Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus

Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglu...
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Autor*in:	Yan Huang [verfasserIn] Yong Xiao [verfasserIn] Linji Li [verfasserIn] Xinglong Feng [verfasserIn] Weixing Ding [verfasserIn] Feng Cai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	anesthesia propofol lateral hypothalamus glutamatergic neurons hM4Di receptors

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 18(2024)
Übergeordnetes Werk:	volume:18 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2024.1327293

Katalog-ID:	DOAJ097715115

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520			\|a Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals’ locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
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language	English
source	In Frontiers in Neuroscience 18(2024) volume:18 year:2024
sourceStr	In Frontiers in Neuroscience 18(2024) volume:18 year:2024
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institution	findex.gbv.de
topic_facet	anesthesia propofol lateral hypothalamus glutamatergic neurons hM4Di receptors Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Neuroscience
authorswithroles_txt_mv	Yan Huang @@aut@@ Yong Xiao @@aut@@ Linji Li @@aut@@ Xinglong Feng @@aut@@ Weixing Ding @@aut@@ Feng Cai @@aut@@
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callnumber-first	R - Medicine
author	Yan Huang
spellingShingle	Yan Huang misc RC321-571 misc anesthesia misc propofol misc lateral hypothalamus misc glutamatergic neurons misc hM4Di receptors misc Neurosciences. Biological psychiatry. Neuropsychiatry Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
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topic_title	RC321-571 Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus anesthesia propofol lateral hypothalamus glutamatergic neurons hM4Di receptors
topic	misc RC321-571 misc anesthesia misc propofol misc lateral hypothalamus misc glutamatergic neurons misc hM4Di receptors misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc anesthesia misc propofol misc lateral hypothalamus misc glutamatergic neurons misc hM4Di receptors misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
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title_full	Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
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title_sort	propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
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title_auth	Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
abstract	Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals’ locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
abstractGer	Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals’ locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
abstract_unstemmed	Propofol is the most widely used intravenous general anesthetic; however, the neuronal circuits that mediate its anesthetic effects are still poorly understood. Glutamatergic neurons in the lateral hypothalamus have been reported to be involved in maintenance of arousal and consciousness. Using Vglut2-Cre transgenic mice, we recorded this group of cells specifically and found that propofol can directly inhibit the glutamatergic neurons, and enhance inhibitory synaptic inputs on these cells, thereby reducing neuronal excitability. Through chemogenetic interventions, we found that inhibition of these neurons increased the duration of propofol-induced anesthesia and reduced movement in the animals after the recovery of right reflex. In contrast, activating this group of cells reduced the duration of propofol anesthesia and increased the animals’ locomotor activity after the recovery of right reflex. These results suggest that propofol-induced anesthesia involves the inhibition of glutamatergic neurons in the lateral hypothalamus.
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title_short	Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus
url	https://doi.org/10.3389/fnins.2024.1327293 https://doaj.org/article/088f93001aca4f5f8b95707c9734d13c https://www.frontiersin.org/articles/10.3389/fnins.2024.1327293/full https://doaj.org/toc/1662-453X
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Propofol-induced anesthesia involves the direct inhibition of glutamatergic neurons in the lateral hypothalamus

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