G-Quadruplexes in Human Telomere: Structures, Properties, and Applications

G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-qua...
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Autor*in:	Yan Xu [verfasserIn] Makoto Komiyama [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	DNA G-quadruplex RNA G-quadruplex DNA:RNA hybrid G-quadruplex

Übergeordnetes Werk:	In: Molecules - MDPI AG, 2003, 29(2023), 1, p 174
Übergeordnetes Werk:	volume:29 ; year:2023 ; number:1, p 174

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/molecules29010174

Katalog-ID:	DOAJ097781568

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spelling	10.3390/molecules29010174 doi (DE-627)DOAJ097781568 (DE-599)DOAJ5862632889434736b14b78cad0ac1975 DE-627 ger DE-627 rakwb eng QD241-441 Yan Xu verfasserin aut G-Quadruplexes in Human Telomere: Structures, Properties, and Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-quadruplexes adds a layer of complexity to their structural diversity. This review provides a comprehensive overview of recent advancements in unraveling the intricacies of DNA and RNA G-quadruplexes within human telomeres. Detailed insights into their structural features are presented, encompassing the latest developments in chemical approaches designed to probe these G-quadruplex structures. Furthermore, this review explores the applications of G-quadruplex structures in targeting human telomeres. Finally, the manuscript outlines the imminent challenges in this evolving field, setting the stage for future investigations. DNA G-quadruplex RNA G-quadruplex DNA:RNA hybrid G-quadruplex Organic chemistry Makoto Komiyama verfasserin aut In Molecules MDPI AG, 2003 29(2023), 1, p 174 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:29 year:2023 number:1, p 174 https://doi.org/10.3390/molecules29010174 kostenfrei https://doaj.org/article/5862632889434736b14b78cad0ac1975 kostenfrei https://www.mdpi.com/1420-3049/29/1/174 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2023 1, p 174
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allfieldsSound	10.3390/molecules29010174 doi (DE-627)DOAJ097781568 (DE-599)DOAJ5862632889434736b14b78cad0ac1975 DE-627 ger DE-627 rakwb eng QD241-441 Yan Xu verfasserin aut G-Quadruplexes in Human Telomere: Structures, Properties, and Applications 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-quadruplexes adds a layer of complexity to their structural diversity. This review provides a comprehensive overview of recent advancements in unraveling the intricacies of DNA and RNA G-quadruplexes within human telomeres. Detailed insights into their structural features are presented, encompassing the latest developments in chemical approaches designed to probe these G-quadruplex structures. Furthermore, this review explores the applications of G-quadruplex structures in targeting human telomeres. Finally, the manuscript outlines the imminent challenges in this evolving field, setting the stage for future investigations. DNA G-quadruplex RNA G-quadruplex DNA:RNA hybrid G-quadruplex Organic chemistry Makoto Komiyama verfasserin aut In Molecules MDPI AG, 2003 29(2023), 1, p 174 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:29 year:2023 number:1, p 174 https://doi.org/10.3390/molecules29010174 kostenfrei https://doaj.org/article/5862632889434736b14b78cad0ac1975 kostenfrei https://www.mdpi.com/1420-3049/29/1/174 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 29 2023 1, p 174
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author	Yan Xu
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topic_title	QD241-441 G-Quadruplexes in Human Telomere: Structures, Properties, and Applications DNA G-quadruplex RNA G-quadruplex DNA:RNA hybrid G-quadruplex
topic	misc QD241-441 misc DNA G-quadruplex misc RNA G-quadruplex misc DNA:RNA hybrid G-quadruplex misc Organic chemistry
topic_unstemmed	misc QD241-441 misc DNA G-quadruplex misc RNA G-quadruplex misc DNA:RNA hybrid G-quadruplex misc Organic chemistry
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title	G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
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title_full	G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
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title_sort	g-quadruplexes in human telomere: structures, properties, and applications
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title_auth	G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
abstract	G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-quadruplexes adds a layer of complexity to their structural diversity. This review provides a comprehensive overview of recent advancements in unraveling the intricacies of DNA and RNA G-quadruplexes within human telomeres. Detailed insights into their structural features are presented, encompassing the latest developments in chemical approaches designed to probe these G-quadruplex structures. Furthermore, this review explores the applications of G-quadruplex structures in targeting human telomeres. Finally, the manuscript outlines the imminent challenges in this evolving field, setting the stage for future investigations.
abstractGer	G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-quadruplexes adds a layer of complexity to their structural diversity. This review provides a comprehensive overview of recent advancements in unraveling the intricacies of DNA and RNA G-quadruplexes within human telomeres. Detailed insights into their structural features are presented, encompassing the latest developments in chemical approaches designed to probe these G-quadruplex structures. Furthermore, this review explores the applications of G-quadruplex structures in targeting human telomeres. Finally, the manuscript outlines the imminent challenges in this evolving field, setting the stage for future investigations.
abstract_unstemmed	G-quadruplexes, intricate four-stranded structures composed of G-tetrads formed by four guanine bases, are prevalent in both DNA and RNA. Notably, these structures play pivotal roles in human telomeres, contributing to essential cellular functions. Additionally, the existence of DNA:RNA hybrid G-quadruplexes adds a layer of complexity to their structural diversity. This review provides a comprehensive overview of recent advancements in unraveling the intricacies of DNA and RNA G-quadruplexes within human telomeres. Detailed insights into their structural features are presented, encompassing the latest developments in chemical approaches designed to probe these G-quadruplex structures. Furthermore, this review explores the applications of G-quadruplex structures in targeting human telomeres. Finally, the manuscript outlines the imminent challenges in this evolving field, setting the stage for future investigations.
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title_short	G-Quadruplexes in Human Telomere: Structures, Properties, and Applications
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Nicht das Richtige dabei?