Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines

IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research...
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Gespeichert in:

Autor*in:	Ha-Young Shin [verfasserIn] Hyung Jun Jin [verfasserIn] Hyun-Jin Tae [verfasserIn] Hong-Geun Oh [verfasserIn] Jeong Ho Hwang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response

Übergeordnetes Werk:	In: Frontiers in Veterinary Science - Frontiers Media S.A., 2015, 11(2024)
Übergeordnetes Werk:	volume:11 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fvets.2024.1296138

Katalog-ID:	DOAJ097540293

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520			\|a IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.
650		4	\|a ovalbumin
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allfields	10.3389/fvets.2024.1296138 doi (DE-627)DOAJ097540293 (DE-599)DOAJcd69eacc93a44e27b0efaeb59807ca4c DE-627 ger DE-627 rakwb eng SF600-1100 Ha-Young Shin verfasserin aut Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs. ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response Veterinary medicine Ha-Young Shin verfasserin aut Hyung Jun Jin verfasserin aut Hyung Jun Jin verfasserin aut Hyun-Jin Tae verfasserin aut Hong-Geun Oh verfasserin aut Jeong Ho Hwang verfasserin aut Jeong Ho Hwang verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 11(2024) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:11 year:2024 https://doi.org/10.3389/fvets.2024.1296138 kostenfrei https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
spelling	10.3389/fvets.2024.1296138 doi (DE-627)DOAJ097540293 (DE-599)DOAJcd69eacc93a44e27b0efaeb59807ca4c DE-627 ger DE-627 rakwb eng SF600-1100 Ha-Young Shin verfasserin aut Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs. ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response Veterinary medicine Ha-Young Shin verfasserin aut Hyung Jun Jin verfasserin aut Hyung Jun Jin verfasserin aut Hyun-Jin Tae verfasserin aut Hong-Geun Oh verfasserin aut Jeong Ho Hwang verfasserin aut Jeong Ho Hwang verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 11(2024) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:11 year:2024 https://doi.org/10.3389/fvets.2024.1296138 kostenfrei https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfields_unstemmed	10.3389/fvets.2024.1296138 doi (DE-627)DOAJ097540293 (DE-599)DOAJcd69eacc93a44e27b0efaeb59807ca4c DE-627 ger DE-627 rakwb eng SF600-1100 Ha-Young Shin verfasserin aut Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs. ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response Veterinary medicine Ha-Young Shin verfasserin aut Hyung Jun Jin verfasserin aut Hyung Jun Jin verfasserin aut Hyun-Jin Tae verfasserin aut Hong-Geun Oh verfasserin aut Jeong Ho Hwang verfasserin aut Jeong Ho Hwang verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 11(2024) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:11 year:2024 https://doi.org/10.3389/fvets.2024.1296138 kostenfrei https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfieldsGer	10.3389/fvets.2024.1296138 doi (DE-627)DOAJ097540293 (DE-599)DOAJcd69eacc93a44e27b0efaeb59807ca4c DE-627 ger DE-627 rakwb eng SF600-1100 Ha-Young Shin verfasserin aut Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs. ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response Veterinary medicine Ha-Young Shin verfasserin aut Hyung Jun Jin verfasserin aut Hyung Jun Jin verfasserin aut Hyun-Jin Tae verfasserin aut Hong-Geun Oh verfasserin aut Jeong Ho Hwang verfasserin aut Jeong Ho Hwang verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 11(2024) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:11 year:2024 https://doi.org/10.3389/fvets.2024.1296138 kostenfrei https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
allfieldsSound	10.3389/fvets.2024.1296138 doi (DE-627)DOAJ097540293 (DE-599)DOAJcd69eacc93a44e27b0efaeb59807ca4c DE-627 ger DE-627 rakwb eng SF600-1100 Ha-Young Shin verfasserin aut Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs. ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response Veterinary medicine Ha-Young Shin verfasserin aut Hyung Jun Jin verfasserin aut Hyung Jun Jin verfasserin aut Hyun-Jin Tae verfasserin aut Hong-Geun Oh verfasserin aut Jeong Ho Hwang verfasserin aut Jeong Ho Hwang verfasserin aut In Frontiers in Veterinary Science Frontiers Media S.A., 2015 11(2024) (DE-627)835029417 (DE-600)2834243-4 22971769 nnns volume:11 year:2024 https://doi.org/10.3389/fvets.2024.1296138 kostenfrei https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c kostenfrei https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full kostenfrei https://doaj.org/toc/2297-1769 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2024
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Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ovalbumin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">atopic dermatitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">canine atopic dermatitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">atopic dermatitis animal model</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">T helper 2 immune response</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Veterinary 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callnumber-first	S - Agriculture
author	Ha-Young Shin
spellingShingle	Ha-Young Shin misc SF600-1100 misc ovalbumin misc atopic dermatitis misc canine atopic dermatitis misc atopic dermatitis animal model misc T helper 2 immune response misc Veterinary medicine Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
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topic_title	SF600-1100 Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines ovalbumin atopic dermatitis canine atopic dermatitis atopic dermatitis animal model T helper 2 immune response
topic	misc SF600-1100 misc ovalbumin misc atopic dermatitis misc canine atopic dermatitis misc atopic dermatitis animal model misc T helper 2 immune response misc Veterinary medicine
topic_unstemmed	misc SF600-1100 misc ovalbumin misc atopic dermatitis misc canine atopic dermatitis misc atopic dermatitis animal model misc T helper 2 immune response misc Veterinary medicine
topic_browse	misc SF600-1100 misc ovalbumin misc atopic dermatitis misc canine atopic dermatitis misc atopic dermatitis animal model misc T helper 2 immune response misc Veterinary medicine
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title	Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
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title_full	Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
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author_browse	Ha-Young Shin Hyung Jun Jin Hyun-Jin Tae Hong-Geun Oh Jeong Ho Hwang
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title_sort	establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
callnumber	SF600-1100
title_auth	Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
abstract	IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.
abstractGer	IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.
abstract_unstemmed	IntroductionA reliable standard model is required to evaluate the efficacy of new drugs for companion animals, especially dogs. Canine atopic dermatitis (cAD), also known as allergic inflammatory skin disease, is a common condition. Currently, the house dust mite animal model is used in the research of cAD; however, this model exhibits significant individual variation and is difficult to standardize. In this study, we used ovalbumin as an antigen to sensitize and stimulate dogs, thereby establishing a stable model mimicking the T-helper 2 (Th2) response seen in cAD. Our objective was to create a cAD model that could be employed to evaluate the efficacy of novel drugs and mimic the Th2 dominant allergic response observed in the pathogenesis of atopic dermatitis of dogs.MethodsIn this study, six beagles were used. Normal saline was applied to two animals, and ovalbumin to four, on their dorsal skin.ResultsThe ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in the ovalbumin-treated group, with infiltration of inflammatory cells observed in the thickened dermis region. In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.
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title_short	Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines
url	https://doi.org/10.3389/fvets.2024.1296138 https://doaj.org/article/cd69eacc93a44e27b0efaeb59807ca4c https://www.frontiersin.org/articles/10.3389/fvets.2024.1296138/full https://doaj.org/toc/2297-1769
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author2	Ha-Young Shin Hyung Jun Jin Hyun-Jin Tae Hong-Geun Oh Jeong Ho Hwang
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up_date	2024-07-04T01:38:55.913Z
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In conclusion, treatment of canine skin with an optimal concentration of ovalbumin induced typical cAD-like symptoms, and histological and molecular analyses confirmed an enhanced Th2-related immune response.ConclusionTherefore, we successfully established a suitable Th2-dominant response mimicking cAD, which will facilitate targeted research of atopic dermatitis in dogs.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ovalbumin</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">atopic dermatitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">canine atopic dermatitis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">atopic dermatitis animal model</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">T helper 2 immune response</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Veterinary 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Establishment of an experimental model of ovalbumin-induced atopic dermatitis in canines

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