The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats

Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar r...
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Autor*in:	Great Iruoghene Edo [verfasserIn] Agatha Ngukuran Jikah [verfasserIn] Favour Ogheneoruese Onoharigho [verfasserIn] Patrick Othuke Akpoghelie [verfasserIn] Joy Johnson Agbo [verfasserIn] Helen Avuokerie Ekokotu [verfasserIn] Ufuoma Ugbune [verfasserIn] Gracious Okeoghene Ezekiel [verfasserIn] Oghenerume Lucky Emakpor [verfasserIn] Ephraim Evi Alex Oghroro [verfasserIn] Aghoghoroghene Elizabeth Ojulari [verfasserIn] Kennedy Ahamefula Okoronkwo [verfasserIn] Omoruwou [verfasserIn] Joseph Oghenewogaga Owheruo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes

Übergeordnetes Werk:	In: Food Chemistry Advances - Elsevier, 2022, 4(2024), Seite 100620-
Übergeordnetes Werk:	volume:4 ; year:2024 ; pages:100620-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.focha.2024.100620

Katalog-ID:	DOAJ097453919

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520			\|a Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats.
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author_variant	g i e gie a n j anj f o o foo p o a poa j j a jja h a e hae u u uu g o e goe o l e ole e e a o eeao a e o aeo k a o kao o j o o joo
matchkey_str	article:2772753X:2024----::haeirtvefcsfennamgaiaxrcosprxddsuaenguahoetaseaenlo
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publishDate	2024
allfields	10.1016/j.focha.2024.100620 doi (DE-627)DOAJ097453919 (DE-599)DOAJ85111c4d37964f80af976c2433f8f37b DE-627 ger DE-627 rakwb eng TP368-456 Great Iruoghene Edo verfasserin aut The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats. Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture Agatha Ngukuran Jikah verfasserin aut Favour Ogheneoruese Onoharigho verfasserin aut Patrick Othuke Akpoghelie verfasserin aut Joy Johnson Agbo verfasserin aut Helen Avuokerie Ekokotu verfasserin aut Ufuoma Ugbune verfasserin aut Gracious Okeoghene Ezekiel verfasserin aut Oghenerume Lucky Emakpor verfasserin aut Ephraim Evi Alex Oghroro verfasserin aut Aghoghoroghene Elizabeth Ojulari verfasserin aut Kennedy Ahamefula Okoronkwo verfasserin aut Omoruwou verfasserin aut Joseph Oghenewogaga Owheruo verfasserin aut In Food Chemistry Advances Elsevier, 2022 4(2024), Seite 100620- (DE-627)1799510484 2772753X nnns volume:4 year:2024 pages:100620- https://doi.org/10.1016/j.focha.2024.100620 kostenfrei https://doaj.org/article/85111c4d37964f80af976c2433f8f37b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772753X24000169 kostenfrei https://doaj.org/toc/2772-753X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2024 100620-
spelling	10.1016/j.focha.2024.100620 doi (DE-627)DOAJ097453919 (DE-599)DOAJ85111c4d37964f80af976c2433f8f37b DE-627 ger DE-627 rakwb eng TP368-456 Great Iruoghene Edo verfasserin aut The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats. Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture Agatha Ngukuran Jikah verfasserin aut Favour Ogheneoruese Onoharigho verfasserin aut Patrick Othuke Akpoghelie verfasserin aut Joy Johnson Agbo verfasserin aut Helen Avuokerie Ekokotu verfasserin aut Ufuoma Ugbune verfasserin aut Gracious Okeoghene Ezekiel verfasserin aut Oghenerume Lucky Emakpor verfasserin aut Ephraim Evi Alex Oghroro verfasserin aut Aghoghoroghene Elizabeth Ojulari verfasserin aut Kennedy Ahamefula Okoronkwo verfasserin aut Omoruwou verfasserin aut Joseph Oghenewogaga Owheruo verfasserin aut In Food Chemistry Advances Elsevier, 2022 4(2024), Seite 100620- (DE-627)1799510484 2772753X nnns volume:4 year:2024 pages:100620- https://doi.org/10.1016/j.focha.2024.100620 kostenfrei https://doaj.org/article/85111c4d37964f80af976c2433f8f37b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772753X24000169 kostenfrei https://doaj.org/toc/2772-753X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2024 100620-
allfields_unstemmed	10.1016/j.focha.2024.100620 doi (DE-627)DOAJ097453919 (DE-599)DOAJ85111c4d37964f80af976c2433f8f37b DE-627 ger DE-627 rakwb eng TP368-456 Great Iruoghene Edo verfasserin aut The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats. Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture Agatha Ngukuran Jikah verfasserin aut Favour Ogheneoruese Onoharigho verfasserin aut Patrick Othuke Akpoghelie verfasserin aut Joy Johnson Agbo verfasserin aut Helen Avuokerie Ekokotu verfasserin aut Ufuoma Ugbune verfasserin aut Gracious Okeoghene Ezekiel verfasserin aut Oghenerume Lucky Emakpor verfasserin aut Ephraim Evi Alex Oghroro verfasserin aut Aghoghoroghene Elizabeth Ojulari verfasserin aut Kennedy Ahamefula Okoronkwo verfasserin aut Omoruwou verfasserin aut Joseph Oghenewogaga Owheruo verfasserin aut In Food Chemistry Advances Elsevier, 2022 4(2024), Seite 100620- (DE-627)1799510484 2772753X nnns volume:4 year:2024 pages:100620- https://doi.org/10.1016/j.focha.2024.100620 kostenfrei https://doaj.org/article/85111c4d37964f80af976c2433f8f37b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772753X24000169 kostenfrei https://doaj.org/toc/2772-753X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2024 100620-
allfieldsGer	10.1016/j.focha.2024.100620 doi (DE-627)DOAJ097453919 (DE-599)DOAJ85111c4d37964f80af976c2433f8f37b DE-627 ger DE-627 rakwb eng TP368-456 Great Iruoghene Edo verfasserin aut The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats. Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture Agatha Ngukuran Jikah verfasserin aut Favour Ogheneoruese Onoharigho verfasserin aut Patrick Othuke Akpoghelie verfasserin aut Joy Johnson Agbo verfasserin aut Helen Avuokerie Ekokotu verfasserin aut Ufuoma Ugbune verfasserin aut Gracious Okeoghene Ezekiel verfasserin aut Oghenerume Lucky Emakpor verfasserin aut Ephraim Evi Alex Oghroro verfasserin aut Aghoghoroghene Elizabeth Ojulari verfasserin aut Kennedy Ahamefula Okoronkwo verfasserin aut Omoruwou verfasserin aut Joseph Oghenewogaga Owheruo verfasserin aut In Food Chemistry Advances Elsevier, 2022 4(2024), Seite 100620- (DE-627)1799510484 2772753X nnns volume:4 year:2024 pages:100620- https://doi.org/10.1016/j.focha.2024.100620 kostenfrei https://doaj.org/article/85111c4d37964f80af976c2433f8f37b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772753X24000169 kostenfrei https://doaj.org/toc/2772-753X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2024 100620-
allfieldsSound	10.1016/j.focha.2024.100620 doi (DE-627)DOAJ097453919 (DE-599)DOAJ85111c4d37964f80af976c2433f8f37b DE-627 ger DE-627 rakwb eng TP368-456 Great Iruoghene Edo verfasserin aut The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats. Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture Agatha Ngukuran Jikah verfasserin aut Favour Ogheneoruese Onoharigho verfasserin aut Patrick Othuke Akpoghelie verfasserin aut Joy Johnson Agbo verfasserin aut Helen Avuokerie Ekokotu verfasserin aut Ufuoma Ugbune verfasserin aut Gracious Okeoghene Ezekiel verfasserin aut Oghenerume Lucky Emakpor verfasserin aut Ephraim Evi Alex Oghroro verfasserin aut Aghoghoroghene Elizabeth Ojulari verfasserin aut Kennedy Ahamefula Okoronkwo verfasserin aut Omoruwou verfasserin aut Joseph Oghenewogaga Owheruo verfasserin aut In Food Chemistry Advances Elsevier, 2022 4(2024), Seite 100620- (DE-627)1799510484 2772753X nnns volume:4 year:2024 pages:100620- https://doi.org/10.1016/j.focha.2024.100620 kostenfrei https://doaj.org/article/85111c4d37964f80af976c2433f8f37b kostenfrei http://www.sciencedirect.com/science/article/pii/S2772753X24000169 kostenfrei https://doaj.org/toc/2772-753X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 4 2024 100620-
language	English
source	In Food Chemistry Advances 4(2024), Seite 100620- volume:4 year:2024 pages:100620-
sourceStr	In Food Chemistry Advances 4(2024), Seite 100620- volume:4 year:2024 pages:100620-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes Food processing and manufacture
isfreeaccess_bool	true
container_title	Food Chemistry Advances
authorswithroles_txt_mv	Great Iruoghene Edo @@aut@@ Agatha Ngukuran Jikah @@aut@@ Favour Ogheneoruese Onoharigho @@aut@@ Patrick Othuke Akpoghelie @@aut@@ Joy Johnson Agbo @@aut@@ Helen Avuokerie Ekokotu @@aut@@ Ufuoma Ugbune @@aut@@ Gracious Okeoghene Ezekiel @@aut@@ Oghenerume Lucky Emakpor @@aut@@ Ephraim Evi Alex Oghroro @@aut@@ Aghoghoroghene Elizabeth Ojulari @@aut@@ Kennedy Ahamefula Okoronkwo @@aut@@ Omoruwou @@aut@@ Joseph Oghenewogaga Owheruo @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	1799510484
id	DOAJ097453919
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">DOAJ097453919</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240413183619.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240413s2024 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.focha.2024.100620</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)DOAJ097453919</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DOAJ85111c4d37964f80af976c2433f8f37b</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">TP368-456</subfield></datafield><datafield tag="100" ind1="0" ind2=" "><subfield code="a">Great Iruoghene Edo</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="4"><subfield code="a">The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. 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author	Great Iruoghene Edo
spellingShingle	Great Iruoghene Edo misc TP368-456 misc Alloxan misc Glutathione s-transferase misc Vernonia amygdalina misc Superoxide dismutase misc Diabetes misc Food processing and manufacture The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats
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topic_title	TP368-456 The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats Alloxan Glutathione s-transferase Vernonia amygdalina Superoxide dismutase Diabetes
topic	misc TP368-456 misc Alloxan misc Glutathione s-transferase misc Vernonia amygdalina misc Superoxide dismutase misc Diabetes misc Food processing and manufacture
topic_unstemmed	misc TP368-456 misc Alloxan misc Glutathione s-transferase misc Vernonia amygdalina misc Superoxide dismutase misc Diabetes misc Food processing and manufacture
topic_browse	misc TP368-456 misc Alloxan misc Glutathione s-transferase misc Vernonia amygdalina misc Superoxide dismutase misc Diabetes misc Food processing and manufacture
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title	The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats
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title_full	The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats
author_sort	Great Iruoghene Edo
journal	Food Chemistry Advances
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author_browse	Great Iruoghene Edo Agatha Ngukuran Jikah Favour Ogheneoruese Onoharigho Patrick Othuke Akpoghelie Joy Johnson Agbo Helen Avuokerie Ekokotu Ufuoma Ugbune Gracious Okeoghene Ezekiel Oghenerume Lucky Emakpor Ephraim Evi Alex Oghroro Aghoghoroghene Elizabeth Ojulari Kennedy Ahamefula Okoronkwo Omoruwou Joseph Oghenewogaga Owheruo
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doi_str_mv	10.1016/j.focha.2024.100620
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title_sort	ameliorative effects of vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male wistar rats
callnumber	TP368-456
title_auth	The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats
abstract	Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats.
abstractGer	Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats.
abstract_unstemmed	Abstracts: Vernonia amygdalina possess specialized metabolites which have been shown to minimize the risk of human diseases. This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. The findings of the current research showed that Vernonia amygdalina ameliorated the enzymatic activities on alloxan induced diabetes on male Wistar rats.
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title_short	The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats
url	https://doi.org/10.1016/j.focha.2024.100620 https://doaj.org/article/85111c4d37964f80af976c2433f8f37b http://www.sciencedirect.com/science/article/pii/S2772753X24000169 https://doaj.org/toc/2772-753X
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up_date	2024-07-04T01:19:48.042Z
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This study was aimed to evaluate the effect of V. amygdalina extracts on Superoxide dismutase (SOD) and Glutathione s-transferase (GST) on alloxan induced diabetes in Wistar rats. Extraction of the V. amygdalina leaves was done manually and extracts were fractionated using Asymmetric Flow Field Flow Fractionation method. The fractions obtained from the crude V. amygdalina were tested to identify phytochemicals such as alkaloids, glycosides and saponins. Meanwhile, the experimental animals were divided into 2 phases. Phase 1 (non-induced) were grouped into 6 groups (control, crude, metformin, saponin, glycoside and alkaloid) of six animals. Phase 2 were grouped into 5 groups (crude, metformin, saponin, glycoside and alkaloid) of 6 animals which were induced intraperitoneally with Alloxan using injection (Alloxan-Induced). The results for the fasting blood glucose level of treated alloxan-induced diabetic showed a significant increase compared to those in control group (61.33±2.0) of the untreated. In addition, the histopathological analysis of the pancreas showed significant resurgence of destroyed pancreatic islet cells. 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The ameliorative effects of Vernonia amygdalina extract on superoxide dismutase and glutathione s-transferase on alloxan induced diabetes on male Wistar rats

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