A genome-wide association study of social trust in 33,882 Danish blood donors

Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other...
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Autor*in:	Celia Burgos Sequeros [verfasserIn] Thomas Folkmann Hansen [verfasserIn] David Westergaard [verfasserIn] Ioannis Louloudis [verfasserIn] Sebastian Kalamajski [verfasserIn] Timo Röder [verfasserIn] Palle Duun Rohde [verfasserIn] Michael Schwinn [verfasserIn] Line Harder Clemmensen [verfasserIn] Maria Didriksen [verfasserIn] Mette Nyegaard [verfasserIn] Henrik Hjalgrim [verfasserIn] Kaspar René Nielsen [verfasserIn] Mie Topholm Bruun [verfasserIn] Sisse Rye Ostrowski [verfasserIn] Christian Erikstrup [verfasserIn] Susan Mikkelsen [verfasserIn] Erik Sørensen [verfasserIn] DBDS Genomic Consortium [verfasserIn] Ole Birger Vestager Pedersen [verfasserIn] Søren Brunak [verfasserIn] Karina Banasik [verfasserIn] Giuseppe Nicola Giordano [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Übergeordnetes Werk:	In: Scientific Reports - Nature Portfolio, 2011, 14(2024), 1, Seite 12
Übergeordnetes Werk:	volume:14 ; year:2024 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41598-024-51636-0

Katalog-ID:	DOAJ097429147

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allfields	10.1038/s41598-024-51636-0 doi (DE-627)DOAJ097429147 (DE-599)DOAJd96e3c40e2494c5ca9ab43de70e7412e DE-627 ger DE-627 rakwb eng Celia Burgos Sequeros verfasserin aut A genome-wide association study of social trust in 33,882 Danish blood donors 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. Medicine R Science Q Thomas Folkmann Hansen verfasserin aut David Westergaard verfasserin aut Ioannis Louloudis verfasserin aut Sebastian Kalamajski verfasserin aut Timo Röder verfasserin aut Palle Duun Rohde verfasserin aut Michael Schwinn verfasserin aut Line Harder Clemmensen verfasserin aut Maria Didriksen verfasserin aut Mette Nyegaard verfasserin aut Henrik Hjalgrim verfasserin aut Kaspar René Nielsen verfasserin aut Mie Topholm Bruun verfasserin aut Sisse Rye Ostrowski verfasserin aut Christian Erikstrup verfasserin aut Susan Mikkelsen verfasserin aut Erik Sørensen verfasserin aut DBDS Genomic Consortium verfasserin aut Ole Birger Vestager Pedersen verfasserin aut Søren Brunak verfasserin aut Karina Banasik verfasserin aut Giuseppe Nicola Giordano verfasserin aut In Scientific Reports Nature Portfolio, 2011 14(2024), 1, Seite 12 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e kostenfrei https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12
spelling	10.1038/s41598-024-51636-0 doi (DE-627)DOAJ097429147 (DE-599)DOAJd96e3c40e2494c5ca9ab43de70e7412e DE-627 ger DE-627 rakwb eng Celia Burgos Sequeros verfasserin aut A genome-wide association study of social trust in 33,882 Danish blood donors 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. Medicine R Science Q Thomas Folkmann Hansen verfasserin aut David Westergaard verfasserin aut Ioannis Louloudis verfasserin aut Sebastian Kalamajski verfasserin aut Timo Röder verfasserin aut Palle Duun Rohde verfasserin aut Michael Schwinn verfasserin aut Line Harder Clemmensen verfasserin aut Maria Didriksen verfasserin aut Mette Nyegaard verfasserin aut Henrik Hjalgrim verfasserin aut Kaspar René Nielsen verfasserin aut Mie Topholm Bruun verfasserin aut Sisse Rye Ostrowski verfasserin aut Christian Erikstrup verfasserin aut Susan Mikkelsen verfasserin aut Erik Sørensen verfasserin aut DBDS Genomic Consortium verfasserin aut Ole Birger Vestager Pedersen verfasserin aut Søren Brunak verfasserin aut Karina Banasik verfasserin aut Giuseppe Nicola Giordano verfasserin aut In Scientific Reports Nature Portfolio, 2011 14(2024), 1, Seite 12 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e kostenfrei https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12
allfields_unstemmed	10.1038/s41598-024-51636-0 doi (DE-627)DOAJ097429147 (DE-599)DOAJd96e3c40e2494c5ca9ab43de70e7412e DE-627 ger DE-627 rakwb eng Celia Burgos Sequeros verfasserin aut A genome-wide association study of social trust in 33,882 Danish blood donors 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. Medicine R Science Q Thomas Folkmann Hansen verfasserin aut David Westergaard verfasserin aut Ioannis Louloudis verfasserin aut Sebastian Kalamajski verfasserin aut Timo Röder verfasserin aut Palle Duun Rohde verfasserin aut Michael Schwinn verfasserin aut Line Harder Clemmensen verfasserin aut Maria Didriksen verfasserin aut Mette Nyegaard verfasserin aut Henrik Hjalgrim verfasserin aut Kaspar René Nielsen verfasserin aut Mie Topholm Bruun verfasserin aut Sisse Rye Ostrowski verfasserin aut Christian Erikstrup verfasserin aut Susan Mikkelsen verfasserin aut Erik Sørensen verfasserin aut DBDS Genomic Consortium verfasserin aut Ole Birger Vestager Pedersen verfasserin aut Søren Brunak verfasserin aut Karina Banasik verfasserin aut Giuseppe Nicola Giordano verfasserin aut In Scientific Reports Nature Portfolio, 2011 14(2024), 1, Seite 12 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e kostenfrei https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12
allfieldsGer	10.1038/s41598-024-51636-0 doi (DE-627)DOAJ097429147 (DE-599)DOAJd96e3c40e2494c5ca9ab43de70e7412e DE-627 ger DE-627 rakwb eng Celia Burgos Sequeros verfasserin aut A genome-wide association study of social trust in 33,882 Danish blood donors 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. Medicine R Science Q Thomas Folkmann Hansen verfasserin aut David Westergaard verfasserin aut Ioannis Louloudis verfasserin aut Sebastian Kalamajski verfasserin aut Timo Röder verfasserin aut Palle Duun Rohde verfasserin aut Michael Schwinn verfasserin aut Line Harder Clemmensen verfasserin aut Maria Didriksen verfasserin aut Mette Nyegaard verfasserin aut Henrik Hjalgrim verfasserin aut Kaspar René Nielsen verfasserin aut Mie Topholm Bruun verfasserin aut Sisse Rye Ostrowski verfasserin aut Christian Erikstrup verfasserin aut Susan Mikkelsen verfasserin aut Erik Sørensen verfasserin aut DBDS Genomic Consortium verfasserin aut Ole Birger Vestager Pedersen verfasserin aut Søren Brunak verfasserin aut Karina Banasik verfasserin aut Giuseppe Nicola Giordano verfasserin aut In Scientific Reports Nature Portfolio, 2011 14(2024), 1, Seite 12 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e kostenfrei https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12
allfieldsSound	10.1038/s41598-024-51636-0 doi (DE-627)DOAJ097429147 (DE-599)DOAJd96e3c40e2494c5ca9ab43de70e7412e DE-627 ger DE-627 rakwb eng Celia Burgos Sequeros verfasserin aut A genome-wide association study of social trust in 33,882 Danish blood donors 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it. Medicine R Science Q Thomas Folkmann Hansen verfasserin aut David Westergaard verfasserin aut Ioannis Louloudis verfasserin aut Sebastian Kalamajski verfasserin aut Timo Röder verfasserin aut Palle Duun Rohde verfasserin aut Michael Schwinn verfasserin aut Line Harder Clemmensen verfasserin aut Maria Didriksen verfasserin aut Mette Nyegaard verfasserin aut Henrik Hjalgrim verfasserin aut Kaspar René Nielsen verfasserin aut Mie Topholm Bruun verfasserin aut Sisse Rye Ostrowski verfasserin aut Christian Erikstrup verfasserin aut Susan Mikkelsen verfasserin aut Erik Sørensen verfasserin aut DBDS Genomic Consortium verfasserin aut Ole Birger Vestager Pedersen verfasserin aut Søren Brunak verfasserin aut Karina Banasik verfasserin aut Giuseppe Nicola Giordano verfasserin aut In Scientific Reports Nature Portfolio, 2011 14(2024), 1, Seite 12 (DE-627)663366712 (DE-600)2615211-3 20452322 nnns volume:14 year:2024 number:1 pages:12 https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e kostenfrei https://doi.org/10.1038/s41598-024-51636-0 kostenfrei https://doaj.org/toc/2045-2322 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024 1 12
language	English
source	In Scientific Reports 14(2024), 1, Seite 12 volume:14 year:2024 number:1 pages:12
sourceStr	In Scientific Reports 14(2024), 1, Seite 12 volume:14 year:2024 number:1 pages:12
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Medicine R Science Q
isfreeaccess_bool	true
container_title	Scientific Reports
authorswithroles_txt_mv	Celia Burgos Sequeros @@aut@@ Thomas Folkmann Hansen @@aut@@ David Westergaard @@aut@@ Ioannis Louloudis @@aut@@ Sebastian Kalamajski @@aut@@ Timo Röder @@aut@@ Palle Duun Rohde @@aut@@ Michael Schwinn @@aut@@ Line Harder Clemmensen @@aut@@ Maria Didriksen @@aut@@ Mette Nyegaard @@aut@@ Henrik Hjalgrim @@aut@@ Kaspar René Nielsen @@aut@@ Mie Topholm Bruun @@aut@@ Sisse Rye Ostrowski @@aut@@ Christian Erikstrup @@aut@@ Susan Mikkelsen @@aut@@ Erik Sørensen @@aut@@ DBDS Genomic Consortium @@aut@@ Ole Birger Vestager Pedersen @@aut@@ Søren Brunak @@aut@@ Karina Banasik @@aut@@ Giuseppe Nicola Giordano @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	663366712
id	DOAJ097429147
language_de	englisch
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author	Celia Burgos Sequeros
spellingShingle	Celia Burgos Sequeros misc Medicine misc R misc Science misc Q A genome-wide association study of social trust in 33,882 Danish blood donors
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topic_title	A genome-wide association study of social trust in 33,882 Danish blood donors
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title	A genome-wide association study of social trust in 33,882 Danish blood donors
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title_full	A genome-wide association study of social trust in 33,882 Danish blood donors
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author_browse	Celia Burgos Sequeros Thomas Folkmann Hansen David Westergaard Ioannis Louloudis Sebastian Kalamajski Timo Röder Palle Duun Rohde Michael Schwinn Line Harder Clemmensen Maria Didriksen Mette Nyegaard Henrik Hjalgrim Kaspar René Nielsen Mie Topholm Bruun Sisse Rye Ostrowski Christian Erikstrup Susan Mikkelsen Erik Sørensen DBDS Genomic Consortium Ole Birger Vestager Pedersen Søren Brunak Karina Banasik Giuseppe Nicola Giordano
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title_sort	genome-wide association study of social trust in 33,882 danish blood donors
title_auth	A genome-wide association study of social trust in 33,882 Danish blood donors
abstract	Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
abstractGer	Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
abstract_unstemmed	Abstract Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
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title_short	A genome-wide association study of social trust in 33,882 Danish blood donors
url	https://doi.org/10.1038/s41598-024-51636-0 https://doaj.org/article/d96e3c40e2494c5ca9ab43de70e7412e https://doaj.org/toc/2045-2322
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A genome-wide association study of social trust in 33,882 Danish blood donors

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