Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database

Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical In...
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Autor*in:	Zhi-Peng Zhou [verfasserIn] Li Zhong [verfasserIn] Yan Liu [verfasserIn] Zhen-Jia Yang [verfasserIn] Jia-Jia Huang [verfasserIn] Da-Zheng Li [verfasserIn] Yu-Hua Chen [verfasserIn] Ying-Yi Luan [verfasserIn] Yong-Ming Yao [verfasserIn] Ming Wu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 14(2024)
Übergeordnetes Werk:	volume:14 ; year:2024

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2023.1261305

Katalog-ID:	DOAJ097751421

Internformat


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520			\|a Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3.
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allfields	10.3389/fphar.2023.1261305 doi (DE-627)DOAJ097751421 (DE-599)DOAJ69eed00d569c4086b350abe1a990d9db DE-627 ger DE-627 rakwb eng RM1-950 Zhi-Peng Zhou verfasserin aut Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3. heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology Li Zhong verfasserin aut Yan Liu verfasserin aut Yan Liu verfasserin aut Zhen-Jia Yang verfasserin aut Zhen-Jia Yang verfasserin aut Jia-Jia Huang verfasserin aut Da-Zheng Li verfasserin aut Yu-Hua Chen verfasserin aut Yu-Hua Chen verfasserin aut Ying-Yi Luan verfasserin aut Yong-Ming Yao verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2024 https://doi.org/10.3389/fphar.2023.1261305 kostenfrei https://doaj.org/article/69eed00d569c4086b350abe1a990d9db kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
spelling	10.3389/fphar.2023.1261305 doi (DE-627)DOAJ097751421 (DE-599)DOAJ69eed00d569c4086b350abe1a990d9db DE-627 ger DE-627 rakwb eng RM1-950 Zhi-Peng Zhou verfasserin aut Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3. heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology Li Zhong verfasserin aut Yan Liu verfasserin aut Yan Liu verfasserin aut Zhen-Jia Yang verfasserin aut Zhen-Jia Yang verfasserin aut Jia-Jia Huang verfasserin aut Da-Zheng Li verfasserin aut Yu-Hua Chen verfasserin aut Yu-Hua Chen verfasserin aut Ying-Yi Luan verfasserin aut Yong-Ming Yao verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2024 https://doi.org/10.3389/fphar.2023.1261305 kostenfrei https://doaj.org/article/69eed00d569c4086b350abe1a990d9db kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfields_unstemmed	10.3389/fphar.2023.1261305 doi (DE-627)DOAJ097751421 (DE-599)DOAJ69eed00d569c4086b350abe1a990d9db DE-627 ger DE-627 rakwb eng RM1-950 Zhi-Peng Zhou verfasserin aut Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3. heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology Li Zhong verfasserin aut Yan Liu verfasserin aut Yan Liu verfasserin aut Zhen-Jia Yang verfasserin aut Zhen-Jia Yang verfasserin aut Jia-Jia Huang verfasserin aut Da-Zheng Li verfasserin aut Yu-Hua Chen verfasserin aut Yu-Hua Chen verfasserin aut Ying-Yi Luan verfasserin aut Yong-Ming Yao verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2024 https://doi.org/10.3389/fphar.2023.1261305 kostenfrei https://doaj.org/article/69eed00d569c4086b350abe1a990d9db kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsGer	10.3389/fphar.2023.1261305 doi (DE-627)DOAJ097751421 (DE-599)DOAJ69eed00d569c4086b350abe1a990d9db DE-627 ger DE-627 rakwb eng RM1-950 Zhi-Peng Zhou verfasserin aut Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3. heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology Li Zhong verfasserin aut Yan Liu verfasserin aut Yan Liu verfasserin aut Zhen-Jia Yang verfasserin aut Zhen-Jia Yang verfasserin aut Jia-Jia Huang verfasserin aut Da-Zheng Li verfasserin aut Yu-Hua Chen verfasserin aut Yu-Hua Chen verfasserin aut Ying-Yi Luan verfasserin aut Yong-Ming Yao verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2024 https://doi.org/10.3389/fphar.2023.1261305 kostenfrei https://doaj.org/article/69eed00d569c4086b350abe1a990d9db kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
allfieldsSound	10.3389/fphar.2023.1261305 doi (DE-627)DOAJ097751421 (DE-599)DOAJ69eed00d569c4086b350abe1a990d9db DE-627 ger DE-627 rakwb eng RM1-950 Zhi-Peng Zhou verfasserin aut Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3. heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology Li Zhong verfasserin aut Yan Liu verfasserin aut Yan Liu verfasserin aut Zhen-Jia Yang verfasserin aut Zhen-Jia Yang verfasserin aut Jia-Jia Huang verfasserin aut Da-Zheng Li verfasserin aut Yu-Hua Chen verfasserin aut Yu-Hua Chen verfasserin aut Ying-Yi Luan verfasserin aut Yong-Ming Yao verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut Ming Wu verfasserin aut In Frontiers in Pharmacology Frontiers Media S.A., 2010 14(2024) (DE-627)642889392 (DE-600)2587355-6 16639812 nnns volume:14 year:2024 https://doi.org/10.3389/fphar.2023.1261305 kostenfrei https://doaj.org/article/69eed00d569c4086b350abe1a990d9db kostenfrei https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full kostenfrei https://doaj.org/toc/1663-9812 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2024
language	English
source	In Frontiers in Pharmacology 14(2024) volume:14 year:2024
sourceStr	In Frontiers in Pharmacology 14(2024) volume:14 year:2024
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model Therapeutics. Pharmacology
isfreeaccess_bool	true
container_title	Frontiers in Pharmacology
authorswithroles_txt_mv	Zhi-Peng Zhou @@aut@@ Li Zhong @@aut@@ Yan Liu @@aut@@ Zhen-Jia Yang @@aut@@ Jia-Jia Huang @@aut@@ Da-Zheng Li @@aut@@ Yu-Hua Chen @@aut@@ Ying-Yi Luan @@aut@@ Yong-Ming Yao @@aut@@ Ming Wu @@aut@@
publishDateDaySort_date	2024-01-01T00:00:00Z
hierarchy_top_id	642889392
id	DOAJ097751421
language_de	englisch
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callnumber-first	R - Medicine
author	Zhi-Peng Zhou
spellingShingle	Zhi-Peng Zhou misc RM1-950 misc heparin misc sepsis-associated acute kidney injury misc outcome misc mortality misc marginal structural Cox model misc Therapeutics. Pharmacology Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
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topic_title	RM1-950 Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database heparin sepsis-associated acute kidney injury outcome mortality marginal structural Cox model
topic	misc RM1-950 misc heparin misc sepsis-associated acute kidney injury misc outcome misc mortality misc marginal structural Cox model misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc heparin misc sepsis-associated acute kidney injury misc outcome misc mortality misc marginal structural Cox model misc Therapeutics. Pharmacology
topic_browse	misc RM1-950 misc heparin misc sepsis-associated acute kidney injury misc outcome misc mortality misc marginal structural Cox model misc Therapeutics. Pharmacology
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title	Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
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title_full	Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
author_sort	Zhi-Peng Zhou
journal	Frontiers in Pharmacology
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author_browse	Zhi-Peng Zhou Li Zhong Yan Liu Zhen-Jia Yang Jia-Jia Huang Da-Zheng Li Yu-Hua Chen Ying-Yi Luan Yong-Ming Yao Ming Wu
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title_sort	impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the mimic-iv database
callnumber	RM1-950
title_auth	Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
abstract	Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3.
abstractGer	Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3.
abstract_unstemmed	Background: Inflammatory-coagulation dysfunction plays an increasingly important role in sepsis associated acute kidney injury (SAKI). This study aimed to investigate whether early heparin therapy improves survival in patients with SAKI.Methods: Patients with SAKI were identified from the Medical Information Mart for Intensive Care-IV database. The patients were divided into two groups: those who received heparin subcutaneously within 48 h after intensive care unit (ICU) admission and the control group, who received no heparin. The primary endpoint was ICU mortality, the secondary outcomes were 7-day, 14-day, 28-day, and hospital mortality. Propensity score matching (PSM), marginal structural Cox model (MSCM), and E-value analyses were performed.Results: The study included 5623 individuals with SAKI, 2410 of whom received heparin and 3213 of whom did not. There were significant effects on ICU and 28-day mortality in the overall population with PSM. MSCM further reinforces the efficacy of heparin administration reduces ICU mortality in the general population. Stratification analysis with MSCM showed that heparin administration was associated with decreased ICU mortality at various AKI stages. Heparin use was also associated with reduced 28-day mortality in patients with only female, age >60 years, and AKI stage 3, with HRs of 0.79, 0.77, and 0.60, respectively (p < 0.05). E-value analysis suggests robustness to unmeasured confounding.Conclusion: Early heparin therapy for patients with SAKI decreased ICU mortality. Further analysis demonstrated that heparin therapy was associated with reduced 28-day mortality rate in patients only among female, age > 60 years and AKI stage 3.
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title_short	Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database
url	https://doi.org/10.3389/fphar.2023.1261305 https://doaj.org/article/69eed00d569c4086b350abe1a990d9db https://www.frontiersin.org/articles/10.3389/fphar.2023.1261305/full https://doaj.org/toc/1663-9812
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author2	Li Zhong Yan Liu Zhen-Jia Yang Jia-Jia Huang Da-Zheng Li Yu-Hua Chen Ying-Yi Luan Yong-Ming Yao Ming Wu
author2Str	Li Zhong Yan Liu Zhen-Jia Yang Jia-Jia Huang Da-Zheng Li Yu-Hua Chen Ying-Yi Luan Yong-Ming Yao Ming Wu
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up_date	2024-07-03T13:34:51.852Z
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Impact of early heparin therapy on mortality in critically ill patients with sepsis associated acute kidney injury: a retrospective study from the MIMIC-IV database

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