jia Yu [verfasserIn] Shuo Yang [verfasserIn] Wanying Wang [verfasserIn] Keyi Jia [verfasserIn] Libo Luo [verfasserIn] Xinyu Liu [verfasserIn] Tao Jiang [verfasserIn] Fei Zhou [verfasserIn] Bin Chen [verfasserIn] Lei Wang [verfasserIn] Guanghui Gao [verfasserIn] Jingyun Shi [verfasserIn] Xiaoxia Chen [verfasserIn] Fengying Wu [verfasserIn] Shengxiang Ren [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Thoracic Cancer - Wiley, 2015, 15(2024), 10, Seite 778-787 |
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| Übergeordnetes Werk: |
volume:15 ; year:2024 ; number:10 ; pages:778-787 |
| Links: |
Link aufrufen |
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| DOI / URN: |
10.1111/1759-7714.15258 |
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| Katalog-ID: |
DOAJ097321338 |
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| 245 | 1 | 0 | |a Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease |
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| 520 | |a Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. | ||
| 650 | 4 | |a adverse event | |
| 650 | 4 | |a efficacy | |
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| 650 | 4 | |a local ablative therapy | |
| 650 | 4 | |a NSCLC | |
| 653 | 0 | |a Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| 700 | 0 | |a Xinxin Zhi |e verfasserin |4 aut | |
| 700 | 0 | |a Shiqi Mao |e verfasserin |4 aut | |
| 700 | 0 | |a Leilei Wu |e verfasserin |4 aut | |
| 700 | 0 | |a Jia Yu |e verfasserin |4 aut | |
| 700 | 0 | |a Shuo Yang |e verfasserin |4 aut | |
| 700 | 0 | |a Wanying Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Keyi Jia |e verfasserin |4 aut | |
| 700 | 0 | |a Libo Luo |e verfasserin |4 aut | |
| 700 | 0 | |a Xinyu Liu |e verfasserin |4 aut | |
| 700 | 0 | |a Tao Jiang |e verfasserin |4 aut | |
| 700 | 0 | |a Fei Zhou |e verfasserin |4 aut | |
| 700 | 0 | |a Bin Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Lei Wang |e verfasserin |4 aut | |
| 700 | 0 | |a Guanghui Gao |e verfasserin |4 aut | |
| 700 | 0 | |a Jingyun Shi |e verfasserin |4 aut | |
| 700 | 0 | |a Xiaoxia Chen |e verfasserin |4 aut | |
| 700 | 0 | |a Fengying Wu |e verfasserin |4 aut | |
| 700 | 0 | |a Shengxiang Ren |e verfasserin |4 aut | |
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10.1111/1759-7714.15258 doi (DE-627)DOAJ097321338 (DE-599)DOAJda7002b8558a4abe886832810f433e58 DE-627 ger DE-627 rakwb eng RC254-282 Chuchu Shao verfasserin aut Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. adverse event efficacy ILD local ablative therapy NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xinxin Zhi verfasserin aut Shiqi Mao verfasserin aut Leilei Wu verfasserin aut Jia Yu verfasserin aut Shuo Yang verfasserin aut Wanying Wang verfasserin aut Keyi Jia verfasserin aut Libo Luo verfasserin aut Xinyu Liu verfasserin aut Tao Jiang verfasserin aut Fei Zhou verfasserin aut Bin Chen verfasserin aut Lei Wang verfasserin aut Guanghui Gao verfasserin aut Jingyun Shi verfasserin aut Xiaoxia Chen verfasserin aut Fengying Wu verfasserin aut Shengxiang Ren verfasserin aut In Thoracic Cancer Wiley, 2015 15(2024), 10, Seite 778-787 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:15 year:2024 number:10 pages:778-787 https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/article/da7002b8558a4abe886832810f433e58 kostenfrei https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 10 778-787 |
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10.1111/1759-7714.15258 doi (DE-627)DOAJ097321338 (DE-599)DOAJda7002b8558a4abe886832810f433e58 DE-627 ger DE-627 rakwb eng RC254-282 Chuchu Shao verfasserin aut Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. adverse event efficacy ILD local ablative therapy NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xinxin Zhi verfasserin aut Shiqi Mao verfasserin aut Leilei Wu verfasserin aut Jia Yu verfasserin aut Shuo Yang verfasserin aut Wanying Wang verfasserin aut Keyi Jia verfasserin aut Libo Luo verfasserin aut Xinyu Liu verfasserin aut Tao Jiang verfasserin aut Fei Zhou verfasserin aut Bin Chen verfasserin aut Lei Wang verfasserin aut Guanghui Gao verfasserin aut Jingyun Shi verfasserin aut Xiaoxia Chen verfasserin aut Fengying Wu verfasserin aut Shengxiang Ren verfasserin aut In Thoracic Cancer Wiley, 2015 15(2024), 10, Seite 778-787 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:15 year:2024 number:10 pages:778-787 https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/article/da7002b8558a4abe886832810f433e58 kostenfrei https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 10 778-787 |
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10.1111/1759-7714.15258 doi (DE-627)DOAJ097321338 (DE-599)DOAJda7002b8558a4abe886832810f433e58 DE-627 ger DE-627 rakwb eng RC254-282 Chuchu Shao verfasserin aut Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. adverse event efficacy ILD local ablative therapy NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xinxin Zhi verfasserin aut Shiqi Mao verfasserin aut Leilei Wu verfasserin aut Jia Yu verfasserin aut Shuo Yang verfasserin aut Wanying Wang verfasserin aut Keyi Jia verfasserin aut Libo Luo verfasserin aut Xinyu Liu verfasserin aut Tao Jiang verfasserin aut Fei Zhou verfasserin aut Bin Chen verfasserin aut Lei Wang verfasserin aut Guanghui Gao verfasserin aut Jingyun Shi verfasserin aut Xiaoxia Chen verfasserin aut Fengying Wu verfasserin aut Shengxiang Ren verfasserin aut In Thoracic Cancer Wiley, 2015 15(2024), 10, Seite 778-787 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:15 year:2024 number:10 pages:778-787 https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/article/da7002b8558a4abe886832810f433e58 kostenfrei https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 10 778-787 |
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10.1111/1759-7714.15258 doi (DE-627)DOAJ097321338 (DE-599)DOAJda7002b8558a4abe886832810f433e58 DE-627 ger DE-627 rakwb eng RC254-282 Chuchu Shao verfasserin aut Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. adverse event efficacy ILD local ablative therapy NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xinxin Zhi verfasserin aut Shiqi Mao verfasserin aut Leilei Wu verfasserin aut Jia Yu verfasserin aut Shuo Yang verfasserin aut Wanying Wang verfasserin aut Keyi Jia verfasserin aut Libo Luo verfasserin aut Xinyu Liu verfasserin aut Tao Jiang verfasserin aut Fei Zhou verfasserin aut Bin Chen verfasserin aut Lei Wang verfasserin aut Guanghui Gao verfasserin aut Jingyun Shi verfasserin aut Xiaoxia Chen verfasserin aut Fengying Wu verfasserin aut Shengxiang Ren verfasserin aut In Thoracic Cancer Wiley, 2015 15(2024), 10, Seite 778-787 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:15 year:2024 number:10 pages:778-787 https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/article/da7002b8558a4abe886832810f433e58 kostenfrei https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 10 778-787 |
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10.1111/1759-7714.15258 doi (DE-627)DOAJ097321338 (DE-599)DOAJda7002b8558a4abe886832810f433e58 DE-627 ger DE-627 rakwb eng RC254-282 Chuchu Shao verfasserin aut Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. adverse event efficacy ILD local ablative therapy NSCLC Neoplasms. Tumors. Oncology. Including cancer and carcinogens Xinxin Zhi verfasserin aut Shiqi Mao verfasserin aut Leilei Wu verfasserin aut Jia Yu verfasserin aut Shuo Yang verfasserin aut Wanying Wang verfasserin aut Keyi Jia verfasserin aut Libo Luo verfasserin aut Xinyu Liu verfasserin aut Tao Jiang verfasserin aut Fei Zhou verfasserin aut Bin Chen verfasserin aut Lei Wang verfasserin aut Guanghui Gao verfasserin aut Jingyun Shi verfasserin aut Xiaoxia Chen verfasserin aut Fengying Wu verfasserin aut Shengxiang Ren verfasserin aut In Thoracic Cancer Wiley, 2015 15(2024), 10, Seite 778-787 (DE-627)629836809 (DE-600)2559245-2 17597714 nnns volume:15 year:2024 number:10 pages:778-787 https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/article/da7002b8558a4abe886832810f433e58 kostenfrei https://doi.org/10.1111/1759-7714.15258 kostenfrei https://doaj.org/toc/1759-7706 Journal toc kostenfrei https://doaj.org/toc/1759-7714 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_636 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2232 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2024 10 778-787 |
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Chuchu Shao @@aut@@ Xinxin Zhi @@aut@@ Shiqi Mao @@aut@@ Leilei Wu @@aut@@ Jia Yu @@aut@@ Shuo Yang @@aut@@ Wanying Wang @@aut@@ Keyi Jia @@aut@@ Libo Luo @@aut@@ Xinyu Liu @@aut@@ Tao Jiang @@aut@@ Fei Zhou @@aut@@ Bin Chen @@aut@@ Lei Wang @@aut@@ Guanghui Gao @@aut@@ Jingyun Shi @@aut@@ Xiaoxia Chen @@aut@@ Fengying Wu @@aut@@ Shengxiang Ren @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ097321338</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413181553.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240413s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/1759-7714.15258</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ097321338</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJda7002b8558a4abe886832810f433e58</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">RC254-282</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Chuchu Shao</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">adverse event</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">efficacy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ILD</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">local ablative therapy</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NSCLC</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Neoplasms. Tumors. Oncology. 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R - Medicine |
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Chuchu Shao |
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Chuchu Shao misc RC254-282 misc adverse event misc efficacy misc ILD misc local ablative therapy misc NSCLC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease |
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RC254-282 Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease adverse event efficacy ILD local ablative therapy NSCLC |
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misc RC254-282 misc adverse event misc efficacy misc ILD misc local ablative therapy misc NSCLC misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
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Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease |
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Chuchu Shao Xinxin Zhi Shiqi Mao Leilei Wu Jia Yu Shuo Yang Wanying Wang Keyi Jia Libo Luo Xinyu Liu Tao Jiang Fei Zhou Bin Chen Lei Wang Guanghui Gao Jingyun Shi Xiaoxia Chen Fengying Wu Shengxiang Ren |
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efficacy and safety of local ablative therapy for patients with nsclc and coexisting interstitial lung disease |
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RC254-282 |
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Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease |
| abstract |
Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. |
| abstractGer |
Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. |
| abstract_unstemmed |
Abstract Background The effective therapeutic approach is still an unmet need for patients diagnosed with both lung cancer and interstitial lung disease (ILD). This is primarily due to the possible risk of ILD exacerbation caused by surgery or radiotherapy. The current study aimed to investigate the efficacy and safety of local ablative therapy (LAT) for this specific population. Methods Consecutive patients with non‐small cell lung cancer (NSCLC) and ILD who received LAT between January 2018 and August 2022 were enrolled, and propensity score matching (PSM) was utilized to match the non‐ILD group. The primary endpoint was recurrence‐free survival (RFS), and secondary endpoints included overall survival (OS), adverse events (AEs) and hospital length of stay (HLOS). Results The PSM algorithm yielded matched pairs in the ILD group (n = 25) and non‐ILD group (n = 72) at a ratio of 1:3. There were no statistically significant differences in RFS (median 16.4 vs. 18 months; HR = 1.452, p = 0.259) and OS (median: not reached vs. 47.9 months; HR = 1.096, p = 0.884) between the two groups. Meanwhile, no acute exacerbation of ILD was observed in the ILD group. However, the incidence of pneumothorax, especially pneumothorax requiring chest tube drainage, was significantly higher (36.0% vs. 11.2%, p = 0.005) among patients with NSCLC and co‐existing ILD, which resulted in longer HLOS (p = 0.045). Conclusion Although ILD was associated with a higher incidence of pneumothorax, the efficacy of LAT for NSCLC patients with ILD was comparable to those without ILD, suggesting that LAT might be a reliable and effective treatment option for this population, particularly in the early stage. |
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Efficacy and safety of local ablative therapy for patients with NSCLC and coexisting interstitial lung disease |
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https://doi.org/10.1111/1759-7714.15258 https://doaj.org/article/da7002b8558a4abe886832810f433e58 https://doaj.org/toc/1759-7706 https://doaj.org/toc/1759-7714 |
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Xinxin Zhi Shiqi Mao Leilei Wu Jia Yu Shuo Yang Wanying Wang Keyi Jia Libo Luo Xinyu Liu Tao Jiang Fei Zhou Bin Chen Lei Wang Guanghui Gao Jingyun Shi Xiaoxia Chen Fengying Wu Shengxiang Ren |
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Xinxin Zhi Shiqi Mao Leilei Wu Jia Yu Shuo Yang Wanying Wang Keyi Jia Libo Luo Xinyu Liu Tao Jiang Fei Zhou Bin Chen Lei Wang Guanghui Gao Jingyun Shi Xiaoxia Chen Fengying Wu Shengxiang Ren |
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RC - Internal Medicine |
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10.1111/1759-7714.15258 |
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2024-07-04T00:47:29.230Z |
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