Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor

A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was in...
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Autor*in:	Yao Wu [verfasserIn] Guiyu Wang [verfasserIn] Xiujuan Yu [verfasserIn] Yuanji Fan [verfasserIn] Xuefeng Chen [verfasserIn] Shengchun Liu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity

Übergeordnetes Werk:	In: Sensors - MDPI AG, 2003, 24(2024), 1, p 278
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1, p 278

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/s24010278

Katalog-ID:	DOAJ097769320

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520			\|a A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.
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allfields	10.3390/s24010278 doi (DE-627)DOAJ097769320 (DE-599)DOAJ8fc215d2c45f445baa2ead8dbfa58ef1 DE-627 ger DE-627 rakwb eng TP1-1185 Yao Wu verfasserin aut Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields. optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity Chemical technology Guiyu Wang verfasserin aut Xiujuan Yu verfasserin aut Yuanji Fan verfasserin aut Xuefeng Chen verfasserin aut Shengchun Liu verfasserin aut In Sensors MDPI AG, 2003 24(2024), 1, p 278 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:24 year:2024 number:1, p 278 https://doi.org/10.3390/s24010278 kostenfrei https://doaj.org/article/8fc215d2c45f445baa2ead8dbfa58ef1 kostenfrei https://www.mdpi.com/1424-8220/24/1/278 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1, p 278
spelling	10.3390/s24010278 doi (DE-627)DOAJ097769320 (DE-599)DOAJ8fc215d2c45f445baa2ead8dbfa58ef1 DE-627 ger DE-627 rakwb eng TP1-1185 Yao Wu verfasserin aut Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields. optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity Chemical technology Guiyu Wang verfasserin aut Xiujuan Yu verfasserin aut Yuanji Fan verfasserin aut Xuefeng Chen verfasserin aut Shengchun Liu verfasserin aut In Sensors MDPI AG, 2003 24(2024), 1, p 278 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:24 year:2024 number:1, p 278 https://doi.org/10.3390/s24010278 kostenfrei https://doaj.org/article/8fc215d2c45f445baa2ead8dbfa58ef1 kostenfrei https://www.mdpi.com/1424-8220/24/1/278 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1, p 278
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allfieldsSound	10.3390/s24010278 doi (DE-627)DOAJ097769320 (DE-599)DOAJ8fc215d2c45f445baa2ead8dbfa58ef1 DE-627 ger DE-627 rakwb eng TP1-1185 Yao Wu verfasserin aut Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields. optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity Chemical technology Guiyu Wang verfasserin aut Xiujuan Yu verfasserin aut Yuanji Fan verfasserin aut Xuefeng Chen verfasserin aut Shengchun Liu verfasserin aut In Sensors MDPI AG, 2003 24(2024), 1, p 278 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:24 year:2024 number:1, p 278 https://doi.org/10.3390/s24010278 kostenfrei https://doaj.org/article/8fc215d2c45f445baa2ead8dbfa58ef1 kostenfrei https://www.mdpi.com/1424-8220/24/1/278 kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1, p 278
language	English
source	In Sensors 24(2024), 1, p 278 volume:24 year:2024 number:1, p 278
sourceStr	In Sensors 24(2024), 1, p 278 volume:24 year:2024 number:1, p 278
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topic_facet	optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity Chemical technology
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authorswithroles_txt_mv	Yao Wu @@aut@@ Guiyu Wang @@aut@@ Xiujuan Yu @@aut@@ Yuanji Fan @@aut@@ Xuefeng Chen @@aut@@ Shengchun Liu @@aut@@
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callnumber-first	T - Technology
author	Yao Wu
spellingShingle	Yao Wu misc TP1-1185 misc optical fiber sensor misc Mach–Zehnder interferometer misc DNA hybridization detection misc label-free biosensor misc open cavity misc Chemical technology Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor
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topic_title	TP1-1185 Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor optical fiber sensor Mach–Zehnder interferometer DNA hybridization detection label-free biosensor open cavity
topic	misc TP1-1185 misc optical fiber sensor misc Mach–Zehnder interferometer misc DNA hybridization detection misc label-free biosensor misc open cavity misc Chemical technology
topic_unstemmed	misc TP1-1185 misc optical fiber sensor misc Mach–Zehnder interferometer misc DNA hybridization detection misc label-free biosensor misc open cavity misc Chemical technology
topic_browse	misc TP1-1185 misc optical fiber sensor misc Mach–Zehnder interferometer misc DNA hybridization detection misc label-free biosensor misc open cavity misc Chemical technology
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title	Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor
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title_full	Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor
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title_sort	label-free dna hybridization detection using a highly sensitive fiber microcavity biosensor
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title_auth	Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor
abstract	A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.
abstractGer	A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.
abstract_unstemmed	A novel label-free optical fiber biosensor, based on a microcavity fiber Mach–Zehnder interferometer, was developed and practically demonstrated for DNA detection. The biosensor was fabricated using offset splicing standard communication single-mode fibers (SMFs). The light path of the sensor was influenced by the liquid sample in the offset open cavity. In the experiment, a high sensitivity of −17,905 nm/RIU was achieved in the refractive index (RI) measurement. On this basis, the probe DNA (pDNA) was immobilized onto the sensor’s surface using APTES, enabling real-time monitoring of captured complementary DNA (cDNA) samples. The experimental results demonstrate that the biosensor exhibited a high sensitivity of 0.32 nm/fM and a limit of detection of 48.9 aM. Meanwhile, the sensor has highly repeatable and specific performance. This work reports an easy-to-manufacture, ultrasensitive, and label-free DNA biosensor, which has significant potential applications in medical diagnostics, bioengineering, gene identification, environmental science, and other biological fields.
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container_issue	1, p 278
title_short	Label-Free DNA Hybridization Detection Using a Highly Sensitive Fiber Microcavity Biosensor
url	https://doi.org/10.3390/s24010278 https://doaj.org/article/8fc215d2c45f445baa2ead8dbfa58ef1 https://www.mdpi.com/1424-8220/24/1/278 https://doaj.org/toc/1424-8220
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author2	Guiyu Wang Xiujuan Yu Yuanji Fan Xuefeng Chen Shengchun Liu
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up_date	2024-07-03T13:40:43.133Z
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