Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality

Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here,...
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Autor*in:	Akira Nishimura [verfasserIn] Sunghyeon Yoon [verfasserIn] Tetsuro Matsunaga [verfasserIn] Tomoaki Ida [verfasserIn] Minkyung Jung [verfasserIn] Seiryo Ogata [verfasserIn] Masanobu Morita [verfasserIn] Jun Yoshitake [verfasserIn] Yuka Unno [verfasserIn] Uladzimir Barayeu [verfasserIn] Tsuyoshi Takata [verfasserIn] Hiroshi Takagi [verfasserIn] Hozumi Motohashi [verfasserIn] Albert van der Vliet [verfasserIn] Takaaki Akaike [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity

Übergeordnetes Werk:	In: Redox Biology - Elsevier, 2013, 69(2024), Seite 103018-
Übergeordnetes Werk:	volume:69 ; year:2024 ; pages:103018-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.redox.2023.103018

Katalog-ID:	DOAJ097749222

Internformat


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520			\|a Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity.
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650		4	\|a ER stress
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700	0		\|a Sunghyeon Yoon \|e verfasserin \|4 aut
700	0		\|a Tetsuro Matsunaga \|e verfasserin \|4 aut
700	0		\|a Tomoaki Ida \|e verfasserin \|4 aut
700	0		\|a Minkyung Jung \|e verfasserin \|4 aut
700	0		\|a Seiryo Ogata \|e verfasserin \|4 aut
700	0		\|a Masanobu Morita \|e verfasserin \|4 aut
700	0		\|a Jun Yoshitake \|e verfasserin \|4 aut
700	0		\|a Yuka Unno \|e verfasserin \|4 aut
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700	0		\|a Tsuyoshi Takata \|e verfasserin \|4 aut
700	0		\|a Hiroshi Takagi \|e verfasserin \|4 aut
700	0		\|a Hozumi Motohashi \|e verfasserin \|4 aut
700	0		\|a Albert van der Vliet \|e verfasserin \|4 aut
700	0		\|a Takaaki Akaike \|e verfasserin \|4 aut
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allfields	10.1016/j.redox.2023.103018 doi (DE-627)DOAJ097749222 (DE-599)DOAJ7f0b088435fd49b3b0b93a146c4667df DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Akira Nishimura verfasserin aut Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity. Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General) Sunghyeon Yoon verfasserin aut Tetsuro Matsunaga verfasserin aut Tomoaki Ida verfasserin aut Minkyung Jung verfasserin aut Seiryo Ogata verfasserin aut Masanobu Morita verfasserin aut Jun Yoshitake verfasserin aut Yuka Unno verfasserin aut Uladzimir Barayeu verfasserin aut Tsuyoshi Takata verfasserin aut Hiroshi Takagi verfasserin aut Hozumi Motohashi verfasserin aut Albert van der Vliet verfasserin aut Takaaki Akaike verfasserin aut In Redox Biology Elsevier, 2013 69(2024), Seite 103018- (DE-627)735687307 (DE-600)2701011-9 22132317 nnns volume:69 year:2024 pages:103018- https://doi.org/10.1016/j.redox.2023.103018 kostenfrei https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df kostenfrei http://www.sciencedirect.com/science/article/pii/S2213231723004196 kostenfrei https://doaj.org/toc/2213-2317 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 69 2024 103018-
spelling	10.1016/j.redox.2023.103018 doi (DE-627)DOAJ097749222 (DE-599)DOAJ7f0b088435fd49b3b0b93a146c4667df DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Akira Nishimura verfasserin aut Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity. Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General) Sunghyeon Yoon verfasserin aut Tetsuro Matsunaga verfasserin aut Tomoaki Ida verfasserin aut Minkyung Jung verfasserin aut Seiryo Ogata verfasserin aut Masanobu Morita verfasserin aut Jun Yoshitake verfasserin aut Yuka Unno verfasserin aut Uladzimir Barayeu verfasserin aut Tsuyoshi Takata verfasserin aut Hiroshi Takagi verfasserin aut Hozumi Motohashi verfasserin aut Albert van der Vliet verfasserin aut Takaaki Akaike verfasserin aut In Redox Biology Elsevier, 2013 69(2024), Seite 103018- (DE-627)735687307 (DE-600)2701011-9 22132317 nnns volume:69 year:2024 pages:103018- https://doi.org/10.1016/j.redox.2023.103018 kostenfrei https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df kostenfrei http://www.sciencedirect.com/science/article/pii/S2213231723004196 kostenfrei https://doaj.org/toc/2213-2317 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 69 2024 103018-
allfields_unstemmed	10.1016/j.redox.2023.103018 doi (DE-627)DOAJ097749222 (DE-599)DOAJ7f0b088435fd49b3b0b93a146c4667df DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Akira Nishimura verfasserin aut Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity. Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General) Sunghyeon Yoon verfasserin aut Tetsuro Matsunaga verfasserin aut Tomoaki Ida verfasserin aut Minkyung Jung verfasserin aut Seiryo Ogata verfasserin aut Masanobu Morita verfasserin aut Jun Yoshitake verfasserin aut Yuka Unno verfasserin aut Uladzimir Barayeu verfasserin aut Tsuyoshi Takata verfasserin aut Hiroshi Takagi verfasserin aut Hozumi Motohashi verfasserin aut Albert van der Vliet verfasserin aut Takaaki Akaike verfasserin aut In Redox Biology Elsevier, 2013 69(2024), Seite 103018- (DE-627)735687307 (DE-600)2701011-9 22132317 nnns volume:69 year:2024 pages:103018- https://doi.org/10.1016/j.redox.2023.103018 kostenfrei https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df kostenfrei http://www.sciencedirect.com/science/article/pii/S2213231723004196 kostenfrei https://doaj.org/toc/2213-2317 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 69 2024 103018-
allfieldsGer	10.1016/j.redox.2023.103018 doi (DE-627)DOAJ097749222 (DE-599)DOAJ7f0b088435fd49b3b0b93a146c4667df DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Akira Nishimura verfasserin aut Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity. Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General) Sunghyeon Yoon verfasserin aut Tetsuro Matsunaga verfasserin aut Tomoaki Ida verfasserin aut Minkyung Jung verfasserin aut Seiryo Ogata verfasserin aut Masanobu Morita verfasserin aut Jun Yoshitake verfasserin aut Yuka Unno verfasserin aut Uladzimir Barayeu verfasserin aut Tsuyoshi Takata verfasserin aut Hiroshi Takagi verfasserin aut Hozumi Motohashi verfasserin aut Albert van der Vliet verfasserin aut Takaaki Akaike verfasserin aut In Redox Biology Elsevier, 2013 69(2024), Seite 103018- (DE-627)735687307 (DE-600)2701011-9 22132317 nnns volume:69 year:2024 pages:103018- https://doi.org/10.1016/j.redox.2023.103018 kostenfrei https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df kostenfrei http://www.sciencedirect.com/science/article/pii/S2213231723004196 kostenfrei https://doaj.org/toc/2213-2317 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 69 2024 103018-
allfieldsSound	10.1016/j.redox.2023.103018 doi (DE-627)DOAJ097749222 (DE-599)DOAJ7f0b088435fd49b3b0b93a146c4667df DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Akira Nishimura verfasserin aut Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity. Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General) Sunghyeon Yoon verfasserin aut Tetsuro Matsunaga verfasserin aut Tomoaki Ida verfasserin aut Minkyung Jung verfasserin aut Seiryo Ogata verfasserin aut Masanobu Morita verfasserin aut Jun Yoshitake verfasserin aut Yuka Unno verfasserin aut Uladzimir Barayeu verfasserin aut Tsuyoshi Takata verfasserin aut Hiroshi Takagi verfasserin aut Hozumi Motohashi verfasserin aut Albert van der Vliet verfasserin aut Takaaki Akaike verfasserin aut In Redox Biology Elsevier, 2013 69(2024), Seite 103018- (DE-627)735687307 (DE-600)2701011-9 22132317 nnns volume:69 year:2024 pages:103018- https://doi.org/10.1016/j.redox.2023.103018 kostenfrei https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df kostenfrei http://www.sciencedirect.com/science/article/pii/S2213231723004196 kostenfrei https://doaj.org/toc/2213-2317 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2088 GBV_ILN_2106 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 69 2024 103018-
language	English
source	In Redox Biology 69(2024), Seite 103018- volume:69 year:2024 pages:103018-
sourceStr	In Redox Biology 69(2024), Seite 103018- volume:69 year:2024 pages:103018-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity Medicine (General) Biology (General)
isfreeaccess_bool	true
container_title	Redox Biology
authorswithroles_txt_mv	Akira Nishimura @@aut@@ Sunghyeon Yoon @@aut@@ Tetsuro Matsunaga @@aut@@ Tomoaki Ida @@aut@@ Minkyung Jung @@aut@@ Seiryo Ogata @@aut@@ Masanobu Morita @@aut@@ Jun Yoshitake @@aut@@ Yuka Unno @@aut@@ Uladzimir Barayeu @@aut@@ Tsuyoshi Takata @@aut@@ Hiroshi Takagi @@aut@@ Hozumi Motohashi @@aut@@ Albert van der Vliet @@aut@@ Takaaki Akaike @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	735687307
id	DOAJ097749222
language_de	englisch
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callnumber-first	R - Medicine
author	Akira Nishimura
spellingShingle	Akira Nishimura misc R5-920 misc QH301-705.5 misc Supersulfides misc Cysteinyl-tRNA synthetase misc ER stress misc Mitochondrial energy metabolism misc Longevity misc Medicine (General) misc Biology (General) Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
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topic_title	R5-920 QH301-705.5 Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality Supersulfides Cysteinyl-tRNA synthetase ER stress Mitochondrial energy metabolism Longevity
topic	misc R5-920 misc QH301-705.5 misc Supersulfides misc Cysteinyl-tRNA synthetase misc ER stress misc Mitochondrial energy metabolism misc Longevity misc Medicine (General) misc Biology (General)
topic_unstemmed	misc R5-920 misc QH301-705.5 misc Supersulfides misc Cysteinyl-tRNA synthetase misc ER stress misc Mitochondrial energy metabolism misc Longevity misc Medicine (General) misc Biology (General)
topic_browse	misc R5-920 misc QH301-705.5 misc Supersulfides misc Cysteinyl-tRNA synthetase misc ER stress misc Mitochondrial energy metabolism misc Longevity misc Medicine (General) misc Biology (General)
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title	Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
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title_full	Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
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author_browse	Akira Nishimura Sunghyeon Yoon Tetsuro Matsunaga Tomoaki Ida Minkyung Jung Seiryo Ogata Masanobu Morita Jun Yoshitake Yuka Unno Uladzimir Barayeu Tsuyoshi Takata Hiroshi Takagi Hozumi Motohashi Albert van der Vliet Takaaki Akaike
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title_sort	longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
callnumber	R5-920
title_auth	Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
abstract	Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity.
abstractGer	Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity.
abstract_unstemmed	Supersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related supersulfides by cysteinyl-tRNA synthetase (CARS). Here, we investigated the physiological role of CysSSH in budding yeast (Saccharomyces cerevisiae) by generating a PLP-binding site mutation K109A in CRS1 (the yeast ortholog of CARS), which decreased the synthesis of CysSSH and related supersulfides and also led to reduced chronological aging, effects that were associated with an increased endoplasmic reticulum stress response and impaired mitochondrial bioenergetics. Reduced chronological aging in the K109A mutant could be rescued by using exogenous supersulfide donors. Our findings indicate important roles for CARS in the production and metabolism of supersulfides—to mediate mitochondrial function and to regulate longevity.
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title_short	Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality
url	https://doi.org/10.1016/j.redox.2023.103018 https://doaj.org/article/7f0b088435fd49b3b0b93a146c4667df http://www.sciencedirect.com/science/article/pii/S2213231723004196 https://doaj.org/toc/2213-2317
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up_date	2024-07-03T13:34:01.915Z
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Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality

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