IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients

Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these pa...
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Autor*in:	Huan Xie [verfasserIn] Jing Zhang [verfasserIn] Ran Luo [verfasserIn] Yan Qi [verfasserIn] Yizhang Lin [verfasserIn] Changhao Han [verfasserIn] Xi Li [verfasserIn] Dongfeng Zeng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Lymphoma COVID-19 SARS-CoV-2 Antibody CD20

Übergeordnetes Werk:	In: BMC Immunology - BMC, 2003, 25(2024), 1, Seite 11
Übergeordnetes Werk:	volume:25 ; year:2024 ; number:1 ; pages:11

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12865-024-00596-1

Katalog-ID:	DOAJ097665010

Internformat


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520			\|a Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients.
650		4	\|a Lymphoma
650		4	\|a COVID-19
650		4	\|a SARS-CoV-2
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650		4	\|a CD20
653		0	\|a Immunologic diseases. Allergy
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912			\|a GBV_ILN_110
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912			\|a GBV_ILN_170
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912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2008
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912			\|a GBV_ILN_2010
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allfields	10.1186/s12865-024-00596-1 doi (DE-627)DOAJ097665010 (DE-599)DOAJ35b9b110fe554845bfb4c935a16c67ab DE-627 ger DE-627 rakwb eng RC581-607 Huan Xie verfasserin aut IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients. Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy Jing Zhang verfasserin aut Ran Luo verfasserin aut Yan Qi verfasserin aut Yizhang Lin verfasserin aut Changhao Han verfasserin aut Xi Li verfasserin aut Dongfeng Zeng verfasserin aut In BMC Immunology BMC, 2003 25(2024), 1, Seite 11 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:25 year:2024 number:1 pages:11 https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab kostenfrei https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 1 11
spelling	10.1186/s12865-024-00596-1 doi (DE-627)DOAJ097665010 (DE-599)DOAJ35b9b110fe554845bfb4c935a16c67ab DE-627 ger DE-627 rakwb eng RC581-607 Huan Xie verfasserin aut IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients. Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy Jing Zhang verfasserin aut Ran Luo verfasserin aut Yan Qi verfasserin aut Yizhang Lin verfasserin aut Changhao Han verfasserin aut Xi Li verfasserin aut Dongfeng Zeng verfasserin aut In BMC Immunology BMC, 2003 25(2024), 1, Seite 11 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:25 year:2024 number:1 pages:11 https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab kostenfrei https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 1 11
allfields_unstemmed	10.1186/s12865-024-00596-1 doi (DE-627)DOAJ097665010 (DE-599)DOAJ35b9b110fe554845bfb4c935a16c67ab DE-627 ger DE-627 rakwb eng RC581-607 Huan Xie verfasserin aut IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients. Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy Jing Zhang verfasserin aut Ran Luo verfasserin aut Yan Qi verfasserin aut Yizhang Lin verfasserin aut Changhao Han verfasserin aut Xi Li verfasserin aut Dongfeng Zeng verfasserin aut In BMC Immunology BMC, 2003 25(2024), 1, Seite 11 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:25 year:2024 number:1 pages:11 https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab kostenfrei https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 1 11
allfieldsGer	10.1186/s12865-024-00596-1 doi (DE-627)DOAJ097665010 (DE-599)DOAJ35b9b110fe554845bfb4c935a16c67ab DE-627 ger DE-627 rakwb eng RC581-607 Huan Xie verfasserin aut IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients. Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy Jing Zhang verfasserin aut Ran Luo verfasserin aut Yan Qi verfasserin aut Yizhang Lin verfasserin aut Changhao Han verfasserin aut Xi Li verfasserin aut Dongfeng Zeng verfasserin aut In BMC Immunology BMC, 2003 25(2024), 1, Seite 11 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:25 year:2024 number:1 pages:11 https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab kostenfrei https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 1 11
allfieldsSound	10.1186/s12865-024-00596-1 doi (DE-627)DOAJ097665010 (DE-599)DOAJ35b9b110fe554845bfb4c935a16c67ab DE-627 ger DE-627 rakwb eng RC581-607 Huan Xie verfasserin aut IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients. Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy Jing Zhang verfasserin aut Ran Luo verfasserin aut Yan Qi verfasserin aut Yizhang Lin verfasserin aut Changhao Han verfasserin aut Xi Li verfasserin aut Dongfeng Zeng verfasserin aut In BMC Immunology BMC, 2003 25(2024), 1, Seite 11 (DE-627)326644962 (DE-600)2041500-X 14712172 nnns volume:25 year:2024 number:1 pages:11 https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab kostenfrei https://doi.org/10.1186/s12865-024-00596-1 kostenfrei https://doaj.org/toc/1471-2172 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2024 1 11
language	English
source	In BMC Immunology 25(2024), 1, Seite 11 volume:25 year:2024 number:1 pages:11
sourceStr	In BMC Immunology 25(2024), 1, Seite 11 volume:25 year:2024 number:1 pages:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Lymphoma COVID-19 SARS-CoV-2 Antibody CD20 Immunologic diseases. Allergy
isfreeaccess_bool	true
container_title	BMC Immunology
authorswithroles_txt_mv	Huan Xie @@aut@@ Jing Zhang @@aut@@ Ran Luo @@aut@@ Yan Qi @@aut@@ Yizhang Lin @@aut@@ Changhao Han @@aut@@ Xi Li @@aut@@ Dongfeng Zeng @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	326644962
id	DOAJ097665010
language_de	englisch
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callnumber-first	R - Medicine
author	Huan Xie
spellingShingle	Huan Xie misc RC581-607 misc Lymphoma misc COVID-19 misc SARS-CoV-2 misc Antibody misc CD20 misc Immunologic diseases. Allergy IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients
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topic_title	RC581-607 IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients Lymphoma COVID-19 SARS-CoV-2 Antibody CD20
topic	misc RC581-607 misc Lymphoma misc COVID-19 misc SARS-CoV-2 misc Antibody misc CD20 misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc Lymphoma misc COVID-19 misc SARS-CoV-2 misc Antibody misc CD20 misc Immunologic diseases. Allergy
topic_browse	misc RC581-607 misc Lymphoma misc COVID-19 misc SARS-CoV-2 misc Antibody misc CD20 misc Immunologic diseases. Allergy
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title	IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients
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title_full	IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients
author_sort	Huan Xie
journal	BMC Immunology
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author_browse	Huan Xie Jing Zhang Ran Luo Yan Qi Yizhang Lin Changhao Han Xi Li Dongfeng Zeng
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class	RC581-607
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author-letter	Huan Xie
doi_str_mv	10.1186/s12865-024-00596-1
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title_sort	igg antibody response to sars-cov-2 infection and its influencing factors in lymphoma patients
callnumber	RC581-607
title_auth	IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients
abstract	Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients.
abstractGer	Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients.
abstract_unstemmed	Abstract Background The ability of generating effective humoral immune responses to SARS-CoV-2 infection has not been clarified in lymphoma patients. The study aimed to investigate the antibody (Ab) production after SARS-Cov-2 infection and clarify the factors affecting the Ab generation in these patients. Patients & methods 80 lymphoma patients and 51 healthy controls were included in this prospective observational study. Clinical factors and treatment regimens affecting Ab positive rate (APR) and Ab levels were analyzed by univariate and multivariate methods. Results The anti-SARS-CoV-2 IgG APR and Ab levels in lymphoma patients were significantly lower than those in healthy controls. Lymphoma patients with COVID-19 vaccination had significantly higher APR and Ab levels compared with those without vaccination. Additionally, the use of dexamethasone for COVID-19 treatment had a negative impact on Ab levels. For the impact of treatment regimens on the APR and Ab levels, the results showed that patients treated with ≥ 6 times CD20 monoclonal Ab (mAb) and patients treated with autologous hematopoietic stem cell transplantation (ASCT) prior to infection produced a statistically lower APR and Ab levels compared with those treated with 1–5 times CD20 mAb and those treated without ASCT, respectively. Furthermore, multiple regression analysis indicated that the number of anti-CD20 treatment was an independent predictor for both APR and Ab levels. Conclusions Humoral immune response to SARS-CoV-2 infection was impaired in lymphoma patients partly due to anti-CD20 and ASCT treatment. COVID-19 vaccination may be more needed for these patients.
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container_issue	1
title_short	IgG antibody response to SARS-CoV-2 infection and its influencing factors in lymphoma patients
url	https://doi.org/10.1186/s12865-024-00596-1 https://doaj.org/article/35b9b110fe554845bfb4c935a16c67ab https://doaj.org/toc/1471-2172
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author2	Jing Zhang Ran Luo Yan Qi Yizhang Lin Changhao Han Xi Li Dongfeng Zeng
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